LOCUS       NM_001413582            5785 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus N(alpha)-acetyltransferase 25, NatB auxiliary
            subunit (Naa25), mRNA.
ACCESSION   NM_001413582 XM_006249394
VERSION     NM_001413582.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5785)
  AUTHORS   Yasuda,K., Ohyama,K., Onga,K., Kakizuka,A. and Mori,N.
  TITLE     Mdm20 stimulates polyQ aggregation via inhibiting autophagy through
            Akt-Ser473 phosphorylation
  JOURNAL   PLoS One 8 (12), e82523 (2013)
   PUBMED   24358196
  REMARK    GeneRIF: Mdm20, the so-called auxiliary subunit of the
            translation-coupled protein N-acetylation complex, contributes to
            protein clearance and/or aggregate formation by affecting the
            phosphorylation level of Akt indepenently from the function of
            Nat5.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5785)
  AUTHORS   Ohyama,K., Yasuda,K., Onga,K., Kakizuka,A. and Mori,N.
  TITLE     Spatio-temporal expression pattern of the NatB complex, Nat5/Mdm20
            in the developing mouse brain: implications for co-operative versus
            non-co-operative actions of Mdm20 and Nat5
  JOURNAL   Gene Expr Patterns 12 (1-2), 36-45 (2012)
   PUBMED   22101279
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Nov 3, 2022 this sequence version replaced XM_006249394.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.3249207.1,
                                           SRR26360194.2186330.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                JAXUCZ010000012.1  40811051-40811145   c
            96-181              JAXUCZ010000012.1  40799288-40799373   c
            182-320             JAXUCZ010000012.1  40798029-40798167   c
            321-439             JAXUCZ010000012.1  40795994-40796112   c
            440-514             JAXUCZ010000012.1  40790716-40790790   c
            515-622             JAXUCZ010000012.1  40789267-40789374   c
            623-701             JAXUCZ010000012.1  40788911-40788989   c
            702-813             JAXUCZ010000012.1  40786988-40787099   c
            814-903             JAXUCZ010000012.1  40786514-40786603   c
            904-1073            JAXUCZ010000012.1  40784260-40784429   c
            1074-1186           JAXUCZ010000012.1  40783625-40783737   c
            1187-1394           JAXUCZ010000012.1  40781022-40781229   c
            1395-1484           JAXUCZ010000012.1  40780116-40780205   c
            1485-1665           JAXUCZ010000012.1  40778624-40778804   c
            1666-1765           JAXUCZ010000012.1  40777986-40778085   c
            1766-1917           JAXUCZ010000012.1  40774139-40774290   c
            1918-2043           JAXUCZ010000012.1  40773291-40773416   c
            2044-2287           JAXUCZ010000012.1  40769891-40770134   c
            2288-2411           JAXUCZ010000012.1  40769358-40769481   c
            2412-2477           JAXUCZ010000012.1  40768264-40768329   c
            2478-2575           JAXUCZ010000012.1  40766795-40766892   c
            2576-2686           JAXUCZ010000012.1  40765440-40765550   c
            2687-2833           JAXUCZ010000012.1  40762196-40762342   c
            2834-5785           JAXUCZ010000012.1  40758909-40761860   c
FEATURES             Location/Qualifiers
     source          1..5785
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..5785
                     /gene="Naa25"
