LOCUS       NM_001037768            1203 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus N-acetylglucosamine kinase (Nagk), mRNA.
ACCESSION   NM_001037768 XM_216188
VERSION     NM_001037768.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1203)
  AUTHORS   Islam,M.A., Sharif,S.R., Lee,H. and Moon,I.S.
  TITLE     N-Acetyl-D-Glucosamine Kinase Promotes the Axonal Growth of
            Developing Neurons
  JOURNAL   Mol Cells 38 (10), 876-885 (2015)
   PUBMED   26467288
  REMARK    GeneRIF: this work studied the role played by NAGK in axonal
            development.
REFERENCE   2  (bases 1 to 1203)
  AUTHORS   Islam,M.A., Sharif,S.R., Lee,H., Seog,D.H. and Moon,I.S.
  TITLE     N-acetyl-D-glucosamine kinase interacts with dynein light-chain
            roadblock type 1 at Golgi outposts in neuronal dendritic branch
            points
  JOURNAL   Exp Mol Med 47 (8), e177 (2015)
   PUBMED   26272270
  REMARK    GeneRIF: The interaction between NAGK and Dynlrb1 frequently occurs
            at dendritic branch points.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1203)
  AUTHORS   Sharif,S.R., Lee,H., Islam,M.A., Seog,D.H. and Moon,I.S.
  TITLE     N-acetyl-D-glucosamine kinase is a component of nuclear speckles
            and paraspeckles
  JOURNAL   Mol Cells 38 (5), 402-408 (2015)
   PUBMED   25921606
  REMARK    GeneRIF: Data shows associations between NAGK, speckle, paraspeckle
            and general transcription factor suggesting its regulatory roles in
            gene expression.
REFERENCE   4  (bases 1 to 1203)
  AUTHORS   Lee,H., Cho,S.J. and Moon,I.S.
  TITLE     The non-canonical effect of N-acetyl-D-glucosamine kinase on the
            formation of neuronal dendrites
  JOURNAL   Mol Cells 37 (3), 248-256 (2014)
   PUBMED   24625575
  REMARK    GeneRIF: Upregulation of dendritic complexity is a non-canonical
            function of NAGK.
REFERENCE   5  (bases 1 to 1203)
  AUTHORS   Bergfeld,A.K., Pearce,O.M., Diaz,S.L., Pham,T. and Varki,A.
  TITLE     Metabolism of vertebrate amino sugars with N-glycolyl groups:
            elucidating the intracellular fate of the non-human sialic acid
            N-glycolylneuraminic acid
  JOURNAL   J Biol Chem 287 (34), 28865-28881 (2012)
   PUBMED   22692205
REFERENCE   6  (bases 1 to 1203)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 1203)
  AUTHORS   Ghaderi,D., Strauss,H.M., Reinke,S., Cirak,S., Reutter,W., Lucka,L.
            and Hinderlich,S.
  TITLE     Evidence for dynamic interplay of different oligomeric states of
            UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase by
            biophysical methods
  JOURNAL   J Mol Biol 369 (3), 746-758 (2007)
   PUBMED   17448495
  REMARK    GeneRIF: analysis of oligomeric states of UDP-N-acetylglucosamine
            2-epimerase/N-acetylmannosamine kinase by biophysical methods
REFERENCE   8  (bases 1 to 1203)
  AUTHORS   Hinderlich,S., Berger,M., Schwarzkopf,M., Effertz,K. and Reutter,W.
  TITLE     Molecular cloning and characterization of murine and human
            N-acetylglucosamine kinase
  JOURNAL   Eur J Biochem 267 (11), 3301-3308 (2000)
   PUBMED   10824116
REFERENCE   9  (bases 1 to 1203)
  AUTHORS   Hinderlich,S., Nohring,S., Weise,C., Franke,P., Stasche,R. and
            Reutter,W.
  TITLE     Purification and characterization of N-acetylglucosamine kinase
            from rat liver--comparison with UDP-N-acetylglucosamine
            2-epimerase/N-acetylmannosamine kinase
  JOURNAL   Eur J Biochem 252 (1), 133-139 (1998)
   PUBMED   9523722
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC107647.1.
