LOCUS       NM_053888               7382 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus myelin transcription factor 1-like (Myt1l), mRNA.
ACCESSION   NM_053888
VERSION     NM_053888.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7382)
  AUTHORS   Mall,M., Kareta,M.S., Chanda,S., Ahlenius,H., Perotti,N., Zhou,B.,
            Grieder,S.D., Ge,X., Drake,S., Euong Ang,C., Walker,B.M.,
            Vierbuchen,T., Fuentes,D.R., Brennecke,P., Nitta,K.R., Jolma,A.,
            Steinmetz,L.M., Taipale,J., Sudhof,T.C. and Wernig,M.
  TITLE     Myt1l safeguards neuronal identity by actively repressing many
            non-neuronal fates
  JOURNAL   Nature 544 (7649), 245-249 (2017)
   PUBMED   28379941
  REMARK    Erratum:[Nature. 2024 Jun;630(8017):E11. doi:
            10.1038/s41586-024-07594-8.. PMID: 38834754]
REFERENCE   2  (bases 1 to 7382)
  AUTHORS   Wapinski,O.L., Vierbuchen,T., Qu,K., Lee,Q.Y., Chanda,S.,
            Fuentes,D.R., Giresi,P.G., Ng,Y.H., Marro,S., Neff,N.F.,
            Drechsel,D., Martynoga,B., Castro,D.S., Webb,A.E., Sudhof,T.C.,
            Brunet,A., Guillemot,F., Chang,H.Y. and Wernig,M.
  TITLE     Hierarchical mechanisms for direct reprogramming of fibroblasts to
            neurons
  JOURNAL   Cell 155 (3), 621-635 (2013)
   PUBMED   24243019
REFERENCE   3  (bases 1 to 7382)
  AUTHORS   Berkovits-Cymet,H.J., Amann,B.T. and Berg,J.M.
  TITLE     Solution structure of a CCHHC domain of neural zinc finger factor-1
            and its implications for DNA binding
  JOURNAL   Biochemistry 43 (4), 898-903 (2004)
   PUBMED   14744132
  REMARK    GeneRIF: Structure determination of NZF-1 amino acid residues
            487-548 reveals a novel fold for its zinc-binding domain that
            provides at least a partial explanation for the conservation of two
            histidine resiues within this sequence family.
REFERENCE   4  (bases 1 to 7382)
  AUTHORS   Berkovits,H.J. and Berg,J.M.
  TITLE     Metal and DNA binding properties of a two-domain fragment of neural
            zinc finger factor 1, a CCHC-type zinc binding protein
  JOURNAL   Biochemistry 38 (51), 16826-16830 (1999)
   PUBMED   10606515
REFERENCE   5  (bases 1 to 7382)
  AUTHORS   Kim,J.G., Armstrong,R.C., v Agoston,D., Robinsky,A., Wiese,C.,
            Nagle,J. and Hudson,L.D.
  TITLE     Myelin transcription factor 1 (Myt1) of the oligodendrocyte
            lineage, along with a closely related CCHC zinc finger, is
            expressed in developing neurons in the mammalian central nervous
            system
  JOURNAL   J Neurosci Res 50 (2), 272-290 (1997)
   PUBMED   9373037
REFERENCE   6  (bases 1 to 7382)
  AUTHORS   Bellefroid,E.J., Bourguignon,C., Hollemann,T., Ma,Q.,
            Anderson,D.J., Kintner,C. and Pieler,T.
  TITLE     X-MyT1, a Xenopus C2HC-type zinc finger protein with a regulatory
            function in neuronal differentiation
  JOURNAL   Cell 87 (7), 1191-1202 (1996)
   PUBMED   8980226
REFERENCE   7  (bases 1 to 7382)
  AUTHORS   Jiang,Y., Yu,V.C., Buchholz,F., O'Connell,S., Rhodes,S.J.,
            Candeloro,C., Xia,Y.R., Lusis,A.J. and Rosenfeld,M.G.
