LOCUS       NM_001109678            3443 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus NAD kinase (Nadk), mRNA.
ACCESSION   NM_001109678
VERSION     NM_001109678.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3443)
  AUTHORS   Zhang,R.
  TITLE     MNADK, a Long-Awaited Human Mitochondrion-Localized NAD Kinase
  JOURNAL   J Cell Physiol 230 (8), 1697-1701 (2015)
   PUBMED   25641397
  REMARK    Review article
REFERENCE   2  (bases 1 to 3443)
  AUTHORS   Gray,J.P., Alavian,K.N., Jonas,E.A. and Heart,E.A.
  TITLE     NAD kinase regulates the size of the NADPH pool and insulin
            secretion in pancreatic beta-cells
  JOURNAL   Am J Physiol Endocrinol Metab 303 (2), E191-E199 (2012)
   PUBMED   22550069
  REMARK    GeneRIF: The data suggested that NADK kinase regulates
            intracellular redox and affects insulin secretion and oxidative
            defense in the pancreatic beta cell.
REFERENCE   3  (bases 1 to 3443)
  AUTHORS   Lerner,F., Niere,M., Ludwig,A. and Ziegler,M.
  TITLE     Structural and functional characterization of human NAD kinase
  JOURNAL   Biochem Biophys Res Commun 288 (1), 69-74 (2001)
   PUBMED   11594753
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473968.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00155318,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3443
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3443
                     /gene="Nadk"
                     /note="NAD kinase"
                     /db_xref="GeneID:100125370"
                     /db_xref="RGD:1642420"
     exon            1..287
                     /gene="Nadk"
                     /inference="alignment:Splign:2.1.0"
     exon            288..769
                     /gene="Nadk"
                     /inference="alignment:Splign:2.1.0"
     CDS             591..1925
                     /gene="Nadk"
                     /EC_number="2.7.1.23"
                     /codon_start=1
                     /product="NAD kinase"
                     /protein_id="NP_001103148.1"
                     /db_xref="GeneID:100125370"
                     /db_xref="RGD:1642420"
                     /translation="MEMEQEKMNLSKELNPDSASYNCSACHGDETWSYNHPIRGRAKS
                     RSLSASPALGSTKEFRRTRSLHGPCPVTTFGPKACVLQNPQTIMHIQDPASQRLTWNK
                     SPKSVLVIKKIRDASLLQPFKELCIYLMEENNMIVYVEKKVLEDPAIVGDENFGPVKK
                     KFCTFREDYDDISNQIDFIICLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFNF
                     ENFQSQVNQVIEGNAAVILRSRLKVRVVKEPRDKKTAIHNGLSENGLDTEGGKQAMQY
                     QVLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASMVHP
                     NVPAIMVTPICPHSLSFRPIVVPAGVELKIMLSPEARNTAWVSFDGRKRQEIRHGDSI
                     SITTSCYPLPSICVCDPVSDWFESLAQCLHWNVRKKQAHFPEDEEDQDEEDS"
     exon            770..853
                     /gene="Nadk"
                     /inference="alignment:Splign:2.1.0"
     exon            854..983
                     /gene="Nadk"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1092
                     /gene="Nadk"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1178
                     /gene="Nadk"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1281
                     /gene="Nadk"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1421
                     /gene="Nadk"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1521
                     /gene="Nadk"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1679
                     /gene="Nadk"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1762
                     /gene="Nadk"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..3443
                     /gene="Nadk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccttggccta caaagggttt ggcgaaatcc aaagtttgag tgcctgtctt gtgtaggtgc
       61 ggtgcgccgc gctacccccc cccacgtgct ctactgcgca tgcgtgcggg ctgcgcttgc
      121 gcactgacat ccgcggcgca gctctgcttg gtggtgccgg cctctggacc gagcggccat
      181 ggggtggcgg gcggctgggt cgctgagagc caggtagcag tagggcagca gggaccgctg
