LOCUS       NM_032072               1803 bp    mRNA    linear   ROD 04-APR-2024
DEFINITION  Rattus norvegicus NEDD8 activating enzyme E1 subunit 1 (Nae1),
            mRNA.
ACCESSION   NM_032072
VERSION     NM_032072.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1803)
  AUTHORS   Joo,Y., Lee,S.H., Ha,S., Hong,B.H., Kim,J.H., Suh,Y.H. and Kim,H.S.
  TITLE     Focal transient ischemia increases APP-BP1 expression in neural
            progenitor cells
  JOURNAL   Neuroreport 22 (5), 200-205 (2011)
   PUBMED   21386696
  REMARK    GeneRIF: The upregulation of APP-BP1 expression in neural
            progenitor cells after focal transient ischemia suggests that this
            protein contributes to the neurogenesis induced by transient
            ischemia and reperfusion
REFERENCE   2  (bases 1 to 1803)
  AUTHORS   Joo,Y., Ha,S., Hong,B.H., Kim,Ja., Chang,K.A., Liew,H., Kim,S.,
            Sun,W., Kim,J.H., Chong,Y.H., Suh,Y.H. and Kim,H.S.
  TITLE     Amyloid precursor protein binding protein-1 modulates cell cycle
            progression in fetal neural stem cells
  JOURNAL   PLoS One 5 (12), e14203 (2010)
   PUBMED   21151996
  REMARK    GeneRIF: APP-BP1 plays an important role in the cell cycle
            progression of fetal neural stem cells
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1803)
  AUTHORS   Park,Y., Yoon,S.K. and Yoon,J.B.
  TITLE     TRIP12 functions as an E3 ubiquitin ligase of APP-BP1
  JOURNAL   Biochem Biophys Res Commun 374 (2), 294-298 (2008)
   PUBMED   18627766
REFERENCE   4  (bases 1 to 1803)
  AUTHORS   Laifenfeld,D., Patzek,L.J., McPhie,D.L., Chen,Y., Levites,Y.,
            Cataldo,A.M. and Neve,R.L.
  TITLE     Rab5 mediates an amyloid precursor protein signaling pathway that
            leads to apoptosis
  JOURNAL   J Neurosci 27 (27), 7141-7153 (2007)
   PUBMED   17611268
REFERENCE   5  (bases 1 to 1803)
  AUTHORS   Chen,Y., Liu,W., McPhie,D.L., Hassinger,L. and Neve,R.L.
  TITLE     APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is
            increased in Alzheimer's disease brain
  JOURNAL   J Cell Biol 163 (1), 27-33 (2003)
   PUBMED   14557245
REFERENCE   6  (bases 1 to 1803)
  AUTHORS   Walden,H., Podgorski,M.S. and Schulman,B.A.
  TITLE     Insights into the ubiquitin transfer cascade from the structure of
            the activating enzyme for NEDD8
  JOURNAL   Nature 422 (6929), 330-334 (2003)
   PUBMED   12646924
REFERENCE   7  (bases 1 to 1803)
  AUTHORS   Chen,Y., McPhie,D.L., Hirschberg,J. and Neve,R.L.
  TITLE     The amyloid precursor protein-binding protein APP-BP1 drives the
            cell cycle through the S-M checkpoint and causes apoptosis in
            neurons
  JOURNAL   J Biol Chem 275 (12), 8929-8935 (2000)
   PUBMED   10722740
REFERENCE   8  (bases 1 to 1803)
  AUTHORS   Gong,L. and Yeh,E.T.
  TITLE     Identification of the activating and conjugating enzymes of the
            NEDD8 conjugation pathway
  JOURNAL   J Biol Chem 274 (17), 12036-12042 (1999)
   PUBMED   10207026
REFERENCE   9  (bases 1 to 1803)
  AUTHORS   Osaka,F., Kawasaki,H., Aida,N., Saeki,M., Chiba,T., Kawashima,S.,
            Tanaka,K. and Kato,S.
  TITLE     A new NEDD8-ligating system for cullin-4A
  JOURNAL   Genes Dev 12 (15), 2263-2268 (1998)
   PUBMED   9694792
REFERENCE   10 (bases 1 to 1803)
  AUTHORS   Chow,N., Korenberg,J.R., Chen,X.N. and Neve,R.L.