  TITLE     A novel family of Cys-Cys, His-Cys zinc finger transcription
            factors expressed in developing nervous system and pituitary gland
  JOURNAL   J Biol Chem 271 (18), 10723-10730 (1996)
   PUBMED   8631881
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Mar 5, 2021 this sequence version replaced NM_053888.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U48809.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-627               JAXUCZ010000006.1  51899082-51899708
            628-721             JAXUCZ010000006.1  51931530-51931623
            722-828             JAXUCZ010000006.1  52009058-52009164
            829-964             JAXUCZ010000006.1  52105334-52105469
            965-1118            JAXUCZ010000006.1  52147102-52147255
            1119-1173           JAXUCZ010000006.1  52155754-52155808
            1174-1207           JAXUCZ010000006.1  52155982-52156015
            1208-1270           JAXUCZ010000006.1  52156373-52156435
            1271-1632           JAXUCZ010000006.1  52182875-52183236
            1633-2598           JAXUCZ010000006.1  52198355-52199320
            2599-2733           JAXUCZ010000006.1  52203835-52203969
            2734-2824           JAXUCZ010000006.1  52207863-52207953
            2825-2932           JAXUCZ010000006.1  52209563-52209670
            2933-3147           JAXUCZ010000006.1  52214378-52214592
            3148-3398           JAXUCZ010000006.1  52220836-52221086
            3399-3635           JAXUCZ010000006.1  52223108-52223344
            3636-3757           JAXUCZ010000006.1  52226215-52226336
            3758-3826           JAXUCZ010000006.1  52227146-52227214
            3827-3889           JAXUCZ010000006.1  52256717-52256779
            3890-3973           JAXUCZ010000006.1  52264726-52264809
            3974-4195           JAXUCZ010000006.1  52266663-52266884
            4196-4287           JAXUCZ010000006.1  52279723-52279814
            4288-4397           JAXUCZ010000006.1  52283065-52283174
            4398-4541           JAXUCZ010000006.1  52288542-52288685
            4542-7382           JAXUCZ010000006.1  52288988-52291828
FEATURES             Location/Qualifiers
     source          1..7382
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q16"
     gene            1..7382
                     /gene="Myt1l"
                     /gene_synonym="Nzf-1; Nzf1; Nztf1"
                     /note="myelin transcription factor 1-like"
                     /db_xref="GeneID:116668"
                     /db_xref="RGD:620550"
     exon            1..627
                     /gene="Myt1l"
                     /gene_synonym="Nzf-1; Nzf1; Nztf1"
                     /inference="alignment:Splign:2.1.0"
     exon            628..721
                     /gene="Myt1l"
                     /gene_synonym="Nzf-1; Nzf1; Nztf1"
                     /inference="alignment:Splign:2.1.0"
     exon            722..828
                     /gene="Myt1l"
                     /gene_synonym="Nzf-1; Nzf1; Nztf1"
