LOCUS       NM_181480               2672 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus NAD synthetase 1 (Nadsyn1), mRNA.
ACCESSION   NM_181480
VERSION     NM_181480.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2672)
  AUTHORS   Foucan,L., Velayoudom-Cephise,F.L., Larifla,L., Armand,C.,
            Deloumeaux,J., Fagour,C., Plumasseau,J., Portlis,M.L., Liu,L.,
            Bonnet,F. and Ducros,J.
  TITLE     Polymorphisms in GC and NADSYN1 Genes are associated with vitamin D
            status and metabolic profile in Non-diabetic adults
  JOURNAL   BMC Endocr Disord 13, 36 (2013)
   PUBMED   24073860
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2672)
  AUTHORS   Anic,G.M., Thompson,R.C., Nabors,L.B., Olson,J.J., Browning,J.E.,
            Madden,M.H., Murtagh,F.R., Forsyth,P.A. and Egan,K.M.
  TITLE     An exploratory analysis of common genetic variants in the vitamin D
            pathway including genome-wide associated variants in relation to
            glioma risk and outcome
  JOURNAL   Cancer Causes Control 23 (9), 1443-1449 (2012)
   PUBMED   22740028
  REMARK    Erratum:[Cancer Causes Control. 2012 Oct;23(10):1745. Burton
            Nabors, L [corrected to Nabors, L Burton]; Reed Murtagh, F
            [corrected to Murtagh, F Reed]]
REFERENCE   3  (bases 1 to 2672)
  AUTHORS   Kitanaka,S., Isojima,T., Takaki,M., Numakura,C., Hayasaka,K. and
            Igarashi,T.
  TITLE     Association of vitamin D-related gene polymorphisms with
            manifestation of vitamin D deficiency in children
  JOURNAL   Endocr J 59 (11), 1007-1014 (2012)
   PUBMED   22785457
REFERENCE   4  (bases 1 to 2672)
  AUTHORS   Houtkooper,R.H., Canto,C., Wanders,R.J. and Auwerx,J.
  TITLE     The secret life of NAD+: an old metabolite controlling new
            metabolic signaling pathways
  JOURNAL   Endocr Rev 31 (2), 194-223 (2010)
   PUBMED   20007326
  REMARK    Review article
REFERENCE   5  (bases 1 to 2672)
  AUTHORS   Hara,N., Yamada,K., Terashima,M., Osago,H., Shimoyama,M. and
            Tsuchiya,M.
  TITLE     Molecular identification of human glutamine- and ammonia-dependent
            NAD synthetases. Carbon-nitrogen hydrolase domain confers glutamine
            dependency
  JOURNAL   J Biol Chem 278 (13), 10914-10921 (2003)
   PUBMED   12547821
  REMARK    Erratum:[J Biol Chem. 2003 Oct 17;278(42):41572]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Oct 6, 2022 this sequence version replaced NM_181480.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC161832.1, AB090805.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-184               JAXUCZ010000001.1  208439024-208439207 c
            185-245             JAXUCZ010000001.1  208437323-208437383 c
            246-362             JAXUCZ010000001.1  208434941-208435057 c
            363-416             JAXUCZ010000001.1  208433044-208433097 c
            417-506             JAXUCZ010000001.1  208432432-208432521 c
            507-558             JAXUCZ010000001.1  208427532-208427583 c
            559-647             JAXUCZ010000001.1  208426893-208426981 c
            648-765             JAXUCZ010000001.1  208426601-208426718 c
            766-897             JAXUCZ010000001.1  208425293-208425424 c
            898-972             JAXUCZ010000001.1  208423516-208423590 c
            973-1097            JAXUCZ010000001.1  208422716-208422840 c
            1098-1146           JAXUCZ010000001.1  208422158-208422206 c
            1147-1249           JAXUCZ010000001.1  208421646-208421748 c
            1250-1418           JAXUCZ010000001.1  208420680-208420848 c
            1419-1554           JAXUCZ010000001.1  208419048-208419183 c
            1555-1661           JAXUCZ010000001.1  208418323-208418429 c
            1662-1793           JAXUCZ010000001.1  208415004-208415135 c
