LOCUS       NM_001108615            5468 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus myelin transcription factor 1 (Myt1), mRNA.
ACCESSION   NM_001108615 XM_001055147 XM_342605
VERSION     NM_001108615.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5468)
  AUTHORS   Bahi,A. and Dreyer,J.L.
  TITLE     Viral-mediated overexpression of the Myelin Transcription Factor 1
            (MyT1) in the dentate gyrus attenuates anxiety- and ethanol-related
            behaviors in rats
  JOURNAL   Psychopharmacology (Berl) 234 (12), 1829-1840 (2017)
   PUBMED   28303373
  REMARK    GeneRIF: MyT1 overexpression produced anxiolytic-like effects and
            decreased ethanol intake.
REFERENCE   2  (bases 1 to 5468)
  AUTHORS   Andrews,J.L., Newell,K.A., Matosin,N., Huang,X.F. and
            Fernandez-Enright,F.
  TITLE     Alterations of p75 neurotrophin receptor and Myelin transcription
            factor 1 in the hippocampus of perinatal phencyclidine treated rats
  JOURNAL   Prog Neuropsychopharmacol Biol Psychiatry 63, 91-97 (2015)
   PUBMED   26071990
  REMARK    GeneRIF: This study suggested that alterations of p75 neurotrophin
            receptor and Myelin transcription factor 1 in the hippocampus of
            perinatal phencyclidine treated rats
REFERENCE   3  (bases 1 to 5468)
  AUTHORS   Wang,S., Zhang,J., Zhao,A., Hipkens,S., Magnuson,M.A. and Gu,G.
  TITLE     Loss of Myt1 function partially compromises endocrine islet cell
            differentiation and pancreatic physiological function in the mouse
  JOURNAL   Mech Dev 124 (11-12), 898-910 (2007)
   PUBMED   17928203
REFERENCE   4  (bases 1 to 5468)
  AUTHORS   Aruga,J., Yoshikawa,F., Nozaki,Y., Sakaki,Y., Toyoda,A. and
            Furuichi,T.
  TITLE     An oligodendrocyte enhancer in a phylogenetically conserved intron
            region of the mammalian myelin gene Opalin
  JOURNAL   J Neurochem 102 (5), 1533-1547 (2007)
   PUBMED   17442045
REFERENCE   5  (bases 1 to 5468)
  AUTHORS   Kim,J.G., Armstrong,R.C., v Agoston,D., Robinsky,A., Wiese,C.,
            Nagle,J. and Hudson,L.D.
  TITLE     Myelin transcription factor 1 (Myt1) of the oligodendrocyte
            lineage, along with a closely related CCHC zinc finger, is
            expressed in developing neurons in the mammalian central nervous
            system
  JOURNAL   J Neurosci Res 50 (2), 272-290 (1997)
   PUBMED   9373037
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474066.1.
            
            [WARNING] On Apr 9, 2024 this sequence was replaced by
            NM_001108615.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_342605.3, XM_001055147.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132276,
                              SAMD00132278 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5468
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q43"
     gene            1..5468
                     /gene="Myt1"
                     /note="myelin transcription factor 1"
                     /db_xref="GeneID:362291"
                     /db_xref="RGD:1304899"
     exon            1..1664
                     /gene="Myt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             983..3751
                     /gene="Myt1"
                     /codon_start=1
                     /product="myelin transcription factor 1"
                     /protein_id="NP_001102085.1"
