LOCUS       NM_001010967            1830 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus N-acylethanolamine acid amidase (Naaa), mRNA.
ACCESSION   NM_001010967 XM_223237
VERSION     NM_001010967.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1830)
  AUTHORS   Zhou,P., Xiang,L., Yang,Y., Wu,Y., Hu,T., Liu,X., Lin,F., Xiu,Y.,
            Wu,K., Lu,C., Ren,J., Qiu,Y. and Li,Y.
  TITLE     N-Acylethanolamine acid amidase (NAAA) inhibitor F215 as a novel
            therapeutic agent for osteoarthritis
  JOURNAL   Pharmacol Res 145, 104264 (2019)
   PUBMED   31063807
  REMARK    GeneRIF: Taken together, this study identified the association
            between NAAA and steoarthritis (OA) progression, and suggested that
            NAAA inhibitors could be a novel therapeutic approach for OA.
REFERENCE   2  (bases 1 to 1830)
  AUTHORS   Gorelik,A., Gebai,A., Illes,K., Piomelli,D. and Nagar,B.
  TITLE     Molecular mechanism of activation of the immunoregulatory amidase
            NAAA
  JOURNAL   Proc Natl Acad Sci U S A 115 (43), E10032-E10040 (2018)
   PUBMED   30301806
REFERENCE   3  (bases 1 to 1830)
  AUTHORS   Danyukova,T., Ariunbat,K., Thelen,M., Brocke-Ahmadinejad,N.,
            Mole,S.E. and Storch,S.
  TITLE     Loss of CLN7 results in depletion of soluble lysosomal proteins and
            impaired mTOR reactivation
  JOURNAL   Hum Mol Genet 27 (10), 1711-1722 (2018)
   PUBMED   29514215
REFERENCE   4  (bases 1 to 1830)
  AUTHORS   Tai,T., Tsuboi,K., Uyama,T., Masuda,K., Cravatt,B.F., Houchi,H. and
            Ueda,N.
  TITLE     Endogenous molecules stimulating N-acylethanolamine-hydrolyzing
            acid amidase (NAAA)
  JOURNAL   ACS Chem Neurosci 3 (5), 379-385 (2012)
   PUBMED   22860206
REFERENCE   5  (bases 1 to 1830)
  AUTHORS   Dhennin-Duthille,I., Nyga,R., Yahiaoui,S., Gouilleux-Gruart,V.,
            Regnier,A., Lassoued,K. and Gouilleux,F.
  TITLE     The tumor suppressor hTid1 inhibits STAT5b activity via functional
            interaction
  JOURNAL   J Biol Chem 286 (7), 5034-5042 (2011)
   PUBMED   21106534
REFERENCE   6  (bases 1 to 1830)
  AUTHORS   Zhao,L.Y., Tsuboi,K., Okamoto,Y., Nagahata,S. and Ueda,N.
  TITLE     Proteolytic activation and glycosylation of
            N-acylethanolamine-hydrolyzing acid amidase, a lysosomal enzyme
            involved in the endocannabinoid metabolism
  JOURNAL   Biochim Biophys Acta 1771 (11), 1397-1405 (2007)
   PUBMED   17980170
REFERENCE   7  (bases 1 to 1830)
  AUTHORS   Tsuboi,K., Zhao,L.Y., Okamoto,Y., Araki,N., Ueno,M., Sakamoto,H.
            and Ueda,N.
  TITLE     Predominant expression of lysosomal N-acylethanolamine-hydrolyzing
            acid amidase in macrophages revealed by immunochemical studies
  JOURNAL   Biochim Biophys Acta 1771 (5), 623-632 (2007)
   PUBMED   17462942
  REMARK    GeneRIF: mRNA and protein levels and activity of NAAA in alveolar
            macrophages are much higher than those in the whole lung tissue.
REFERENCE   8  (bases 1 to 1830)
  AUTHORS   Tsuboi,K., Sun,Y.X., Okamoto,Y., Araki,N., Tonai,T. and Ueda,N.
