LOCUS       NM_022856               4525 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus Ngfi-A binding protein 1 (Nab1), mRNA.
ACCESSION   NM_022856
VERSION     NM_022856.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4525)
  AUTHORS   Mager,G.M., Ward,R.M., Srinivasan,R., Jang,S.W., Wrabetz,L. and
            Svaren,J.
  TITLE     Active gene repression by the Egr2.NAB complex during peripheral
            nerve myelination
  JOURNAL   J Biol Chem 283 (26), 18187-18197 (2008)
   PUBMED   18456662
  REMARK    GeneRIF: Egr2 directly represses genes during myelination in
            conjunction with NAB corepressors
REFERENCE   2  (bases 1 to 4525)
  AUTHORS   Le,N., Nagarajan,R., Wang,J.Y., Svaren,J., LaPash,C., Araki,T.,
            Schmidt,R.E. and Milbrandt,J.
  TITLE     Nab proteins are essential for peripheral nervous system
            myelination
  JOURNAL   Nat Neurosci 8 (7), 932-940 (2005)
   PUBMED   16136673
REFERENCE   3  (bases 1 to 4525)
  AUTHORS   Snyder-Keller,A., Chandra,R., Lin,Y. and Mitchell,E.S.
  TITLE     Basal EGR-1 (zif268, NGFI-A, Krox-24) expression in developing
            striatal patches: role of dopamine and glutamate
  JOURNAL   Brain Res 958 (2), 297-304 (2002)
   PUBMED   12470865
  REMARK    GeneRIF: NGFI-A protein expression in the developing striatum
            appears to be driven first by dopaminergic afferents, and then
            later in development by excitatory glutamatergic afferents.
REFERENCE   4  (bases 1 to 4525)
  AUTHORS   Swirnoff,A.H., Apel,E.D., Svaren,J., Sevetson,B.R., Zimonjic,D.B.,
            Popescu,N.C. and Milbrandt,J.
  TITLE     Nab1, a corepressor of NGFI-A (Egr-1), contains an active
            transcriptional repression domain
  JOURNAL   Mol Cell Biol 18 (1), 512-524 (1998)
   PUBMED   9418898
REFERENCE   5  (bases 1 to 4525)
  AUTHORS   Svaren,J., Sevetson,B.R., Apel,E.D., Zimonjic,D.B., Popescu,N.C.
            and Milbrandt,J.
  TITLE     NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by
            proliferative and differentiative stimuli
  JOURNAL   Mol Cell Biol 16 (7), 3545-3553 (1996)
   PUBMED   8668170
REFERENCE   6  (bases 1 to 4525)
  AUTHORS   Russo,M.W., Sevetson,B.R. and Milbrandt,J.
  TITLE     Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated
            transcription
  JOURNAL   Proc Natl Acad Sci U S A 92 (15), 6873-6877 (1995)
   PUBMED   7624335
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Oct 8, 2014 this sequence version replaced NM_022856.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.31526.1,
                                           SRR26643290.32365.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               JAXUCZ010000009.1  56545642-56545819
            179-1013            JAXUCZ010000009.1  56554882-56555716
            1014-1147           JAXUCZ010000009.1  56564239-56564372
            1148-1199           JAXUCZ010000009.1  56565679-56565730
            1200-1289           JAXUCZ010000009.1  56574540-56574629
            1290-1449           JAXUCZ010000009.1  56576466-56576625
            1450-1566           JAXUCZ010000009.1  56579103-56579219
            1567-4525           JAXUCZ010000009.1  56582087-56585045
FEATURES             Location/Qualifiers
     source          1..4525
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q22"
     gene            1..4525
                     /gene="Nab1"
                     /note="Ngfi-A binding protein 1"
                     /db_xref="GeneID:64824"
                     /db_xref="RGD:70882"
     exon            1..178
                     /gene="Nab1"
                     /inference="alignment:Splign:2.1.0"
     exon            179..1013