      241 gctcggccca gcatgtagac gtccacgcgg gcgcgcggca gccgacgata cagatagcag
      301 tgacaaatga tctcaaccaa gtacaggagt gaatttattg ctacttacag gaaggtgtac
      361 caccacagtc taactggcag agttcactgt ttatatacct tcagggaggg gagtggcctc
      421 aggaatcttc ccctccttcc actgggcaag tcaggaagaa cttgttgtga gaggcagata
      481 tcacacccaa cccttcctgg gacagcactg aatgtctgtt attgctgctc atatatgtaa
      541 cttgctttat tttatcaaat taaagcacca gtgttttttt catatcaact atggaaatgg
      601 aacaagaaaa gatgaacctg agtaaggagc tgaatcctga ctcagcctcc tacaactgtt
      661 cagcatgcca tggggatgag acctggagct acaatcaccc catccggggc cgggccaagt
      721 ctcggagcct gtcagcctca cctgccctgg gcagcaccaa ggagttcagg agaacccgct
      781 ctctccatgg gccgtgccca gtgacaacgt ttggaccaaa agcctgcgtg ctgcagaacc
      841 cccagaccat catgcacatc caggaccctg caagccaacg gttgacatgg aacaagtctc
      901 caaagagtgt gcttgttatc aaaaagatcc gagatgccag cttactgcag cccttcaagg
      961 agctctgcat atacctcatg gaggaaaaca acatgatcgt gtatgtggaa aagaaagttc
     1021 tggaagaccc tgctatagtg ggtgatgaaa actttggacc agtgaagaag aagttctgca
     1081 ctttccgtga agattatgat gacatttcca accagataga cttcatcata tgccttggag
     1141 gagatggtac cttgctctat gcctcctcac ttttccaggg cagtgtgcct cctgttatgg
     1201 cctttcacct tggatccctg ggctttctga ccccattcaa ctttgagaac ttccaatccc
     1261 aagtgaatca ggtgatagag gggaatgctg ctgttatcct gaggagccgg ctaaaggtca
     1321 gggtggtgaa agagcccaga gacaagaaga cagccatcca caacggcctc agtgaaaatg
     1381 gtctggacac agagggcgga aaacaagcta tgcaatacca ggtcttgaat gaagtggtga
     1441 ttgacagagg cccttcctca tacctgtcca acgttgatgt ctacctggat ggacacctta
     1501 ttaccactgt gcagggcgat ggagtgatcg tgtccacccc gacgggcagc acagcctatg
     1561 cagctgcagc cggggcctcc atggtccacc ccaacgtgcc ggccatcatg gttacaccca
     1621 tctgccccca ctcgctgtca ttccggccta tcgtggtccc tgcaggggtc gagctgaaga
     1681 ttatgctgtc accagaagcc aggaacacgg catgggtgtc ttttgatgga cggaaaagac
     1741 aggaaattcg ccatggagac agcatcagca tcaccacctc ctgctaccca ctgccctcca
     1801 tctgtgtgtg tgaccctgtg agtgactggt tcgagagcct tgctcagtgt ctgcactgga
     1861 atgttcgaaa gaagcaagct cactttccag aagatgagga ggaccaggat gaggaggaca
     1921 gctagactac atttcccagc ttctaacccg atcaggccct caagcccttg ggagccttct
     1981 ttctcttgct ctcttgctgg ccttctggct gacctggcct tgacaaacca catggctgtc
     2041 caggcatcta tgtcctgtct gccttgctgg gagagcttgg gtctgccttt tgcagaacag
     2101 atcagctttt taatgttttt aaatctcttt ttcatttcta aagaagcaaa atgagaactg
     2161 ggctgggtgt cctacatctc tcccatgggc ccccaagtcc ccctgagatt tctaggtcag
     2221 gaattcccat aaatcagtct gttgaaattc tgagggggtc agaatgattt gatcttcctt
     2281 ctgatattga aataaatgtc tcagccagaa atcttccttt aactgcagtg ctttccccca
     2341 gggcctgtac ctttccccgt ggcagctttg ctctgggttg gcaaggcaag cttgctttct
     2401 gtgtttctgg agatggctcg gttccctctg agtctggccc caagacctct gactccttcc
     2461 agagcagaca gaggtaacac ttggcacagc catccagcaa cctcacattc ctcacacatc
     2521 agggcagcag ctcctgggga cattttaaat cctatataca ctttttagag gttattttaa
     2581 actttctgaa gtgattatgt acatattttc ttgtacacac tttgtgaaga tttagagggg
     2641 actgcctgtt gtctggtgtt tacattgtat ccaggattac attgtatcca ggacagggct
     2701 ctgtgctgcc actcctccct tacacagtgg ccacaagggt tttgagacca gctcactatt
     2761 gacttcaggc ttgtgggcct gctctccttc cacaagaatc ttaggtttgc aactgagagg
     2821 cagccatatg gagcctgtgt gcaacacatg tatgtagtgc aagtaacgca cgtgagtgcc
     2881 acactggccc tggagccttt gtggggtcag tggtcggccc cagcacctca gctaggtatc
     2941 cgctttcagt tttgtgctca cctcttacgg caggagtagg gaggactgcc tgttctttga
     3001 ctggctttcc aggtgaagtc aggcttttgt ctcatgcttc tagggaaggt ttgtcagctg
     3061 ctatagaacc gactactctg agctttcttc tacctgttaa agttgggacc tactgggcac
     3121 ccgtgcagcc ccaagtggtc tggcttgagt gctgttaagc catggtggct catccccacg
     3181 gttcacctgt gctgttcatc tgtgactgcg cacagcaggc tctgctatga tccagaggaa
     3241 agcaaggtct gaagcatagt ccatgcatct aaaaagcgag tgttgacaag tacagaagca
     3301 gctgccacca gactgatctc aaacacatgg aattttcacg taaattctta atgtttcata
     3361 ttgttaatat cttaaaattt tgttaattgt taatgaaggc cttattacta ttttcagatt
     3421 ctttcaataa ataaacttgt ttt
//
