LOCUS       NM_001014226            2293 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus N(alpha)-acetyltransferase 60, NatF catalytic
            subunit (Naa60), mRNA.
ACCESSION   NM_001014226 XM_343861
VERSION     NM_001014226.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2293)
  AUTHORS   Chen,J.Y., Liu,L., Cao,C.L., Li,M.J., Tan,K., Yang,X. and Yun,C.H.
  TITLE     Structure and function of human Naa60 (NatF), a Golgi-localized
            bi-functional acetyltransferase
  JOURNAL   Sci Rep 6, 31425 (2016)
   PUBMED   27550639
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2293)
  AUTHORS   Stove,S.I., Magin,R.S., Foyn,H., Haug,B.E., Marmorstein,R. and
            Arnesen,T.
  TITLE     Crystal Structure of the Golgi-Associated Human
            Nalpha-Acetyltransferase 60 Reveals the Molecular Determinants for
            Substrate-Specific Acetylation
  JOURNAL   Structure 24 (7), 1044-1056 (2016)
   PUBMED   27320834
REFERENCE   3  (bases 1 to 2293)
  AUTHORS   Aksnes,H., Van Damme,P., Goris,M., Starheim,K.K., Marie,M.,
            Stove,S.I., Hoel,C., Kalvik,T.V., Hole,K., Glomnes,N., Furnes,C.,
            Ljostveit,S., Ziegler,M., Niere,M., Gevaert,K. and Arnesen,T.
  TITLE     An organellar nalpha-acetyltransferase, naa60, acetylates cytosolic
            N termini of transmembrane proteins and maintains Golgi integrity
  JOURNAL   Cell Rep 10 (8), 1362-1374 (2015)
   PUBMED   25732826
REFERENCE   4  (bases 1 to 2293)
  AUTHORS   Yang,X., Yu,W., Shi,L., Sun,L., Liang,J., Yi,X., Li,Q., Zhang,Y.,
            Yang,F., Han,X., Zhang,D., Yang,J., Yao,Z. and Shang,Y.
  TITLE     HAT4, a Golgi apparatus-anchored B-type histone acetyltransferase,
            acetylates free histone H4 and facilitates chromatin assembly
  JOURNAL   Mol Cell 44 (1), 39-50 (2011)
   PUBMED   21981917
REFERENCE   5  (bases 1 to 2293)
  AUTHORS   Van Damme,P., Hole,K., Pimenta-Marques,A., Helsens,K.,
            Vandekerckhove,J., Martinho,R.G., Gevaert,K. and Arnesen,T.
  TITLE     NatF contributes to an evolutionary shift in protein N-terminal
            acetylation and is important for normal chromosome segregation
  JOURNAL   PLoS Genet 7 (7), e1002169 (2011)
   PUBMED   21750686
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC105304.1.
            
            On Sep 25, 2005 this sequence version replaced NM_001014226.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC105304.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate          :: translation inferred from conservation
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2293
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..2293
                     /gene="Naa60"
                     /gene_synonym="HAT4; Nat15; NatF; RGD1308915"
                     /note="N(alpha)-acetyltransferase 60, NatF catalytic
                     subunit"
                     /db_xref="GeneID:363545"
                     /db_xref="RGD:1308915"
     exon            1..103
                     /gene="Naa60"
                     /gene_synonym="HAT4; Nat15; NatF; RGD1308915"
                     /inference="alignment:Splign:2.1.0"
     exon            104..219
                     /gene="Naa60"
                     /gene_synonym="HAT4; Nat15; NatF; RGD1308915"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..838
                     /gene="Naa60"
                     /gene_synonym="HAT4; Nat15; NatF; RGD1308915"
                     /EC_number="2.3.1.48"
                     /EC_number="2.3.1.259"
                     /note="GNAT acetytransferase; N-acetyltransferase 15
                     (GCN5-related, putative); natF catalytic subunit; GNAT
                     acetyltransferase; N-alpha-acetyltransferase F; histone
                     acetyltransferase type B protein 4"
                     /codon_start=1
                     /product="N-alpha-acetyltransferase 60"
                     /protein_id="NP_001014248.2"
                     /db_xref="GeneID:363545"
                     /db_xref="RGD:1308915"
                     /translation="MTEVVPSSALSEVSLRLLCHDDIDTVKHLCGDWFPIEYPDSWYR
