LOCUS       NM_138824               5133 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus NLR family, apoptosis inhibitory protein 6
            (Naip6), mRNA.
ACCESSION   NM_138824 XM_008760698
VERSION     NM_138824.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5133)
  AUTHORS   Plaza-Diaz,J., Alvarez-Mercado,A.I., Robles-Sanchez,C.,
            Navarro-Oliveros,M., Moron-Calvente,V., Toribio-Castello,S.,
            Saez-Lara,M.J., MacKenzie,A., Fontana,L. and Abadia-Molina,F.
  TITLE     NAIP expression increases in a rat model of liver mass restoration
  JOURNAL   J Mol Histol 52 (1), 113-123 (2021)
   PUBMED   33237375
  REMARK    GeneRIF: NAIP expression increases in a rat model of liver mass
            restoration.
REFERENCE   2  (bases 1 to 5133)
  AUTHORS   Kofoed,E.M. and Vance,R.E.
  TITLE     Innate immune recognition of bacterial ligands by NAIPs determines
            inflammasome specificity
  JOURNAL   Nature 477 (7366), 592-595 (2011)
   PUBMED   21874021
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5133)
  AUTHORS   Chen,Y.K., Huse,S.S. and Lin,L.M.
  TITLE     Expression of inhibitor of apoptosis family proteins in human oral
            squamous cell carcinogenesis
  JOURNAL   Head Neck 33 (7), 985-998 (2011)
   PUBMED   20967871
REFERENCE   4  (bases 1 to 5133)
  AUTHORS   Karimpour,S., Davoodi,J. and Ghahremani,M.H.
  TITLE     Integrity of ATP binding site is essential for effective inhibition
            of the intrinsic apoptosis pathway by NAIP
  JOURNAL   Biochem Biophys Res Commun 407 (1), 158-162 (2011)
   PUBMED   21371431
REFERENCE   5  (bases 1 to 5133)
  AUTHORS   Yin,Y., Huang,W.W., Lin,C., Chen,H., MacKenzie,A. and Ma,L.
  TITLE     Estrogen suppresses uterine epithelial apoptosis by inducing birc1
            expression
  JOURNAL   Mol Endocrinol 22 (1), 113-125 (2008)
   PUBMED   17901126
REFERENCE   6  (bases 1 to 5133)
  AUTHORS   Wang,Y., Asselin,E. and Tsang,B.K.
  TITLE     Involvement of transforming growth factor alpha in the regulation
            of rat ovarian X-linked inhibitor of apoptosis protein expression
            and follicular growth by follicle-stimulating hormone
  JOURNAL   Biol Reprod 66 (6), 1672-1680 (2002)
   PUBMED   12021046
  REMARK    GeneRIF: XIAP up-regulation in response to FSH suppresses granulosa
            cell apoptosis and facilitates FSH-induced follicular growth.
REFERENCE   7  (bases 1 to 5133)
  AUTHORS   Maier,J.K., Lahoua,Z., Gendron,N.H., Fetni,R., Johnston,A.,
            Davoodi,J., Rasper,D., Roy,S., Slack,R.S., Nicholson,D.W. and
            MacKenzie,A.E.
  TITLE     The neuronal apoptosis inhibitory protein is a direct inhibitor of
            caspases 3 and 7
  JOURNAL   J Neurosci 22 (6), 2035-2043 (2002)
   PUBMED   11896143
REFERENCE   8  (bases 1 to 5133)
  AUTHORS   Perrelet,D., Ferri,A., Liston,P., Muzzin,P., Korneluk,R.G. and
            Kato,A.C.
  TITLE     IAPs are essential for GDNF-mediated neuroprotective effects in
            injured motor neurons in vivo
  JOURNAL   Nat Cell Biol 4 (2), 175-179 (2002)
   PUBMED   11813002
  REMARK    GeneRIF: Results show that inhibition of XIAP or NAIP activity
            prevents GDNF-mediated neuroprotective effects, suggesting that
            XIAP and NAIP are essential for intracellular signalling of GDNF in
            motor neuron survival.
REFERENCE   9  (bases 1 to 5133)
  AUTHORS   Xu,D.G., Crocker,S.J., Doucet,J.P., St-Jean,M., Tamai,K.,
            Hakim,A.M., Ikeda,J.E., Liston,P., Thompson,C.S., Korneluk,R.G.,
            MacKenzie,A. and Robertson,G.S.