                     /inference="alignment:Splign:2.1.0"
     exon            829..964
                     /gene="Myt1l"
                     /gene_synonym="Nzf-1; Nzf1; Nztf1"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1118
                     /gene="Myt1l"
                     /gene_synonym="Nzf-1; Nzf1; Nztf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             1119..4682
                     /gene="Myt1l"
                     /gene_synonym="Nzf-1; Nzf1; Nztf1"
                     /note="neural zinc finger factor 1; myT1-L; neural zinc
                     finger transcription factor 1"
                     /codon_start=1
                     /product="myelin transcription factor 1-like protein"
                     /protein_id="NP_446340.2"
                     /db_xref="GeneID:116668"
                     /db_xref="RGD:620550"
                     /translation="MDVDAEEKRHRTRSKGVRVPVEPAIQELFSCPTPGCDGSGHVSG
                     KYARHRSVYGCPLAKKRKTQDKQPQEPAPKRKPFAVKADSSSVDECYESDGTEDMDDK
                     EEDDDEEFSEDNDEQGDDDDEDEVDREDEEEIEEEDDEDDEDDDDGDDVEEEEDDDDE
                     EEEEEEEEEENEDHQMSCTRIMQDPEKDDNNNDEYDNYDELVAKSLLNLGKIAEDAAY
                     RARTESEMNSNTSNSLEDDSDKNENLGRKSELSLDLDSDVVRETVDSLKLLAQGHGVV
                     LSENISDRSYAEGMSQQDSRNMNYVMLGKPMNNGLMEKMVEESDEEVCLSSLECLRNQ
                     CFDLARKLSETNPQDRSQPPNMSVRQHVRQEDDFPGRTPDRSYSDMMNLMRLEEQLSP
                     RSRTFSSCAKEDGCHERDDDTTSVNSDRSEEVFDMTKGNLTLLEKAIALETERAKAMR
                     EKMAMDAGRRDNLRSYEDQSPRQLAGEDRKSKSSDSHVKKPYYDPSRTEKRESKCPTP
                     GCDGTGHVTGLYPHHRSLSGCPHKDRVPPEILAMHENVLKCPTPGCTGRGHVNSNRNS
                     HRSLSGCPIAAAEKLAKAQEKHQSCDVSKSNQASDRVLRPMCFVKQLEIPQYGYRNNV
                     PTTTPRSNLAKELEKYSKTSFEYNSYDNHTYGKRAIAPKVQTRDISPKGYDDAKRYCK
                     NASPSSSTTSSYAPSSSSNLSCGGGSSASSTCSKSSFDYTHDMEAAHMAATAILNLST
                     RCREMPQNLSTKPQDLCTARNPDMEVDENGTLDLSMNKQRPRDSCCPVLTPLEPMSPQ
                     QQAVMSSRCFQLSEGDCWDLPVDYTKMKPRRVDEEDPKEITPEDLDPFQEALEERRYP
                     GEVTIPSPKPKYPQCKESKKDLITLSGCPLADKSIRSMLATSSQELKCPTPGCDGSGH
                     ITGNYASHRSLSGCPRAKKSGIRIAQSKEDKEDQEPIRCPVPGCDGQGHITGKYASHR
                     SASGCPLAAKRQKDGYLNGSQFSWKSVKTEGMSCPTPGCDGSGHVSGSFLTHRSLSGC
                     PRATSAMKKAKLSGEQMLTIKQRASNGIENDEEIKQLDEEIKELNESNSQMEADMIKL
                     RTQVTITTMESNLKTIEEENKVIEQQNESLLHELANLSQSLIHSLANIQLPHMDPINE
                     QNFDAYVTTLTEMYTNQDRYQSPENKALLENIKQAVRGIQV"
     exon            1119..1173
                     /gene="Myt1l"
                     /gene_synonym="Nzf-1; Nzf1; Nztf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1207
                     /gene="Myt1l"
                     /gene_synonym="Nzf-1; Nzf1; Nztf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1270
                     /gene="Myt1l"
                     /gene_synonym="Nzf-1; Nzf1; Nztf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1632
                     /gene="Myt1l"
