LOCUS       NM_001191592             920 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus N-6 adenine-specific DNA methyltransferase 1
            (N6amt1), mRNA.
ACCESSION   NM_001191592 XM_213675
VERSION     NM_001191592.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 920)
  AUTHORS   Metzger,E., Wang,S., Urban,S., Willmann,D., Schmidt,A.,
            Offermann,A., Allen,A., Sum,M., Obier,N., Cottard,F., Ulferts,S.,
            Preca,B.T., Hermann,B., Maurer,J., Greschik,H., Hornung,V.,
            Einsle,O., Perner,S., Imhof,A., Jung,M. and Schule,R.
  TITLE     KMT9 monomethylates histone H4 lysine 12 and controls proliferation
            of prostate cancer cells
  JOURNAL   Nat Struct Mol Biol 26 (5), 361-371 (2019)
   PUBMED   31061526
REFERENCE   2  (bases 1 to 920)
  AUTHORS   Xiao,C.L., Zhu,S., He,M., Chen,D., Zhang,Q., Chen,Y., Yu,G.,
            Liu,J., Xie,S.Q., Luo,F., Liang,Z., Wang,D.P., Bo,X.C., Gu,X.F.,
            Wang,K. and Yan,G.R.
  TITLE     N6-Methyladenine DNA Modification in the Human Genome
  JOURNAL   Mol Cell 71 (2), 306-318 (2018)
   PUBMED   30017583
REFERENCE   3  (bases 1 to 920)
  AUTHORS   Kusevic,D., Kudithipudi,S. and Jeltsch,A.
  TITLE     Substrate Specificity of the HEMK2 Protein Glutamine
            Methyltransferase and Identification of Novel Substrates
  JOURNAL   J Biol Chem 291 (12), 6124-6133 (2016)
   PUBMED   26797129
REFERENCE   4  (bases 1 to 920)
  AUTHORS   Zhang,H., Ge,Y., He,P., Chen,X., Carina,A., Qiu,Y., Aga,D.S. and
            Ren,X.
  TITLE     Interactive Effects of N6AMT1 and As3MT in Arsenic Biomethylation
  JOURNAL   Toxicol Sci 146 (2), 354-362 (2015)
   PUBMED   25997655
REFERENCE   5  (bases 1 to 920)
  AUTHORS   Nie,D.S., Liu,Y.B. and Lu,G.X.
  TITLE     Cloning and primarily function study of two novel putative
            N5-glutamine methyltransferase (Hemk) splice variants from mouse
            stem cells
  JOURNAL   Mol Biol Rep 36 (8), 2221-2228 (2009)
   PUBMED   19116772
REFERENCE   6  (bases 1 to 920)
  AUTHORS   Figaro,S., Scrima,N., Buckingham,R.H. and Heurgue-Hamard,V.
  TITLE     HemK2 protein, encoded on human chromosome 21, methylates
            translation termination factor eRF1
  JOURNAL   FEBS Lett 582 (16), 2352-2356 (2008)
   PUBMED   18539146
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Jul 17, 2010 this sequence version replaced XM_213675.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ210046.1, DV215331.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               JAXUCZ010000011.1  40071017-40071164
            149-235             JAXUCZ010000011.1  40072989-40073075
            236-326             JAXUCZ010000011.1  40074032-40074122
            327-410             JAXUCZ010000011.1  40078566-40078649
            411-552             JAXUCZ010000011.1  40081680-40081821
            553-920             JAXUCZ010000011.1  40083096-40083463
FEATURES             Location/Qualifiers
     source          1..920
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..920
                     /gene="N6amt1"
                     /gene_synonym="Hemk2; RGD1311843"
                     /note="N-6 adenine-specific DNA methyltransferase 1"
                     /db_xref="GeneID:288309"
                     /db_xref="RGD:1311843"
     exon            1..148
                     /gene="N6amt1"
                     /gene_synonym="Hemk2; RGD1311843"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..659
                     /gene="N6amt1"
                     /gene_synonym="Hemk2; RGD1311843"
                     /EC_number="2.1.1.72"
                     /note="HemK methyltransferase family member 2; N-6
                     adenine-specific DNA methyltransferase 1 (putative)"
                     /codon_start=1
                     /product="methyltransferase N6AMT1"
                     /protein_id="NP_001178521.1"
                     /db_xref="GeneID:288309"
                     /db_xref="RGD:1311843"
                     /translation="MAAPSVPTPLYGHVGRGAFSDVYEPAEDTFLLLDALEAAAAELA
                     GVELCLEVGAGSGVVSAFLASMIGPQALYMCTDINPKAAACTLETARCNRVHLQPVIT
                     DLVQGLLPRLKGKVDLLVFNPPYVVTPPEEVGSHGIEAAWAGGRNGREVMDRFFPLAS
                     QLLSPRGLFYLVTIKENNPEEIFKIMKTRGLQGTTALCRQAGQETLSVLRFSKS"
     exon            149..235
                     /gene="N6amt1"
                     /gene_synonym="Hemk2; RGD1311843"
                     /inference="alignment:Splign:2.1.0"
     exon            236..326
                     /gene="N6amt1"
                     /gene_synonym="Hemk2; RGD1311843"
                     /inference="alignment:Splign:2.1.0"
     exon            327..410
                     /gene="N6amt1"
                     /gene_synonym="Hemk2; RGD1311843"
                     /inference="alignment:Splign:2.1.0"
     exon            411..552
                     /gene="N6amt1"
                     /gene_synonym="Hemk2; RGD1311843"
                     /inference="alignment:Splign:2.1.0"
     exon            553..920
                     /gene="N6amt1"
                     /gene_synonym="Hemk2; RGD1311843"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcggaaggg gaagatggcg gcgccgagtg tccccacgcc gttgtacggg cacgtgggtc
       61 gtggagcctt cagcgacgtg tacgagccag cggaggacac gttcctgtta ctggacgcgc
      121 tcgaggcggc agcagcagag ctagcaggag tggaactatg cctggaagta ggagcaggat
      181 ctggggtggt gtctgcattc ctagcctcca tgataggtcc tcaggccttg tacatgtgca
      241 ccgatatcaa ccccaaggca gctgcatgta ccttggaaac agcgcgctgt aacagagtcc
      301 accttcagcc agtaattaca gatttggtcc aaggcttgct gcccagattg aaggggaaag
      361 tagacctgct ggtgttcaac cccccttacg tcgtgactcc gcctgaagag gtaggaagcc
      421 acggaataga agcagcttgg gctggtggaa gaaacggccg ggaagtcatg gacaggttct
      481 tcccactggc ctcacaactt ctctccccaa gagggctgtt ctacttagtt accataaaag
      541 aaaacaatcc agaggaaatc tttaaaataa tgaagacaag aggactacaa ggaaccacgg
      601 cactttgcag gcaagcaggc caagaaaccc tgtcagtcct caggttcagc aagtcctgaa
      661 agcccctgaa gtaaataaac tagctaccgg ttgctgaaca ctcagtaggt ttgagactga
      721 tgccattccc tggccaagaa gttttaccaa aatttgtcat ttaaagaaaa agtggatcca
      781 agtggtagtg gcataggcac tcaggagaca gaggcagggg gtctctaagt tcaaggcctg
      841 gtctacagag tgaattccag gaccctcagg gctacacaga gaaaccaaaa ccaaacgacg
      901 aacggaaagg aaaagaaaaa
//