  TITLE     Elevation of neuronal expression of NAIP reduces ischemic damage in
            the rat hippocampus
  JOURNAL   Nat Med 3 (9), 997-1004 (1997)
   PUBMED   9288726
REFERENCE   10 (bases 1 to 5133)
  AUTHORS   Xu,D.G., Korneluk,R.G., Tamai,K., Wigle,N., Hakim,A., Mackenzie,A.
            and Robertson,G.S.
  TITLE     Distribution of neuronal apoptosis inhibitory protein-like
            immunoreactivity in the rat central nervous system
  JOURNAL   J Comp Neurol 382 (2), 247-259 (1997)
   PUBMED   9183692
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Apr 19, 2023 this sequence version replaced XM_008760698.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR26643292.7386.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA5760383,
                                    SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                JAXUCZ010000002.1  33279521-33279612   c
            93-663              JAXUCZ010000002.1  33276093-33276663   c
            664-763             JAXUCZ010000002.1  33274125-33274224   c
            764-845             JAXUCZ010000002.1  33269713-33269794   c
            846-897             JAXUCZ010000002.1  33268845-33268896   c
            898-1017            JAXUCZ010000002.1  33265946-33266065   c
            1018-1117           JAXUCZ010000002.1  33265090-33265189   c
            1118-1199           JAXUCZ010000002.1  33260593-33260674   c
            1200-1257           JAXUCZ010000002.1  33257129-33257186   c
            1258-3369           JAXUCZ010000002.1  33254569-33256680   c
            3370-3537           JAXUCZ010000002.1  33250696-33250863   c
            3538-3690           JAXUCZ010000002.1  33249054-33249206   c
            3691-3777           JAXUCZ010000002.1  33248668-33248754   c
            3778-3942           JAXUCZ010000002.1  33245004-33245168   c
            3943-5133           JAXUCZ010000002.1  33241520-33242710   c
FEATURES             Location/Qualifiers
     source          1..5133
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     gene            1..5133
                     /gene="Naip6"
                     /gene_synonym="Birc1; Birc1a; Birc1b; Naip; Naip2"
                     /note="NLR family, apoptosis inhibitory protein 6"
                     /db_xref="GeneID:191568"
                     /db_xref="RGD:621281"
     exon            1..92
                     /gene="Naip6"
                     /gene_synonym="Birc1; Birc1a; Birc1b; Naip; Naip2"
                     /inference="alignment:Splign:2.1.0"
     exon            93..663
                     /gene="Naip6"
                     /gene_synonym="Birc1; Birc1a; Birc1b; Naip; Naip2"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..4307
                     /gene="Naip6"
                     /gene_synonym="Birc1; Birc1a; Birc1b; Naip; Naip2"
                     /note="baculoviral IAP repeat-containing 1b; neuronal
                     apoptosis inhibitory protein; NLR family, apoptosis
                     inhibitory protein 2; baculoviral IAP repeat-containing
                     protein 1b"
                     /codon_start=1
                     /product="NLR family, apoptosis inhibitory protein 6"
                     /protein_id="NP_620179.1"
                     /db_xref="GeneID:191568"
                     /db_xref="RGD:621281"
                     /translation="MAAQGEAFEERICEFDDDLVSEFSTLLRVDALQVLKRQQEEDHK
                     TRMKMKKGFNAQMRSEAKRLKTFVTYDTFRSWTPQEMAAAGFYYTGVRHGVQCFCCSL
