LOCUS       NM_182844               4806 bp    mRNA    linear   ROD 24-SEP-2023
DEFINITION  Rattus norvegicus myosin VIIA and Rab interacting protein (Myrip),
            mRNA.
ACCESSION   NM_182844 XM_006244110
VERSION     NM_182844.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4806)
  AUTHORS   Goehring AS, Pedroja BS, Hinke SA, Langeberg LK and Scott JD.
  TITLE     MyRIP anchors protein kinase A to the exocyst complex
  JOURNAL   J Biol Chem 282 (45), 33155-33167 (2007)
   PUBMED   17827149
REFERENCE   2  (bases 1 to 4806)
  AUTHORS   Imai A, Yoshie S, Nashida T, Shimomura H and Fukuda M.
  TITLE     The small GTPase Rab27B regulates amylase release from rat parotid
            acinar cells
  JOURNAL   J Cell Sci 117 (Pt 10), 1945-1953 (2004)
   PUBMED   15039459
  REMARK    GeneRIF: the Rab27B-Slac2-c complex is an important constituent of
            secretory granule exocytosis in parotid acinar cells
REFERENCE   3  (bases 1 to 4806)
  AUTHORS   Fukuda M and Kuroda TS.
  TITLE     Slac2-c (synaptotagmin-like protein homologue lacking C2
            domains-c), a novel linker protein that interacts with Rab27,
            myosin Va/VIIa, and actin
  JOURNAL   J Biol Chem 277 (45), 43096-43103 (2002)
   PUBMED   12221080
REFERENCE   4  (bases 1 to 4806)
  AUTHORS   El-Amraoui A, Schonn JS, Kussel-Andermann P, Blanchard S, Desnos C,
            Henry JP, Wolfrum U, Darchen F and Petit C.
  TITLE     MyRIP, a novel Rab effector, enables myosin VIIa recruitment to
            retinal melanosomes
  JOURNAL   EMBO Rep 3 (5), 463-470 (2002)
   PUBMED   11964381
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000200.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_182844.3.
            
            On or before Sep 26, 2022 this sequence version replaced
            XM_006244110.4, NM_182844.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: AY331984.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA5760383, SAMEA5760384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-228               JACYVU010000200.1  22976532-22976759
            229-371             JACYVU010000200.1  23008151-23008293
            372-593             JACYVU010000200.1  23063385-23063606
            594-730             JACYVU010000200.1  23094462-23094598
            731-811             JACYVU010000200.1  23097097-23097177
            812-909             JACYVU010000200.1  23099783-23099880
            910-990             JACYVU010000200.1  23100075-23100155
            991-1137            JACYVU010000200.1  23102219-23102365
            1138-1291           JACYVU010000200.1  23103795-23103948
            1292-1917           JACYVU010000200.1  23105949-23106574
            1918-2157           JACYVU010000200.1  23115761-23116000
            2158-2352           JACYVU010000200.1  23128207-23128401
            2353-2514           JACYVU010000200.1  23134991-23135152
            2515-2619           JACYVU010000200.1  23137161-23137265
            2620-2680           JACYVU010000200.1  23137359-23137419
            2681-2799           JACYVU010000200.1  23139145-23139263
            2800-4806           JACYVU010000200.1  23141598-23143604
FEATURES             Location/Qualifiers
     source          1..4806
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..4806
                     /gene="Myrip"
                     /gene_synonym="Slac2c"
                     /note="myosin VIIA and Rab interacting protein"
                     /db_xref="GeneID:360034"