            
            On Dec 16, 2005 this sequence version replaced XM_216188.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC107647.1, SRR8487231.87796.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1203
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..1203
                     /gene="Nagk"
                     /note="N-acetylglucosamine kinase"
                     /db_xref="GeneID:297393"
                     /db_xref="RGD:1305057"
     exon            1..66
                     /gene="Nagk"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1069
                     /gene="Nagk"
                     /EC_number="2.7.1.60"
                     /EC_number="2.7.1.59"
                     /note="glcNAc kinase; muramyl dipeptide kinase;
                     N-acetyl-D-mannosamine kinase"
                     /codon_start=1
                     /product="N-acetyl-D-glucosamine kinase"
                     /protein_id="NP_001032857.1"
                     /db_xref="GeneID:297393"
                     /db_xref="RGD:1305057"
                     /translation="MAALYGGVEGGGTRSKVLLLSEDGQILAEADGLSTNHWLIGTGT
                     CVERINEMVDRAKRKAGVDPLVPLRSLGLSLSGGEQEDAVRLLMEELRDRFPYLSESY
                     FITTDAAGSIATATPDGGIVLISGTGSNCRLINPDGSESGCGGWGHMMGDEGSAYWIA
                     HQAVKIVFDSIDNLEAAPHDIGHVKQAMFNYFQVPDRLGILTHLYRDFDKSKFAGFCQ
                     KIAEGAQQGDPLSRFIFRKAGEMLGRHVVAVLPEIDPVLFQGELGLPILCVGSVWKSW
                     ELLKEGFLLALTQGREQQAQNSFSSFTLMKLRHSSALGGASLGARHIGHHLPMDYSVN
                     AIAFYSYTF"
     exon            67..151
                     /gene="Nagk"
                     /inference="alignment:Splign:2.1.0"
     exon            152..250
                     /gene="Nagk"
                     /inference="alignment:Splign:2.1.0"
     exon            251..392
                     /gene="Nagk"
                     /inference="alignment:Splign:2.1.0"
     exon            393..503
                     /gene="Nagk"
                     /inference="alignment:Splign:2.1.0"
     exon            504..616
                     /gene="Nagk"
                     /inference="alignment:Splign:2.1.0"
     exon            617..704
                     /gene="Nagk"
                     /inference="alignment:Splign:2.1.0"
     exon            705..802
                     /gene="Nagk"
                     /inference="alignment:Splign:2.1.0"
     exon            803..881
                     /gene="Nagk"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1184
                     /gene="Nagk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcttgctac ggcgagacct gcggtggtga cggtagtatg gccgcacttt atggtggcgt
       61 ggaaggggga ggcacacggt ccaaagtcct tttactttct gaggatgggc agatcctggc
      121 agaagcagat ggactgagca caaatcactg gctgattggc acaggtacct gtgtggagag
      181 gatcaatgag atggtggaca gggctaaacg gaaggctgga gtggatcctc tggtacccct
      241 tcgaagcctg ggcttgtccc tgagtggtgg ggagcaggag gatgcagtga ggctcctgat
      301 ggaggagttg agggaccgat ttccctacct gagtgaaagt tacttcatca ccactgatgc
      361 agcaggttcc atcgccacag ctacaccgga tggtgggatt gtgctcatct ctggaacagg
      421 ctccaactgt aggcttatca accctgatgg ctctgagagt ggctgtggtg gctggggcca
      481 catgatggga gacgagggat cagcctactg gattgcacac caagctgtga aaattgtgtt
      541 tgactccatt gacaacctgg aagcagctcc tcatgatatt ggccatgtca agcaggccat
      601 gttcaactac ttccaggtgc cagatcggct aggaatcctc actcacttgt atagggactt
      661 tgataagtcc aagtttgctg gattttgtca gaaaattgca gaaggtgcac agcagggaga
      721 ccctctttcc aggttcatct tcagaaaggc tggggagatg ctgggcagac acgttgtggc
      781 agtattgcca gagattgacc cagttttgtt ccaaggggag cttggcctcc ccattctgtg
      841 tgtgggctca gtgtggaaga gctgggagct actgaaggaa ggctttctcc tggcactgac
      901 gcagggccga gagcaacagg cacagaactc cttctccagt ttcaccctga tgaagttgag
      961 gcactcttct gcactgggag gggccagcct gggggccagg cacattggac accaccttcc
     1021 catggactac agcgtcaatg ccattgcctt ctattcctat accttctagg ggctgcccct
     1081 cttcccattc agccaacact gagtgttggg agatttctct tttttaaaaa cacatgagaa
     1141 aataaatgca ctttactccc tccccagcag ggtgttatcc tcaaaaaaaa aaaaaaaaaa
     1201 aaa
//