                     /gene_synonym="LRRGT00164; Mdm20; RGD1305685"
                     /note="N(alpha)-acetyltransferase 25, NatB auxiliary
                     subunit"
                     /db_xref="GeneID:360811"
                     /db_xref="RGD:1305685"
     exon            1..95
                     /gene="Naa25"
                     /gene_synonym="LRRGT00164; Mdm20; RGD1305685"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..2956
                     /gene="Naa25"
                     /gene_synonym="LRRGT00164; Mdm20; RGD1305685"
                     /note="N-terminal acetyltransferase B complex subunit
                     MDM20; natB complex subunit MDM20; liver
                     regeneration-related protein LRRGT00164; mitochondrial
                     distribution and morphology protein 20; N-terminal
                     acetyltransferase B complex subunit NAA25"
                     /codon_start=1
                     /product="N-alpha-acetyltransferase 25, NatB auxiliary
                     subunit"
                     /protein_id="NP_001400511.1"
                     /db_xref="GeneID:360811"
                     /db_xref="RGD:1305685"
                     /translation="MATRGHVQDPNDRRLRPIYDYLDNGNNKMAIQQADKLLKKHRDL
                     HCAKVLKAIGLQRTGRQEEAFTLAQEVAALEPTDDNSLQALTILYREMHRPELVTKLY
                     EAAVKKVPNSEEYHSHLFMAYARVGEYKKMQQAGMALYKIVPKNPYYFWSVMSLIMQS
                     ISARDENLSKTMFLPLAERMVEKMVKEDKIEAEAEVELYYMILERLGKYQEALDVIRG
                     KLGEKLTSEIQSRENKCMAMYKKLSKWPECNALSRRLLLKNSDDWQFYLTYFDSVFRL
                     IEEAWTPPAEGEHSLEGEVHCSAEDAVKFIEDRITEASQSSRHVRGPHLAKLELIRRL
                     RSQGCNDEFRLGDPEELMFQYFKKFGDKPCCFTDLKVFVDLLPAAQCTQFINQLLGVV
                     PLSTPTEDKLALPADIRGLQQHLCVVQLTRLLGLYHSMDKNQKLDVVRELMLRYQHGL
                     EFGRSCLKTELQFSDYYCLLAVHVLIDIWREAGEETAVWQALTLLEEGLTHSPSNAQF
                     KLLLVRIYCVLGAFEPVVDLYSSLDAKHIQHDTIGYLLTRYAASLGQYAAASQSCNFA
                     LRFFHSNQKDTSEYIIQAYKYGAFEKIPEFIAFRNRLNNSLHFAQVRTERMLLDLLLE
                     ANISTSLAESIKSMNLRPEEDDVPWEDLRDNRDLDVFFSWDPKDRNVSEEHKKLSLEE
                     ETMWLRIRSLTLRLISALPSLTHPVEPRNSEKTSENGVSSRVDVLRLLLQQLEVAVET
                     GKRFIEKEIQYPFLGPVPTRMGRFFSSGCCQCQVHSFHLVSDVYELDTSGLEGTVDIQ
                     ERIENSLASLLELLKGVFSTCKGDLLEVKDGNVKTQPAVLENLVFFVETISIVLWVSS
                     YCESVLRPYKLNIQKKKKKKKETSIVMPPIFTSFQDYVTGLQTVISNAVDHIKGLEAH
                     LIALKLEELTLEDTSISPEERKFSRTVQGKVQSSYLHSLLETGELLRKRLETTKKLKI
                     "
     exon            96..181
                     /gene="Naa25"
                     /gene_synonym="LRRGT00164; Mdm20; RGD1305685"
                     /inference="alignment:Splign:2.1.0"
     exon            182..320
                     /gene="Naa25"
                     /gene_synonym="LRRGT00164; Mdm20; RGD1305685"
                     /inference="alignment:Splign:2.1.0"
     exon            321..439
                     /gene="Naa25"
                     /gene_synonym="LRRGT00164; Mdm20; RGD1305685"
                     /inference="alignment:Splign:2.1.0"
     exon            440..514
                     /gene="Naa25"
                     /gene_synonym="LRRGT00164; Mdm20; RGD1305685"
                     /inference="alignment:Splign:2.1.0"
     exon            515..622
                     /gene="Naa25"
                     /gene_synonym="LRRGT00164; Mdm20; RGD1305685"
                     /inference="alignment:Splign:2.1.0"
