LOCUS       NM_001309804            1851 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus N(alpha)-acetyltransferase 50, NatE catalytic
            subunit (Naa50), transcript variant 1, mRNA.
ACCESSION   NM_001309804 XM_006248326
VERSION     NM_001309804.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1851)
  AUTHORS   Reddi R, Saddanapu V, Chinthapalli DK, Sankoju P, Sripadi P and
            Addlagatta A.
  TITLE     Human Naa50 Protein Displays Broad Substrate Specificity for
            Amino-terminal Acetylation: DETAILED STRUCTURAL AND BIOCHEMICAL
            ANALYSIS USING TETRAPEPTIDE LIBRARY
  JOURNAL   J Biol Chem 291 (39), 20530-20538 (2016)
   PUBMED   27484799
REFERENCE   2  (bases 1 to 1851)
  AUTHORS   Rong Z, Ouyang Z, Magin RS, Marmorstein R and Yu H.
  TITLE     Opposing Functions of the N-terminal Acetyltransferases Naa50 and
            NatA in Sister-chromatid Cohesion
  JOURNAL   J Biol Chem 291 (36), 19079-19091 (2016)
   PUBMED   27422821
REFERENCE   3  (bases 1 to 1851)
  AUTHORS   Aksnes H, Van Damme P, Goris M, Starheim KK, Marie M, Stove SI,
            Hoel C, Kalvik TV, Hole K, Glomnes N, Furnes C, Ljostveit S,
            Ziegler M, Niere M, Gevaert K and Arnesen T.
  TITLE     An organellar nalpha-acetyltransferase, naa60, acetylates cytosolic
            N termini of transmembrane proteins and maintains Golgi integrity
  JOURNAL   Cell Rep 10 (8), 1362-1374 (2015)
   PUBMED   25732826
REFERENCE   4  (bases 1 to 1851)
  AUTHORS   Evjenth RH, Brenner AK, Thompson PR, Arnesen T, Froystein NA and
            Lillehaug JR.
  TITLE     Human protein N-terminal acetyltransferase hNaa50p (hNAT5/hSAN)
            follows ordered sequential catalytic mechanism: combined kinetic
            and NMR study
  JOURNAL   J Biol Chem 287 (13), 10081-10088 (2012)
   PUBMED   22311970
REFERENCE   5  (bases 1 to 1851)
  AUTHORS   Liszczak G, Arnesen T and Marmorstein R.
  TITLE     Structure of a ternary Naa50p (NAT5/SAN) N-terminal
            acetyltransferase complex reveals the molecular basis for
            substrate-specific acetylation
  JOURNAL   J Biol Chem 286 (42), 37002-37010 (2011)
   PUBMED   21900231
REFERENCE   6  (bases 1 to 1851)
  AUTHORS   Evjenth R, Hole K, Karlsen OA, Ziegler M, Arnesen T and Lillehaug
            JR.
  TITLE     Human Naa50p (Nat5/San) displays both protein N alpha- and N
            epsilon-acetyltransferase activity
  JOURNAL   J Biol Chem 284 (45), 31122-31129 (2009)
   PUBMED   19744929
REFERENCE   7  (bases 1 to 1851)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   8  (bases 1 to 1851)
  AUTHORS   Hou F, Chu CW, Kong X, Yokomori K and Zou H.
  TITLE     The acetyltransferase activity of San stabilizes the mitotic
            cohesin at the centromeres in a shugoshin-independent manner
  JOURNAL   J Cell Biol 177 (4), 587-597 (2007)
   PUBMED   17502424
REFERENCE   9  (bases 1 to 1851)
  AUTHORS   Arnesen T, Anderson D, Torsvik J, Halseth HB, Varhaug JE and
            Lillehaug JR.
  TITLE     Cloning and characterization of hNAT5/hSAN: an evolutionarily
            conserved component of the NatA protein N-alpha-acetyltransferase
            complex
  JOURNAL   Gene 371 (2), 291-295 (2006)
   PUBMED   16507339
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC169000.1.
