LOCUS       NM_001305181            6401 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus Nedd4 binding protein 1 (N4bp1), mRNA.
ACCESSION   NM_001305181 XM_001068071 XM_214648
VERSION     NM_001305181.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6401)
  AUTHORS   Sharma,P., Murillas,R., Zhang,H. and Kuehn,M.R.
  TITLE     N4BP1 is a newly identified nucleolar protein that undergoes
            SUMO-regulated polyubiquitylation and proteasomal turnover at
            promyelocytic leukemia nuclear bodies
  JOURNAL   J Cell Sci 123 (Pt 8), 1227-1234 (2010)
   PUBMED   20233849
REFERENCE   2  (bases 1 to 6401)
  AUTHORS   Oberst,A., Malatesta,M., Aqeilan,R.I., Rossi,M., Salomoni,P.,
            Murillas,R., Sharma,P., Kuehn,M.R., Oren,M., Croce,C.M.,
            Bernassola,F. and Melino,G.
  TITLE     The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the
            E3 ligase Itch
  JOURNAL   Proc Natl Acad Sci U S A 104 (27), 11280-11285 (2007)
   PUBMED   17592138
REFERENCE   3  (bases 1 to 6401)
  AUTHORS   Murillas,R., Simms,K.S., Hatakeyama,S., Weissman,A.M. and
            Kuehn,M.R.
  TITLE     Identification of developmentally expressed proteins that
            functionally interact with Nedd4 ubiquitin ligase
  JOURNAL   J Biol Chem 277 (4), 2897-2907 (2002)
   PUBMED   11717310
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Feb 10, 2021 this sequence version replaced NM_001305181.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments and orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.2235467.1,
                                           SRR21887622.358311.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-198               JAXUCZ010000019.1  36396324-36396521
            199-1883            JAXUCZ010000019.1  36423854-36425538
            1884-2014           JAXUCZ010000019.1  36434804-36434934
            2015-2111           JAXUCZ010000019.1  36436759-36436855
            2112-2219           JAXUCZ010000019.1  36439552-36439659
            2220-2327           JAXUCZ010000019.1  36441039-36441146
            2328-6401           JAXUCZ010000019.1  36442762-36446835
FEATURES             Location/Qualifiers
     source          1..6401
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p11"
     gene            1..6401
                     /gene="N4bp1"
                     /gene_synonym="RGD1305179"
                     /note="Nedd4 binding protein 1"
                     /db_xref="GeneID:291921"
                     /db_xref="RGD:1305179"
     CDS             1..2682
                     /gene="N4bp1"
                     /gene_synonym="RGD1305179"
                     /codon_start=1
                     /product="NEDD4-binding protein 1"
                     /protein_id="NP_001292110.1"
                     /db_xref="GeneID:291921"
                     /db_xref="RGD:1305179"
                     /translation="MAARVVLDEFTAPAEKAALLERSRGRIEALFGVGLAVLGALGAE
                     EPLPARIWLQLRGAQEAVHSAKEYIKGLCEPELEERECYPKAMHCIFVGAQSLFLKSL
                     IQDTCADLCVLDTGLLGIRGSAEAVVMARSHIQQFVKLFESKESLPSHQKESEIKREF
                     RQFVEAHADSYTMDLLILPTSLKKELLSLTQGEENLFETGDDDVITVGDVRPPEFTQS
                     TAAGPSIARDDIVVQEESRNKARTPVSELTKQMDTVFSSSPDVLFVPVNGLSPDEDAL
                     SKDRVCHKRRSSDTEERHTKKQFSLENVPEGELLQDGKASAENEVIDLSDAASNSTNL