                     /db_xref="GeneID:362291"
                     /db_xref="RGD:1304899"
                     /translation="MVANSDEGEKDLFIQPEDVEEVIEVTSERSQEPCPQSLKDMVNE
                     ESSKQKGVLGHEEEEEEEEEEEEEEEEGEEGEEEEEEEEEEDEEDEEEDEEEEEEEEE
                     AASNVLFGDDTTHTSVQKASSEFRGPELSSPKPEYSVIVEVRSDDDKDEDSHSQKSAV
                     TDESEMYDMMTRGNLGLLEQAIALKAEQVRAVCESGCPPAEQGHLGPGEPGKMAKPLD
                     VVRKSCYNKDPSRVEKREIKCPTPGCDGTGHVTGLYPHHRSLSGCPHKDRIPPEILAM
                     HENVLKCPTPGCTGQGHVNSNRNTHRSLSGCPIAAAEKLAKSHEKQQLQTGDPPKNNS
                     NSDRILRPMCFVKQLEVPPYGSYRPNVAPTTPRANLAKELEKFSKVTFDYASFDAQVF
                     GKRMLAPKIQTSETSPKAFQCFDYSHDAEAAHMAATAILNLSTRCWEMPENLSTKPQD
                     LPSKAVDIEVDENGTLDLSMHKHRKRENTFPSSSSCSSSPGVKSPDVSQRQSSTSAPS
                     SSMTSPQSSQASRQDEWDRPLDYTKPSRLREEEPEESEPAAHSFASSEADDQEVSEEN
                     FEERKYPGEVTLTNFKLKFLSKDIKKELLTCPTPGCDGSGHITGNYASHRSLSGCPLA
                     DKSLRNLMAAHSADLKCPTPGCDGSGHITGNYASHRSLSGCPRAKKSGLKVAPTKDDK
                     EDPELMKCPVPGCVGLGHISGKYASHRSASGCPLAARRQKEGALNGSSFSWKSLKNEG
                     PTCPTPGCDGSGHANGSFLTHRSLSGCPRATFAGKKGKLSGDEILSPKFKTSDVLEND
                     EEIKQLNQEIRDLNESNLEMEAAMVQLQSQISSMEKNLKNIEEENKLIEEQNEALFLE
                     LSGLSQALIQSLANIRLPHLEPICEQNFDAYVNTLTDMYSNQDCYQNPENKGLLETIK
                     QAVRGIQV"
     exon            1665..1799
                     /gene="Myt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1890
                     /gene="Myt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..2004
                     /gene="Myt1"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..2219
                     /gene="Myt1"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2344
                     /gene="Myt1"
                     /inference="alignment:Splign:2.1.0"
     exon            2345..2614
                     /gene="Myt1"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..2769
                     /gene="Myt1"
                     /inference="alignment:Splign:2.1.0"
     exon            2770..2832
                     /gene="Myt1"
                     /inference="alignment:Splign:2.1.0"
     exon            2833..2901
                     /gene="Myt1"
                     /inference="alignment:Splign:2.1.0"
     exon            2902..2964
                     /gene="Myt1"
                     /inference="alignment:Splign:2.1.0"
     exon            2965..3048
                     /gene="Myt1"
                     /inference="alignment:Splign:2.1.0"
     exon            3049..3270
                     /gene="Myt1"
                     /inference="alignment:Splign:2.1.0"
     exon            3271..3362
                     /gene="Myt1"
                     /inference="alignment:Splign:2.1.0"
     exon            3363..3466
                     /gene="Myt1"
                     /inference="alignment:Splign:2.1.0"
     exon            3467..3610
                     /gene="Myt1"
                     /inference="alignment:Splign:2.1.0"
     exon            3611..5468
                     /gene="Myt1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttgacctcc tccacatctt tctggttgaa atatctcagt tcaggatgaa tcaggactct
       61 gaaggtgggc tgctcataga agccaggaga agaaagaagg catctgagag tccgctgacc
