LOCUS       NM_177928               2590 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus nicotinamide phosphoribosyltransferase (Nampt),
            mRNA.
ACCESSION   NM_177928
VERSION     NM_177928.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2590)
  AUTHORS   Li,D., Chen,Y., Wang,Y., Liu,J., Chai,L., Zhang,Q., Qiu,Y.,
            Chen,H., Shen,N., Shi,X. and Li,M.
  TITLE     NAMPT mediates PDGF-induced pulmonary arterial smooth muscle cell
            proliferation by TLR4/NF-kappaB/PLK4 signaling pathway
  JOURNAL   Eur J Pharmacol 961, 176151 (2023)
   PUBMED   37914064
  REMARK    GeneRIF: NAMPT mediates PDGF-induced pulmonary arterial smooth
            muscle cell proliferation by TLR4/NF-kappaB/PLK4 signaling pathway.
REFERENCE   2  (bases 1 to 2590)
  AUTHORS   Miao,J., He,X., Hu,J. and Cai,W.
  TITLE     Emodin inhibits NF-kappaB signaling pathway to protect obese
            asthmatic rats from pathological damage via Visfatin
  JOURNAL   Tissue Cell 74, 101713 (2022)
   PUBMED   34952398
  REMARK    GeneRIF: Emodin inhibits NF-kappaB signaling pathway to protect
            obese asthmatic rats from pathological damage via Visfatin.
REFERENCE   3  (bases 1 to 2590)
  AUTHORS   Lei,M., Tao,M.Q., Wu,Y.J., Xu,L., Yang,Z., Li,Y., Olatunji,O.J.,
            Wang,X.W. and Zuo,J.
  TITLE     Metabolic Enzyme Triosephosphate Isomerase 1 and Nicotinamide
            Phosphoribosyltransferase, Two Independent Inflammatory Indicators
            in Rheumatoid Arthritis: Evidences From Collagen-Induced Arthritis
            and Clinical Samples
  JOURNAL   Front Immunol 12, 795626 (2022)
   PUBMED   35111160
  REMARK    GeneRIF: Metabolic Enzyme Triosephosphate Isomerase 1 and
            Nicotinamide Phosphoribosyltransferase, Two Independent
            Inflammatory Indicators in Rheumatoid Arthritis: Evidences From
            Collagen-Induced Arthritis and Clinical Samples.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2590)
  AUTHORS   Zhang,H., Wang,L., Xiang,Y., Wang,Y. and Li,H.
  TITLE     Nampt promotes fibroblast extracellular matrix degradation in
            stress urinary incontinence by inhibiting autophagy
  JOURNAL   Bioengineered 13 (1), 481-495 (2022)
   PUBMED   34967693
  REMARK    GeneRIF: Nampt promotes fibroblast extracellular matrix degradation
            in stress urinary incontinence by inhibiting autophagy.
REFERENCE   5  (bases 1 to 2590)
  AUTHORS   Sun,Y., Li,X., Yang,X., Chen,B. and Zhang,W.
  TITLE     Small Extracellular Vesicles Derived from Adipocytes Attenuate
            Intervertebral Disc Degeneration in Rats by Rejuvenating Senescent
            Nucleus Pulposus Cells and Endplate Cells by Delivering Exogenous
            NAMPT
  JOURNAL   Oxid Med Cell Longev 2021, 9955448 (2021)
   PUBMED   34434488
  REMARK    GeneRIF: Small Extracellular Vesicles Derived from Adipocytes
            Attenuate Intervertebral Disc Degeneration in Rats by Rejuvenating
            Senescent Nucleus Pulposus Cells and Endplate Cells by Delivering
            Exogenous NAMPT.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2590)
  AUTHORS   Wang,T., Zhang,X., Bheda,P., Revollo,J.R., Imai,S. and Wolberger,C.
  TITLE     Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic
            enzyme
  JOURNAL   Nat Struct Mol Biol 13 (7), 661-662 (2006)
   PUBMED   16783373
REFERENCE   7  (bases 1 to 2590)
  AUTHORS   Kloting,N. and Kloting,I.
  TITLE     Visfatin: gene expression in isolated adipocytes and sequence
            analysis in obese WOKW rats compared with lean control rats
  JOURNAL   Biochem Biophys Res Commun 332 (4), 1070-1072 (2005)
   PUBMED   15922301
  REMARK    GeneRIF: relative visfatin gene expression is not associated with
            the metabolic syndrome in WOKW rats [Pbef, also called visfatin]
REFERENCE   8  (bases 1 to 2590)
  AUTHORS   Revollo,J.R., Grimm,A.A. and Imai,S.
