LOCUS       NM_001012120            1785 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus alpha-N-acetylgalactosaminidase (Naga), mRNA.
ACCESSION   NM_001012120 XM_235515
VERSION     NM_001012120.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1785)
  AUTHORS   Clark,N.E. and Garman,S.C.
  TITLE     The 1.9 a structure of human alpha-N-acetylgalactosaminidase: The
            molecular basis of Schindler and Kanzaki diseases
  JOURNAL   J Mol Biol 393 (2), 435-447 (2009)
   PUBMED   19683538
REFERENCE   2  (bases 1 to 1785)
  AUTHORS   Asfaw,B., Schindler,D., Ledvinova,J., Cerny,B., Smid,F. and
            Conzelmann,E.
  TITLE     Degradation of blood group A glycolipid A-6-2 by normal and mutant
            human skin fibroblasts
  JOURNAL   J Lipid Res 39 (9), 1768-1780 (1998)
   PUBMED   9741689
REFERENCE   3  (bases 1 to 1785)
  AUTHORS   Wang,A.M., Kanzaki,T. and Desnick,R.J.
  TITLE     The molecular lesion in the alpha-N-acetylgalactosaminidase gene
            that causes angiokeratoma corporis diffusum with glycopeptiduria
  JOURNAL   J Clin Invest 94 (2), 839-845 (1994)
   PUBMED   8040340
REFERENCE   4  (bases 1 to 1785)
  AUTHORS   Wang,A.M., Schindler,D. and Desnick,R.
  TITLE     Schindler disease: the molecular lesion in the
            alpha-N-acetylgalactosaminidase gene that causes an infantile
            neuroaxonal dystrophy
  JOURNAL   J Clin Invest 86 (5), 1752-1756 (1990)
   PUBMED   2243144
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC082084.1.
            
            On Feb 11, 2005 this sequence version replaced XM_235515.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082084.1, SRR8487231.20403.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1785
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1785
                     /gene="Naga"
                     /note="alpha-N-acetylgalactosaminidase"
                     /db_xref="GeneID:315165"
                     /db_xref="RGD:1306025"
     exon            1..68
                     /gene="Naga"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..1300
                     /gene="Naga"
                     /EC_number="3.2.1.49"
                     /note="alpha-galactosidase B; N-acetyl galactosaminidase,
                     alpha"
                     /codon_start=1
                     /product="alpha-N-acetylgalactosaminidase precursor"
                     /protein_id="NP_001012120.1"
                     /db_xref="GeneID:315165"
                     /db_xref="RGD:1306025"
                     /translation="MLQKTVLLLALVAQVLMLENGLLRTPPMGWLAWERFRCNINCEE
                     DPKNCISERLFMEMADRLAQDGWRDLGYVYLNIDDCWIGGRDATGRLIPDPKRFPHGI
                     AFLADYAHSLGLKLGIYEDMGKMTCMGYPGTTLDKVELDAATFAEWKVDMLKLDGCYS
                     TPKERAEGYPKMAAALNATGRPIAFSCSWPAYEGGLPPKVNYTEVAGTCNLWRNYKDI
                     QDSWKSVLSILDWFVKHQDILQPVSGPGHWNDPDMLLIGNFGLSFDESRAQMALWTVL
                     AAPLFMSTDLRTISPQNIDILQNPLLIKINQDPLGIQGRLIFKSKSHIEVFKRNLSDD
                     ASALVFFSRRTDMPYHFHCSLLELNYPKGSVYEGQNVFTGDIISGLHPETNFTVIINP
                     SGVVMWYLYPVKGLGIYTMMSQL"
     exon            69..204
                     /gene="Naga"
                     /inference="alignment:Splign:2.1.0"
     exon            205..376
                     /gene="Naga"
                     /inference="alignment:Splign:2.1.0"
     exon            377..554
                     /gene="Naga"
                     /inference="alignment:Splign:2.1.0"
     exon            555..649
                     /gene="Naga"
                     /inference="alignment:Splign:2.1.0"
     exon            650..811
                     /gene="Naga"
                     /inference="alignment:Splign:2.1.0"
     exon            812..1009
                     /gene="Naga"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1153
                     /gene="Naga"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1781
                     /gene="Naga"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 taaaactgat aagagcagat tcgattgggt cctgagattt gactccgagg caatgttgca
       61 gaagacagtg ctcttactgg ccctggtggc tcaggtactg atgctggaga atgggctact
      121 gcggacacca cccatgggct ggctggcctg ggaacgtttc cgctgtaaca tcaactgtga
      181 ggaggacccg aagaactgca tcagtgagcg actctttatg gagatggctg acagattggc
      241 tcaggatgga tggcgggacc taggctatgt atacctcaac atcgatgact gctggattgg
      301 tggacgtgat gccacaggcc gcctgatacc tgatcccaag cgattccctc acgggattgc
      361 cttcctggct gactatgctc attctttggg tctgaagcta ggcatctatg aggacatggg
      421 caaaatgacc tgcatgggtt accctggcac cactctagac aaagtggagc tagacgctgc
      481 aaccttcgca gagtggaagg tggacatgct gaaactggat ggctgttact ccactcccaa
      541 ggagcgtgca gaggggtacc ccaagatggc tgctgccctg aatgccacag gccgtcccat
      601 cgccttttct tgcagctggc cagcctatga agggggccta ccccccaagg tgaactacac
      661 tgaggtcgcc ggcacctgca atctctggcg caactataaa gacatccagg actcctggaa
      721 gagtgtgctg tccattctgg actggtttgt gaaacaccag gacatactgc agcccgtgtc
      781 gggtcctggg cactggaatg acccagatat gctgctcatc gggaacttcg gcctcagctt
      841 cgatgaatcc cgggcccaga tggccctgtg gacagtgctg gcagcccccc tcttcatgtc
      901 cacggacctg cgtaccatct ccccccagaa tatagacatt cttcagaatc cactcctgat
      961 caaaatcaat caggacccct taggcatcca gggacgcttg atcttcaaga gcaaatccca
     1021 catcgaagtg ttcaagcgga atctgtctga cgatgccagt gccctggtct tcttcagccg
     1081 caggacagac atgccttacc acttccattg ttccctcttg gaactgaact accccaaagg
     1141 cagtgtgtat gagggccaga acgtcttcac aggagacatc atcagcgggc tccaccctga
     1201 aaccaacttc actgtgatca tcaacccttc cggggttgtg atgtggtacc tatatcccgt
     1261 caagggcttg gggatataca caatgatgtc ccagttgtga ggacccaaga atgacaggct
     1321 acggcagctc cactgggcct agaccacgga gccttggcac gccaagggca tggcagggcc
     1381 ctgcctcccc aggctacttg ggaatgtgcc ggccatcatg cccaaagtgc gtttgcaggg
     1441 tcaggatcca cgccatgccc ggctgaggca ggggccccct tggaaacttg gaactcttgg
     1501 ggcagtttcc tgtggccttt gggcctctgt ccccacacag ctctgcagat ttcgctgaac
     1561 aactgggcca gtctcctgag ccccctcggg cagggccctg atgcccattg gactccagcc
     1621 tctgactttg ctgactcaga aatcaggatt tggaattttt aaaattaaga atagagactt
     1681 gaggggggtt ggggatttag ctcagtggta gagcacttgc ctaggaagcg caaggccctg
     1741 ggttcggtcc ccagctccag aaaaaaaaaa aaaaaaaaaa aaaaa
//