                     ILFATRLRKVPIEVHRKLQPECEFLSGKDVGNIGKYDIRVKSPETLPRGGRARYHEEE
                     ARLESFEDWPFYAHGTSPRVLSAAGFVFTGKRDTVQCFSCGGCLGNWEEGDDPWKEHA
                     KWFPKCEFLQSKKSAEEIAKYIQTYEGFLHVTGEHFVNSWVRRELPVVSAYSNDSVFA
                     NEGLRMDTFKDWPHESPMAVEALVKAGLFYTGKKDIVQCFSCGGCMENWKEGDDPIED
                     HTKFFPNCVFLQTLKSSAEVIPALQSHCARPEAMETTSESNHEDGVAVHSSVADLGQS
                     EAQWCQEARSLSEQLRGTYTKASFRHMNLPEAYSSLGTDHLLGCEVFLISKHVSRPVQ
                     VALTIPEVFANLSSVMCVEGEAGSGKTTFLKRIAFLWASGCCPLLNRFQLVFYLSLRS
                     IRADQGLADIICAQLLEAGGCISEVSLSSGIQHLQHQVLFLLDDYSGMDSLPQALDTL
                     ITKNYLSRTCLLMAVHTNRVRDIRPYLETVLQIKEFPFYNTVYILKKIFSHDIIRVRR
                     FINYFGFHEYLQGIHKTPLFVAGVCADWLQNPSDQPFQDVTIFKSYMQYLFLKHKATA
                     GPLQATVSSCGHLALTGLFSSSFEFSSDDLIEAGVDEDEELSTCLMSKFTAQRLRPVY
                     RFLSPLFQEFLAAMRLSELLGSDSQEDQDLGLYYLRQINSPLKAMSIYHTFLRYVSNH
                     PSSKAGPKVISHLLQLVDEKESPENTSENEDYMKLHPETLLWSQCLRGLLQLSPESFS
                     LFISERLLNIALNFAYQSNTVAACSPVILQFLQGRTLDLKVLNLQYFWDHPETLLLLK
                     SIQVLFNGNNRVQRIDFSLMDKSFEKIQPPTIDQDYAFAFQPMSECQRNLAEKENIIK
                     NYDDMKYQDPLNISSGYWKLSPKPYKIPRLEVGVNNMGPADQALLHVLMEVFSASQSI
                     EFHLFNSSGFLESIRPALELNKTSVTKCSMSRLELSRAEQELLLTLPALQSLEVSGTS
                     QIPDQLFHNLDKFLGLKELSVRLDGTQDMLSVLPGEFPNLHHMEKLSIHTSTESDLSK
                     LVKLIQNSPNLHDFHLKCDFLSNCESLMAALASCKKLREIEFSGRCFEAVPFVNILSN
                     FASLKILNLRNQQFPDKETSEKFAQALGSLRNLEELHLPTGDGIHQVAKPIVRRCLQL
                     PCLRVLVFAETLDDDSVLEIAKGATSGGFQNLENLDLTLNHKITEEGYRNFFQALDNL
                     PNLQNLDISRHIPECIQVQASTVKALGQCVSRLPSLTRLGMLSWLLDEEDMKVINDVK
                     ERHPQSKRLTVHWRWVVPFSPVIQK"
     exon            664..763
                     /gene="Naip6"
                     /gene_synonym="Birc1; Birc1a; Birc1b; Naip; Naip2"
                     /inference="alignment:Splign:2.1.0"
     exon            764..845
                     /gene="Naip6"
                     /gene_synonym="Birc1; Birc1a; Birc1b; Naip; Naip2"
                     /inference="alignment:Splign:2.1.0"
     exon            846..897
                     /gene="Naip6"
                     /gene_synonym="Birc1; Birc1a; Birc1b; Naip; Naip2"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1017
                     /gene="Naip6"
                     /gene_synonym="Birc1; Birc1a; Birc1b; Naip; Naip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1117
                     /gene="Naip6"
                     /gene_synonym="Birc1; Birc1a; Birc1b; Naip; Naip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1199
                     /gene="Naip6"
                     /gene_synonym="Birc1; Birc1a; Birc1b; Naip; Naip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1257
                     /gene="Naip6"
                     /gene_synonym="Birc1; Birc1a; Birc1b; Naip; Naip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..3369
                     /gene="Naip6"
                     /gene_synonym="Birc1; Birc1a; Birc1b; Naip; Naip2"
                     /inference="alignment:Splign:2.1.0"
     exon            3370..3537
                     /gene="Naip6"
                     /gene_synonym="Birc1; Birc1a; Birc1b; Naip; Naip2"
                     /inference="alignment:Splign:2.1.0"
     exon            3538..3690
                     /gene="Naip6"
                     /gene_synonym="Birc1; Birc1a; Birc1b; Naip; Naip2"
                     /inference="alignment:Splign:2.1.0"
