LOCUS       NM_001170487            5531 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus myelin regulatory factor (Myrf), mRNA.
ACCESSION   NM_001170487
VERSION     NM_001170487.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5531)
  AUTHORS   Ouyang,J., Sun,W., Shen,H., Liu,X., Wu,Y., Jiang,H., Li,X.,
            Wang,Y., Jiang,Y., Li,S., Xiao,X., Hejtmancik,J.F., Tan,Z. and
            Zhang,Q.
  TITLE     Truncation mutations in MYRF underlie primary angle closure
            glaucoma
  JOURNAL   Hum Genet 142 (1), 103-123 (2023)
   PUBMED   36129575
REFERENCE   2  (bases 1 to 5531)
  AUTHORS   Shi,M., Kelly,T.N., Zhu,Z., Li,C., Shen,C., Sun,Y., Wang,A.,
            Shan,G., Bu,X., Guo,D., Zhao,J., Xu,T., Peng,H., Xu,T., Zhong,C.,
            Sun,X., Chen,J., Zhang,Y. and He,J.
  TITLE     Large-Scale Targeted Sequencing Study of Ischemic Stroke in the Han
            Chinese Population
  JOURNAL   J Am Heart Assoc 11 (19), e025245 (2022)
   PUBMED   36193932
REFERENCE   3  (bases 1 to 5531)
  AUTHORS   Thamizhoviya,G. and Vanisree,A.J.
  TITLE     Enriched Environment Enhances the Myelin Regulatory Factor by mTOR
            Signaling and Protects the Myelin Membrane Against Oxidative Damage
            in Rats Exposed to Chronic Immobilization Stress
  JOURNAL   Neurochem Res 46 (12), 3314-3324 (2021)
   PUBMED   34449011
REFERENCE   4  (bases 1 to 5531)
  AUTHORS   Zhang,Z., Wang,J., Song,Z., Wang,Y., Cheng,Z., Guo,Q., Wang,E.,
            Jian,Y. and Wu,L.
  TITLE     Downregulation of microRNA-199a-5p alleviated lidocaine-induced
            sensory dysfunction and spinal cord myelin lesions in a rat model
  JOURNAL   Toxicol Lett 336, 1-10 (2021)
   PUBMED   33166664
REFERENCE   5  (bases 1 to 5531)
  AUTHORS   Gawlinska,K., Frankowska,M., Gawlinski,D., Piechota,M.,
            Korostynski,M. and Filip,M.
  TITLE     Cocaine Administration and Its Abstinence Conditions Modulate
            Neuroglia
  JOURNAL   Int J Mol Sci 21 (21), 7970 (2020)
   PUBMED   33120991
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5531)
  AUTHORS   Xie,X.M., Shi,L.L., Shen,L., Wang,R., Qi,Q., Wang,Q.Y., Zhang,L.J.,
            Lu,H.Z. and Hu,J.G.
  TITLE     Co-transplantation of MRF-overexpressing oligodendrocyte precursor
            cells and Schwann cells promotes recovery in rat after spinal cord
            injury
  JOURNAL   Neurobiol Dis 94, 196-204 (2016)
   PUBMED   27370227
REFERENCE   7  (bases 1 to 5531)
  AUTHORS   Hornig,J., Frob,F., Vogl,M.R., Hermans-Borgmeyer,I., Tamm,E.R. and
            Wegner,M.
  TITLE     The transcription factors Sox10 and Myrf define an essential
            regulatory network module in differentiating oligodendrocytes
  JOURNAL   PLoS Genet 9 (10), e1003907 (2013)
   PUBMED   24204311
REFERENCE   8  (bases 1 to 5531)
  AUTHORS   Li,Z., Park,Y. and Marcotte,E.M.
  TITLE     A Bacteriophage tailspike domain promotes self-cleavage of a human
            membrane-bound transcription factor, the myelin regulatory factor
            MYRF
  JOURNAL   PLoS Biol 11 (8), e1001624 (2013)
   PUBMED   23966832
REFERENCE   9  (bases 1 to 5531)
  AUTHORS   Koenning,M., Jackson,S., Hay,C.M., Faux,C., Kilpatrick,T.J.,
            Willingham,M. and Emery,B.