     exon            623..701
                     /gene="Naa25"
                     /gene_synonym="LRRGT00164; Mdm20; RGD1305685"
                     /inference="alignment:Splign:2.1.0"
     exon            702..813
                     /gene="Naa25"
                     /gene_synonym="LRRGT00164; Mdm20; RGD1305685"
                     /inference="alignment:Splign:2.1.0"
     exon            814..903
                     /gene="Naa25"
                     /gene_synonym="LRRGT00164; Mdm20; RGD1305685"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1073
                     /gene="Naa25"
                     /gene_synonym="LRRGT00164; Mdm20; RGD1305685"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1186
                     /gene="Naa25"
                     /gene_synonym="LRRGT00164; Mdm20; RGD1305685"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1394
                     /gene="Naa25"
                     /gene_synonym="LRRGT00164; Mdm20; RGD1305685"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1484
                     /gene="Naa25"
                     /gene_synonym="LRRGT00164; Mdm20; RGD1305685"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1665
                     /gene="Naa25"
                     /gene_synonym="LRRGT00164; Mdm20; RGD1305685"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1765
                     /gene="Naa25"
                     /gene_synonym="LRRGT00164; Mdm20; RGD1305685"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1917
                     /gene="Naa25"
                     /gene_synonym="LRRGT00164; Mdm20; RGD1305685"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2043
                     /gene="Naa25"
                     /gene_synonym="LRRGT00164; Mdm20; RGD1305685"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2287
                     /gene="Naa25"
                     /gene_synonym="LRRGT00164; Mdm20; RGD1305685"
                     /inference="alignment:Splign:2.1.0"
     exon            2288..2411
                     /gene="Naa25"
                     /gene_synonym="LRRGT00164; Mdm20; RGD1305685"
                     /inference="alignment:Splign:2.1.0"
     exon            2412..2477
                     /gene="Naa25"
                     /gene_synonym="LRRGT00164; Mdm20; RGD1305685"
                     /inference="alignment:Splign:2.1.0"
     exon            2478..2575
                     /gene="Naa25"
                     /gene_synonym="LRRGT00164; Mdm20; RGD1305685"
                     /inference="alignment:Splign:2.1.0"
     exon            2576..2686
                     /gene="Naa25"
                     /gene_synonym="LRRGT00164; Mdm20; RGD1305685"
                     /inference="alignment:Splign:2.1.0"
     exon            2687..2833
                     /gene="Naa25"
                     /gene_synonym="LRRGT00164; Mdm20; RGD1305685"
                     /inference="alignment:Splign:2.1.0"
     exon            2834..5785
                     /gene="Naa25"
                     /gene_synonym="LRRGT00164; Mdm20; RGD1305685"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccagcgcgt gcgcattacg gttctgcgct tgtcatcatg gcgacgcggg gccatgtgca
       61 ggaccctaac gaccggcgcc tcaggcccat ttacgattat cttgataatg gaaataataa
      121 aatggcaatt cagcaagctg acaaactgct gaagaaacac agagatctcc actgtgcgaa
      181 ggttctcaag gcgattggtt tacagagaac cggaagacag gaggaagcct tcaccttggc
      241 tcaggaggtg gctgcccttg agcccacaga tgacaattcc ctgcaggccc tgaccatcct