      121 tcccaacctt ctgggatcag ctgactttaa acggttgagt tagagtttta ccatattttt
      181 gaagcaatct atgttgagcc ctcactgatt tccttcttgg gattcaagtg aatgaatggc
      241 ccatggaata aagcaagttt gtgttccatg tagaaaaggc ccacaactca cctgcctctt
      301 gggatattat atagtagggc tggctcctac tgttgctaag aacactggtt cacgagttcc
      361 acagaaccag caggtagaaa gaactgttgc tatgtttaaa agatttaaat tcatgttctt
      421 tcaaaataga agtggttttc aattatgaaa tgacttttca tctgtgtttt ttttctttaa
      481 gttccattat ataaaatgca gatctatctg atttgagaaa ataaatgatg gggtagtaat
      541 acgaaaaata tcaaagtaat ctagctaaaa ttgattcccc caaggtttgt gaatcaaagc
      601 agaaggctga cagggtggct cacacttcat ttccatgttt tctgggctac agtgttgagg
      661 gtgagcaggg tggggccaag tagagggttg gctactgttg ggggtagaga cctggaaaca
      721 ttcctctctt gctgtcttca aggccctatg gtctttcttg ttttatgcag gaaaaagcct
      781 gatcaagccc cattttggct ccaaccccac aagcagccct tctggcttct ccaagggcag
      841 ctacagtagc tatcagggca tcattgcaac ttccctccta aatctgggcc aaattgctga
      901 agagaccctt gtgcaggagg attcagtctc agtagctaag ttgggcccca ctgttgttca
      961 ccagcttcag gatgaggctg caatggtggc caacagtgat gagggtgaaa aggacctctt
     1021 tatacagcca gaagatgtgg aggaggtcat tgaagtcacc agtgaacgct cccaggagcc
     1081 atgccctcag tctctgaagg atatggttaa tgaagagtca agcaaacaga aaggtgtcct
     1141 aggtcatgag gaggaggaag aggaagagga agaagaggag gaggaagaag aggagggaga
     1201 ggaaggagag gaggaagagg aagaggagga ggaagaagat gaagaagatg aggaggaaga
     1261 tgaggaggag gaggaggagg aggaggaagc agcttcaaat gtcctctttg gggacgacac
     1321 cactcatacc tctgtccaga aggcttcttc tgagttccga ggcccagagc tatccagtcc
     1381 taaacctgag tactcagtca tcgtggaggt ccgttctgat gacgacaagg atgaggattc
     1441 acactcccag aagtcagcag tcacagatga atcagaaatg tatgacatga tgacccgtgg
     1501 gaatctgggc cttttggagc aggccattgc cctaaaggct gagcaggtgc gagcggtctg
     1561 tgagtctggc tgcccacctg ctgagcaggg ccatctgggc ccaggagagc cagggaaaat
     1621 ggcaaagccc ttggatgtgg tgaggaagag ctgctacaac aaagatcctt ccagggtgga
     1681 gaagcgtgaa atcaagtgtc cgacacctgg ctgtgatggc actggccatg ttactgggtt
     1741 gtaccctcat caccgcagcc tgtctggctg tccccacaag gatagaattc ctccagagat
     1801 cttggccatg catgaaaatg tgctgaagtg ccccactccc ggctgcacgg gccaaggcca
     1861 tgtgaacagc aaccgcaata cccacagaag tttgtctgga tgtcccattg ctgctgctga
     1921 aaaattagcc aaatctcatg agaagcagca gttgcagaca ggagatcctc ccaaaaataa
     1981 ctccaattca gatcggatcc tcaggcccat gtgttttgtg aagcagctcg aggttcctcc
     2041 ttatgggagc taccgaccca atgtggctcc caccacaccc agggccaact tggccaagga
     2101 gctggagaag ttctccaaag tcacctttga ctacgcaagt tttgatgctc aggtttttgg
     2161 caaacgtatg cttgccccaa agattcagac cagcgaaacc tcacccaaag ccttccaatg
     2221 cttcgattac tctcatgatg ctgaggctgc acacatggct gccacagcca tcctgaacct
     2281 ctccactcgg tgttgggaaa tgccagagaa cctcagcaca aagccacagg acctccccag
     2341 caaggctgtg gacattgagg tagatgagaa cggaactctg gacctgagca tgcacaagca
     2401 ccgcaagcga gaaaacactt ttcccagcag cagcagctgc agtagcagcc ctggtgtcaa
     2461 gtctcctgat gtctctcagc gtcagagcag taccagcgcc cccagcagct ctatgacctc
     2521 accccagtcc agccaggcct ctcgccagga tgagtgggac cgtcctctag actacaccaa
     2581 acctagccga ctccgagagg aagagcctga ggagtcggag ccagcagcac actcttttgc
     2641 ttcttctgaa gcagatgatc aggaggtgtc agaagagaac tttgaagagc gaaagtaccc
     2701 aggggaagtc accctaacca actttaagct gaagtttctt tccaaggaca taaagaagga
     2761 gcttctcacc tgtcccaccc ccggctgtga cggtagtggc catatcaccg ggaactatgc