                     /gene_synonym="Nzf-1; Nzf1; Nztf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..2598
                     /gene="Myt1l"
                     /gene_synonym="Nzf-1; Nzf1; Nztf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2599..2733
                     /gene="Myt1l"
                     /gene_synonym="Nzf-1; Nzf1; Nztf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2734..2824
                     /gene="Myt1l"
                     /gene_synonym="Nzf-1; Nzf1; Nztf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2825..2932
                     /gene="Myt1l"
                     /gene_synonym="Nzf-1; Nzf1; Nztf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2933..3147
                     /gene="Myt1l"
                     /gene_synonym="Nzf-1; Nzf1; Nztf1"
                     /inference="alignment:Splign:2.1.0"
     exon            3148..3398
                     /gene="Myt1l"
                     /gene_synonym="Nzf-1; Nzf1; Nztf1"
                     /inference="alignment:Splign:2.1.0"
     exon            3399..3635
                     /gene="Myt1l"
                     /gene_synonym="Nzf-1; Nzf1; Nztf1"
                     /inference="alignment:Splign:2.1.0"
     exon            3636..3757
                     /gene="Myt1l"
                     /gene_synonym="Nzf-1; Nzf1; Nztf1"
                     /inference="alignment:Splign:2.1.0"
     exon            3758..3826
                     /gene="Myt1l"
                     /gene_synonym="Nzf-1; Nzf1; Nztf1"
                     /inference="alignment:Splign:2.1.0"
     exon            3827..3889
                     /gene="Myt1l"
                     /gene_synonym="Nzf-1; Nzf1; Nztf1"
                     /inference="alignment:Splign:2.1.0"
     exon            3890..3973
                     /gene="Myt1l"
                     /gene_synonym="Nzf-1; Nzf1; Nztf1"
                     /inference="alignment:Splign:2.1.0"
     exon            3974..4195
                     /gene="Myt1l"
                     /gene_synonym="Nzf-1; Nzf1; Nztf1"
                     /inference="alignment:Splign:2.1.0"
     exon            4196..4287
                     /gene="Myt1l"
                     /gene_synonym="Nzf-1; Nzf1; Nztf1"
                     /inference="alignment:Splign:2.1.0"
     exon            4288..4397
                     /gene="Myt1l"
                     /gene_synonym="Nzf-1; Nzf1; Nztf1"
                     /inference="alignment:Splign:2.1.0"
     exon            4398..4541
                     /gene="Myt1l"
                     /gene_synonym="Nzf-1; Nzf1; Nztf1"
                     /inference="alignment:Splign:2.1.0"
     exon            4542..7382
                     /gene="Myt1l"
                     /gene_synonym="Nzf-1; Nzf1; Nztf1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgtaggaag cacacagcac acatcccaat cttgcctgac tgctgaaagc ctagtaaaca
       61 ggaaggctag aaattactgg ttttaactca cagctgttag gttgagaaac gtctagatca
      121 gtgatgaagt tagggtttga ggaaatggct gcgttttgtg ttgcttaaag gacagcagcc
