LOCUS       NM_001024240             900 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus marginal zone B and B1 cell-specific protein
            (Mzb1), mRNA.
ACCESSION   NM_001024240 XM_214585
VERSION     NM_001024240.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 900)
  AUTHORS   Zhang,H., Chen,X. and Sairam,M.R.
  TITLE     Novel hormone-regulated genes in visceral adipose tissue: cloning
            and identification of proinflammatory cytokine-like mouse and human
            MEDA-7: implications for obesity, insulin resistance and the
            metabolic syndrome
  JOURNAL   Diabetologia 54 (9), 2368-2380 (2011)
   PUBMED   21688198
REFERENCE   2  (bases 1 to 900)
  AUTHORS   Hu,E., Demmou,L., Cauli,B., Gallopin,T., Geoffroy,H.,
            Harris-Warrick,R.M., Paupardin-Tritsch,D., Lambolez,B., Vincent,P.
            and Hepp,R.
  TITLE     VIP, CRF, and PACAP act at distinct receptors to elicit different
            cAMP/PKA dynamics in the neocortex
  JOURNAL   Cereb Cortex 21 (3), 708-718 (2011)
   PUBMED   20699230
  REMARK    GeneRIF: VIP and CRF, originating from interneurons, and PACAP,
            expressed mainly by pyramidal cells, finely tune the excitability
            and gene expression in the neocortical network
REFERENCE   3  (bases 1 to 900)
  AUTHORS   Endo,K., Nakamachi,T., Seki,T., Kagami,N., Wada,Y., Nakamura,K.,
            Kishimoto,K., Hori,M., Tsuchikawa,D., Shinntani,N., Hashimoto,H.,
            Baba,A., Koide,R. and Shioda,S.
  TITLE     Neuroprotective effect of PACAP against NMDA-induced retinal damage
            in the mouse
  JOURNAL   J Mol Neurosci 43 (1), 22-29 (2011)
   PUBMED   20703829
  REMARK    GeneRIF: Data suggest that exogenous PACAP is able to counteract
            NMDA-induced toxicity, and that endogenous PACAP exerts a
            neuroprotective effect in the retina.
REFERENCE   4  (bases 1 to 900)
  AUTHORS   Flach,H., Rosenbaum,M., Duchniewicz,M., Kim,S., Zhang,S.L.,
            Cahalan,M.D., Mittler,G. and Grosschedl,R.
  TITLE     Mzb1 protein regulates calcium homeostasis, antibody secretion, and
            integrin activation in innate-like B cells
  JOURNAL   Immunity 33 (5), 723-735 (2010)
   PUBMED   21093319
REFERENCE   5  (bases 1 to 900)
  AUTHORS   Dong,Y.X., Fukuchi,M., Inoue,M., Takasaki,I., Tabuchi,A., Wu,C.F.
            and Tsuda,M.
  TITLE     Pituitary adenylate cyclase-activating polypeptide (PACAP) is an
            upstream regulator of prodynorphin mRNA expression in neurons
  JOURNAL   Neurosci Lett 484 (3), 174-177 (2010)
   PUBMED   20728507
  REMARK    GeneRIF: It is evident that PACAP-induced prodynorphin mRNA
            expression is mediated by the activation of the protein kinase A
            (PKA) pathway.
REFERENCE   6  (bases 1 to 900)
  AUTHORS   Ferencz,A., Kiss,P., Weber,G., Helyes,Z., Shintani,N., Baba,A. and
            Reglodi,D.
  TITLE     Comparison of intestinal warm ischemic injury in PACAP knockout and
            wild-type mice
  JOURNAL   J Mol Neurosci 42 (3), 435-442 (2010)
   PUBMED   20387008
  REMARK    GeneRIF: Results propose an important protective effect of
            endogenous PACAP-38 against intestinal warm ischemia, which
            provides basis for further investigation to elucidate the mechanism
            of this protective effect.
REFERENCE   7  (bases 1 to 900)
  AUTHORS   Ferencz,A., Weber,G., Helyes,Z., Hashimoto,H., Baba,A. and
            Reglodi,D.
  TITLE     Presence of endogenous PACAP-38 ameliorated intestinal cold
            preservation tissue injury
  JOURNAL   J Mol Neurosci 42 (3), 428-434 (2010)
   PUBMED   20379803
  REMARK    GeneRIF: Data show that the presence of PACAP-38 in the small bowel
            tissue has a key role in the protection against intestinal cold
            preservation injury.
REFERENCE   8  (bases 1 to 900)
  AUTHORS   Shimizu,Y., Meunier,L. and Hendershot,L.M.