  TITLE     Molecular characterization of N-acylethanolamine-hydrolyzing acid
            amidase, a novel member of the choloylglycine hydrolase family with
            structural and functional similarity to acid ceramidase
  JOURNAL   J Biol Chem 280 (12), 11082-11092 (2005)
   PUBMED   15655246
REFERENCE   9  (bases 1 to 1830)
  AUTHORS   Ueda,N., Yamanaka,K. and Yamamoto,S.
  TITLE     Purification and characterization of an acid amidase selective for
            N-palmitoylethanolamine, a putative endogenous anti-inflammatory
            substance
  JOURNAL   J Biol Chem 276 (38), 35552-35557 (2001)
   PUBMED   11463796
REFERENCE   10 (bases 1 to 1830)
  AUTHORS   Hong,S.B., Li,C.M., Rhee,H.J., Park,J.H., He,X., Levy,B., Yoo,O.J.
            and Schuchman,E.H.
  TITLE     Molecular cloning and characterization of a human cDNA and gene
            encoding a novel acid ceramidase-like protein
  JOURNAL   Genomics 62 (2), 232-241 (1999)
   PUBMED   10610717
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC105771.1.
            
            On Oct 16, 2005 this sequence version replaced NM_001010967.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC105771.1, AB162193.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132281, SAMD00132292
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1830
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..1830
                     /gene="Naaa"
                     /gene_synonym="Asahl"
                     /note="N-acylethanolamine acid amidase"
                     /db_xref="GeneID:497009"
                     /db_xref="RGD:1307267"
     exon            1..238
                     /gene="Naaa"
                     /gene_synonym="Asahl"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..1106
                     /gene="Naaa"
                     /gene_synonym="Asahl"
                     /EC_number="3.5.1.23"
                     /EC_number="3.5.1.60"
                     /note="N-acylethanolamine-hydrolyzing acid amidase;
                     ASAH-like protein; acylsphingosine deacylase NAAA"
                     /codon_start=1
                     /product="N-acylethanolamine-hydrolyzing acid amidase
                     precursor"
                     /protein_id="NP_001010967.1"
                     /db_xref="GeneID:497009"
                     /db_xref="RGD:1307267"
                     /translation="MGTPAIRAACHGAHLALALLLLLSLSDPWLWATAPGTPPLFNVS
                     LDAAPELRWLPMLQHYDPDFVRAAVAQVIGDRVPQWILEMIGEIVQKVESFLPQPFTS
                     EIRGICDYLNLSLAEGVLVNLAYEASAFCTSIVAQDSQGRIYHGRNLDYPFGNALRKL
                     TADVQFVKNGQIVFTATTFVGYVGLWTGQSPHKFTISGDERDKGWWWENMIAALSLGH
                     SPISWLIRKTLTESEDFEAAVYTLAKTPLIADVYYIVGGTSPQEGVVITRDRGGPADI
                     WPLDPLNGAWFRVETNYDHWEPVPKRDDRRTPAIKALNATGQAHLSLETLFQVLSVFP
                     VYNNYTIYTTVMSAAEPDKYMTMIRNPS"
     exon            239..403
                     /gene="Naaa"
                     /gene_synonym="Asahl"
                     /inference="alignment:Splign:2.1.0"
     exon            404..530
                     /gene="Naaa"
                     /gene_synonym="Asahl"
                     /inference="alignment:Splign:2.1.0"
     exon            531..621
                     /gene="Naaa"
                     /gene_synonym="Asahl"