  TITLE     The NAD biosynthesis pathway mediated by nicotinamide
            phosphoribosyltransferase regulates Sir2 activity in mammalian
            cells
  JOURNAL   J Biol Chem 279 (49), 50754-50763 (2004)
   PUBMED   15381699
REFERENCE   9  (bases 1 to 2590)
  AUTHORS   Kitani,T., Okuno,S. and Fujisawa,H.
  TITLE     Growth phase-dependent changes in the subcellular localization of
            pre-B-cell colony-enhancing factor
  JOURNAL   FEBS Lett 544 (1-3), 74-78 (2003)
   PUBMED   12782293
  REMARK    GeneRIF: PBEF is not a cytokine-like secreted protein but an
            intracellular protein associated with the cell cycle
REFERENCE   10 (bases 1 to 2590)
  AUTHORS   Dietrich,L.S. and Muniz,O.
  TITLE     Inhibition of nicotinamide phosphoribosyltransferase by pyridine
            nucleotides
  JOURNAL   Biochemistry 11 (9), 1691-1695 (1972)
   PUBMED   4402158
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085681.1.
            
            On Nov 15, 2004 this sequence version replaced NM_177928.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085681.1, AB081730.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2590
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q16"
     gene            1..2590
                     /gene="Nampt"
                     /gene_synonym="Pbef; Pbef1"
                     /note="nicotinamide phosphoribosyltransferase"
                     /db_xref="GeneID:297508"
                     /db_xref="RGD:631365"
     exon            1..84
                     /gene="Nampt"
                     /gene_synonym="Pbef; Pbef1"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..1503
                     /gene="Nampt"
                     /gene_synonym="Pbef; Pbef1"
                     /EC_number="2.4.2.12"
                     /note="visfatin; NAmPRTase; pre-B-cell colony-enhancing
                     factor 1 homolog; pre-B-cell colony enhancing factor 1"
                     /codon_start=1
                     /product="nicotinamide phosphoribosyltransferase"
                     /protein_id="NP_808789.1"
                     /db_xref="GeneID:297508"
                     /db_xref="RGD:631365"
                     /translation="MNAAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKT
                     ENSKVRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKEVYREHFQDDVFNERGWN
                     YILEKYDGHLPIEVKAVPEGSVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPIT
                     VATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGT
                     DTVAGIALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSV
                     VSDSYDIYNACEKIWGEDLRHLIVSRSTEAPLIIRPDSGNPLDTVLKVLDILGKKFPV
                     SENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKKWSIENVSFGSGGALLQKLTR
                     DLLNCSFKCSYVVTNGLGVNVFKDPVADPNKRSKKGRLSLHRTPAGTFVTLEEGKGDL
                     EEYGHDLLHTVFKNGKVTKSYSFDEVRKNAQLNMEQDVAPH"
     exon            85..241
                     /gene="Nampt"
                     /gene_synonym="Pbef; Pbef1"
                     /inference="alignment:Splign:2.1.0"
     exon            242..345
                     /gene="Nampt"
                     /gene_synonym="Pbef; Pbef1"
                     /inference="alignment:Splign:2.1.0"
     exon            346..474
                     /gene="Nampt"
                     /gene_synonym="Pbef; Pbef1"
                     /inference="alignment:Splign:2.1.0"
     exon            475..633
                     /gene="Nampt"
                     /gene_synonym="Pbef; Pbef1"
                     /inference="alignment:Splign:2.1.0"
     exon            634..770
                     /gene="Nampt"
                     /gene_synonym="Pbef; Pbef1"
                     /inference="alignment:Splign:2.1.0"
     exon            771..996
                     /gene="Nampt"