      181 cgcccgagca gggtaagtca gcaggatgct cccggtgtgc ctctgcggca gcgatgtggt
      241 ctctaaggaa acctgtgcct gatgctcgca gcctgggcag tgctggcggc ccagggccgt
      301 ctgtctgctg cctgctgatg gaggctgcgc cgcatccacc aggcagggct ctgcacgcat
      361 gcccgtcttc cccggcgttt agtggtgtca acttattaat ttccatcttc gacttcaggc
      421 ctgttagttt cctgtctgaa agcattatta cttttgtcca tgtggcaaaa taattagcat
      481 acagatgaga agtggccccg tgtctgcgcg ccgatagaga gaagatgtgc ggttcgaagt
      541 tgattggatg aatggagaac aaatggtggg cgttcaaaag cattagaaga gttttgtagt
      601 cgcggagcag gctggagaat tttctggggg ttccacagag gctgcagctg aggtccagaa
      661 gtgtgcaatt ctcagctgcg ctttgccctt cccagggtga cgactgaaga atcagagtgt
      721 ggaaaagaac ggtaggagga attggtgaga acatccagct agcatcttca agtcctgtgg
      781 tgggaggcag cagtgctggt ccaaagagga cccagagagt gaactcagag tgaccacatc
      841 tggtagaaga ggggaagatg tagttactga gtccagtcca gtgtttgtgt ctctcacatt
      901 gccaacaaaa gaaagactcc agctggcccc acagacatat ggatattcca ggagccacgt
      961 aaagatggag aaatggaggc acagagaaat taagtgactt ggccacagtc acaagctggg
     1021 gaggaccagg gaaagcctaa agagagctgg ctctgggcct gcatcctgcc cacggagtca
     1081 ccctgcctcc gttcttggga gagaaggctt cctacaagat ggacgtggac gctgaggaga
     1141 agcgccatcg cacacggtcc aaaggggttc gagttcctgt ggagccagcc atacaagagc
     1201 tgttcagctg tcccactcca ggctgcgacg gcagcggtca tgtcagtggc aaatatgcac
     1261 gacacagaag tgtatatggt tgtcccttgg ctaaaaagag aaagacgcaa gataaacagc
     1321 cccaagaacc tgctcccaag cgaaaaccat ttgcagtaaa agcagatagt tcttcagtag
     1381 acgaatgcta tgagagtgat ggcactgaag acatggatga taaggaagag gatgatgatg
     1441 aggagttctc tgaagacaat gatgagcaag gggatgatga tgatgaagat gaggtggatc
     1501 gggaagacga ggaggagatt gaggaggaag atgatgaaga tgatgaagat gatgatgatg
     1561 gtgatgatgt agaagaggaa gaagatgatg atgatgaaga ggaggaagaa gaggaagagg
     1621 aagaagaaaa tgaagaccat caaatgagtt gtactcgaat aatgcaggac ccagaaaagg
     1681 atgataacaa caatgacgag tatgataact atgatgaact ggtagctaag tcactattaa
     1741 atcttggcaa aattgctgag gacgcagcat accgggccag gactgagtca gaaatgaaca
     1801 gcaatacctc caatagtctg gaggatgata gtgacaaaaa cgaaaacctc ggtcggaaaa
     1861 gcgaactgag tctagactta gacagtgatg ttgttcgaga aacagtggac tcccttaagc
     1921 tgttagcaca aggacatggt gttgtgctat cagagaacat cagtgacaga agttatgctg
     1981 aggggatgtc acagcaggac agtagaaata tgaactatgt catgctaggg aagcccatga
     2041 acaatggact catggagaag atggtggagg agagtgatga ggaggtgtgt ctaagtagtc
     2101 ttgagtgcct gaggaaccag tgctttgacc tggccaggaa actcagcgag accaacccgc
     2161 aggacaggag tcagccaccc aacatgagtg tgcgccaaca tgtccggcaa gaggacgact
     2221 tccctgggag gacgccagac aggagctact cggatatgat gaaccttatg cggctggagg
     2281 agcagctaag ccccaggtct agaacgttct ccagctgtgc caaggaggat gggtgtcatg
     2341 agagggatga tgacaccacc tcagtgaact cagacaggtc tgaggaagta tttgacatga
     2401 ccaagggcaa cctgactctg ctagagaaag ccattgcctt ggagacagag agagccaagg
     2461 ccatgcgaga gaagatggcc atggatgctg ggagaaggga taacctgaga tcctatgagg
     2521 accagtctcc aagacagctg gctggggaag acagaaaatc caaatccagt gacagccatg