     exon            3691..3777
                     /gene="Naip6"
                     /gene_synonym="Birc1; Birc1a; Birc1b; Naip; Naip2"
                     /inference="alignment:Splign:2.1.0"
     exon            3778..3942
                     /gene="Naip6"
                     /gene_synonym="Birc1; Birc1a; Birc1b; Naip; Naip2"
                     /inference="alignment:Splign:2.1.0"
     exon            3943..5133
                     /gene="Naip6"
                     /gene_synonym="Birc1; Birc1a; Birc1b; Naip; Naip2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctgcctgt ttgctgctga tgcactgtga ccagctggtt tcctgctcct gtcaagcctt
       61 ctgtgccacc atgaaataca gatcttcaaa ctaaaatggc agcccaggga gaagcctttg
      121 aggagagaat ttgtgagttt gatgatgact tggtctctga gttctctact cttctccgag
      181 tggatgcact tcaagtctta aagagacaac aagaagaaga ccataaaaca cgaatgaaaa
      241 tgaagaaagg ttttaatgca cagatgcgca gtgaagccaa acggctgaag acttttgtga
      301 cctatgacac attcagatca tggaccccac aggagatggc agctgctggg ttttactaca
      361 cgggtgtgag acatggggtt cagtgcttct gctgtagctt aatccttttt gccaccagac
      421 tcaggaaagt tcccatagaa gttcaccgga aattacaacc agaatgtgag ttcctctcgg
      481 gcaaagatgt tggaaacatt ggcaagtacg acatacgggt gaagagtcca gagacgctgc
      541 cgagaggtgg cagagcaagg taccatgagg aggaggccag actggagtcc tttgaggact
      601 ggccgtttta tgcccatggg acatcacctc gtgtactctc agctgctggc tttgtcttca
      661 caggtaaaag ggacactgtg cagtgtttct cctgtggcgg atgcttggga aactgggaag
      721 aaggagatga tccctggaag gagcatgcca agtggttccc caaatgtgaa tttcttcaaa
      781 gcaagaagtc cgcagaggaa attgccaagt acatacaaac ctacgaggga tttcttcatg
      841 taacgggaga acattttgtg aattcctggg tcagaagaga attacctgta gtatcagctt
      901 acagcaatga cagtgtcttt gctaatgaag gactaagaat ggacacgttt aaggactggc
      961 cccacgaatc acctatggct gttgaagctc tggtcaaagc aggtcttttc tacacaggca
     1021 aaaaggacat cgtccagtgt ttctcctgtg gaggatgcat ggagaattgg aaggaaggtg
     1081 atgacccaat agaagatcac accaagtttt ttcccaactg tgtatttctt caaaccctga
     1141 agtcctctgc agaagtgatt ccagcccttc agagccactg tgcacgtcca gaagccatgg
     1201 aaaccacaag tgaaagcaac catgaggatg gagtggcagt tcattcttct gtagcggact
     1261 tgggtcagag tgaagcccag tggtgtcaag aggccaggag tctgagtgag cagctgagag
     1321 gcacctacac caaagccagt ttccgacaca tgaacctgcc cgaggcgtat tccagcctcg
     1381 gcactgacca cttgctcggc tgcgaggtgt tcctcatttc aaagcacgtc agccggccag
     1441 tgcaagtggc cctgacaatc cccgaggtct tcgccaatct tagctctgtc atgtgtgtgg
     1501 agggggaagc tggcagtggg aagaccacct tcctgaagag gatagctttc ctctgggcat
     1561 caggatgctg tcccctgttg aacaggttcc agctggtctt ctacctctcc cttcgttcca
     1621 tcagagcaga ccagggactg gccgacatca tctgtgccca gctcctagag gcaggaggat
     1681 gcatcagtga agtgagcctg agcagcggca tccagcactt acaacaccag gtcctgtttc
     1741 tgttggatga ctacagtggg atggactccc tcccccaagc cctagacaca ctgattacca
     1801 aaaactactt gtcacggacc tgcttactga tggccgtcca taccaacagg gtcagggaca
     1861 tccgcccata tctagagaca gttctacaga tcaaagagtt tcccttttat aatactgtct
     1921 atatattaaa gaagatcttc tcacatgaca taattcgtgt gcgaagattt ataaattact
     1981 ttggatttca tgaatattta cagggaattc acaaaacccc cctctttgtg gcaggagtat
     2041 gcgctgactg gcttcaaaat ccatctgacc agccctttca ggatgtgacc attttcaagt
     2101 cctacatgca atacctgttc ttaaagcaca aagctacagc cgggcctctc caggccaccg
     2161 tgtcctcctg tgggcatctg gccttgacag ggcttttctc atcgagcttt gagttcagta
     2221 gtgatgacct catagaggca ggagttgatg aagacgaaga gctcagcacc tgcttgatga
     2281 gcaaattcac cgcccagagg ctgagaccag tctaccggtt tttaagtcct ctgttccaag