                     /gene="Nab1"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..1655
                     /gene="Nab1"
                     /note="EGR-1-binding protein 1"
                     /codon_start=1
                     /product="NGFI-A-binding protein 1"
                     /protein_id="NP_074047.2"
                     /db_xref="GeneID:64824"
                     /db_xref="RGD:70882"
                     /translation="MATALPRTLGELQLYRILQKANLLSYFDAFIQQGGDDVQQLCEA
                     GEEEFLEIMALVGMASKPLHVRRLQKALRDWVTNPGLFNQPLTSLPVSSIPIYKLPEG
                     SPTWLGISCNSYERSSSAREPHLKVPKCAATTCVQSLGQGKSEVGSLALQSVSESRLW
                     QGHHTTESEHSLSPADLGSPASPKESSEALDAAAALSVAECVERMAPTLPKSDLNEVK
                     ELLKNNKKLAKMIGHIFEMSDEDPHKEEEIRKYSAIYGRFDSKRKDGKHLTLHELTVN
                     EAAAQLCVKDNALLTRRDELFALARQVSREVTYKYTYRTTRLKCGERDELSPKRIKME
                     DGFPDFQESVPTLFQQARAKSEELAGLSSQAEKGMAKQMELLCAQAGYERLQQERRLM
                     AGLYRQSSGEQSPDGGLPSDGSDGQGERPLNLRIPSVQNRQPHHFVVDGELSRLYSNE
                     VKSHSSESLGILKDYPHSAFTLEKKVIKTEPEDSR"
     exon            1014..1147
                     /gene="Nab1"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1199
                     /gene="Nab1"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1289
                     /gene="Nab1"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1449
                     /gene="Nab1"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1566
                     /gene="Nab1"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..4525
                     /gene="Nab1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccacccgag cctccgcccg cgcggccaag cgagcgccgt cggggcgggc gggggacaga
       61 gcgcacgccc accacgtccc tgcccccctc gatgggcgcg ggggcgtccc ggccgccgca
      121 gccgccgcag gagcccggca gagccgttgt cgcggatcgc tccgcagccg cgggccgcgt
      181 taagcccatc cacagtaatg gccacagcct tacctaggac cctgggagag ctgcagctgt
      241 atcgaatatt gcagaaagct aatctgcttt cttactttga tgcctttatc caacaaggtg
      301 gtgatgatgt ccagcaactg tgcgaagctg gagaagaaga atttttggaa atcatggcac
      361 tggtgggcat ggcaagcaag ccccttcatg ttagacggct tcagaaggct ttgagagatt
      421 gggttacaaa tcctggcctt ttcaaccagc cattgacttc ccttcctgtc agtagcatac
      481 ccatctataa attaccagag ggatcaccaa catggctggg aatatcctgc aatagttatg
      541 aaaggagtag cagtgcccga gagccacatt taaaggtccc taaatgcgct gccaccacct
      601 gtgttcagag cttgggtcag ggcaagtcag aggtgggaag tctagcactg cagagtgtca
      661 gtgaatccag actctggcaa ggacaccaca ccactgaaag cgagcatagt ctctccccag
      721 cagacctggg ctccccagcc tccccaaagg aaagcagtga agccctggat gctgccgccg
      781 cgctctctgt ggccgagtgt gtggagcgga tggcccccac gctgcccaaa agtgacttga
      841 atgaagtgaa agagctgctg aagaacaata agaagttggc caaaatgatt ggtcacatct
      901 tcgagatgag cgacgaggat ccacacaagg aggaggagat cagaaagtac agcgccatct
      961 atgggcgatt tgactccaaa agaaaggatg gtaaacacct cacattgcat gagctcacgg
     1021 ttaacgaggc agctgctcag ctgtgtgtga aggacaatgc cctgctgacg agaagagatg
     1081 agcttttcgc cctggccagg caggtttctc gagaagttac ctacaaatac acttacagga
     1141 ccaccaggtt aaaatgtggt gaaagagatg aattgtctcc aaagagaatt aaaatggagg
     1201 atggatttcc ggacttccag gaatctgtgc caacactctt ccagcaggcc agagccaaaa
     1261 gtgaagagct tgcaggtctc agttcacagg ctgagaaggg gatggcaaag caaatggagc
     1321 tcctgtgtgc ccaggccggc tatgagaggc tgcagcagga gaggagactc atggccgggc
     1381 tctacaggca gagctctgga gagcagagcc ctgatggcgg ccttccttct gatggctccg
     1441 atggacaagg agaaaggcct ttgaatctcc gaattcctag tgtgcagaac agacagcccc
     1501 atcattttgt ggtggatggg gagctcagta gactttactc caacgaggtg aagtcccact
     1561 catcagagag ccttgggatt ctaaaagact atcctcactc tgcattcacc ttggaaaaga
