LOCUS       NM_134413               2044 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus nucleus accumbens associated 1 (Nacc1), mRNA.
ACCESSION   NM_134413
VERSION     NM_134413.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2044)
  AUTHORS   Nakayama,K., Nakayama,N., Wang,T.L. and Shih,Ie.M.
  TITLE     NAC-1 controls cell growth and survival by repressing transcription
            of Gadd45GIP1, a candidate tumor suppressor
  JOURNAL   Cancer Res 67 (17), 8058-8064 (2007)
   PUBMED   17804717
REFERENCE   2  (bases 1 to 2044)
  AUTHORS   Davidson,B., Berner,A., Trope',C.G., Wang,T.L. and Shih,I.M.
  TITLE     Expression and clinical role of the bric-a-brac tramtrack broad
            complex/poxvirus and zinc protein NAC-1 in ovarian carcinoma
            effusions
  JOURNAL   Hum Pathol 38 (7), 1030-1036 (2007)
   PUBMED   17391728
REFERENCE   3  (bases 1 to 2044)
  AUTHORS   Korutla,L., Degnan,R., Wang,P. and Mackler,S.A.
  TITLE     NAC1, a cocaine-regulated POZ/BTB protein interacts with CoREST
  JOURNAL   J Neurochem 101 (3), 611-618 (2007)
   PUBMED   17254023
REFERENCE   4  (bases 1 to 2044)
  AUTHORS   Nakayama,K., Nakayama,N., Davidson,B., Sheu,J.J., Jinawath,N.,
            Santillan,A., Salani,R., Bristow,R.E., Morin,P.J., Kurman,R.J.,
            Wang,T.L. and Shih,Ie.M.
  TITLE     A BTB/POZ protein, NAC-1, is related to tumor recurrence and is
            essential for tumor growth and survival
  JOURNAL   Proc Natl Acad Sci U S A 103 (49), 18739-18744 (2006)
   PUBMED   17130457
REFERENCE   5  (bases 1 to 2044)
  AUTHORS   Korutla,L., Wang,P.J. and Mackler,S.A.
  TITLE     The POZ/BTB protein NAC1 interacts with two different histone
            deacetylases in neuronal-like cultures
  JOURNAL   J Neurochem 94 (3), 786-793 (2005)
   PUBMED   16033423
REFERENCE   6  (bases 1 to 2044)
  AUTHORS   Korutla,L., Champtiaux,N., Shen,H.W., Klugmann,M., Kalivas,P.W. and
            Mackler,S.A.
  TITLE     Activity-dependent subcellular localization of NAC1
  JOURNAL   Eur J Neurosci 22 (2), 397-403 (2005)
   PUBMED   16045493
  REMARK    Erratum:[Eur J Neurosci. 2005 Sep;22(6):1552. Klugman, Matthias
            [corrected to Klugmann, Matthias]]
REFERENCE   7  (bases 1 to 2044)
  AUTHORS   Korutla,L., Neustadter,J.H., Fournier,K.M. and Mackler,S.A.
  TITLE     NAC1, a POZ/BTB protein present in the adult mammalian brain,
            triggers apoptosis after adenovirus-mediated overexpression in
            PC-12 cells
  JOURNAL   Neurosci Res 46 (1), 33-39 (2003)
   PUBMED   12725910
  REMARK    GeneRIF: aberrantly regulated NAC1 expression in the mammalian
            brain may contribute to programmed cell death
REFERENCE   8  (bases 1 to 2044)
  AUTHORS   Korutla,L., Wang,P.J., Lewis,D.M., Neustadter,J.H., Stromberg,M.F.
            and Mackler,S.A.
  TITLE     Differences in expression, actions and cocaine regulation of two
            isoforms for the brain transcriptional regulator NAC1
  JOURNAL   Neuroscience 110 (3), 421-429 (2002)
   PUBMED   11906783
  REMARK    GeneRIF: The two isoforms of NAC-1 may differentially affect
            neuronal functions, including the regulation of cocaine-induced
            locomotion. The longer isoform was the more abundant of the two
            NAC1 proteins and the ratio between them differed throughout the
            rat brain.
REFERENCE   9  (bases 1 to 2044)
  AUTHORS   Cha,X.Y., Pierce,R.C., Kalivas,P.W. and Mackler,S.A.
  TITLE     NAC-1, a rat brain mRNA, is increased in the nucleus accumbens
            three weeks after chronic cocaine self-administration
  JOURNAL   J Neurosci 17 (18), 6864-6871 (1997)
   PUBMED   9278521
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF015911.1.
