LOCUS       NM_001100781            2358 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus Nanog homeobox (Nanog), mRNA.
ACCESSION   NM_001100781 XM_001060618 XM_575662
VERSION     NM_001100781.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2358)
  AUTHORS   Ding Z, Dai C, Shan W, Liu R, Lu W, Gao W, Zhang H, Huang W, Guan J
            and Yin Z.
  TITLE     TNF-alpha up-regulates Nanog by activating NF-kappaB pathway to
            induce primary rat spinal cord astrocytes dedifferentiation
  JOURNAL   Life Sci 287, 120126 (2021)
   PUBMED   34758295
  REMARK    GeneRIF: TNF-alpha up-regulates Nanog by activating NF-kappaB
            pathway to induce primary rat spinal cord astrocytes
            dedifferentiation.
REFERENCE   2  (bases 1 to 2358)
  AUTHORS   Chang CC, Li HH, Tsou SH, Hung HC, Liu GY, Korolenko TA, Lai TJ, Ho
            YJ and Lin CL.
  TITLE     The Pluripotency Factor Nanog Protects against Neuronal Amyloid
            beta-Induced Toxicity and Oxidative Stress through Insulin
            Sensitivity Restoration
  JOURNAL   Cells 9 (6), 1339 (2020)
   PUBMED   32471175
  REMARK    GeneRIF: The Pluripotency Factor Nanog Protects against Neuronal
            Amyloid beta-Induced Toxicity and Oxidative Stress through Insulin
            Sensitivity Restoration.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2358)
  AUTHORS   Festuccia N, Dubois A, Vandormael-Pournin S, Gallego Tejeda E,
            Mouren A, Bessonnard S, Mueller F, Proux C, Cohen-Tannoudji M and
            Navarro P.
  TITLE     Mitotic binding of Esrrb marks key regulatory regions of the
            pluripotency network
  JOURNAL   Nat Cell Biol 18 (11), 1139-1148 (2016)
   PUBMED   27723719
REFERENCE   4  (bases 1 to 2358)
  AUTHORS   Gu J, Ni Y, Xu L, Xu H and Cai Z.
  TITLE     Nanog interact with CDK6 to regulates astrocyte cells proliferation
            following spinal cord injury
  JOURNAL   Biochem Biophys Res Commun 469 (4), 1097-1103 (2016)
   PUBMED   26707878
  REMARK    GeneRIF: Taken together, these data suggested that both Nanog may
            play important roles in spinal cord pathophysiology via interact
            with CDK6.
REFERENCE   5  (bases 1 to 2358)
  AUTHORS   Hayashi Y, Caboni L, Das D, Yumoto F, Clayton T, Deller MC, Nguyen
            P, Farr CL, Chiu HJ, Miller MD, Elsliger MA, Deacon AM, Godzik A,
            Lesley SA, Tomoda K, Conklin BR, Wilson IA, Yamanaka S and
            Fletterick RJ.
  TITLE     Structure-based discovery of NANOG variant with enhanced properties
            to promote self-renewal and reprogramming of pluripotent stem cells
  JOURNAL   Proc Natl Acad Sci U S A 112 (15), 4666-4671 (2015)
   PUBMED   25825768
REFERENCE   6  (bases 1 to 2358)
  AUTHORS   Strumpf D, Mao CA, Yamanaka Y, Ralston A, Chawengsaksophak K, Beck
            F and Rossant J.
  TITLE     Cdx2 is required for correct cell fate specification and
            differentiation of trophectoderm in the mouse blastocyst
  JOURNAL   Development 132 (9), 2093-2102 (2005)
   PUBMED   15788452
REFERENCE   7  (bases 1 to 2358)
  AUTHORS   Hatano SY, Tada M, Kimura H, Yamaguchi S, Kono T, Nakano T, Suemori
            H, Nakatsuji N and Tada T.
  TITLE     Pluripotential competence of cells associated with Nanog activity
  JOURNAL   Mech Dev 122 (1), 67-79 (2005)
   PUBMED   15582778
REFERENCE   8  (bases 1 to 2358)
  AUTHORS   Hart AH, Hartley L, Ibrahim M and Robb L.
  TITLE     Identification, cloning and expression analysis of the pluripotency
            promoting Nanog genes in mouse and human
  JOURNAL   Dev Dyn 230 (1), 187-198 (2004)
   PUBMED   15108323
REFERENCE   9  (bases 1 to 2358)
  AUTHORS   Chambers I, Colby D, Robertson M, Nichols J, Lee S, Tweedie S and
            Smith A.
  TITLE     Functional expression cloning of Nanog, a pluripotency sustaining
            factor in embryonic stem cells
  JOURNAL   Cell 113 (5), 643-655 (2003)
   PUBMED   12787505
REFERENCE   10 (bases 1 to 2358)
  AUTHORS   Mitsui K, Tokuzawa Y, Itoh H, Segawa K, Murakami M, Takahashi K,
            Maruyama M, Maeda M and Yamanaka S.
  TITLE     The homeoprotein Nanog is required for maintenance of pluripotency
            in mouse epiblast and ES cells
  JOURNAL   Cell 113 (5), 631-642 (2003)
   PUBMED   12787504
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473964.2.