                     /db_xref="RGD:727731"
     exon            1..228
                     /gene="Myrip"
                     /gene_synonym="Slac2c"
                     /inference="alignment:Splign:2.1.0"
     exon            229..371
                     /gene="Myrip"
                     /gene_synonym="Slac2c"
                     /inference="alignment:Splign:2.1.0"
     CDS             262..2832
                     /gene="Myrip"
                     /gene_synonym="Slac2c"
                     /note="slaC2-c; exophilin-8; slp homolog lacking C2
                     domains c; myosin-VIIa- and Rab-interacting protein;
                     synaptotagmin-like protein lacking C2 domains C"
                     /codon_start=1
                     /product="rab effector MyRIP"
                     /protein_id="NP_878264.2"
                     /db_xref="GeneID:360034"
                     /db_xref="RGD:727731"
                     /translation="MGRKLDLSGLTDDETEHVLQVVQRDFNLRKKEEDRLSEMKQRLA
                     EENSKCSILSKHQKFVERCCMRCCSPFTFLVNARRRCGECKFSVCKSCCSYQKHEKLW
                     VCCVCQQARLLRTQSLEWFYNNVKTRFKRFGSAKVLKNLYKKHRLESGACFDILGGGL
                     YEPNLENEGSISGSDSTFYRQSEGHSMMDTLAVALQVAEEAIEEAISKAESQRDSLDK
                     QNEASYLRDHRQELAEELAGTILQRIIRKQKDKADLHAEEEEPECTRPQSGGVKARGE
                     GTAAPPGRHKARAALWRSQSAFSFTTEDTLKTSSAEAAPRQPKDRAQRLLEESALPSW
                     RSMDGLDGKNLVPLLQSPDGNWMTLKDSSRQPPTRLLAKPKSRTFQALEVASSVASAY
                     DELGSDSEEDFDYSEALSKLRPPSQGRLKQPQPQPAQAQSSGQGPLATSPSNPEAMCS
                     DSETSSTSSSREAGCRAKLLWLQRKAPKNPSAEKTHLQGELDVNFNPQAAGGETSDSS
                     DPEETLHTADRRARRWRRARVGPEESNRGLPSPSAYPPALHTAQVSDNVSETDISNEA
                     QNSRSSTDSAEEKLRNRLYELAMKMSEKETSSGEDQESESKTEPKNQKGSLSSEENNQ
                     GVQEELKKKCSAVSLCNISTEVLKVINATEELIAESAGPWEIPPVSTDRDNGMFPLGT
                     DQRSLDKQLTSLEENVYLAAGTVYGLEGQLSELEDAARCIHSSTGETELADLEDQVAA
                     AAAQVHHAELQISDIESRISALTIAGLNIAPCVRLTRRRDQKQRSQVQTIDTSRQQRR
                     KLPAPPVKAEKIEASSVTPIKTFNRNFLLQGSSTNRPTASTSNTKDLMEPVLESAVMY
                     "
     exon            372..593
                     /gene="Myrip"
                     /gene_synonym="Slac2c"
                     /inference="alignment:Splign:2.1.0"
     exon            594..730
                     /gene="Myrip"
                     /gene_synonym="Slac2c"
                     /inference="alignment:Splign:2.1.0"
     exon            731..811
                     /gene="Myrip"
                     /gene_synonym="Slac2c"
                     /inference="alignment:Splign:2.1.0"
     exon            812..909
                     /gene="Myrip"
                     /gene_synonym="Slac2c"
                     /inference="alignment:Splign:2.1.0"
     exon            910..990
                     /gene="Myrip"
                     /gene_synonym="Slac2c"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1137
                     /gene="Myrip"
                     /gene_synonym="Slac2c"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1291
                     /gene="Myrip"
                     /gene_synonym="Slac2c"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1917
                     /gene="Myrip"
                     /gene_synonym="Slac2c"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2157
                     /gene="Myrip"
                     /gene_synonym="Slac2c"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2352