            
            On Jun 12, 2015 this sequence version replaced XM_006248326.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC169000.1, FQ216855.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1851              BC169000.1         1-1851
FEATURES             Location/Qualifiers
     source          1..1851
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..1851
                     /gene="Naa50"
                     /gene_synonym="Mak3; Nat13"
                     /note="N(alpha)-acetyltransferase 50, NatE catalytic
                     subunit"
                     /db_xref="GeneID:288108"
                     /db_xref="RGD:1310944"
     exon            1..299
                     /gene="Naa50"
                     /gene_synonym="Mak3; Nat13"
                     /inference="alignment:Splign:2.1.0"
     CDS             292..801
                     /gene="Naa50"
                     /gene_synonym="Mak3; Nat13"
                     /EC_number="2.3.1.-"
                     /note="isoform 1 is encoded by transcript variant 1;
                     N-acetyltransferase 13; N-alpha-acetyltransferase 50-like"
                     /codon_start=1
                     /product="N-alpha-acetyltransferase 50 isoform 1"
                     /protein_id="NP_001296733.1"
                     /db_xref="GeneID:288108"
                     /db_xref="RGD:1310944"
                     /translation="MKGSRIELGDVTPHNIKQLKRLNQVIFPVSYNDKFYKDVLEVGE
                     LAKLAYFNDIAVGAVCCRVDHSQNQKRLYIMTLGCLAPYRRLGIGTKMLNHVLNICEK
                     DGTFDNIYLHVQISNESAIDFYRKFGFEIIETKKNYYKRIEPADAHVLQKSLRVPSGQ
                     SAETQKTDN"
     exon            300..436
                     /gene="Naa50"
                     /gene_synonym="Mak3; Nat13"
                     /inference="alignment:Splign:2.1.0"
     exon            437..556
                     /gene="Naa50"
                     /gene_synonym="Mak3; Nat13"
                     /inference="alignment:Splign:2.1.0"
     exon            557..623
                     /gene="Naa50"
                     /gene_synonym="Mak3; Nat13"
                     /inference="alignment:Splign:2.1.0"
     exon            624..1828
                     /gene="Naa50"
                     /gene_synonym="Mak3; Nat13"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaaggtcac agcgcggcgg cgggtctggc tggcggcagc tgcgggcggg agctgagtgt
       61 ccggagtgca cgtgtggaga agcgacggcg gcagcagcgc ggcggcggca gatctccccg
      121 cgtcttctag agcttcaggg cctggcttgg ctttcgaggc ctcgtcgtcc cctcagccaa
      181 gaggccggcg tgtgaggttg agtggcctga gcttagggcg cggagagctc ggggcgacga
      241 ggacgacggc gttggtggcg gctgtaacga cggcctcagc agacggagaa gatgaaaggt
      301 agccggatcg agctgggaga tgtgacaccc cacaatatta aacagttgaa gagattgaac
      361 caggtcatct ttccagtcag ctataatgat aaattctaca aggatgtact agaggttggt
      421 gagctagcaa aacttgcgta tttcaatgat atagctgtag gtgcagtgtg ctgcagggtg
      481 gatcattcac agaatcaaaa gagactttac atcatgacac taggatgcct tgcaccttac
      541 cgaagactag gaataggaac taaaatgtta aatcatgtcc taaacatctg tgagaaagat
      601 ggcacttttg acaacatcta tctgcatgtc cagatcagca atgagtcagc gattgacttc
      661 tacaggaagt ttggctttga gattatcgag actaagaaga actactataa gaggatagaa
      721 cccgcagacg cgcatgtgct tcagaaaagc ctcagagtcc catccggtca gagtgcagag
      781 acacaaaaga cagacaactg aacacatctc aaatgaactc tcttgcactt gcttgtcgcc
      841 aaataaaaga aagacagacc cactggttcc cttccccctt tcttcagctt tcctcctttg
      901 ttactccttt tttctttcct cttacagttt ttaatacttt catggactct taaaaatgat
      961 catgtttgga ttgttttagt tctcttactt ttgtgaggtg gttgaaggaa gaagaagata
     1021 gatctctata atttcacagt taagatgtcc ccaaaattgg gtgtcagatg attttaaatt
     1081 tttaactgaa aaaaaagtgt tttttttttt ttaaaccaac atcctgcttt cacattgaag
     1141 ggcagagcct actatactgt ttatttcaaa agacaaagca gcagcaatat cttgtgctct
     1201 aattcataga caagcttagt ggatttgtgg tactttgagt tttcaagacc gtctgtgggg
     1261 tcctatcccc agcattgcct tcactctacc tttagtcctt tgagcactct caggagttgg
     1321 accattgtta tccttgtgag aagataccat gcttatttag gtttttaaag caattttttc
     1381 tatttgctga ttggtgggac agtttgtata ggtagtatta tactttggtc aaagaatttc
     1441 aattaaactg ctccccccgc accccctgca cccgcccccc ccccctcagg ctgaggaatg
     1501 ggtttcttgt tagcagggtt tttttttttt ttttgctttg tttttttttt ttttttttgc
     1561 tttgtttttt tttttttttt tccttctttc ctgctgttaa tcttgttact agaggaatta
     1621 actggtagag tgtgggctgg tgaaattagc tgttttaata tcccagctag agatatggcc
     1681 tttaactgac ctaaagaaga ttgttataat agattttgtt ttctcttgtt tttcagtaag
     1741 cccaataata gtgtaacctt ataaatggag ttatgccctt ataagtcaat acccctaaat
     1801 aaacctgaag caagtgtttt ctcttggaaa aaaaaaaaaa aaaaaaaaaa a
//