  TITLE     pERp1 is significantly up-regulated during plasma cell
            differentiation and contributes to the oxidative folding of
            immunoglobulin
  JOURNAL   Proc Natl Acad Sci U S A 106 (40), 17013-17018 (2009)
   PUBMED   19805157
REFERENCE   9  (bases 1 to 900)
  AUTHORS   van Anken,E., Pena,F., Hafkemeijer,N., Christis,C., Romijn,E.P.,
            Grauschopf,U., Oorschot,V.M., Pertel,T., Engels,S., Ora,A.,
            Lastun,V., Glockshuber,R., Klumperman,J., Heck,A.J., Luban,J. and
            Braakman,I.
  TITLE     Efficient IgM assembly and secretion require the plasma cell
            induced endoplasmic reticulum protein pERp1
  JOURNAL   Proc Natl Acad Sci U S A 106 (40), 17019-17024 (2009)
   PUBMED   19805154
REFERENCE   10 (bases 1 to 900)
  AUTHORS   Bonfoco,E., Li,E., Kolbinger,F. and Cooper,N.R.
  TITLE     Characterization of a novel proapoptotic caspase-2- and
            caspase-9-binding protein
  JOURNAL   J Biol Chem 276 (31), 29242-29250 (2001)
   PUBMED   11350957
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC093397.1.
            
            On May 27, 2005 this sequence version replaced XM_214585.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC093397.1, CV076226.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676787, SAMN16676810
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..900
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p11"
     gene            1..900
                     /gene="Mzb1"
                     /gene_synonym="Pacap; pERp1; RGD1310251"
                     /note="marginal zone B and B1 cell-specific protein"
                     /db_xref="GeneID:291675"
                     /db_xref="RGD:1310251"
     exon            1..175
                     /gene="Mzb1"
                     /gene_synonym="Pacap; pERp1; RGD1310251"
                     /inference="alignment:Splign:2.1.0"
     CDS             2..568
                     /gene="Mzb1"
                     /gene_synonym="Pacap; pERp1; RGD1310251"
                     /note="plasma cell-induced resident endoplasmic reticulum
                     protein; plasma cell-induced resident ER protein;
                     proapoptotic caspase adapter protein"
                     /codon_start=1
                     /product="marginal zone B- and B1-cell-specific protein
                     precursor"
                     /protein_id="NP_001019411.1"
                     /db_xref="GeneID:291675"
                     /db_xref="RGD:1310251"
                     /translation="MRLPLPLLLLFGCRAILGSFGDRVSLSATAPTLDDEEKYASHMP
                     THLRCDACRAVAYQMGQHLAKAEAKSHTPDSSGSQELSESTYTDVLDRTCSQNWQSYG
                     VQEVNQMKRLMGPGLSKGPEPSISVMITGGPWPNRLSMTCFHYLGEFGEDQIYEAYRQ
                     GHETLEALLCGGTHGSCSQEIPAQREEL"
     exon            176..300
                     /gene="Mzb1"
                     /gene_synonym="Pacap; pERp1; RGD1310251"
                     /inference="alignment:Splign:2.1.0"
     exon            301..411
                     /gene="Mzb1"
                     /gene_synonym="Pacap; pERp1; RGD1310251"
                     /inference="alignment:Splign:2.1.0"
     exon            412..877
                     /gene="Mzb1"
                     /gene_synonym="Pacap; pERp1; RGD1310251"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catgagacta cccctgccgc tgttgctact gttcgggtgc agggctatcc tggggagctt
       61 cggggatagg gtttccctct cagctacagc tcctacactg gatgatgaag agaagtacgc
      121 atcccatatg ccgactcacc tgcgctgcga tgcctgccgg gctgtggcct accagatggg
      181 ccaacatctg gcgaaagcag aggctaaatc tcacactcca gactccagtg gatcgcagga
      241 gctgagtgaa tccacgtaca cagatgtgct ggaccggacc tgctctcaga actggcagtc
      301 ctatggagtc caagaagtga accagatgaa gcgtctcatg ggcccgggac ttagcaaggg
      361 gccagagccc agcatcagcg tgatgattac tgggggtccc tggcccaata ggctctccat
      421 gacgtgtttc cactacctgg gagagtttgg agaggaccag atctatgaag cctaccgcca
      481 aggccacgag actctggagg cgctactctg tgggggcacc cacgggtcct gctcacagga
      541 gatcccggct cagagagaag agctttagtc caagctgtga cacctatgga ccgtgtctat
      601 atttttttaa ttaattatta ttattaatgg ctgtttagag acaggctctc atcatgtagt
      661 ccaggctggc cttgaacttg tcctcctgct cagccttgaa attgctgaag tcctgagcct
      721 ttgtgcttga ccctcctata cctttctttc agcagtggtg gtggggagga ggcagggaag
      781 cctgactcca gctgtcaatc ttctccctcc actcctccct ggagtactgg ggctgaggct
      841 gcctttctac tttcaaataa agttcactga ctttgaaaaa aaaaaaaaaa aaaaaaaaaa
//