            
            On or before Sep 6, 2008 this sequence version replaced
            XM_575662.2, XM_001060618.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2358
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..2358
                     /gene="Nanog"
                     /note="Nanog homeobox"
                     /db_xref="GeneID:414065"
                     /db_xref="RGD:1303178"
     exon            1..357
                     /gene="Nanog"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..1142
                     /gene="Nanog"
                     /codon_start=1
                     /product="homeobox protein NANOG"
                     /protein_id="NP_001094251.1"
                     /db_xref="GeneID:414065"
                     /db_xref="RGD:1303178"
                     /translation="MSVDLSGPHSLPSCEEASNSGDSSPMPAVHLPEENYSCLQVSAT
                     EMLCTETASPPPSSGDLPLQDSPDSSSNPKLKLSGPEADEGPEKKEENKVLTKKQKMR
                     TVFSQAQLCALKDRFQRQRYLSLQQMQDLSTILNLSYKQVKTWFQNQRMKCKRWQKNQ
                     WLKTSNGLTQKGSAPVEYPSIHCSYSQGYLMNASGNLPVWGSQTWTNPTWNNQTWTNP
                     TWSNQTWTNPTWSNQAWSTQSWCTQAWNSQTWNAAPLHNFGEDSLQPYVPLQQNFSAS
                     DLEANLEATRESQAHFSTPQALELFLNYSVNSPGEI"
     exon            358..626
                     /gene="Nanog"
                     /inference="alignment:Splign:2.1.0"
     exon            627..713
                     /gene="Nanog"
                     /inference="alignment:Splign:2.1.0"
     exon            714..2358
                     /gene="Nanog"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcagataggc tgatttcgag tctttctctt ttgtgggaag accgaggctc gcttcttttt
       61 ggcttgttga ctcttttaca tctggacatt taactcttac ttttaagatc tttccctcta
      121 gacactgagt tttaaagtct taactttttg gttgttaaaa actttttttt ttttaaagtc
      181 ccttcccttg ccgttgggct gacatgagcg tggatctttc tggtccccac agtctgccta
      241 gttgtgagga agcatcgaac tctggggatt cctcgccgat gcctgccgtt catcttcctg
      301 aggaaaatta ttcttgctta caagtgtctg ctactgagat gctctgcaca gagactgcct
      361 ctcctccgcc ttcctctggg gacctacctc ttcaagatag ccctgattct tctagcaatc
      421 ccaagctaaa gctgtctggt cccgaggctg acgagggccc tgagaagaaa gaagagaaca
      481 aggtcctcac caagaagcag aagatgcgga ctgtgttctc tcaggcccag ttgtgtgcac
      541 tcaaggatag gtttcagagg caaaggtacc tcagcctcca gcagatgcaa gatctctcta
      601 ccattctgaa cctgagctat aagcaggtga agacctggtt ccaaaaccaa agaatgaagt
      661 gcaagaggtg gcagaaaaac caatggttga agactagcaa cggcctgact cagaagggct
      721 cagcgccggt ggagtatccc agcatccatt gcagctattc tcagggctat ctgatgaacg
      781 cgtctggaaa ccttccagta tggggcagtc agacctggac caacccaact tggaacaacc
      841 agacctggac caacccaacc tggagcaacc agacctggac caacccaact tggagcaacc
      901 aggcctggag cactcagtcc tggtgtactc aggcctggaa cagccagact tggaacgctg
      961 ctccgctcca taacttcggg gaggactccc tgcagcctta tgtgccgttg cagcaaaact
     1021 tctccgccag tgatttggag gcgaatttgg aagccactag ggaaagccag gcgcatttta
     1081 gtaccccgca agccttggaa ttgttcctga actactccgt gaattctcca ggcgaaatat
     1141 gaggtttaca caacaactgg gcttaaagtc agggcagggc cagggtcagc tttcttcctt
     1201 cttccaaaga gttttatatt gttcttattt tttttttaat tattattttg tttttgtttt
     1261 ttgtttatca aggtagggtt tctctgtgtg gttctggctg tcctggaatt cactctgtag
     1321 accaggctgg cctcgtactc agagatctgc ctacttttgc ctcctgaagg ctagggctaa
     1381 agattttcta aagattttca tagtttttat ttttttaatt attatctgtt ttcatgtttg
     1441 tgtttttttg ttttgttttt gtttttgttt ttgtttatca agatagggtt tctctgtgtg
     1501 gctctagtag tcccggaaac tggctctgta gaccaggctg tccttgaact cagaaatctg
     1561 cctttgcctc cggactgcgg ggactaaagg cagtatataa ccacctggca cattgttttt
     1621 atttttattc ttttggtgcc agaaagcaaa cctaggactt tgagctgggc acccactcaa
     1681 ccactgagct ctgtttgcga cccccgtgtt ggctgcattt gtctgagctg ggtaacttgt
     1741 ctttttttcc gtgttaacga tgggcttcgg agacagtgca ctatacactc tatcctcccc
     1801 caggtctcac acacccaccc tactccatac caacccaggc ttgtctgtct tttttttttt
     1861 tggagctgag gactgaaccc agggccttgc gctttctagg caagcgctct acctctgagc
     1921 taaatcccca acccttgtct gtctttttag aagcttgggt cttggtgtgc actgtgtatc
     1981 gttttgaggg gtgaggttta aaagtataca aattataaag attcatgcag atatggtggc
     2041 tcctctcaag gacgagacag aaggatcacc agtttgaggc tatctcagat ataaaataag
     2101 ttcaagacca gcctgtacta tgtctaaata gtaagacagc atctcaacaa aataataaaa
     2161 ctaaggtaag gagataaaag taaagtctca acaaaataca agatctcgcc tgttacagtt
     2221 ctttgatttc ctccgtgtct ttgcagttcc gccaagaggc ttctatgtta atatctgtag
     2281 aaagatgttt atatttgact gtaccatgat aaaccagtgc cagctggact agtttaaata
     2341 aaacactaat tttaccca
//