     1621 aagttattaa aacagagccc gaagactcaa gatagctgag attctccccc tgctctctgg
     1681 aaatgacacc agatccgagg atatgctcca tcgtagatta agccttaata accagtgttg
     1741 cctcattcag ctcccagacc atagccaaag cgtaagaact cacacagtcg tctgtgggca
     1801 ccaggacaaa gcaacagcca cagaagaggg aaccgagata gcattgcaaa gtaacgggca
     1861 ccgaccggtt accttcctgt gtaagttgct tgtgtggaaa ggctcaatac cgtaggcatt
     1921 cactatttaa gaatgtacaa tgtgtctgta atttatagaa gcaaatctag gtgttgatac
     1981 cttgcagtct aatagacgtg gatcccactt attttacttg aaattctgtt gtcgacttta
     2041 agtgtattta ccgtaaatgt tacttgtcag cattcagaac tttcacagtc ctagaaagaa
     2101 agcctgggca atgtagttat ttgcaaggtg actggagaaa gaagataaat acaaagttta
     2161 caccaaggag aagacccatg tgcttgctac ttgataacat tgatgttgat caataggaaa
     2221 taggtagctg tcaactaaat aatgtcactt tcattggttt aatcaatgca caaattaaaa
     2281 attggtagta gcattcccaa gatgcggtcg gctacattta tgacagctgc tcaagatgta
     2341 acagaagttg gacagaggac ttgaaataaa tgggttactg tgtaaagcct tgacttaaac
     2401 attgatattt cagaatgtgt taaacaaatt aaggcatagt aagttaaccc taaatgtgat
     2461 aaagatgatg atgttggtga attgacatgg cgtgtgtgtg tttttagttc tgttttagat
     2521 catgctgtca tagatatgag ttcctaatct gttatactga aatctgttgg ccagatgttc
     2581 gatgaaatgt ctgcaccgta agctctaagc actgtctcat agataatcac atttcaattt
     2641 gatctgtaag agttttacag taaaaacacc agtaaacagc gtttctacta ttacaaggct
     2701 ttttccttcc taaatgtttc tattggacca tagattcttg cccactgaag aagtatctta
     2761 gggaccacgt gcctctgttg ctactgtgag gttgattact gtggtctcac tatccactgt
     2821 gtgtagagct agtgcaatac catttaaata gagtgtttag ttctaatctt agccacagtg
     2881 ctggctagtg cccctgtact ctcatgaact gtttcctgtg ttccataatc tattttgaga
     2941 aattttgtgg tcctttttgt taaaaaaaaa aaaactatgc catacagttc aagtttgtag
     3001 attttaacac gcaagtttta aaagatgcag tggtcttcca gctaatattt gtttctcctg
     3061 gacctagaac ctgcattttt aaatccagaa ttaagtctcc ttaagtagca tacttttttg
     3121 acttccaagc ttagagataa agaagtgtgc acgcacactc atgtagagcg cgcacgcgta
     3181 cacacacaca cacacacaca cacacacaca cacaaatttt cagtagaata cagtttttat
     3241 cttgtgaaca ctaatgtatt aaacttgcta tacattaaag caaataatat atatttttat
     3301 ttggtaaata taaattagat gttataacta gttgggtttt tatttttaat tttgtttaag
     3361 atatttccac tgaacaaggt caattggtta cctcagtatt acagccaata taacccaagg
     3421 gaccatttct ccctaagtct gtgttattct ttattgtgtg aattctgcat ttttgtgatt
     3481 cttaaaactg ttgaagagat gagtgcactt gcttcctgtg gcaataaagg agttctctgc
     3541 ctcacaaatc ctggctcaga gtgcttgcat agcacgcgat gttcatccac accgcctcct
     3601 ttacagcatg tcaggggaca ggaagagctt ctatcttttt cctttttgtg acactgagag
     3661 ttgaacccag aggctctacc actgagtgat agtcccaata ctcatgttac ttttttattc
     3721 tgaaacaggc ttactaactt tccccagctg gccttgaact cactttgtag accacaaagg
     3781 tggtggtcac acaaggaggc ctttcctagt gtgtggttcg tacatttcag ttttgaaatg
     3841 gcagagtatt tctagcacag gaccattttg ttttcggctt tgatgctgct ctgaatcttc
     3901 aaaggaaaac caaccaggtt gtcaaccaag tgagagcagg agcctgtgtc tgtctcttgt
     3961 agatgggaga aaatacgaca gccaatattt aatgaaagcc cacttctgac ccagctgtgc
     4021 gaagttggtt ctgggaatcc aagcgcatgc atttgctgtt atctctgggc attctcatga
     4081 atgacattct ccagtgggct tcaaattaac aaaggatgac tcagcatcct gacaccatta
     4141 ttgaaaacac acatcaatct caaagacctt gatgatagct atttccatag tcacttcaca
     4201 aaacaaacgt tcctgacacc taagtgatca gaagctgaca ttatgctaat gttttcattt
     4261 cagaatgtgt gatggctaaa tctttagatc tatcatccct ggattctcct ctgactgact
     4321 tacaaaaatg aagaaagcaa tcacttggtt cttgtgcaga aaatatgaat cagaatttaa
     4381 gtttttaatt tttttaaact agttttatgt ttacttacat atatttttct gtcttttttt
     4441 tttaccatgg ctttagaaag aatgataaat aattgctggt tttgttataa atttaataaa
     4501 attccttctt tttttcctat tttca
//
