LOCUS       NM_001107053            2111 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus N-acetylglutamate synthase (Nags), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_001107053 XM_001081489 XM_220939
VERSION     NM_001107053.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2111)
  AUTHORS   Zhao G, Jin Z, Allewell NM, Tuchman M and Shi D.
  TITLE     Crystal structure of the N-acetyltransferase domain of human
            N-acetyl-L-glutamate synthase in complex with N-acetyl-L-glutamate
            provides insights into its catalytic and regulatory mechanisms
  JOURNAL   PLoS One 8 (7), e70369 (2013)
   PUBMED   23894642
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2111)
  AUTHORS   Morizono H, Caldovic L, Shi D and Tuchman M.
  TITLE     Mammalian N-acetylglutamate synthase
  JOURNAL   Mol Genet Metab 81 Suppl 1 (Suppl 1), S4-S11 (2004)
   PUBMED   15050968
  REMARK    Review article
REFERENCE   3  (bases 1 to 2111)
  AUTHORS   Caldovic L, Morizono H, Panglao MG, Cheng SF, Packman S and Tuchman
            M.
  TITLE     Null mutations in the N-acetylglutamate synthase gene associated
            with acute neonatal disease and hyperammonemia
  JOURNAL   Hum Genet 112 (4), 364-368 (2003)
   PUBMED   12594532
REFERENCE   4  (bases 1 to 2111)
  AUTHORS   Caldovic L, Morizono H, Gracia Panglao M, Gallegos R, Yu X, Shi D,
            Malamy MH, Allewell NM and Tuchman M.
  TITLE     Cloning and expression of the human N-acetylglutamate synthase gene
  JOURNAL   Biochem Biophys Res Commun 299 (4), 581-586 (2002)
   PUBMED   12459178
REFERENCE   5  (bases 1 to 2111)
  AUTHORS   Caldovic L, Morizono H, Yu X, Thompson M, Shi D, Gallegos R,
            Allewell NM, Malamy MH and Tuchman M.
  TITLE     Identification, cloning and expression of the mouse
            N-acetylglutamate synthase gene
  JOURNAL   Biochem J 364 (Pt 3), 825-831 (2002)
   PUBMED   12049647
REFERENCE   6  (bases 1 to 2111)
  AUTHORS   Colombo JP, Pfister U and Cervantes H.
  TITLE     The regulation of N-acetylglutamate synthetase in rat liver by
            protein intake
  JOURNAL   Biochem Biophys Res Commun 172 (3), 1239-1245 (1990)
   PUBMED   2244909
REFERENCE   7  (bases 1 to 2111)
  AUTHORS   Bachmann,C., Krahenbuhl,S. and Colombo,J.P.
  TITLE     Purification and properties of acetyl-CoA:L-glutamate
            N-acetyltransferase from human liver
  JOURNAL   Biochem J 205 (1), 123-127 (1982)
   PUBMED   7126172
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_220939.3, XM_001081489.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5756307,
                              SAMEA5760383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2111
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..2111
                     /gene="Nags"
                     /gene_synonym="RGD1565783"
                     /note="N-acetylglutamate synthase"
                     /db_xref="GeneID:303563"
                     /db_xref="RGD:1565783"
     exon            1..479
                     /gene="Nags"
                     /gene_synonym="RGD1565783"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1658
                     /gene="Nags"
                     /gene_synonym="RGD1565783"
                     /EC_number="2.3.1.1"
                     /codon_start=1
                     /product="N-acetylglutamate synthase, mitochondrial"
                     /protein_id="NP_001100523.1"
                     /db_xref="GeneID:303563"
                     /db_xref="RGD:1565783"
                     /translation="MATAWVATALRSAAAARRLRSPGGPGGSRRLSGSARRRGARSAS
                     PGRRLSTARAHVEDNEGTKGRVQSPAVEEPPWTPLPTPLESPAPPAGKSLVQRDIQAF
                     LNQCGASPGEARHWLTQFQTCYHSVDKPFAVVEVDEEVFGCPQAVSRLAFALAFLQRM
                     DMKPLVVLGLPAPTAPSGCLSFWEAKAQLAQSCKVLVNELRHNAATAVPFFGGGSVLS
                     AAEPAPHASYGGIVAVETDLLQWCLESNSIPILCPIGETAARRSVLLDSLEVTASLAK