  TITLE     APP-BP1, a novel protein that binds to the carboxyl-terminal region
            of the amyloid precursor protein
  JOURNAL   J Biol Chem 271 (19), 11339-11346 (1996)
   PUBMED   8626687
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC127481.1.
            
            On Sep 25, 2014 this sequence version replaced NM_032072.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC127481.1, U90829.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1803              BC127481.1         1-1803
FEATURES             Location/Qualifiers
     source          1..1803
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p14"
     gene            1..1803
                     /gene="Nae1"
                     /gene_synonym="Appbp1; RGD1563180"
                     /note="NEDD8 activating enzyme E1 subunit 1"
                     /db_xref="GeneID:84019"
                     /db_xref="RGD:619945"
     exon            1..96
                     /gene="Nae1"
                     /gene_synonym="Appbp1; RGD1563180"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..1648
                     /gene="Nae1"
                     /gene_synonym="Appbp1; RGD1563180"
                     /note="amyloid beta precursor protein-binding protein 1,
                     59 kDa; APP-binding protein 1"
                     /codon_start=1
                     /product="NEDD8-activating enzyme E1 regulatory subunit"
                     /protein_id="NP_114461.3"
                     /db_xref="GeneID:84019"
                     /db_xref="RGD:619945"
                     /translation="MAQQGKILKEQKYDRQLRLWGDHGQEALESAHVCLINATATGTE
                     ILKNLVLPGIGSFTIIDGNQVSGEDVGNNFFLQKCSIGKNRAQAAMEFLQELNSDVSG
                     SFVEESPENLLDNDPSFFCRFTIVVATQLLESTLLRLADVLWNSQIPLLICRTYGLVG
                     YMRIIIKEHPVIESHPDNALEDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVII
                     AKYLAQWYSETNGRIPKSYKEKEDFRELIRQGILKNENGAPEDEENFEEAIKNVNTAL
                     NTTQIPSSIEDIFNDDRCINITKQTPSFWILARALKEFVAKEGQGNLPVRGTIPDMIA
                     DSSKYIKLQNVYREKAKKDAAAVGNHVAKLLQSVGQAPESISEKELKLLCSNSAFLRV
                     VRCRSLAEEYGLHTVNKDEIISSMDNPDNEIVLYLMLRAVDRFHKQHGRYPGVSNYQV
                     EEDIGKLKSCLTGFLQEYGLSVMVKDDYVHEFCRYGAAEPHTVAAFLGGAAAQEVIKI
                     ITKQFVIFNNTYIYSGMSQTSATFQL"
     exon            97..200
                     /gene="Nae1"
                     /gene_synonym="Appbp1; RGD1563180"
                     /inference="alignment:Splign:2.1.0"
     exon            201..261
                     /gene="Nae1"
                     /gene_synonym="Appbp1; RGD1563180"
                     /inference="alignment:Splign:2.1.0"
     exon            262..292
                     /gene="Nae1"
                     /gene_synonym="Appbp1; RGD1563180"
                     /inference="alignment:Splign:2.1.0"
     exon            293..364
                     /gene="Nae1"
                     /gene_synonym="Appbp1; RGD1563180"
                     /inference="alignment:Splign:2.1.0"
     exon            365..444
                     /gene="Nae1"
                     /gene_synonym="Appbp1; RGD1563180"
                     /inference="alignment:Splign:2.1.0"
     exon            445..554
                     /gene="Nae1"
                     /gene_synonym="Appbp1; RGD1563180"
                     /inference="alignment:Splign:2.1.0"
     exon            555..664
                     /gene="Nae1"
                     /gene_synonym="Appbp1; RGD1563180"
                     /inference="alignment:Splign:2.1.0"
     exon            665..727
                     /gene="Nae1"
                     /gene_synonym="Appbp1; RGD1563180"
                     /inference="alignment:Splign:2.1.0"
     exon            728..791
                     /gene="Nae1"
                     /gene_synonym="Appbp1; RGD1563180"