  TITLE     Myelin gene regulatory factor is required for maintenance of myelin
            and mature oligodendrocyte identity in the adult CNS
  JOURNAL   J Neurosci 32 (36), 12528-12542 (2012)
   PUBMED   22956843
REFERENCE   10 (bases 1 to 5531)
  AUTHORS   Emery,B., Agalliu,D., Cahoy,J.D., Watkins,T.A., Dugas,J.C.,
            Mulinyawe,S.B., Ibrahim,A., Ligon,K.L., Rowitch,D.H. and
            Barres,B.A.
  TITLE     Myelin gene regulatory factor is a critical transcriptional
            regulator required for CNS myelination
  JOURNAL   Cell 138 (1), 172-185 (2009)
   PUBMED   19596243
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.4994.1,
                                           SRR26643298.7168.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                JAXUCZ010000001.1  216310935-216310980 c
            47-134              JAXUCZ010000001.1  216299235-216299322 c
            135-398             JAXUCZ010000001.1  216298867-216299130 c
            399-460             JAXUCZ010000001.1  216295360-216295421 c
            461-740             JAXUCZ010000001.1  216294293-216294572 c
            741-988             JAXUCZ010000001.1  216293283-216293530 c
            989-1112            JAXUCZ010000001.1  216293078-216293201 c
            1113-1308           JAXUCZ010000001.1  216291245-216291440 c
            1309-1385           JAXUCZ010000001.1  216289899-216289975 c
            1386-1496           JAXUCZ010000001.1  216289618-216289728 c
            1497-1587           JAXUCZ010000001.1  216289151-216289241 c
            1588-1788           JAXUCZ010000001.1  216288579-216288779 c
            1789-1900           JAXUCZ010000001.1  216288262-216288373 c
            1901-2010           JAXUCZ010000001.1  216287699-216287808 c
            2011-2171           JAXUCZ010000001.1  216286903-216287063 c
            2172-2244           JAXUCZ010000001.1  216286750-216286822 c
            2245-2333           JAXUCZ010000001.1  216286395-216286483 c
            2334-2402           JAXUCZ010000001.1  216286067-216286135 c
            2403-2483           JAXUCZ010000001.1  216285571-216285651 c
            2484-2572           JAXUCZ010000001.1  216285315-216285403 c
            2573-2752           JAXUCZ010000001.1  216285045-216285224 c
            2753-3004           JAXUCZ010000001.1  216284588-216284839 c
            3005-3092           JAXUCZ010000001.1  216282949-216283036 c
            3093-3167           JAXUCZ010000001.1  216282655-216282729 c
            3168-3273           JAXUCZ010000001.1  216282219-216282324 c
            3274-3348           JAXUCZ010000001.1  216281334-216281408 c
            3349-5531           JAXUCZ010000001.1  216279057-216281239 c
FEATURES             Location/Qualifiers
     source          1..5531
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..5531
                     /gene="Myrf"
                     /gene_synonym="Mrf; RGD1306622"
                     /note="myelin regulatory factor"
                     /db_xref="GeneID:293736"
                     /db_xref="RGD:1306622"
     CDS             1..3429
                     /gene="Myrf"
                     /gene_synonym="Mrf; RGD1306622"
                     /note="myelin gene regulatory factor"
                     /codon_start=1
                     /product="myelin regulatory factor"
                     /protein_id="NP_001163958.1"
                     /db_xref="GeneID:293736"
                     /db_xref="RGD:1306622"
                     /translation="MEVVDETEALQRFFEGHDISGALEPSNIDTSILEEYIGKEDASD
                     LCFPEISAPASTASFPHGPPAIPGSSGLHHLSPPGSGPSPGRHGPLPPPTYGTPLNCN
                     NNNGMGTAPKPFLGGSGPPIKAEPKAPYAPGTLPDSPPDSGSEAYSPQQVNDPHLLRT
                     ITPETLCHVGVPSRLEHPPPPPAHLPGPPPPPPPPPHYPVLQRDIYMKAEPPVPPYAA