            1794-1863           JAXUCZ010000001.1  208414263-208414332 c
            1864-1992           JAXUCZ010000001.1  208413702-208413830 c
            1993-2169           JAXUCZ010000001.1  208413085-208413261 c
            2170-2672           JAXUCZ010000001.1  208410914-208411416 c
FEATURES             Location/Qualifiers
     source          1..2672
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q42"
     gene            1..2672
                     /gene="Nadsyn1"
                     /note="NAD synthetase 1"
                     /db_xref="GeneID:353255"
                     /db_xref="RGD:727801"
     exon            1..184
                     /gene="Nadsyn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..2277
                     /gene="Nadsyn1"
                     /EC_number="6.3.5.1"
                     /note="NAD(+) synthase; NAD(+) synthetase"
                     /codon_start=1
                     /product="glutamine-dependent NAD(+) synthetase"
                     /protein_id="NP_852145.2"
                     /db_xref="GeneID:353255"
                     /db_xref="RGD:727801"
                     /translation="MGRKVTVATCALNQWALDFEGNFQRILKSIQIAKGKGARYRLGP
                     ELEICGYGCWDHYHESDTLLHSLQVLAALLDAPATQDIICDVGMPIMHRNVRYNCRVI
                     FLNRKILLIRPKMALANEGNYRELRWFTPWARSRQTEEYVLPRMLQDLTKQKTVPFGD
                     VVLATQDTCIGSEICEELWTPCSPHVNMGLDGVEIITNASGSHHVLRKAHTRVDLVTM
                     ATSKNGGIYLLANQKGCDGDRLYYDGCAMIAMNGSIFAQGTQFSLDDVEVLTATLDLE
                     DVRSYRAEISSRNLEATRVNPYPRVTVDFALSVSEDLLEPVSEPVEWTYHRPEEEISL
                     GPACWLWDFLRRSNQAGFFLPLSGGVDSAASACVVYSMCCLVCEAVKSGNQQVLTDVQ
                     NLVDESSYTPQDPRELCGRLLTTCYMASENSSQETHNRATKLAQQIGSYHISLNIDPA
                     VKAILGIFSLVTGKFPRFSAHGGSSRENLALQNVQARIRMVLAYLFAQLSLWSRGARG
                     SLLVLGSANVDESLLGYLTKYDCSSADINPIGGISKTDLRAFVQLCAERFQLPVLQAI
                     LSAPATAELEPLADGQVSQMDEEDMGMTYTELSIFGRLRKVAKAGPYSMFCKLLNMWK
                     DSCTPRQVAEKVKRFFSKYSINRHKMTTLTPAYHAENYSPDDNRFDLRPFLYNTRWPW
                     QFLCIDNQVVQLERKTSQTLEEQIQEHFKEPSPIWKQLLPKDP"
     exon            185..245
                     /gene="Nadsyn1"
                     /inference="alignment:Splign:2.1.0"
     exon            246..362
                     /gene="Nadsyn1"
                     /inference="alignment:Splign:2.1.0"
     exon            363..416
                     /gene="Nadsyn1"
                     /inference="alignment:Splign:2.1.0"
     exon            417..506
                     /gene="Nadsyn1"
                     /inference="alignment:Splign:2.1.0"
     exon            507..558
                     /gene="Nadsyn1"
                     /inference="alignment:Splign:2.1.0"
     exon            559..647
                     /gene="Nadsyn1"
                     /inference="alignment:Splign:2.1.0"
     exon            648..765
                     /gene="Nadsyn1"
                     /inference="alignment:Splign:2.1.0"
     exon            766..897
                     /gene="Nadsyn1"
                     /inference="alignment:Splign:2.1.0"
     exon            898..972
                     /gene="Nadsyn1"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1097
                     /gene="Nadsyn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1146
                     /gene="Nadsyn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1249
                     /gene="Nadsyn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1418
                     /gene="Nadsyn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1554
                     /gene="Nadsyn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1661
                     /gene="Nadsyn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1793
