LOCUS       NP_001128346             525 aa            linear   ROD 30-MAR-2024
DEFINITION  NGFI-A-binding protein 2 [Rattus norvegicus].
ACCESSION   NP_001128346 XP_001056620 XP_235224
VERSION     NP_001128346.1
DBSOURCE    REFSEQ: accession NM_001134874.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 525)
  AUTHORS   Killick,R., Ribe,E.M., Al-Shawi,R., Malik,B., Hooper,C.,
            Fernandes,C., Dobson,R., Nolan,P.M., Lourdusamy,A., Furney,S.,
            Lin,K., Breen,G., Wroe,R., To,A.W., Leroy,K., Causevic,M.,
            Usardi,A., Robinson,M., Noble,W., Williamson,R., Lunnon,K.,
            Kellie,S., Reynolds,C.H., Bazenet,C., Hodges,A., Brion,J.P.,
            Stephenson,J., Simons,J.P. and Lovestone,S.
  TITLE     Clusterin regulates beta-amyloid toxicity via Dickkopf-1-driven
            induction of the wnt-PCP-JNK pathway
  JOURNAL   Mol Psychiatry 19 (1), 88-98 (2014)
   PUBMED   23164821
REFERENCE   2  (residues 1 to 525)
  AUTHORS   Le,N., Nagarajan,R., Wang,J.Y., Svaren,J., LaPash,C., Araki,T.,
            Schmidt,R.E. and Milbrandt,J.
  TITLE     Nab proteins are essential for peripheral nervous system
            myelination
  JOURNAL   Nat Neurosci 8 (7), 932-940 (2005)
   PUBMED   16136673
REFERENCE   3  (residues 1 to 525)
  AUTHORS   Jouvert,P., Dietrich,J.B., Aunis,D. and Zwiller,J.
  TITLE     Differential rat brain expression of EGR proteins and of the
            transcriptional corepressor NAB in response to acute or chronic
            cocaine administration
  JOURNAL   Neuromolecular Med 1 (2), 137-151 (2002)
   PUBMED   12025859
  REMARK    GeneRIF: nab2 protein--a transcripitonal corepresor expressed in
            rat brain in ersponse to cocaine administrtion
REFERENCE   4  (residues 1 to 525)
  AUTHORS   Svaren,J., Sevetson,B.R., Apel,E.D., Zimonjic,D.B., Popescu,N.C.
            and Milbrandt,J.
  TITLE     NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by
            proliferative and differentiative stimuli
  JOURNAL   Mol Cell Biol 16 (7), 3545-3553 (1996)
   PUBMED   8668170
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On or before Sep 13, 2008 this sequence version replaced
            XP_001056620.1, XP_235224.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.39495.1,
                                           SRR26643285.27802.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..525
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     Protein         1..525
                     /product="NGFI-A-binding protein 2"
                     /calculated_mol_wt=56482
     Region          36..114
                     /region_name="NCD1"
                     /note="NAB conserved region 1 (NCD1); pfam04904"
                     /db_xref="CDD:461473"
     Region          236..364
                     /region_name="NCD2"
                     /note="NAB conserved region 2 (NCD2); pfam04905"
                     /db_xref="CDD:461474"
     CDS             1..525
                     /gene="Nab2"
                     /coded_by="NM_001134874.1:211..1788"
                     /db_xref="GeneID:314910"
                     /db_xref="RGD:1311712"
ORIGIN      
        1 mhrapsptae qppgradntr rtpqprvkas astmalprtl gelqlyrvlq ranllsyyet
       61 fiqqggddvq qlceageeef leimalvgma tkplhvrrlq kalrewatnp glfsqpvpav
      121 pvssiplfki setagtrkgs msnghgspge kagsarsfsp ksplelgekl splpggpgag
      181 dpriwpgqst pesdvgagge eeagsppfsp pagggvpegt gaggvaaggt gggpdrlepe
      241 mvrmvvesve rifrsfprgd tgeitsllkl nkklarsvgh ifemddndsq keeeirkysi
      301 iygrldskrr egkqlslhel tineaaaqfc mrdntlllrr velfslsrqv arestylssl
      361 kgsrlhseel ggpplkklkq evgeqshtei qqpppgpepy appyrpslee dsaslsgesl
      421 dghlqavgsc prltpppadl plalpahglw srhilqqtlm deglrlarlv shdrvgrlsp
      481 cvpakpplae feeglldrcp apgphpalve grrssvkvea easrq
//