     2341 agtttcttgc tgccatgagg ctctcagaac tcctggggtc agatagtcaa gaagaccaag
     2401 atctgggact gtattatttg agacaaatta actcacctct gaaggccatg agcatctacc
     2461 acactttttt gaggtatgtc tccaaccacc cttcatcaaa ggcagggcca aaagttatat
     2521 ctcatttgct tcagttggtg gatgagaaag agtccccgga gaacacgtct gaaaatgagg
     2581 attacatgaa gctccatcca gaaactttgc tgtggagtca gtgtcttaga gggctgttgc
     2641 agctgtctcc tgaatctttc tctttgttca tttcagaacg tttactgaac attgccctaa
     2701 actttgctta tcaaagcaac acagttgctg catgctctcc agttattttg cagttccttc
     2761 aagggaggac actggatttg aaagtactga atttacagta cttttgggac cacccagaaa
     2821 ccctgttact attgaagagt attcaggtct tatttaatgg gaataacagg gtacagagaa
     2881 ttgatttttc tctcatggac aaatcttttg aaaaaataca gccaccaact atagatcagg
     2941 actatgcctt tgcctttcaa cctatgagtg aatgccagag aaatttagct gaaaaggaaa
     3001 acataataaa gaactatgat gatatgaaat atcaggatcc actaaatatt agtagtggct
     3061 attggaaact gtcccccaag ccttacaaga tccctaggct ggaagttgga gtgaacaaca
     3121 tgggtccggc agaccaggct ctgctccatg tcctaatgga agtcttctca gcctcacaga
     3181 gtattgagtt ccatttattc aacagcagtg gctttcttga aagcatccgc ccagctctgg
     3241 agctgaataa gacctctgtc accaagtgtt ccatgtccag gctggagctc agcagagcag
     3301 aacaggagct gcttctcacc ctgcctgccc tgcagtctct tgaggtctca ggaacaagcc
     3361 agattccaga tcagctcttc cataacttgg acaagttcct gggcctgaaa gaactgtctg
     3421 tgagactaga tggcacacag gacatgctct cagtccttcc gggagagttc ccaaacctcc
     3481 atcacatgga gaagttatcc atccacacct ccacggagtc tgacctctcc aaactagtta
     3541 aattgattca gaactctcca aatctgcatg atttccacct gaaatgtgat ttcctttcga
     3601 attgtgagtc tctcatggct gcgcttgctt cctgcaagaa actcagagag attgagtttt
     3661 ctgggcgatg ctttgaagcc gtgccctttg tcaacatttt gtcaaatttt gcttctttga
     3721 agatattgaa tcttagaaac caacaattcc cagataagga aacatcagaa aagtttgccc
     3781 aggctctggg ttctctcagg aacctggagg aactgcacct tcccactggg gatgggatcc
     3841 accaagtggc caaaccgatt gtccggcggt gtctgcagct tccctgtctc cgagttctcg
     3901 tctttgcaga gacattggat gatgacagtg tgctggaaat tgccaaggga gcaaccagtg
     3961 gaggcttcca aaatctggag aacttagacc tcacactgaa tcacaagatt actgaggaag
     4021 gctacaggaa tttctttcaa gccctggaca acctgccaaa cctgcaaaat ctggacatct
     4081 ccaggcatat cccagaatgc atccaagttc aggccagcac cgtcaaggct ctgggtcagt
     4141 gtgtgtcccg actgcccagc ctcaccaggc tggggatgct cagttggctg ctggatgaag
     4201 aggacatgaa agtgattaat gacgtgaagg aaagacaccc tcagtccaaa cgcctgactg
     4261 tgcactggag gtgggtggtg ccgttctctc ctgtcattca gaagtgaagg atgcaggggc
     4321 agcctactgg caggtctaaa accctgtttt caaatacatt tcactctaga caggcatggc
     4381 gtaatcctag tacttagact gagcaggagg gtcaagagtt tgggtccagc ctgggctatg
     4441 tgacaatact ttagacccca atcaaaacca aatcgtttac tattcatata caaaatattc
     4501 ttgaactgta tcaggctggt aactatttga ggcctgcacg cctacaccaa gctatgatgc
     4561 cttggcagtc ctcgtatggt ccctcttgta caaagactag agcttcaggc aagttcacac
     4621 agagaaccct ccattatcca gatcaataga agggggctgt ggaaagaaac attgatctat
     4681 gtcaagacta cattgtggaa ggaatgatcc acataagtaa gaaacggcca gtttaaggat
     4741 tgaatcagtt ccacatctga tgagacggga gttgacttca ccacaggatg cagcgaactc
     4801 tctccgggag gtgatctttg gtttttgtaa gacttctgtg tgttcaccag tcttggtgtg
     4861 gccatgtttg tttacaccgt ctcttaccta tttgaaaaca tgggcttaga gaaaactgcc
     4921 tttgttccag gggctttggg gagttatttt tgttaggata gctttataat tttgttggaa
     4981 acccagtctg ttcagggtat atgatttaat cttgtaagga tttctgggta tattaacttg
     5041 ggtgtgagaa ttgtcatttc ataactgtca cctctctaga agcaggggga cctgggagaa
     5101 tggagccaat aaatgcagtg gacgaaagtc tca
//