                     /gene="Nadsyn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..1863
                     /gene="Nadsyn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..1992
                     /gene="Nadsyn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1993..2169
                     /gene="Nadsyn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2672
                     /gene="Nadsyn1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaaaactac gctacgcagg cgtggacagg tcagccgggc tagtatcctc tgtgaggtct
       61 ccgttccaac gccgtcccag cctggaacct gcaaccagga tgggccggaa agtgaccgtg
      121 gctacctgtg cactcaatca atgggccctg gactttgagg gcaatttcca gaggatttta
      181 aagagtattc aaattgccaa aggcaaaggt gcgagataca ggcttggacc ggaactagaa
      241 atatgcggct atggatgttg ggatcactat catgagtcag acactctctt gcactcgctc
      301 caagttctgg ctgctcttct ggatgctccg gccactcagg acatcatctg tgacgtgggg
      361 atgcctataa tgcaccggaa tgttcgttac aactgcagag tcatctttct caacaggaag
      421 attctgctca tcagacccaa gatggccttg gccaatgaag gcaactacag ggaactgcgc
      481 tggttcaccc cctgggccag gagccgacaa actgaggaat atgtcctccc tcggatgtta
      541 caggacctga caaagcagaa aactgtgccc tttggagatg tggtactggc cacccaggac
      601 acctgtattg ggagtgagat ctgtgaggag ctctggacgc catgcagccc ccacgtcaac
      661 atgggcctgg atggtgtgga aatcatcacc aatgcctcgg gcagccacca cgtgctacga
      721 aaagcccata ccagagtgga tctggtaacc atggctacct ccaagaatgg tggcatctac
      781 ctgctagcca atcagaaggg ctgtgacggt gaccgactct actatgatgg ctgtgccatg
      841 attgcgatga atgggagcat ctttgcccag ggaacccagt tctcattgga tgatgtggag
      901 gttctcactg ccacgctgga cctggaggac gtcaggagct acagggcaga gatctcatca
      961 cggaacctgg aggcaaccag agtgaaccca tacccccggg taacagtgga ctttgccctt
     1021 tcggtcagtg aagacttgtt ggagccagtg tcagagcctg tggagtggac ataccacagg
     1081 cctgaggagg agataagcct cgggcctgcc tgctggctct gggacttcct tcgacggagc
     1141 aatcaggccg ggtttttcct gcccctgagt ggcggtgtgg acagtgcagc cagcgcctgc
     1201 gtcgtctact ccatgtgctg cctggtctgt gaggctgtga agagcggaaa tcagcaagtg
     1261 ctgacagacg tccaaaacct ggtggacgag agcagctaca cccctcagga tccccgggag
     1321 ctctgcggac ggctgctcac tacttgctac atggccagtg agaactcctc ccaggagacc
     1381 cacaacaggg ccacaaaact ggctcagcag attggaagct accacatcag tctgaacatc
     1441 gaccctgctg tgaaggccat cttgggcatc ttcagcctgg tgactgggaa gttccctcgg
     1501 ttctcagcac atggagggag cagcagggag aacctggccc tgcagaatgt gcaggctcgg
     1561 attaggatgg tccttgccta cctgtttgct cagctgagcc tctggtctcg gggtgctcga
     1621 ggaagtcttc ttgtgcttgg atctgccaat gtagatgaga gtctcctcgg ctacctgact
     1681 aagtatgact gctccagtgc ggacatcaac cccataggcg gcatcagcaa gacggatctg
     1741 agagccttcg tccagttgtg tgcagagcgc ttccagctcc ctgttctgca ggccatcctg
     1801 tcagcgccgg ccactgcaga actagagccc ttagccgatg ggcaggtgtc tcagatggat
     1861 gaggaagaca tggggatgac gtacacagaa ctctccatct tcggcaggct ccggaaggtc
     1921 gccaaggcag ggccctacag catgttctgc aaactgctca acatgtggaa agacagctgt
     1981 acaccgagac aggtggctga gaaggtaaag cgatttttct caaagtactc cataaacagg
     2041 cacaagatga caaccctcac gccagcatat catgctgaaa actacagtcc ggacgacaac
     2101 aggtttgacc tgagaccctt tctgtacaac acgaggtggc cctggcagtt cctctgcatt
     2161 gacaaccagg ttgtacagct cgagaggaaa acatcgcaga ccctggaaga acagatccag
     2221 gagcatttca aagagccatc acctatatgg aaacagctcc tccccaagga cccctaatat
     2281 gaattcacat caccagtggc ccctgacaca gcccgccttg ggccaggttt tgtttatatt
     2341 tcaaggaaga gagatttctt ctgatgatat aaaaaatata aacaaaaatg atctttttaa
     2401 gatgtatttt attattttat atgtatgcat ggtctctggc ctacatatat gtctgtgtac
     2461 tacatgcttg cctggtaccc acagagccca gaagggggca ttaggtcctc tgggactaga
     2521 gctaaagaca gttgtgaacc accacgtggg tgttgggaat tggacctggg tcctctgtga
     2581 aagcagccag tgtagtgtgg cttcataggc atgtgtgtag gcaaaagggc catgcacatg
     2641 aaaataaaat caataaaatt ctaaagacaa aa
//