                     MGPGLVPPELHHTQQTQVLQQLLQQHGAELPPHPSKKRKHSESPPNTLNAQILNGMIK
                     QEPGTVTALPPHPARAPSPPWPQGPLSPGTGSLPLSIARAQTPPWHPPGAPSPGLLQD
                     SDSLSGSYLDPNYQSIKWQPHQQNKWATLYDANYKELPMLTYRVDADKGFNFSVGDDA
                     FVCQKKNHFQVTVYIGMLGEPKYVKTPEGLKPLDCFYLKLHGVKLEALNQSINIEQSQ
                     SDRSKRPFNPVTVNLPPEQVTKVTVGRLHFSETTANNMRKKGKPNPDQRYFMLVVALQ
                     AHAQNQNYTLAAQISERIIVRASNPGQFESDSDVLWQRAQLPDTVFHHGRVGINTDRP
                     DEALVVHGNVKVMGSLMHPSDLRAKEHVQEVDTTEQLKRISRMRLVHYRYKPEFAASA
                     GIEATAPETGVIAQEVKEILPEAVKDTGDVVFANGKTIENFLVVNKERIFMENVGAVK
                     ELCKLTDNLETRIDELERWSHKLAKLRRLDSLKSTGSSGAFSHAGSQFSRAGSVPHKK
                     RPPKLANKSSPVVPDQACISQRFLQGTIIALVVVMAFSVVSMSTLYVLSLRSEEDLVD
                     ADGSLAVSTSCLLALLRPQDPGGSVAVCPCRSSQSFGTTQLRQSSMTTGLPGTQPSLL
                     LVTSSASGPALRALDLCSSQPCPIVCCSTPVSSPATDPSLGPIVTPTPSPSPSPNPNP
                     KHSGPGQMAPLPVTNIRAKSWGISANGISYSKHPKSLEPLASPVVPFPGGQSKTKNSP
                     SFSLQSRARRGAPQPSPSPAQFTQTQGQLDPVPSLTSIQLLENSMPITSQYCVPEDAC
                     RLGNFTYHIPVSSSTPLHLSLTLQMNSSTPVSVVLCSLISKEEPCEEGGFLQTLHSHQ
                     DTQGTSHQWPVTILSFREFTYHFRVALLGQADCSSEAAVQPATDYYFHFYRLCD"
     exon            1..46
                     /gene="Myrf"
                     /gene_synonym="Mrf; RGD1306622"
                     /inference="alignment:Splign:2.1.0"
     exon            47..134
                     /gene="Myrf"
                     /gene_synonym="Mrf; RGD1306622"
                     /inference="alignment:Splign:2.1.0"
     exon            135..398
                     /gene="Myrf"
                     /gene_synonym="Mrf; RGD1306622"
                     /inference="alignment:Splign:2.1.0"
     exon            399..460
                     /gene="Myrf"
                     /gene_synonym="Mrf; RGD1306622"
                     /inference="alignment:Splign:2.1.0"
     exon            461..740
                     /gene="Myrf"
                     /gene_synonym="Mrf; RGD1306622"
                     /inference="alignment:Splign:2.1.0"
     exon            741..988
                     /gene="Myrf"
                     /gene_synonym="Mrf; RGD1306622"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1112
                     /gene="Myrf"
                     /gene_synonym="Mrf; RGD1306622"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1308
                     /gene="Myrf"
                     /gene_synonym="Mrf; RGD1306622"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1385
                     /gene="Myrf"
                     /gene_synonym="Mrf; RGD1306622"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1496
                     /gene="Myrf"
                     /gene_synonym="Mrf; RGD1306622"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1587
                     /gene="Myrf"
                     /gene_synonym="Mrf; RGD1306622"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1788
                     /gene="Myrf"
                     /gene_synonym="Mrf; RGD1306622"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..1900
                     /gene="Myrf"
                     /gene_synonym="Mrf; RGD1306622"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2010
                     /gene="Myrf"
                     /gene_synonym="Mrf; RGD1306622"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2171
                     /gene="Myrf"
                     /gene_synonym="Mrf; RGD1306622"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2244
                     /gene="Myrf"
                     /gene_synonym="Mrf; RGD1306622"
                     /inference="alignment:Splign:2.1.0"