      301 ctaccgagag atgcaccggc cggagttggt cacaaagcta tatgaggcgg ctgtgaagaa
      361 agtccccaac agcgaggagt atcactctca cctcttcatg gcctatgcca gagtgggcga
      421 gtacaagaag atgcagcagg ctggcatggc tctgtataag atcgtcccca aaaaccctta
      481 ctacttttgg tccgtgatga gcttaatcat gcaatctata tccgcacgag atgagaacct
      541 ctcgaaaacc atgtttctgc ccctggcaga gaggatggta gaaaaaatgg tgaaggagga
      601 caagatagaa gctgaagctg aagttgaact ttattacatg atcctggaac gcttgggaaa
      661 gtaccaagaa gccctggatg tcattagagg gaaattagga gaaaagttga caagtgaaat
      721 tcagagtcgg gaaaacaaat gcatggccat gtacaagaaa ctgagcaagt ggccggagtg
      781 caacgccctt tcccgacgcc tcctgttgaa aaactcagat gactggcagt tctatctgac
      841 ttatttcgat tctgtctttc gactgattga agaagcctgg acgcctcctg cagaagggga
      901 gcactcctta gaaggggaag tacactgctc tgcagaggat gctgtgaagt ttatagagga
      961 ccggataaca gaggcatcac aaagctctcg ccatgtccgg ggcccacacc tagctaagct
     1021 ggagctcatc aggcgccttc ggagccaagg ctgcaacgac gagttcagac tgggtgaccc
     1081 agaagagtta atgttccagt atttcaagaa gttcggggac aagccatgtt gcttcacaga
     1141 cctgaaggtg ttcgttgacc tcttgcctgc tgcccagtgc acacaattca ttaaccagct
     1201 cctcggagtt gttccactgt cgacgccgac agaggataag cttgccctgc cggctgacat
     1261 ccgaggcctg cagcagcatc tgtgtgttgt gcagctgacg aggctcctcg gcttgtacca
     1321 cagcatggat aagaaccaga agctggatgt ggtcagagaa ttgatgttac ggtaccagca
     1381 cggactggag tttgggcgct cttgcttgaa gacagagttg cagttctctg actattactg
     1441 cctcctcgct gttcacgtgc tcattgacat atggagagaa gcaggtgagg agactgctgt
     1501 gtggcaggcc ctgactctgc tggaagaagg cttaacccac agcccatcca atgctcagtt
     1561 caaattgctg cttgttcgaa tctactgcgt gctgggtgca tttgaacccg tggtggatct
     1621 ttactccagc cttgatgcca agcacatcca gcacgacacc attggctacc ttctgacccg
     1681 atacgctgca tccctgggtc agtacgctgc tgcctcccag tcctgtaact tcgcactcag
     1741 gtttttccac tccaaccaga aagatacctc agaatacatt attcaagctt acaaatatgg
     1801 tgcatttgag aagatcccag agtttatcgc ttttaggaac aggctgaata attctctcca
     1861 ctttgcacaa gtgcgcactg aacggatgct gttagacctt ctacttgaag caaacatatc
     1921 aactagctta gcagaaagca tcaaatccat gaacctgagg ccagaggaag atgatgttcc
     1981 atgggaggat ttgcgagaca acagagactt ggacgttttc ttcagctggg atccaaaaga
     2041 caggaatgtt tctgaagagc ataagaagct ctccctggag gaggagacca tgtggttaag
     2101 aattcgctcc ttaacattga ggctgatcag cgcccttcca agtcttaccc accccgtgga
     2161 gccaaggaac tcagagaaga cgtcagagaa cggcgtgtcc tctcgggtcg acgtcctccg
     2221 tttgctcctc caacagctag aagtggccgt ggagactggg aagcggttca ttgagaagga
     2281 aattcagtac cccttccttg ggccggtccc caccaggatg ggcaggttct tcagttctgg
     2341 ctgctgtcag tgccaggtcc actcctttca tcttgtcagt gatgtgtacg agctcgacac
     2401 cagtggctta gagggtacag tggatataca ggaacggata gaaaatagtc ttgcatcttt
     2461 actagaacta ttgaaaggtg tcttcagcac atgtaagggt gacctcttag aagttaaaga
     2521 cggcaatgtg aagacccagc ctgcagtcct agagaatctg gtcttctttg ttgagactat
     2581 ttctatcgtc ctttgggtgt ccagctactg tgagagtgtc ttgcgaccat acaaattaaa
     2641 tattcagaaa aagaaaaaga agaaaaaaga aaccagcatc gtcatgcctc cgattttcac
     2701 cagtttccag gactatgtta ctgggcttca aactgtaatt tccaatgctg tggatcatat
     2761 taaaggactt gaagcacatc taattgcact taaacttgag gagctcacgt tagaggacac
     2821 gtctatctct ccggaggaaa gaaagttttc aaggactgtg cagggcaaag tgcagagcag
     2881 ttacctgcac tcgcttctgg agacggggga gctgctgagg aaaaggcttg agactacaaa
     2941 gaaactaaaa atttaaggaa gaagtatgac ccacagacac cgaagactcc atagcagaag
     3001 acgacaccac cttccccagc aaaaacaaca tctggctggc atcgttctaa tccagaactt