     2581 tcaaaaagcc atactatgat ccctcaagaa cagaaaagag agagagcaag tgtccaaccc
     2641 ccgggtgtga tggaaccggc cacgtaactg ggctttaccc gcatcaccgc agtctgtctg
     2701 gatgcccgca caaagatagg gtccctccag aaattcttgc catgcatgaa aatgttctca
     2761 agtgtcccac tccaggctgc acagggcgag ggcatgtgaa tagcaacagg aactcgcaca
     2821 gaagcctctc tggatgccct attgctgctg cagaaaaact ggcaaaggcc caggagaaac
     2881 atcagagctg tgatgtgtcc aaatccaacc aggcctcaga ccgagtcctc aggccaatgt
     2941 gctttgtcaa acagcttgag attcctcagt atggctacag aaacaatgtt cccacaacta
     3001 caccgcgctc caacctggcc aaggagcttg agaaatattc caagacttcg tttgagtaca
     3061 acagttacga caaccatact tatggcaaaa gagccatagc tcccaaggtg caaaccaggg
     3121 acatatcccc caaaggatat gacgatgcca agcggtactg caagaatgcc agccccagca
     3181 gcagcaccac cagcagctat gcacccagca gcagcagcaa cctcagctgt ggtggtggca
     3241 gcagtgccag tagcacgtgt agcaagagca gctttgacta cacacatgac atggaggccg
     3301 cacacatggc agccacagcc attctcaacc tgtccacacg ttgccgggaa atgccacaga
     3361 acctgtccac caagccacag gacctgtgca ctgcccggaa cccagacatg gaggtggatg
     3421 agaatggcac cctggacctg agcatgaaca agcagaggcc tcgagacagc tgctgcccag
     3481 tcctgacacc cctggagccc atgtcccccc agcagcaggc agtgatgagc agccgatgct
     3541 tccaactgag cgagggggat tgttgggact tacccgtaga ctacaccaaa atgaagcctc
     3601 ggagggtaga tgaggaggac cccaaagaga ttaccccaga agacttggac ccattccagg
     3661 aggctctgga agaaagaaga tatccagggg aggtgaccat cccaagcccc aaacccaagt
     3721 accctcaatg caaggaaagc aaaaaggact taataactct gtctggctgc cccctggcgg
     3781 acaaaagcat tcgaagtatg ctggccacca gttcccaaga gctcaagtgc cccacccctg
     3841 gctgtgacgg ttctggacac atcactggca attacgcttc tcatcgaagc ctttccgggt
     3901 gcccaagagc aaagaagagt ggtatccgga tagcacaaag caaagaagac aaggaagacc
     3961 aggagccaat caggtgtccg gtacctggct gtgacggtca gggacatatc actgggaagt
     4021 acgcatccca ccgcagcgcc tctgggtgcc ccttggcagc caagaggcag aaagatgggt
     4081 accttaacgg ctcccagttc tcctggaagt cagtcaagac agagggcatg tcctgcccta
     4141 cacccgggtg tgatgggtca ggacacgtca gtggcagctt cctcacacac cgcagcttgt
     4201 caggatgtcc aagagccaca tcagcaatga agaaagcaaa gctgtctgga gaacagatgt
     4261 tgactatcaa gcagcgagcc agcaacggta tagaaaacga tgaggagatc aagcagttgg
     4321 atgaagagat caaggagctc aatgagtcca attcccagat ggaggccgac atgatcaaac
     4381 tcagaactca ggtaacaatc accacaatgg agagcaacct gaagacgatt gaggaggaga
     4441 acaaagtcat tgagcagcag aatgagtcgc tcctgcacga gttggccaac ctgagccagt
     4501 ccctgatcca cagcctcgcc aacatccagc tgcctcacat ggatccaatc aatgaacaaa
     4561 attttgatgc ttacgtgact actttgacgg aaatgtatac aaatcaagat cgttatcaga
     4621 gtccagaaaa taaagcccta ctggaaaata taaagcaggc tgtgagagga attcaggtct
     4681 gaacagctgc tctagtggtg actcatgctt aaaaaggatg cctcttgttt cttgctgctg
     4741 taacttacca gaaagtgtta tatatttatt tctgtcggaa cagtgttatg ctacaagact
     4801 tcataatggt tttgtgtgct ctcgagatag tacctgcaga ctagttttgg atacattcac
     4861 attttgtacg ttttcatata agctgacata gtgtgatttc ccatgtaatg tttatagctg
     4921 ctgctgtctg cacatttggg ggtctctata tttctgaaga ggtaagctga cgaaaataaa