                     SPDGKDTTEEMEYNILVNFFKTMGYSQEIVEKVIREYGPSTEPLLLLEEIEKENKRLQ
                     EDRDFPPCTVYPEDSQSRSAGGRSTTNELTAESTPKKTQNHTEQTMVERFSQLPFKDS
                     KQCTSNCRINSFKTVPVGQKHEIWASKQNSNCTVDLETDGVLAASASPKDVSFVSRGA
                     LGHQQRNSAFLENGFQQQAEPLLPNNVKPACEKRSGGCGSPQPKPNYHPPLSPPLPPP
                     QLLPSATEARLGGSSDHIDSSVTGVQRFRDTLKIPYKLELKNEPGRADLKHIVIDGSN
                     VAITHGLKKFFSCRGIAIAVEYFWKLGNRNITVFVPQWRTRRDPNITEQHFLTQLQEL
                     GILSLTPARMVFGERIASHDDRFLLHLADKTGGIIVTNDNFREFVTESVSWREIITKR
                     LLQYTFVGDIFMVPDDPLGRNGPRLEEFLRKEVFLRDMQPLLNALPSVGTFDPGFRSP
                     STQVANTSHQPPSRIQTSSNHWLPQQPHFTPLATLPSMQQNLPVPAQRSSAETSELRE
                     ALLKIFPDSEQKLKIDQILVAHPYMKDLNALSALVLD"
     exon            1..198
                     /gene="N4bp1"
                     /gene_synonym="RGD1305179"
                     /inference="alignment:Splign:2.1.0"
     exon            199..1883
                     /gene="N4bp1"
                     /gene_synonym="RGD1305179"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..2014
                     /gene="N4bp1"
                     /gene_synonym="RGD1305179"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..2111
                     /gene="N4bp1"
                     /gene_synonym="RGD1305179"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..2219
                     /gene="N4bp1"
                     /gene_synonym="RGD1305179"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2327
                     /gene="N4bp1"
                     /gene_synonym="RGD1305179"
                     /inference="alignment:Splign:2.1.0"
     exon            2328..6401
                     /gene="N4bp1"
                     /gene_synonym="RGD1305179"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcggccc gggtagtgct ggatgagttc acggcgcccg ccgagaaggc ggcgctgctg
       61 gagcggagcc gcgggcgcat cgaggctctg ttcggcgttg gcctggcggt gctcggcgcc
      121 ctcggggcgg aggagccgct gcctgcgcgc atctggctgc agctccgcgg cgcgcaggag
      181 gcggtgcaca gcgccaagga gtacatcaaa gggctctgcg agcctgagct ggaagaaaga
      241 gagtgctacc ccaaggccat gcactgcatt ttcgttgggg cccagagcct ctttttgaag
      301 agcttaattc aggatacttg tgctgacctc tgtgttttag atactgggct tcttggcatt
      361 cgaggaagcg ctgaggctgt ggtcatggcc agaagtcaca ttcaacagtt tgtgaagctc
      421 tttgagagta aggagagcct ccccagtcac cagaaagagt cagaaattaa gcgggaattc
      481 agacagtttg ttgaagccca tgcagacagt tatacaatgg acctgttgat tctgcctact
      541 tccttgaaga aggaattact gagtctcaca caaggggaag aaaatctgtt tgaaaccgga
      601 gatgatgatg tcattactgt tggagatgta cggccaccag agttcacaca gagtactgcc
      661 gcaggaccga gtattgccag agatgacatt gttgtacagg aagagtccag aaataaagct
      721 aggactcctg tttctgagct tacaaaacaa atggacacag tcttttctag ttcaccagat
      781 gtgctttttg ttccagtgaa tggtctaagt ccagatgaag atgctctttc caaagacaga
      841 gtttgtcaca agaggaggtc ttctgataca gaagaaaggc atacaaaaaa gcagttttcc
      901 ttagagaatg ttccagaagg ggagcttttg caagatggta aggcatcagc tgaaaatgaa
      961 gtcatcgacc tttctgatgc tgcttcgaac tctacaaatc taagccccga tggaaaagac
     1021 actacagaag aaatggagta caatatcctt gttaacttct ttaaaaccat gggctattcc
     1081 caagagattg ttgaaaaggt cattagggag tacgggcctt ctacagaacc actcttgctt