                     /inference="alignment:Splign:2.1.0"
     exon            622..698
                     /gene="Naaa"
                     /gene_synonym="Asahl"
                     /inference="alignment:Splign:2.1.0"
     exon            699..871
                     /gene="Naaa"
                     /gene_synonym="Asahl"
                     /inference="alignment:Splign:2.1.0"
     exon            872..934
                     /gene="Naaa"
                     /gene_synonym="Asahl"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1001
                     /gene="Naaa"
                     /gene_synonym="Asahl"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1030
                     /gene="Naaa"
                     /gene_synonym="Asahl"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1108
                     /gene="Naaa"
                     /gene_synonym="Asahl"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1813
                     /gene="Naaa"
                     /gene_synonym="Asahl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctcagcagc ccgagccatg gggaccccag ccatccgggc cgcgtgccat ggggcacacc
       61 tggcgctggc tctgttgctg ctgctgtcgc tgtcggatcc ctggctgtgg gcgaccgccc
      121 ctggcactcc gcctctcttc aacgtcagtc tggacgcggc cccggagctg cgctggctgc
      181 cgatgctgca gcactacgac ccagacttcg tgcgcgccgc ggtggcgcag gttattggag
      241 acagggttcc ccagtggata ctagagatga tcggagaaat cgtgcagaag gtggagagct
      301 tcctgcctca gcccttcacc tccgagatcc gcggcatatg tgactacctc aacctcagcc
      361 tggcagaggg tgtcttggtc aacttggcct atgaggcttc cgcattctgc accagtattg
      421 tggcccaaga ctcccaaggc cgtatttacc atggccggaa cctggactat ccttttggaa
      481 atgccttacg aaagctgaca gcagacgtgc agtttgtaaa gaacgggcag attgtattca
      541 cagcgaccac ttttgttggc tatgtaggac tgtggacagg tcaaagtccc cacaagttta
      601 caatttctgg tgatgaacga gacaaaggct ggtggtggga gaacatgatt gctgcgcttt
      661 ccttgggaca ctcgcccatc agctggctta tccgcaaaac cctgactgag tccgaagact
      721 tcgaagcggc cgtttacacg ctggccaaga ctcccctcat tgctgatgtg tattacatcg
      781 ttgggggtac atcgccccag gagggagtag tcatcaccag ggacagaggt ggccccgcgg
      841 acatttggcc tcttgaccct ctgaatggag cgtggttccg agtcgagacc aattatgacc
      901 actgggagcc tgtgcccaag agggatgacc gaaggacacc agccatcaaa gccctaaatg
      961 ccacagggca agctcacctc agtctggaga ccctcttcca ggttttatcc gtgtttcctg
     1021 tttataacaa ctacacaatt tataccacag tgatgagcgc tgctgagccc gacaagtaca
     1081 tgaccatgat cagaaaccca agctgaagat gatttattgt caaagagctg catttggaag
     1141 actaagactg gaagtattgt acggtttcct gagcaacgca ggctccctct tcagaaagcc
     1201 tttctgcctt gtggaagggg tagatctctt ggcacacatc tggaggaaga ggagtgtatt
     1261 ctgctgtctt gcatcctcct gatgtcctgg tccccttgag cttcattaac aacccaccct
     1321 ggcttgaaca actcagataa ctgatctcgg aggtcaggct gcacctgact agtcacaggt
     1381 ttcctgtgat tctgtgtcca cgcccctgct tttccactga agaagggaac agacaagata
     1441 gctgtcgtgt ggagggaggc cttgtggaca accccccagg agaaaatttc ccctaaggct
     1501 ggggtgaggc tcagtagcag aatttgcacc actaagtaaa tagtaaatag ataaacgaac
     1561 aaaagttttc tctcaggagt ggaaacctct aatctgagta gaatttgctt gaagatatgt
     1621 tcctctgacc tttgatttca tgtttctata tagtggaaat tcacttttta taaacttcta
     1681 atgtattgtt ttaacgtggg ccttattaaa aataaagcta atttcttagt gcttttgaaa
     1741 attatgtgac aacaaataat ttcctgtcat tctttatcgt ttgttaataa aatgtcaaaa
     1801 aatgctagct gcaaaaaaaa aaaaaaaaaa
//