            
            On Aug 30, 2012 this sequence version replaced NM_134413.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF015911.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2044              AF015911.1         2-2045
FEATURES             Location/Qualifiers
     source          1..2044
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..2044
                     /gene="Nacc1"
                     /gene_synonym="Btbd14b; Nac-1; Nac1"
                     /note="nucleus accumbens associated 1"
                     /db_xref="GeneID:171454"
                     /db_xref="RGD:621003"
     exon            1..125
                     /gene="Nacc1"
                     /gene_synonym="Btbd14b; Nac-1; Nac1"
                     /inference="alignment:Splign:2.1.0"
     exon            126..1037
                     /gene="Nacc1"
                     /gene_synonym="Btbd14b; Nac-1; Nac1"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1678
                     /gene="Nacc1"
                     /gene_synonym="Btbd14b; Nac-1; Nac1"
                     /note="nucleus accumbens-1; BTB/POZ domain-containing
                     protein 14B; BTB (POZ) domain containing 14B;
                     transcriptional repressor NAC1; nucleus accumbens
                     associated 1, BEN and BTB (POZ) domain containing"
                     /codon_start=1
                     /product="nucleus accumbens-associated protein 1"
                     /protein_id="NP_599240.1"
                     /db_xref="GeneID:171454"
                     /db_xref="RGD:621003"
                     /translation="MAQTLQMEIPNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAH
                     RAVLAASSSYFRDLFNSSRSAVVELPAAVQPQSFQQILTFCYTGRLSMNMGDQFLLIY
                     TAGFLQIQEIMEKGTEFFLKVSSPSCDSQGLHPEEAPSSEPQSPVAQILGWPACSTPL
                     PLVSRVKTEQELDSVQCTPMAKRLWDSSQKEAGGSGGNNGSRKMAKFSTPDLAPNRMP
                     QPVSVATATAAVAVVAVGGCVSGPSMSERTSPGTSSAYTSDSPSSYHNEEDEEEDAGE
                     EGTDEQYRQICNMYTMYSMLNVGQTVEKVEALPEQVVLESHSRIRVRQDLASLPAELI
                     NQIGNRCHPKLYDEGDPSEKLELVTGTNVYITRAQLMNCHVSAGTRHKVLLRRLLASF
                     FDRNTLANSCGTGIRSSTNDPRRKPLDSRVLHAVKYYCQNFAPNFKESEMNAIAADMC
                     TNARRVVRKSWLPKTKPLHLVEGDNYSSFISDTGKIEPDMMSMEHSFETASHDGEAGP
                     SAEVLQ"
     exon            1038..1211
                     /gene="Nacc1"
                     /gene_synonym="Btbd14b; Nac-1; Nac1"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1317
                     /gene="Nacc1"
                     /gene_synonym="Btbd14b; Nac-1; Nac1"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1415
                     /gene="Nacc1"
                     /gene_synonym="Btbd14b; Nac-1; Nac1"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..2044
                     /gene="Nacc1"
                     /gene_synonym="Btbd14b; Nac-1; Nac1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgcggcgg ccgcagaggc ggaggccgag gccgaggcgc aggggggcgc gccccgggcc
       61 caggcccggc cccagctgcc gctgcggagc ccgccgggag gccccggagc gcggccacag
      121 cgcagctgct gccatggcgc agaccctgca gatggagatt ccaaactttg gcaacagcat
      181 cctcgagtgc ctcaatgagc agcggctaca gggactgtat tgtgacgtgt cagtggtggt
      241 aaagggccat gccttcaaag cccaccgtgc tgtgttggcc gccagcagct cctacttccg
      301 ggacctattc aacagcagcc gcagtgctgt ggtagaactg ccagccgctg tgcagccaca
      361 gtcattccag cagatcctca cgttttgtta tacaggccgg ctgagcatga acatggggga
      421 ccagttcctg ctcatctaca cagccggctt cctgcagatc caggagatca tggagaaagg
      481 cactgagttc ttcctcaaag ttagctctcc aagttgcgac tcccagggcc tgcacccgga
      541 ggaggcccca tcctcagagc ctcagagtcc tgtagcgcag atattgggct ggccagcctg
      601 tagcacgcca ctgccccttg tgtcacgggt caagacagaa caggagttgg actcggtgca
      661 atgcacaccc atggccaaga ggctatggga tagcagccag aaggaagctg gaggcagtgg
      721 tggcaacaat ggcagccgca agatggccaa gttctccacg ccagacctgg cccctaaccg
      781 gatgccccag ccagtctctg tggccacagc tacagcagca gtggctgtgg ttgcagtggg
      841 gggatgtgtg agtgggccca gcatgtcaga gcggaccagc ccaggtacct ccagtgctta
      901 cactagtgac agccccagct cctaccacaa cgaagaagac gaagaggaag atgcaggtga
      961 ggagggcaca gatgagcagt accgtcagat ctgcaatatg tataccatgt acagtatgtt
     1021 gaacgttggc cagacagttg agaaggtgga ggctcttcct gagcaggtcg tccttgagtc
     1081 ccacagtcgc attcgagtgc ggcaagacct ggcatctctc ccagctgagc tcatcaacca
     1141 gatcggcaat cgctgccacc caaagctcta cgatgaaggc gacccctcag agaagctgga
     1201 gcttgtgaca ggcaccaatg tatacatcac aagggcacaa ctcatgaact gccacgtcag
     1261 tgcaggcacg cggcacaagg tcttgctgcg gcggctcctg gcttccttct ttgaccggaa
     1321 cacactggcc aatagctgtg gcaccggcat ccgttcttcc accaatgacc ctagacgcaa
     1381 gccactggac agtcgtgtcc tccatgctgt caagtactac tgccagaact tcgcccccaa
     1441 cttcaaggag agcgagatga atgccattgc agccgacatg tgcaccaatg cccgccgagt
     1501 ggtccgtaaa agctggctgc ccaagaccaa gccgctacac ctggtggagg gcgataacta
     1561 cagcagcttc atcagcgaca ctggcaagat agaaccggac atgatgagca tggaacacag
     1621 cttcgagaca gccagccacg atggcgaggc tggcccttca gctgaggttc tccagtaaca
     1681 tacatgtgac acccccttac cggatgtcac attccccctc ctatcacacc cccacctacc
     1741 acctacctgg tcacgatcta ctgtctgtcc ctccccagaa cctgtgaggg ggtgttcagt
     1801 gccctctatc ggatgcaaga gctggctgac caaggccaaa gcactgtacc tagcagaggg
     1861 cagtgccgac agcagctttc tcaatgacca tgaggaagag ctgaacttgg taggcataga
     1921 atacagcttc cacacagaca gccccctcag cagaggtcct ccagtacctg cccaggaccc
     1981 tcccatggat gtcacactcc cctcctgtca cacacatacc cccaccttag tcacgagcta
     2041 ctgt
//