     4981 tagagtgtaa attcttttta atgctttagt gattaaatgt tttagtattt tgaactgaaa
     5041 tggacaaaaa agaaaaagaa aaaaaaagca ggtttgactg atcacgtgtg gcctcctggc
     5101 cacttttaga cactgtcctt tggctcaggt tggaggactt ggtggaattt aagaaataca
     5161 ttttgtgtgc atattgtttc atagcaagaa ttggttgcaa aaaaatgctt tatttttgaa
     5221 caatgcttgg aaatattatg tgactttttt gtttgtttgt tttaggagga tggtgtatgg
     5281 tgggggcaat aaatgagttt ttttgcattc caaggaaatg gcatatggat taactgtaag
     5341 aaatgaaata agtaatttat tgtaagacaa catcaagcca tggaaacttg gcagaagatt
     5401 caaagcagct taaacagcac ttttaattaa ctcctaaaca ttacatggtg ggactgtgga
     5461 gactccgtta agacaggagc ttgtcagagg tggacaacac gaagatttcc tttgcgtttt
     5521 cagtaaccta tggagcaccc ttctcttatt tctcctagag ccccgtgccc ctctgaactg
     5581 ttaccacaat ctagcttacc tagctgaagt tgattgtttt ttcaatttga gcaaacaggt
     5641 aatttaagca tttctctccc cctttcactt tcacaaagca tcatcattgg ttattcttgt
     5701 ttcacatctg aggatgaagg ctaatggctg tgcttgccct ggttactgga tgggcttctc
     5761 tgctgggcgg gtgggaaagc agctctaccc ttccccctcc ccgccccgcc ccgcccccac
     5821 tctgactttg aataagcctt ggtcctttcc agaacactct ggacaccaag gccaaggacg
     5881 ttcacgttct gccctcgctg ggtccagctg actctagcgt ctgcacagcc ttgtgtgact
     5941 cgtggtgacc taacctgaga aagagtgcaa tcagatgttc aagtaactaa atagactgcg
     6001 gcactttttt gctttaaact agatcatctt agatttgtcg ataccttcga aatttgatgg
     6061 tttcatccca aatgactgca ctatatgtat gcatacggcc acttttgatt gctgcacccc
     6121 ttctgagtag tctttgacaa tgtgttgtgt tccccgatgt cgacttgatt tccttttagt
     6181 agcatctctc ttccatgtct tgatgttatg caggaagtac aaaagtactt taaaattttg
     6241 ttatgaaata aaaaaaagga tgggttttgt aaaaataata aaaaaaatat ttttagcaga
     6301 acaggactta cagggtcatt gtccccacaa tgtgccagtc ggctctttgc actcgccttg
     6361 tcctatatat ccgtacggag gtgtgcaatc ctgtgtcagt cgccttgtga cactgaagtg
     6421 gatgagttat agaggaggcc ctcgaggctg acccaatacg gttactaagg gagactacag
     6481 ggatctcacg acaaatattc tgatacaata ctcaacctcg gtctatatat atatatgtat
     6541 aaatataaga atatcccagt ggcactttat actgttcact gtacaaaagc ttacagtttt
     6601 ccacaaggac tttaataacg agctggggaa aagattatgt aattacttgg ggctctgcgg
     6661 gaccttctct gtccagcgcc ccctttctgt tgtgcgatta gttgtagctg ccatgctcag
     6721 aattgccttt ttgagagctg aagcaaggtg cttactgtca cctgatgcca tacacacggt
     6781 cccaggccca catccggggg ggcctctgtt catagcggca catgcatttc cccaccgcgt
     6841 cttgtctgca gcttcttggc caatgtagta atgcttttag tagagtaata ggtagtatca
     6901 gtttggattc ttatcgttat cacctatgta caatggagag gggttctaag cacaaatctg
     6961 ctgctcatgt aacgttggta cataatatca aatcaaaagt tatctgtgat tatatatagg
     7021 gatcacacag tgtcacatgt tagaatgctg accttccaca tggggttatt gtgagtcatc
     7081 agagcatatt tattataact tattgttcat attcatttct aagttaattt aagtaatcat
     7141 ttattaagac agaattttgt ataaactatt tattgtgctc tctgtggaac tgaagtttga
     7201 tttatttttg tactacacgg catgggtttg ttgacacttt aattttgcta taaatgtgtg
     7261 gaatcacaag ttgctgtgat acttcatttt taaattgtga actttgtaca aactttgtca
     7321 tgctgatgtg aacacatctt actctgaata aaaaggtgtt gccacgtttg tagcacgaag
     7381 ga
//