                     DITSNKKFFSLAATYRGAIVGMIVAEIKNRTKIHKEDGDILASSFSVDTQVAYILSLG
                     VVKEFRKHGIGSLLLESLKDHISTTAQDHCKAIYLHVLTTNNTAINFYENRDFRQHHY
                     LPYYYSIRGVLKDGFTYVLYINGGHPPWTILDYIQHLGSALANLSPCSIPHRIYRQAH
                     SLLCSFLPWSSISSKGGIEYSRTM"
     exon            220..349
                     /gene="Naa60"
                     /gene_synonym="HAT4; Nat15; NatF; RGD1308915"
                     /inference="alignment:Splign:2.1.0"
     exon            350..446
                     /gene="Naa60"
                     /gene_synonym="HAT4; Nat15; NatF; RGD1308915"
                     /inference="alignment:Splign:2.1.0"
     exon            447..681
                     /gene="Naa60"
                     /gene_synonym="HAT4; Nat15; NatF; RGD1308915"
                     /inference="alignment:Splign:2.1.0"
     exon            682..1050
                     /gene="Naa60"
                     /gene_synonym="HAT4; Nat15; NatF; RGD1308915"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..2263
                     /gene="Naa60"
                     /gene_synonym="HAT4; Nat15; NatF; RGD1308915"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatctgtcgc gggggacccc gcagtcccac gtacggcttc ccggctcccc caggatgcgc
       61 tgagccttgc gacaccgtcc gctgccgccg gctcccgtcc gaggtgtgaa tgacagaggt
      121 ggtgccttcc agcgccctca gcgaggtcag cctgcgcctc ctctgccacg atgacataga
      181 cactgtgaag cacctgtgtg gcgactggtt ccccattgag tacccagact catggtatcg
      241 tgatatcaca tccaacaaga agttcttctc ccttgctgca acctacagag gtgccattgt
      301 gggaatgata gtagctgaaa taaagaatag gaccaaaata cataaagagg atggagatat
      361 tctagcctcc agcttctctg tggatacaca agttgcatac atcctcagtc tgggagtggt
      421 gaaagagttc aggaaacacg gcataggttc cctcttatta gaaagtttaa aggatcatat
      481 ttcaaccacc gcccaggacc actgcaaagc catctacctg cacgttctca ccaccaacaa
      541 cacagcaata aacttctatg aaaacagaga ctttaggcag catcactatc tgccctatta
      601 ctactccatc cgaggggtcc tcaaagatgg cttcacctat gtcctctaca tcaatggcgg
      661 ccaccctccc tggaccatct tagactacat ccagcacctg ggctcagcac tagccaacct
      721 gagcccctgc tccatcccac acaggatcta ccgccaggcc cacagcctgc tttgcagctt
      781 tctgccgtgg tccagcattt ccagcaaagg tggcattgaa tacagccgta ccatgtaatg
      841 ccgttggggc agcctccacc aggcctctgt cctcagcact ttgtggagcc tattttcctg
      901 tctgtctgac ttctgctgtc cttttcgagg agctggtggc cacctgccgg cccatcagcc
      961 tgcctcagct gcaggcccgg tgctatgctg gctgcctcag ctgcaggccc ggtgctatgc
     1021 tggctcagga gcagaatgta cactggtcgg gctctccttc cacctggagt ccttgtcctg
     1081 cctccatgcc ctggcaccac ccaatggcct ggcaggtgtg tctacattca ctgggaaagg
     1141 gcttgccagg cttctcctct gtctcctgct cctttagctc cttcctacaa gatggactga
     1201 actttgctga aaacgtggac atttctgacc ctgaagacac aggaacctta gaataaagag
     1261 gcacagcaag gagaatgtca gtttttgttt aggaatgccc taaagaagct tagatgatgg
     1321 aaacggttct tactcctcca tgaaaggctg gaaactgggg aaagagaaag aggggctggc
     1381 ccttcacaag aacttaaaaa cttcaggaat cagtcctctc catggacaga tgggacagtc
     1441 ccctgttccc agtgttctac tgtccacttc ttcctgtcca gaaggatcat cctgcttgtt
     1501 gaatcctggc atgttccaca tagctgacct acactgggag ctgggctaag gacaggtagc
     1561 tattggcttc tgggtttctt ccctgcttat ccttatagaa gctgaaactt caaggcctgg
     1621 gcctatgcag acaggaggaa gctgagcttt gtattggcat ctctgctact gtggacccat
     1681 ggcacctggc cttgggagca gagggcagct gctgcctttg ggccttcagc ctctgaggca
     1741 gagactttgt cagcaccacg aattgtgctt gcagcagaca tctcaagttt ccagcatccc
     1801 ttcccttgtg cccccatgtg tttgctgtca gagtcctgcc cagaattgct gcagtgttac
     1861 aggatccctt gcagggtctc ctcacagccc ctcactgtgc cagactgagg aagaacagct
     1921 ttattgacag gcctcattac tgagcgcttc cctccctcag cgtctcctgg ctcagggctc
     1981 tcaggctgta gagccagcca aaggctgcct ggcctcagag aggaaagggc ccccacaaag
     2041 gaaggccaag gcagttaagt atcccccttc ctcaagagaa ctagccagca ggtggccagt
     2101 cctgactggt ttgggttgtg tgctgaggcc ccagccccgc atcctctccc ttttcagtca
     2161 atggtgatca tgtgattttc atttctgccc tgtgtagtca aggaagagtc ttccagaagg
     2221 ttctgacttg ggcattcata aatccaactc aaagacctct cgaaaaaaaa aaaaaaaaaa
     2281 aaaaaaaaaa aaa
//