     2821 ctcccatcgc agcctctctg gttgccctct tgctgacaag agcctcagaa acctcatggc
     2881 tgcccactct gctgacctca agtgccccac acctggctgt gatggctctg gccacataac
     2941 agggaactat gcttcacacc ggagtttgtc aggctgccca cgtgccaaga agagtggact
     3001 caaggtggcg cctaccaagg atgacaagga ggaccccgag ttgatgaagt gcccagttcc
     3061 aggatgtgtg gggctcggcc acatcagcgg caaatatgcc tctcacagga gtgcttctgg
     3121 ctgcccactg gctgctcgga ggcagaaaga gggagctctc aatggttcat ctttctcatg
     3181 gaagtcgctg aagaatgagg gccctacttg ccccacccca ggttgtgacg gctctggcca
     3241 tgccaatggc agtttcctca ctcaccgaag tttgtccggc tgtcccagag caacctttgc
     3301 tggaaagaaa ggaaaactct caggggatga gattctcagc ccaaagttca agacaagtga
     3361 tgtgctggag aatgatgagg agatcaagca gctaaatcag gagatacgag acttgaatga
     3421 gtccaacttg gaaatggagg ctgccatggt gcagctgcag tctcagatat cttccatgga
     3481 gaagaacctg aagaacatcg aggaggagaa caagctcatt gaggagcaga atgaggccct
     3541 gtttctggaa ttgtctgggc ttagccaggc cctcatccaa agtcttgcca atattcgcct
     3601 tccacacctg gagccaatat gtgaacagaa ttttgacgcc tatgtgaaca ccctcactga
     3661 catgtactcc aatcaggact gctaccagaa tccggagaac aaaggccttc tggaaacgat
     3721 caagcaagct gtgaggggca ttcaggtcta ggctgcactg cacacaggag tctctgctct
     3781 gatcctcaca gtgaggaccc tgacttatag ccacttctaa ttggaagcct gggtgcagcc
     3841 ttgggcagct tacccaaagg ggagcctgga aatcagtgtc tcctatgatg tccccattag
     3901 gcctaggcat agaagacctc tctatgtgag tgcctgggga cactgaagta ttacaaagcg
     3961 atttattttt gttttttgtt ttgttttgtt ttaaagaagt ctgaagagca gctcaaagtc
     4021 tccggtggaa actcatggac aaggttctca gggaagtttt ggagtttgca gccacagtat
     4081 tccattgttt gtcaaggttg ggagggcatc catggactag acgggtgtta gtctcagcag
     4141 gagggcacgc ctaggtttct ggctatgctc actgaggccc acgtggcaag tatgttttgt
     4201 gttttcattt aattcaattt tgtgttaaag gtgcacaata ctttgcttca gaggtgaatc
     4261 taggaacagg cttcccagat ggcagtctac acagttgatg aacatcatag aaagccagct
     4321 gaaggttttt ttattcagtt ggaggccctg aaaaatcagc cacttatttg ggcagcagat
     4381 gcctttaggc tgtgcagacc tgctttctcc gggctccagt ctttaacccc tggcctgggc
     4441 tctaagtcca agaccactgg gccaaacctc tggttcctgt acctctatcc gggtgctgga
     4501 cccatcattg tgtcttttcc tgtgtaggtt tgctccttgt atccaaggtg accacggtgg
     4561 ggacggtgag accagaggta aattgttacg ggaggccacc aagatttcac ttctttatag
     4621 gttcatttaa gatgtgaaaa ggataaattt taatttaatg tgttaaaaac acaatgttct
     4681 tactgtgtaa atagagtcca agtcaattgt gactgcaatt ccaaattagt atttaaaagt
     4741 agagaaattg cacttcctga aagacactga aagtagttag tttattctgt aaagtattta
     4801 attttgtcat gatataagta tttatattct taccctctta tgttaatgtt tgctatttat
     4861 tatttttatt tatttatttt atactatttc aactagacta cacactaggg caccataaga
     4921 gttaaataag ttaaattgaa acaaaaacat ttatttgact ataagatagg ccacgaagaa
     4981 ttgatataac ctctagttat aattttgatg caactgagtt attttttata tattttgtta
     5041 tttattcttt taataatgga attttttaaa aaagtatttt gtaactgagg aattttgata
     5101 atttgggttt ttcttcccat tggtccacca gagagaaagg tgtttggttt tctttttccc
     5161 attgggttcc ttttgtcagg ccaataacag caaatggaat tctgtattta ttattattta
     5221 agtgtagtgc agatgtgtgt gctctggtgt ttcttgtgtt gcatttgtgg aggttcttat
     5281 ggatgattca tgttgctgtg agggagtgct ggccatggtc agttctaggc aatggactca
     5341 ctggccaacc tgcccaggat cttgataccc caatactgtg accctccttc ctcaggaaac
     5401 acgttggacc cacagtacct cgtggtgtgt ttggagggtg atttctaata aaagtctcac
     5461 tgtgcata
//