                     /gene="Myrip"
                     /gene_synonym="Slac2c"
                     /inference="alignment:Splign:2.1.0"
     exon            2353..2514
                     /gene="Myrip"
                     /gene_synonym="Slac2c"
                     /inference="alignment:Splign:2.1.0"
     exon            2515..2619
                     /gene="Myrip"
                     /gene_synonym="Slac2c"
                     /inference="alignment:Splign:2.1.0"
     exon            2620..2680
                     /gene="Myrip"
                     /gene_synonym="Slac2c"
                     /inference="alignment:Splign:2.1.0"
     exon            2681..2799
                     /gene="Myrip"
                     /gene_synonym="Slac2c"
                     /inference="alignment:Splign:2.1.0"
     exon            2800..4806
                     /gene="Myrip"
                     /gene_synonym="Slac2c"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagcgggcg cctccctcgc cgcggcgcgc cctcgtcctg cccgcgctgc ccggctcccg
       61 ctgtgactgc ggccccagct ccggcgcacc ggcgatccgc agcctcggga tcgcgcgctg
      121 gacgcaggct gcggcaggtg acccggggcc atccgaggcg cggtgactct aagcctggcc
      181 gccatccatg agccccgccg cggacccact ccaggccggc caccccggac ctagctcagt
      241 tgtccgtgtt taaccctgac catggggagg aagctggacc tgtcgggtct gaccgacgat
      301 gagaccgaac acgttctcca agtggtacag agagacttca atcttcgcaa aaaggaggag
      361 gaccggctga gtgagatgaa gcagaggctg gccgaggaga acagcaagtg cagcatcctc
      421 tcgaagcacc agaagttcgt ggagcgctgc tgcatgcggt gctgctcccc cttcaccttc
      481 ttggtcaacg ccaggcgccg ctgtggggaa tgcaagttca gcgtctgcaa gagctgctgc
      541 tcctaccaga agcatgagaa gctatgggtt tgctgtgtct gccagcaagc caggcttctg
      601 aggacgcagt ctctggagtg gttctacaac aacgtgaaga cccgtttcaa gcgcttcggc
      661 agcgccaagg tcctgaagaa cctgtacaag aagcaccgtc tggagagtgg tgcctgcttt
      721 gacatcctag gaggaggact gtatgaacca aacctggaga atgaagggag catttcaggg
      781 agtgactcca cattctacag gcagtcggaa ggacacagca tgatggacac cttggctgtt
      841 gccctacaag tggcagaaga agccatcgaa gaggccattt ctaaagcaga atcccagagg
      901 gacagcctgg acaaacagaa cgaggccagc tacctgcggg accacaggca agagctggcg
      961 gaggagctgg ccggcaccat cctgcagagg attataagaa aacagaagga taaagctgac
     1021 ctgcatgctg aggaggagga gccagagtgt acccggcccc agagtggcgg tgtgaaggcc
     1081 aggggtgagg ggactgcggc ccctccagga cgacacaaag cacgtgctgc cctctggcgg
     1141 tcccagtctg cgttctcctt cactactgaa gacactctga agacctcttc agcagaggct
     1201 gctccaaggc agcccaagga ccgtgcccag cgtctgctgg aggagtctgc tctgcccagc
     1261 tggaggagca tggacggact agacgggaaa aatctggtcc cactcctgca gagccccgac
     1321 gggaactgga tgactttgaa ggacagtagt agacagcccc caacccgcct gctggccaag
     1381 ccgaagagta ggacctttca ggccctggag gtggcgtcca gtgtggcatc tgcctatgat
     1441 gagttaggtt ctgacagtga ggaagacttt gattacagcg aagccttgag taaactgcgt
     1501 ccaccatccc agggcaggct caagcaaccc cagcctcagc ctgcacaggc ccagagttcc
     1561 ggccaaggtc ccttagccac ctctccctca aaccctgagg ccatgtgctc ggattcagag
     1621 acatcctcca ctagctcatc tcgggaagcc ggctgtcggg ctaagctcct ctggctgcag
     1681 aggaaggccc ccaagaaccc ctcagcagag aagacgcacc tccagggaga gctggatgtc
     1741 aatttcaacc ctcaggcagc cggtggagag acttccgaca gcagtgatcc agaggagacc
     1801 ctccacactg cagaccgccg ggccaggagg tggagaaggg cccgggtggg cccagaggag
     1861 tcaaacaggg gtctgccttc acccagtgcc tatccgccgg ctctgcacac agctcaggtg
     1921 tcagacaacg tgtcagagac tgacatcagc aatgaggctc agaattcccg gtccagcaca
     1981 gactctgcag aggagaagct gagaaacaga ctgtacgagt tagccatgaa aatgagcgaa