                     ALQPTKIIFLNNSGGLRDTSQKILSNVNLPADLDLVTNAEWLSTKERQQIRLIVDVLS
                     RLPHYSSAVITAASTLLTELFSNKGCGTLFKNAERMLRVRSLDSLDQGRLVNLVNASF
                     GKKLREDYLESLRPRLHSIYVSEGYNAAAILTVEPVLGGTPYLDKFVVSSSRQGQGSG
                     QMLWECLRRDLQTLFWRSRVTNPINPWYFKHSDGSFSNKQWIFFWFGLADIRDSYELV
                     NHAKGLPDSFCKPASDPGS"
     exon            480..754
                     /gene="Nags"
                     /gene_synonym="RGD1565783"
                     /inference="alignment:Splign:2.1.0"
     exon            755..968
                     /gene="Nags"
                     /gene_synonym="RGD1565783"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1149
                     /gene="Nags"
                     /gene_synonym="RGD1565783"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1321
                     /gene="Nags"
                     /gene_synonym="RGD1565783"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1504
                     /gene="Nags"
                     /gene_synonym="RGD1565783"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..2111
                     /gene="Nags"
                     /gene_synonym="RGD1565783"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaacccctag tgttgtgcgc tccagaccga ccgtcacctg tgggtggggg agaccagtgg
       61 gtttagttgt cgtcatggcg acggcgtggg tggccacagc cctgcgatct gctgcggcgg
      121 ccagaaggct gcgcagcccg ggtggacctg ggggctcacg gagactgagt ggcagcgcga
      181 ggcggcgcgg ggcgaggagc gccagcccgg gacgccggct cagcactgcc agggctcacg
      241 tagaggacaa cgagggcact aagggtcgtg tccagtctcc tgccgtcgag gagccgccgt
      301 ggacacctct tccaaccccc ctcgaatctc ctgcgcctcc tgccggcaaa tcactggtgc
      361 agcgggacat ccaggccttc ctgaatcagt gtggtgccag cccgggggag gcacggcact
      421 ggctcacaca attccagacc tgctatcatt cggtggacaa gcccttcgcc gtcgtggagg
      481 tagatgagga ggtgttcggg tgcccgcagg cggtatcccg cctggctttc gccctagcct
      541 ttctgcaacg catggacatg aagccgctgg tggtcctggg gctgccggcc ccgacggccc
      601 cttccggctg tctctccttc tgggaagcta aggcacagct tgctcagagc tgcaaggtgc
      661 tggtgaatga actacggcac aacgcggcta ctgctgtgcc cttttttggc ggcggatcag
      721 tgctgagtgc tgcggaacca gctccccatg ccagctacgg tggcatcgtc gcggtggaga
      781 cagacctgtt gcagtggtgc ctggagtcca acagcattcc aatcctgtgt cccattgggg
      841 aaacggctgc gcgccgttcg gtgcttctag actcgctgga ggtgactgcg tctctggcca
      901 aggctctgca gcccaccaaa atcatcttcc tcaataattc aggcggcctg cgggatacca
      961 gtcagaagat cctgagcaat gtgaacctgc ccgccgacct tgaccttgtt accaacgctg
     1021 agtggctgag caccaaagag cggcagcaga ttcggctcat cgtggacgtg ctcagccgcc
     1081 tgccgcacta ctcctccgca gtcatcacag ccgctagcac gctgctcacc gaactcttca
     1141 gtaacaaggg ctgtggcacc ctgtttaaaa atgctgagcg gatgctgcgt gtgcgcagcc
     1201 tggacagcct ggaccagggc cgcctagtga acctagtcaa cgctagcttc ggcaagaaac
     1261 tccgagaaga ctatctggag tcactgcgcc cacggttaca ctcgatctat gtctctgagg
     1321 ggtacaacgc ggcagccatt ctgacagtgg agcctgtact agggggcacc ccgtatctgg
     1381 acaaatttgt agtgagctcc agccgccagg gccaaggttc cggacagatg ctgtgggaat
     1441 gccttcggag ggacctgcaa acgttgttct ggcgctcacg ggtcaccaac cccatcaatc
     1501 cttggtactt caagcacagt gatggtagct tctccaacaa gcagtggatc ttcttctggt
     1561 ttggcctagc cgacatccgg gactcctatg aactggtcaa tcatgccaaa gggctgccag
     1621 actccttctg caagccagct tctgacccag gcagctgacc caccatcacc ggccctgtaa
     1681 atcctgggac agtcaggatg gaccaaaagc catacctgct gggggtgacc ccaggcagct
     1741 aggggaggaa gctgcaccat gtctgctgag ggacaccgga gtagagcgac cacagaaaga
     1801 gtgaagccag ctaaagactc tgctccaaag tcaaaccaga tggccttcaa tgttcagcct
     1861 ggggaatggg actaggagag ccttccaggg ctctactcaa ggtaacctta aggggaggcc
     1921 agtgtcaatg gcctctgggc tgtctttagg ctctgttgtc ttacatagag tctaagcctg
     1981 cctgatctgc cactcatttg ggtctcgaaa ttcttcagga ggccttgatt aaaccaaaaa
     2041 atgcttgtct gattcagtca cacttgtctc aaaagacaaa ctaagaaaag tttaattaca
     2101 ggaaggactt c
//