                     /gene_synonym="Pbef; Pbef1"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1116
                     /gene="Nampt"
                     /gene_synonym="Pbef; Pbef1"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1257
                     /gene="Nampt"
                     /gene_synonym="Pbef; Pbef1"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1392
                     /gene="Nampt"
                     /gene_synonym="Pbef; Pbef1"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..2563
                     /gene="Nampt"
                     /gene_synonym="Pbef; Pbef1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgcggcgc ctccgctctg gcccgagatg aatgctgcgg cagaagccga gttcaacatc
       61 ctgctggcca ccgactcgta caaggttact cactataaac aatacccacc caacacaagc
      121 aaagtttatt cctactttga atgccgtgaa aagaagacag aaaactccaa agtaaggaag
      181 gtgaaatacg aggaaacagt attttatggg ttgcagtaca ttcttaataa gtacttaaaa
      241 ggtaaagtag tgaccaaaga gaaaatccag gaggccaaag aagtgtacag agaacatttc
      301 caagatgatg tcttcaatga aaggggatgg aactacatcc ttgagaaata tgacggtcat
      361 ctcccaattg aagtaaaggc tgttcctgag ggctctgtca tccccagagg gaacgtgctg
      421 ttcacagtgg aaaacacaga cccagagtgc tactggctca ccaactggat tgagactatt
      481 cttgtccagt cctggtatcc aattacagtg gccacaaatt caagagagca gaagaaaatc
      541 ctggccaaat atttgttaga aacttctggt aacttagacg gtctggaata taagttacat
      601 gacttcggct acagaggagt ctcttcacaa gagactgccg gcataggggc atctgctcat
      661 ttggttaact tcaaaggaac agatactgtg gcgggaattg ctctaattaa aaaatactat
      721 gggacaaaag atcctgttcc aggctattct gttccagcgg cagagcacag taccataaca
      781 gcgtggggga aagaccatga aaaagatgct tttgaacaca tagtaacaca gttctcatca
      841 gtgcctgtgt ctgtggtcag cgatagctat gacatctata acgcgtgtga gaaaatatgg
      901 ggtgaagacc tgagacacct gatagtgtcg agaagtacag aggcaccact gatcatcaga
      961 cctgattctg gaaatccgct cgacactgtc ctgaaggtct tagatatatt aggcaagaag
     1021 ttccctgtct ctgagaactc caaaggctac aagttgctgc caccttacct tagagtcatt
     1081 caaggggacg gagtggatat caatactcta caggagattg tcgagggaat gaaacagaaa
     1141 aagtggagta ttgagaatgt ctcctttggt tctggtggcg ctttgctaca gaagttaacc
     1201 agagacctct tgaattgctc cttcaagtgc agctatgttg taaccaatgg ccttggggtt
     1261 aatgtcttta aggacccagt tgctgatccc aacaaaaggt cgaaaaaggg ccggctgtct
     1321 ttacatagga caccagcagg gacctttgtc acccttgaag aaggaaaagg agaccttgaa
     1381 gaatatggcc atgatcttct ccatacggtt ttcaagaatg ggaaggtgac aaaaagctac
     1441 tcgtttgacg aagtcagaaa aaatgcacag ctgaacatgg agcaggatgt ggcgcctcac
     1501 taggctttgt gtgagtgggt ggttgtgtgt gcagtgtgtg tgcatacgtg cgcgcatgtg
     1561 tgcgcctgtg cgtgtgtact aacagtcatt gtacagatgt gtgggtttgt ttatgataca
     1621 ctgcagccag gttatttgtt ggtttatgga catactgccc tttttatttt tcccagtgtt
     1681 tagatgatct caaattagaa aacacttata accatgtgca agattaatgc taagtaagct
     1741 tcttagggcc tttgctaata gatagtaact caatccggtg ttgatctttt cacaagtaac
     1801 agaaccaaga aacttttcta tataactaca atcacataaa acagatttgc ataaattacc
     1861 atgcctgctt tatgtttata tttaacttgt atttttgtac aaacgagatt gtgtaagata
     1921 tatttaaagt ttccgtgatt taacagtctg tttccaactt ttcatgattt ttatgagcac
     1981 agactttcaa gaaaatactt gaaataaatt acattgcctt ttgtccatta atcagcaaat
     2041 aaaacatggc cttaacagag ttgtttgtgt tgttgtacat ttggaaatta tgtcaggaca
     2101 tatacccaac agaattacta acatcactgc ccttgtagaa tatgcagtaa tcattgtcca
     2161 ctgaagagaa tcatggttct tccgcgatgt ttaggcattg tacagttctg tagcctggtc
     2221 attgtattgt accagtgatg ccaaatcccg aaggcctgtt ctgcgatttt atatgtcgga
     2281 tattgcctgt ggctctaata tgcacctcaa gattttaaga agataatgtt tttagagaga
     2341 atttctgctt ccactataga atatatacat aaatgtaaaa tattaaaagt ggaagcagtg
     2401 tattttaaag taattacact tctgaattta tttttcatat tctatagttg gtatgactta
     2461 aatgaactgc tggagtgggt agtgagtgta cttattttaa atgttttgat tctgttatat
     2521 tttcattaag ttttttaaaa attaaattgg atattaaact gtaaaaaaaa aaaaaaaaaa
     2581 aaaaaaaaaa
//
