LOCUS       NP_878264                856 aa            linear   ROD 03-APR-2024
DEFINITION  rab effector MyRIP [Rattus norvegicus].
ACCESSION   NP_878264 XP_006244172
VERSION     NP_878264.2
DBSOURCE    REFSEQ: accession NM_182844.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 856)
  AUTHORS   Goehring,A.S., Pedroja,B.S., Hinke,S.A., Langeberg,L.K. and
            Scott,J.D.
  TITLE     MyRIP anchors protein kinase A to the exocyst complex
  JOURNAL   J Biol Chem 282 (45), 33155-33167 (2007)
   PUBMED   17827149
REFERENCE   2  (residues 1 to 856)
  AUTHORS   Imai,A., Yoshie,S., Nashida,T., Shimomura,H. and Fukuda,M.
  TITLE     The small GTPase Rab27B regulates amylase release from rat parotid
            acinar cells
  JOURNAL   J Cell Sci 117 (Pt 10), 1945-1953 (2004)
   PUBMED   15039459
  REMARK    GeneRIF: the Rab27B-Slac2-c complex is an important constituent of
            secretory granule exocytosis in parotid acinar cells
REFERENCE   3  (residues 1 to 856)
  AUTHORS   Fukuda,M. and Kuroda,T.S.
  TITLE     Slac2-c (synaptotagmin-like protein homologue lacking C2
            domains-c), a novel linker protein that interacts with Rab27,
            myosin Va/VIIa, and actin
  JOURNAL   J Biol Chem 277 (45), 43096-43103 (2002)
   PUBMED   12221080
REFERENCE   4  (residues 1 to 856)
  AUTHORS   El-Amraoui,A., Schonn,J.S., Kussel-Andermann,P., Blanchard,S.,
            Desnos,C., Henry,J.P., Wolfrum,U., Darchen,F. and Petit,C.
  TITLE     MyRIP, a novel Rab effector, enables myosin VIIa recruitment to
            retinal melanosomes
  JOURNAL   EMBO Rep 3 (5), 463-470 (2002)
   PUBMED   11964381
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On or before Sep 26, 2022 this sequence version replaced
            XP_006244172.1, NP_878264.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.31259.1,
                                           SRR26643295.33981.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..856
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     Protein         1..856
                     /product="rab effector MyRIP"
                     /note="slaC2-c; exophilin-8; slp homolog lacking C2
                     domains c; myosin-VIIa- and Rab-interacting protein;
                     synaptotagmin-like protein lacking C2 domains C"
                     /calculated_mol_wt=94824
     Region          8..125
                     /region_name="FYVE_2"
                     /note="FYVE-type zinc finger; pfam02318"
                     /db_xref="CDD:426716"
     Region          143..560
                     /region_name="Myosin-binding. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNY7.1)"
     Region          152..856
                     /region_name="Rab_eff_C"
                     /note="Rab effector MyRIP/melanophilin C-terminus;
                     pfam04698"
                     /db_xref="CDD:461398"
     Region          193..209
                     /region_name="PKA-binding. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNY7.1)"
     Region          232..248
                     /region_name="Negative regulation of PKA-binding.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNY7.1)"
     Region          251..287
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNY7.1)"
     Site            299
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8K3I4; propagated from
                     UniProtKB/Swiss-Prot (Q7TNY7.1)"
     Region          302..323
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNY7.1)"
     Region          350..376
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNY7.1)"
     Site            351
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q7TNY7.1)"
     Region          392..578
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNY7.1)"
     Region          495..856
                     /region_name="Actin-binding. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNY7.1)"
     Region          592..625
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNY7.1)"
     Region          778..805
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNY7.1)"
     Region          826..845
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNY7.1)"
     CDS             1..856
                     /gene="Myrip"
                     /gene_synonym="Slac2c"
                     /coded_by="NM_182844.3:262..2832"
                     /db_xref="GeneID:360034"
                     /db_xref="RGD:727731"
ORIGIN      
        1 mgrkldlsgl tddetehvlq vvqrdfnlrk keedrlsemk qrlaeenskc silskhqkfv
       61 erccmrccsp ftflvnarrr cgeckfsvck sccsyqkhek lwvccvcqqa rllrtqslew
      121 fynnvktrfk rfgsakvlkn lykkhrlesg acfdilgggl yepnlenegs isgsdstfyr
      181 qseghsmmdt lavalqvaee aieeaiskae sqrdsldkqn easylrdhrq elaeelagti
      241 lqriirkqkd kadlhaeeee pectrpqsgg vkargegtaa ppgrhkaraa lwrsqsafsf
      301 ttedtlktss aeaaprqpkd raqrlleesa lpswrsmdgl dgknlvpllq spdgnwmtlk
      361 dssrqpptrl lakpksrtfq alevassvas aydelgsdse edfdyseals klrppsqgrl
      421 kqpqpqpaqa qssgqgplat spsnpeamcs dsetsstsss reagcrakll wlqrkapknp
      481 saekthlqge ldvnfnpqaa ggetsdssdp eetlhtadrr arrwrrarvg peesnrglps
      541 psayppalht aqvsdnvset disneaqnsr sstdsaeekl rnrlyelamk mseketssge
      601 dqesesktep knqkgslsse ennqgvqeel kkkcsavslc nistevlkvi nateeliaes
      661 agpweippvs tdrdngmfpl gtdqrsldkq ltsleenvyl aagtvygleg qlseledaar
      721 cihsstgete ladledqvaa aaaqvhhael qisdiesris altiaglnia pcvrltrrrd
      781 qkqrsqvqti dtsrqqrrkl pappvkaeki eassvtpikt fnrnfllqgs stnrptasts
      841 ntkdlmepvl esavmy
//