                     /inference="alignment:Splign:2.1.0"
     exon            792..883
                     /gene="Nae1"
                     /gene_synonym="Appbp1; RGD1563180"
                     /inference="alignment:Splign:2.1.0"
     exon            884..943
                     /gene="Nae1"
                     /gene_synonym="Appbp1; RGD1563180"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1077
                     /gene="Nae1"
                     /gene_synonym="Appbp1; RGD1563180"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1153
                     /gene="Nae1"
                     /gene_synonym="Appbp1; RGD1563180"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1193
                     /gene="Nae1"
                     /gene_synonym="Appbp1; RGD1563180"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1280
                     /gene="Nae1"
                     /gene_synonym="Appbp1; RGD1563180"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1373
                     /gene="Nae1"
                     /gene_synonym="Appbp1; RGD1563180"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1488
                     /gene="Nae1"
                     /gene_synonym="Appbp1; RGD1563180"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1538
                     /gene="Nae1"
                     /gene_synonym="Appbp1; RGD1563180"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1778
                     /gene="Nae1"
                     /gene_synonym="Appbp1; RGD1563180"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcctactta cgcggctctg ctgatcgtgg ggcaagcgcg gccatggctc agcaagggaa
       61 gatactcaag gagcaaaagt acgaccggca gctgaggttg tggggtgatc atggtcaaga
      121 agctttggaa tctgctcacg tttgcttgat aaatgccaca gctacaggaa cggaaattct
      181 taaaaacttg gtactgccag gtataggatc atttacaatt atcgatggaa atcaggtcag
      241 cggagaagat gttggaaaca attttttcct tcaaaaatgc agtattggca agaatcgagc
      301 tcaagctgcc atggaattct tacaagagct aaatagcgat gtctctggaa gttttgtgga
      361 agagagtcca gaaaaccttc tagacaatga tccttcattt ttctgtaggt ttactattgt
      421 ggttgcaact cagcttcttg aaagtacatt actacgttta gcagatgtcc tctggaattc
      481 ccagatccct cttttgatct gtaggacata tggcctagtt ggttatatga ggattattat
      541 aaaagaacat ccagtaatag aatctcatcc agataatgca ttggaggacc tacgactaga
      601 taagccattt cctgaactga gagaacattt tcagtcttat gacttggacc atatggaaaa
      661 aaaggaccat agccatactc catggattgt gatcatagct aaatatttag cccagtggta
      721 tagtgagaca aatggacgaa ttcctaaaag ttataaagaa aaagaggact tcagagaatt
      781 gataagacaa gggattttaa agaatgagaa tggagctcca gaagatgaag agaattttga
      841 agaagctatt aaaaatgtga acacagcact aaatacaact cagatcccaa gcagtattga
      901 agatatattt aatgatgatc gctgcataaa tatcaccaaa cagaccccat ctttttggat
      961 tttagctcgt gccttaaagg aatttgtggc caaggagggt caaggaaatt tacctgttcg
     1021 aggcacaatt cctgatatga ttgcagattc aagcaaatac ataaaattgc agaatgttta
     1081 tcgtgagaaa gcaaagaaag atgctgctgc tgtaggtaat catgttgcca aattgcttca
     1141 gtctgttggc caggcaccag agtccatttc agagaaagaa ttaaaactgc tttgtagcaa
     1201 ttctgcattt cttcgagtgg taagatgtcg gtctttagct gaagagtatg gtttgcatac
     1261 agtcaacaaa gatgaaatta tttctagcat ggacaatccg gataatgaga tagtcctgta
     1321 cctaatgttg cgggctgttg atcgatttca taagcagcat ggcagatacc caggagtatc
     1381 taactatcaa gttgaagaag atatagggaa gttgaagtcc tgtcttactg gcttccttca
     1441 ggaatatggg ttgtctgtaa tggtgaagga cgattatgtc catgaatttt gccggtacgg
     1501 agctgctgag ccacacaccg ttgctgcatt cctgggagga gctgctgctc aagaagttat
     1561 caaaataatc accaaacaat ttgtaatttt taacaatact tatatttata gtggtatgtc
     1621 acaaacttct gcaactttcc aattgtagaa taagcacccc gtgtaatatg ttaatggttg
     1681 aaactgtaat tgtcttcctg ttgtgcttta gtttgtaaac atctgtttag ggacagaagt
     1741 taagttgttt ccttaataaa attttttctc atttgtaaaa aaaaaaaaaa aaaaaaaaaa
     1801 aaa
//