     1141 ttagaagaaa ttgaaaaaga aaataaaagg ctccaagaag acagagactt cccaccgtgc
     1201 actgtttatc cagaggacag tcagagcaga agtgcaggag gtaggagcac gacaaacgag
     1261 ctcacagcag agtccactcc aaagaaaaca cagaatcata cagagcaaac tatggtggaa
     1321 agattctctc agttaccgtt caaagactct aaacagtgta cctcaaattg cagaattaat
     1381 tctttcaaaa cagtgccagt aggtcagaaa catgaaatct gggcttcaaa gcagaactca
     1441 aattgtactg tggacctgga aactgatggt gtcttggccg cctctgccag ccctaaagac
     1501 gtcagttttg tttcaagggg agctttaggg caccagcaaa gaaactcagc ttttcttgaa
     1561 aatggctttc aacagcaagc agaacctttg ctcccaaata acgtgaagcc tgcctgtgaa
     1621 aagcgctctg gcggctgtgg ctctcctcag cctaagccaa attatcaccc cccactttct
     1681 ccaccactgc cgccgcccca gctgctgcct tcagctactg aggctcgatt gggaggatcc
     1741 tctgatcata ttgattcctc agttacgggg gttcaaagat ttcgagatac cttaaaaata
     1801 ccgtacaagc tggagttaaa aaatgagcca ggaagagcag atttgaagca cattgttata
     1861 gacgggagta atgttgccat tacccatggt ctgaaaaagt tcttcagttg ccgtggcata
     1921 gccattgcag ttgagtattt ttggaagctc ggcaacagaa acatcactgt gtttgtcccg
     1981 cagtggagaa caagacggga tcctaatatc acagaacagc acttcttaac ccagctccag
     2041 gagcttggaa tattatcttt aactcctgcc cggatggtct ttggagaaag aattgcttct
     2101 catgatgaca ggttcctcct gcacttagca gacaagaccg ggggcatcat tgtaaccaat
     2161 gataacttca gagagtttgt gaccgagtcc gtgtcctgga gagaaatcat tacgaaaaga
     2221 ctgcttcagt acacattcgt gggggacata tttatggttc ctgatgaccc tctgggaaga
     2281 aacggacctc ggctggaaga atttcttcga aaggaggtct ttcttagaga catgcagccg
     2341 ctactcaatg ccctgccaag tgtgggcacg tttgaccctg gcttccggag tcccagcacc
     2401 caggtagcca acaccagcca ccagcctcca tcccggatcc agacctcctc aaaccattgg
     2461 cttcctcagc agccccactt cacacccctg gccacgcttc ccagtatgca gcagaacctt
     2521 cccgtgccag cacagaggtc ttctgcagag accagcgagc tgagggaagc tctactgaag
     2581 atcttccctg actctgagca gaagctgaag atcgaccaga ttctggtagc tcatccgtac
     2641 atgaaagacc tgaatgcctt gtctgccctg gtgttggact gatggccggg ctagagcccg
     2701 ctgacgatgg ggtgagggag ctgcccactg gggaagtacg gcaatgtgaa gacaccttcc
     2761 cagaaaacat gggtgtcata tagaaaaagg aagatgtttt gtgtctacaa aaatctgggt
     2821 tttcaaagcc agcttttttc tatatataaa ttatgctgct attacagatt taacattttc
     2881 tgtaaaagga aagtacattt tctgcctgtt cagaactgtt taatagcagt tactcttgag
     2941 tgtatttaca attttatgtt ttttaaacta ttttccttaa agcagaagaa aaattgacaa
     3001 atgaatatgg ttagcctttc taaataaaat tttaaaaaaa tatataagaa aaaaaaaagg
     3061 agttgcttcc ttaaggaaag caagacttct taaagtctat tttcttgagg taatctgtcc
     3121 tgtccactaa ccatggcgtg tgctccctgc cttcatccct agagttggct gctctgctcc
     3181 tgtggggcct gtcagcgagc cattgtggga gtggagcagc agagccacta gatggcacct
     3241 ggtgcctggc tgtctcctgt ggccaaaggc agactctgaa gagctggtgg gaagtcttaa
     3301 aggccatgtg gtcctgccct ccttcccctc cgctggacag agaagggaac tgagtcccag
     3361 catactccga ctggctggct ggctggcgta gctccctagt gcactcacca gccatggccg
     3421 ccatgccccc aacctggctc cacggctgcc ttagcctcag aaggcaggat aggccctgaa
     3481 gcctctggtg aggagaccct gtgtggagtt tgtacagctt tgccaaaaag ttttcttctc
     3541 aaggatgacc caagccaata aatagcatta gtagtttcag aggggtaggt atcaaagccc
     3601 ctgcatttcc tttcttttgt cttcttagag gtttcttagc agctcttcct gagtctttca
     3661 gaaccagtta tctcagtgtt gtctcttttc agtgtagctt ggtctgtgtc tgtgaaactt
     3721 cctggttgtt cttagcatcc tgactctcac ctggaccttc aaagggcttt gtgttttcca