     3061 cctcacaaat gcatgaagga ctttgatcgt gaattaattc ttgaggtatt aaatatatac
     3121 aacaaattaa attattgtat ataaaccaga agcaggaccc tcatctgggt ttaccactct
     3181 ttatacctgt tcatacatac aggacagcaa caagagcatc ccaccgtcac tcctgtcagc
     3241 agagatgtct ggggtgggcg tttctgtaca agcagcaata gagaataagt atagcatcgc
     3301 cctcagagcg gctggggcac ttttctatcg tgcagtggga gtttgctttg ggacttgagc
     3361 catatgaggc aaaaagcaaa tgtaggagcc gacttgggag cagggccctt cccttagtgg
     3421 caggttcttt gtgaggtccc acaaaaccac atcccacaga ggatcaggtg agatgtggct
     3481 gagtccatgc cactgcaggg caccacacat gaccacaggt gctcagtttt ggcttcgtag
     3541 acccaacagc caagacgtcc ccagccccgt tcctgggaga gctcagcctc agggcaacaa
     3601 ggaagtccaa ggtgaaccca ctttgaggag gaattctgag cacagcccgc tgtgagcttc
     3661 ataagctgct gcgactgcag cccgacggcc ctctaggaga ggcggaagag ctgttggaag
     3721 aggctgtaca tgctttgtgc aggcgagtct gatgcgtgta ctgtttgtga gccccatcct
     3781 gcagctgact catgtcacac acagacacat atgtataaat atgcttggaa acagatttac
     3841 tactgtagtg cttttaaggg ggaggtttgg gacagaagga attgtatgtt atggatttaa
     3901 cctaggtttc aagttttagg ttgacaaaag ctgttttaca atgggcctgg tgtcggtgta
     3961 ctttggtgac acttgagaac tgcctcagga tgtctttacg ttgttacctg gggttggagg
     4021 tctggtccct gagcctccaa cgtaagaggc tggtctgaga gatgaaaact gctcttgatt
     4081 atgtcatgct gagccctgac agctccttca gtgactgttt tgtgtctgac tctcctcctc
     4141 ctcttctggt cttgttctct gtcacctgac tcgagagagt cagtaactat aaggtgaaaa
     4201 gatgaatttg gtgaggattg gtctttccgt gtaccactcc agcggagagg tgacagacag
     4261 cagctgaagg acagctggcg gtctcagtgg ctatgtctgc atctcttcct ttatcttgac
     4321 agtcttagac tcacaaacca gcataggggt cactaataat ttaaacgtgt aaggaaatct
     4381 gcacaaacta cttcctgact tgtaagctgt gctggagctt cagccacagc attgcgtcag
     4441 agcatcacat gctccgtccc aacacgaaca cgaaggccct tttccaatga gatggaccca
     4501 agaccctgat gttgacttgc cttgaacatc atcaacttgt ggtccccttc tgtagtggtg
     4561 gcctgtttcc cttgggactg ggtgggcttt tgcctgccct gccatggctc ctgcaataat
     4621 gtttttttgg gatattcaaa ttgtactgtg ttcatggtca tagatactct aaaacagctc
     4681 cctcagctga ccgtgaccag ggtggactct gggctggctc tggttctcag gcatggctcc
     4741 ttcctctaat ggtctatcca gtcagtctcc tgccctaacc cggaggacct ccactggtct
     4801 gattggcaaa taatgtcatg ttggggttac acttccttgc tgattttctt actaaatgta
     4861 gcatttcaat cagatctaat tcttacattt tgagataact gtaaaaaaga atgaaattat
     4921 gaaatggcca atatctttta tcagtctatt cttttggaaa ctgtcatgca ctataccttg
     4981 tgtacagcct ccgcccccat gcttgtgtgt cattagtgtc taaggagagg ctcagaggca
     5041 ctgctgctct tctggttata tgggctttct tctgttttgt ttttgtgtga taaattgata
     5101 tttaaaaaac aaaaaacaac aaaaaaccac gactactgtt tacagactga aaaaaaaaat
     5161 cactgctttt tatactactg agatcctaag tcaagacttt gcaaagcagg aattgggttc
     5221 aagttatttc tttgccgtgg acggagagtc ctctgtagtt tctcctcacg agggagagtg
     5281 cacaaactta ggtgcgctgc catcaatttt gtatattttc ataattttaa ttgttcaaaa
     5341 ttgcattata ttttgcaatc accacgttca atctgtatat gtctttcatt tcaacttttt
     5401 caatacaaaa aggggttcaa ttcatctgca ggtttgttga aactcttcct acttttttat
     5461 gtgatttatt ggtatgggaa atctgctctt gagaactaag tgcaggcagc aaatccactt
     5521 tatctggacg ggctaatcta cataaatgtt tttattttaa ggtggccctt tttcttggtt
     5581 catttttgtt gagtcttaaa agttagagct tctagaacag tatacctcat ctcagttctg
     5641 taccattatc cctaacatgg cctagtatgg ggcatttctg tagatccagc tttaaagagg
     5701 tggaggcagg aggagcaggt gaaagccatg cttagctact agacactgtc ttaaaacaaa
     5761 taaatgaaaa taagcaaaac ccaaa
//