     2041 aaggagactt cttctgggga ggaccaggag tccgagtcca agaccgaacc gaagaatcag
     2101 aaggggagtc tctcttctga ggagaacaac cagggtgtcc aggaggagct gaagaagaag
     2161 tgttctgctg tttctctctg caacatctcc acagaagtcc tgaaggtcat caatgctact
     2221 gaggagttga tcgcagagtc tgcagggccc tgggagatcc ccccagtctc tactgacaga
     2281 gacaatggga tgtttcctct tggaacagac caaaggagcc tggacaagca gctgacttcc
     2341 ttggaagaaa acgtgtacct ggcagcaggc acggtgtacg ggctggaggg tcagctgagt
     2401 gagctggaag atgctgcccg ctgcatccac agcagcacgg gtgagacaga actggcagat
     2461 ctggaggacc aggtggctgc agctgcagcc caggtgcacc acgcagagct ccagatctct
     2521 gacatcgaga gccgcatttc agccctgacc atcgctggct taaacatagc gccatgtgtg
     2581 cgtctcacaa gaagacggga tcagaagcaa aggagtcagg tacaaactat agacacgtcg
     2641 aggcagcaga ggaggaaact acctgcccct cctgtgaaag ctgaaaaaat tgaagcatct
     2701 tctgtgaccc ccattaagac atttaaccgc aatttccttc tacaaggctc ctccacaaac
     2761 aggcccacgg caagtaccag taacaccaag gacttgatgg agcctgttct ggagtcagct
     2821 gtgatgtact aaagtccgga actccgcaca cagccagtga cccactgcct ccggccgtac
     2881 acgacagtgc cttgacccaa cagccatcga gtactgtgtg gatttccact gaggcgaggg
     2941 ccagggggag gaggggctgc agtgcactgc tgcacggggc tgtcctgata cctcacccag
     3001 aaggccttct cagtctgcaa cactgaggtc ttgcccactc tctgccttag gctcccaggg
     3061 gaatctgaga ccgaatatca ggacgctggc ttccaatagc agagctctgt gttcagaaga
     3121 tgcattgtgc cagtttaatt tgctcctgtg tgctgtcttt accagcccta tgtgttttta
     3181 atccctttaa tccccatcac cagttcatcc aatagaaagc ttctagtgag gaattggggg
     3241 ctaggaaggt gggggttagt accatcactg agcctttctt gtcacctcct aacagacgct
     3301 aagagcaggg ggccatagaa acagtctcat tgggaaatgc ttgaccacct ccagctaagc
     3361 ccccagcccc cagcccccag ccctatgctt ctgtcctccc cactgcttgg caaccaccag
     3421 atgaaaagct ctgatccacc aatgccatac ccaggtctct ctgaaaccat gtctcattct
     3481 gaattcgggg gtttttgcat ggatttactg agggggagag gggcctaagg gacaacgtca
     3541 ctattagtct aacttaaagg acagctttca gggtcagcat aatgtggctt ggtcatgaat
     3601 gggctgttgt aaaatataac tctgcaggaa aagcattccc attctccaaa atccatctcc
     3661 tgccaaattc aacaggattc agaatggcag caaaccccct tagagaaaag cagtgtgggt
     3721 tgtgagggac gcagaggtgg ccctcacccc aaatttcgct gtttgtttca cggcaggggc
     3781 tggaataaat gcatgagtat gtgaagtgta tttacgcaca caaataggtc tgaccctgtg
     3841 ccggactccc tgggggcctg ctgtgtgctt ctgggatttt ctgaatcata ggatgcggtg
     3901 gggagagggt aaaggaggga ggcacaggag tggccattag tgctggctct gaaggacacg
     3961 gtgtgcccag ttctgtctag tgtctctctc ttatggcttt ccagaatcca taactaaagg
     4021 tcagaccagt gaacttgctg aagccataca tgtgagctgg ttctaactgg aatgccccca
     4081 cccccagaag cccagccctg tcttcccttc cgagttctct ggttctcccg tgcatcccca
     4141 gacttaattg aactgctctc cctgtgttgt gtgccattgc cactgaaggg ggtccttgtg
     4201 tcttcccata atgctcctgc tgatgtgtgt gtcaccccag agaaaggact tcatgaaaac
     4261 agtaaaactt tgacatttta cctagtgggt gtggttcaca ttaaaacaaa atttaaaaaa
     4321 aaaaaaaaaa acaaaaaaca aaaaacaaca caacaaaaag atctgacttc caaacaggat
     4381 gttttccctt aggaggcatg aggctgcctt tgtgctaaca gtgttaaaat actccattct
     4441 cttcggacaa agcgtgtact gtgtaagcct tgcaaaaaat gagaacaacg aagaaaaagc
     4501 ctgtttgaac ttttataaga ggtttccttg tgccaaataa gtacaaagat ttaatttact
     4561 atttaaacca taaacatgtt atagttccag aaattatttt gtcatcagtg attttgatct
     4621 ttagcttcaa tatttatatt tagattaatt tttataaatg aaatattttg atggttgaag
     4681 aagtcgagga caagaaggat gctctctctg acggcttctc aatgccttcc tgtctcacac
     4741 actcggccaa gaatcactgt caagagaaac gaccgcgaac aagcagtaaa gtcacctatg
     4801 aaaaca
//