     3781 tccatgctgt ctccaggccg tggtggtcag tcactgccct gtggatcgtc tttctcccgg
     3841 tcctacaagt aaccgaggac ttggtgctgg tttgttctcc gtggtgcagg gacttcgtag
     3901 atcacagagt gccgccatcg tgttgtgtct tggttcattt gatccctgca tccctcagga
     3961 gatgagcaca gagccttcta ggtggccata cttacatgtt ctctcctgaa tttgttgaag
     4021 atgggagctc tttgtcatct atcactagag ggtttcagac ctgcaggctg tgcaagtgga
     4081 gaacagagac ctctgccagc cccaggttga cccaccacag ccccccaacc ctacccccga
     4141 gcctcagctt gggagcacag caaaggtgcc aagatggagc tgtctccagg gctccctggc
     4201 ctggttagtc ccagtcaagc tttgctggaa accagagcca tggttgcctc accctgacgc
     4261 aggcagggag gagcaaggct gtcagaggcc ctgtagttgg cctgatcttt gaattgcgtg
     4321 tgcctctgtg ttcttagtat tgtttctgag agatacctgc ccatttcccc cttgttcctt
     4381 actggaggga agaaaaagct ggaggaaacc caaaggcatt aattaattac tttgtagatt
     4441 gtaatgtgaa atatcattct agattctttg tgaaatctgt cacatttagg tatgacattt
     4501 aaagcccagt tatctagcca ctggagaaag ctcacagctt gctgctttgc ctcatccaaa
     4561 gctctgttgc tgctaggtgc ttgtagatgt gttacctcca tccctccagt gcctcctcag
     4621 tgaacttggg agtggcttgg aattcctccc catgtggagg ttgagtgcct ctgcctcccg
     4681 tgtatcccga tgtttggctg tggcagccag tgcagctttg gtcactggac agagtgtgtg
     4741 tgtgtgatgt gtgtgtgtgt gatgtgtgcg ttcctctgtg tgtgtgtgtg tgtgtgtgtg
     4801 tgtgtgtgtg tgtgtgtgtg tgtgatgtgt gcattcctct gtgtttgtgt gtctgtccat
     4861 agctgtcctg gtccagtgca gttggcaggc tcagctgtat tgctaggact tgtaaggcat
     4921 gaaagagaac tccacctctc cttgtcagtc ccaagtccac agccctcttc ctggtagggg
     4981 cagctgtcgc aggccctctg caccagcctc acacaggccc tagcctgctc cctcccctgc
     5041 cctcagcatt ctgagccacc tcagctgggt ccattagccc actgctccct gtaccctgct
     5101 tgctgacccc tttggttaaa acaccctgcc tcccattcta gcttcccact ctcccctccc
     5161 cagtttggaa acttggcttt tgcccacctc atgggagttt cctgggaaat cactggttgc
     5221 tattccatta atggaatagc tacagtgaag ccattggcct gctttcttgg ttttccttcc
     5281 tgagcgctcc atctctctct tttcctcgaa ggcctatcct tcatacagtt tctcagcagg
     5341 tgattctcag gccagaccac ccttaggact cagtggaaag ggcggccctt actaaaaggc
     5401 aggctgtgtc agtcaccacc ctaaggggtg gactcagtgc tctagaggag agcctggagg
     5461 cttgtcactg ccacacctca tgccctgagc agctgtggta gggggtctgg aactgggctt
     5521 acttaggagt caccactctc ctaactctac cttccacttt gtgacaccag tcctctcact
     5581 agccctgtgg gatcttagct cccagaacct gggcctgcat cctgccatct cttacctaac
     5641 cctgaggtcc cttatatcct ccttggccct tggcttgcta tactagtagc ccaccacttg
     5701 atcccacaat cctcccacac tggtccctca ctggctacct tacagctctt ccctctccct
     5761 aattccaggg gtaccccaag ttcatctttt ttttttttgg ttcttttttt cggagctggg
     5821 gaccgaaccc cggggccttg cgcttcctag gcaagcgctc taccactgag ctaaatcccc
     5881 aacctccccc cccccaagtt catcttgaga ggaccatttt gcctcatcct tttcctctgt
     5941 gatctttagc tgtgacagag catcaagttc ctaccctctg agccttgtgt ccacggctgc
     6001 tgtcccatgg ccatacttga ctgtctactt tctatctcct accatgatcc tcactccagc
     6061 cacccagatc taggttcccc acgggccctg ttcatgtgta ttcgtcttct agaaatgccc
     6121 ctctgcccta cagcctgcct cctcaaaggc ccagccctga gtctctttgt gttgtgagca
     6181 gaagcagccc tatgctattc catggcccca cagcacttgg tgtcttgctt ctgactctaa
     6241 ccactctggc aggtgtagct gcagcccact gtgtactgtg ttgcctccct ctagactgtg
     6301 agctcctcgt gggcagggac catatggtca ctctgtatct cttgtggcac ctaacagtgc
     6361 cttgcacttg gtaggtgctc aataaatgtc tgttcaagtg a
//
