LOCUS       NM_001012233             496 bp    mRNA    linear   ROD 04-OCT-2024
DEFINITION  Rattus norvegicus neuromedin S (NMS), mRNA.
ACCESSION   NM_001012233 XM_576546
VERSION     NM_001012233.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Mori,K., Ida,T., Fudetani,M., Mori,M., Kaiya,H., Hino,J.,
            Nakahara,K., Murakami,N., Miyazato,M. and Kangawa,K.
  TITLE     Identification of neuromedin U precursor-related peptide and its
            possible role in the regulation of prolactin release
  JOURNAL   Sci Rep 7 (1), 10468 (2017)
   PUBMED   28874765
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Nakahara,K., Akagi,A., Shimizu,S., Tateno,S., Qattali,A.W.,
            Mori,K., Miyazato,M., Kangawa,K. and Murakami,N.
  TITLE     Involvement of endogenous neuromedin U and neuromedin S in
            thermoregulation
  JOURNAL   Biochem Biophys Res Commun 470 (4), 930-935 (2016)
   PUBMED   26826380
  REMARK    GeneRIF: These results suggest that NMU and NMS are involved in
            thermoregulation via the prostaglandin E2 and beta3 adrenergic
            receptors, but that endogenous NMS might play a more predominant
            role than NMU.
REFERENCE   3  (bases 1 to 496)
  AUTHORS   Sakamoto,T., Mori,K., Miyazato,M., Kangawa,K., Sameshima,H.,
            Nakahara,K. and Murakami,N.
  TITLE     Involvement of neuromedin S in the oxytocin release response to
            suckling stimulus
  JOURNAL   Biochem Biophys Res Commun 375 (1), 49-53 (2008)
   PUBMED   18675786
  REMARK    GeneRIF: These results suggest that, in the rat, endogenous NMS
            plays an important role in the oxytocin release response to the
            suckling stimulus.
REFERENCE   4  (bases 1 to 496)
  AUTHORS   Miyazato,M., Mori,K., Ida,T., Kojima,M., Murakami,N. and Kangawa,K.
  TITLE     Identification and functional analysis of a novel ligand for G
            protein-coupled receptor, Neuromedin S
  JOURNAL   Regul Pept 145 (1-3), 37-41 (2008)
   PUBMED   17870195
  REMARK    GeneRIF: NMS is implicated in the regulation of circadian rhythm
            and feeding behavior
REFERENCE   5  (bases 1 to 496)
  AUTHORS   Jaszberenyi,M., Bagosi,Z., Thurzo,B., Foldesi,I. and Telegdy,G.
  TITLE     Endocrine and behavioral effects of neuromedin S
  JOURNAL   Horm Behav 52 (5), 631-639 (2007)
   PUBMED   17900576
  REMARK    GeneRIF: Neuromedin S stimulates the HPA axis through the CRHR(1)
            pathway and evokes stereotyped behavior and anxiety through
            mesolimbic dopamine and corticotrophin releasing hormone release.
REFERENCE   6  (bases 1 to 496)
  AUTHORS   Rucinski,M., Ziolkowska,A., Neri,G., Trejter,M., Zemleduch,T.,
            Tyczewska,M., Nussdorfer,G.G. and Malendowicz,L.K.
  TITLE     Expression of neuromedins S and U and their receptors in the
            hypothalamus and endocrine glands of the rat
  JOURNAL   Int J Mol Med 20 (2), 255-259 (2007)
   PUBMED   17611645
  REMARK    GeneRIF: Neuromedins U and S may play different roles in the
            functional regulation of neuroendocrine axes.
REFERENCE   7  (bases 1 to 496)
  AUTHORS   Vigo,E., Roa,J., Lopez,M., Castellano,J.M., Fernandez-Fernandez,R.,
            Navarro,V.M., Pineda,R., Aguilar,E., Dieguez,C., Pinilla,L. and
            Tena-Sempere,M.
  TITLE     Neuromedin s as novel putative regulator of luteinizing hormone
            secretion
  JOURNAL   Endocrinology 148 (2), 813-823 (2007)
   PUBMED   17110433
  REMARK    GeneRIF: Expression in hypothalamus. Potential role of NMS in
            regulation of gonadotropic axis. May contribute to integration of
            circadian rhythms, energy balance, and reproduction.
REFERENCE   8  (bases 1 to 496)
  AUTHORS   Ida,T., Mori,K., Miyazato,M., Egi,Y., Abe,S., Nakahara,K.,
            Nishihara,M., Kangawa,K. and Murakami,N.
  TITLE     Neuromedin s is a novel anorexigenic hormone
  JOURNAL   Endocrinology 146 (10), 4217-4223 (2005)
   PUBMED   15976061
  REMARK    GeneRIF: may be a potent anorexigenic hormone in the hypothalamus,
            and the expression of proopiomelanocortin mRNA in the Arc and
            corticotropin mRNA in the paraventricular hypothalamic nucleus be
            be involved with appetite.
REFERENCE   9  (bases 1 to 496)
  AUTHORS   Mori,K., Miyazato,M., Ida,T., Murakami,N., Serino,R., Ueta,Y.,
            Kojima,M. and Kangawa,K.
  TITLE     Identification of neuromedin S and its possible role in the
            mammalian circadian oscillator system
  JOURNAL   EMBO J 24 (2), 325-335 (2005)
   PUBMED   15635449
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB164465.1.
            
            On Apr 20, 2005 this sequence version replaced XM_576546.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB164465.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760434 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q22"
     gene            1..496
                     /gene="NMS"
                     /note="neuromedin S"
                     /db_xref="GeneID:497196"
                     /db_xref="RGD:1359122"
     exon            1..92
                     /gene="NMS"
                     /inference="alignment:Splign:2.1.0"
     exon            93..148
                     /gene="NMS"
                     /inference="alignment:Splign:2.1.0"
     exon            149..199
                     /gene="NMS"
                     /inference="alignment:Splign:2.1.0"
     exon            200..223
                     /gene="NMS"
                     /inference="alignment:Splign:2.1.0"
     exon            224..277
                     /gene="NMS"
                     /inference="alignment:Splign:2.1.0"
     exon            278..361
                     /gene="NMS"
                     /inference="alignment:Splign:2.1.0"
     exon            362..397
                     /gene="NMS"
                     /inference="alignment:Splign:2.1.0"
     exon            398..439
                     /gene="NMS"
                     /inference="alignment:Splign:2.1.0"
     exon            440..483
                     /gene="NMS"
                     /inference="alignment:Splign:2.1.0"
     exon            484..496
                     /gene="NMS"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagccagagc ttgaagatga aacatccgtt ccctcagttc cctccaatcc tggtcatcta
       61 ctgcttctgt atgctacaga tcccctcctc aggagcttct ccacctttag ctggtcctcc
      121 tgatggtttg gatgctgtgg acccagagcg actggcacac tttctgaacc agagggaaac
      181 atgttctaac caacctaagg aaagccggga tgtatacaaa aggtttttat ttcactactc
      241 ccgagcttgg aagtcgacac atccagttaa ctccgagttt gctcccgtcc atccattgat
      301 gcgcctggcc gccaagcttc ccagcagaag gatgaaaaga ctaccgcgat tgctgcacac
      361 agattccagg atggctacta tagacttccc taagaaggat cctaccacca gcttggggcg
      421 gccatttttc cttttcaggc ctaggaatgg aagatacact gacaaagtcc agtagacggc
      481 aagaatccta tgtcac
//