     exon            2245..2333
                     /gene="Myrf"
                     /gene_synonym="Mrf; RGD1306622"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..2402
                     /gene="Myrf"
                     /gene_synonym="Mrf; RGD1306622"
                     /inference="alignment:Splign:2.1.0"
     exon            2403..2483
                     /gene="Myrf"
                     /gene_synonym="Mrf; RGD1306622"
                     /inference="alignment:Splign:2.1.0"
     exon            2484..2572
                     /gene="Myrf"
                     /gene_synonym="Mrf; RGD1306622"
                     /inference="alignment:Splign:2.1.0"
     exon            2573..2752
                     /gene="Myrf"
                     /gene_synonym="Mrf; RGD1306622"
                     /inference="alignment:Splign:2.1.0"
     exon            2753..3004
                     /gene="Myrf"
                     /gene_synonym="Mrf; RGD1306622"
                     /inference="alignment:Splign:2.1.0"
     exon            3005..3092
                     /gene="Myrf"
                     /gene_synonym="Mrf; RGD1306622"
                     /inference="alignment:Splign:2.1.0"
     exon            3093..3167
                     /gene="Myrf"
                     /gene_synonym="Mrf; RGD1306622"
                     /inference="alignment:Splign:2.1.0"
     exon            3168..3273
                     /gene="Myrf"
                     /gene_synonym="Mrf; RGD1306622"
                     /inference="alignment:Splign:2.1.0"
     exon            3274..3348
                     /gene="Myrf"
                     /gene_synonym="Mrf; RGD1306622"
                     /inference="alignment:Splign:2.1.0"
     exon            3349..5531
                     /gene="Myrf"
                     /gene_synonym="Mrf; RGD1306622"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggaggtgg tggacgagac cgaagcgctg cagcgcttct tcgaaggcca cgacatcagc
       61 ggtgccctgg agccctccaa tatagacacc agtatcctgg aggagtacat tggcaaagag
      121 gacgcctctg acctctgctt ccctgagatc tctgcaccag ccagcactgc ctccttcccc
      181 cacgggccac cggccattcc cggctccagc gggctccacc atctgagccc ccctgggagc
      241 ggaccatccc ctgggcgcca tggccccctc ccacccccga cctacggcac cccactcaac
      301 tgcaacaaca acaacggcat gggcaccgcc cctaagccct tcctgggggg ctctgggcct
      361 cccatcaagg cagagcccaa ggctccctat gccccaggca cactgccaga ctcgccccca
      421 gactcaggct ctgaggccta ctcccctcag caggtgaatg acccccatct tctgcgcacc
      481 ataaccccgg agacgctctg ccacgtggga gttccttccc gcctggaaca cccgccccca
      541 cctccagctc acttgccagg ccccccgcca cccccgcctc ccccacctca ctaccctgtc
      601 ctgcaacggg acatctacat gaaggctgag ccccctgtac ccccttatgc tgccatgggg
      661 ccgggtttgg tgccccctga gctccaccac acccagcaga cccaggtgct acagcagctg
      721 ctgcaacagc acggagctga gctccctcca cacccctcta agaagaggaa gcactccgaa
      781 tcacccccca acaccctcaa tgcccaaata ctgaatggaa tgatcaagca ggaacctggg
      841 actgtcacag ccttgcctcc acaccctgcc agagccccgt cccctccgtg gcctcagggc
      901 ccactctcac ctggcactgg ctccttgccc ctcagcattg cccgagccca gactccaccc
      961 tggcacccac cgggtgctcc ctccccaggc ctcctgcagg acagtgatag cctcagtggc
     1021 tcctatttgg accccaacta ccaatctatc aaatggcaac cacatcagca gaacaagtgg
     1081 gcgaccctat atgatgccaa ctacaaggag ctgcctatgc tcacctatcg tgtggatgca
     1141 gacaagggct tcaacttttc cgtgggtgac gatgcttttg tgtgccagaa gaagaaccac
     1201 ttccaggtga ccgtgtacat tggcatgctg ggcgagccca agtatgtcaa gacgccggaa
     1261 ggcctcaagc ccctggactg cttctatctg aagctgcatg gagtgaagct agaggccttg
     1321 aaccagtcta tcaacatcga gcagtcacag tcagacagga gcaagaggcc cttcaacccc
     1381 gtcacggtca atcttccccc tgagcaggtc acaaaggtga ccgtggggcg actccatttc
     1441 agtgagacca ctgccaacaa catgcggaag aagggcaagc ccaaccctga ccagaggtat
     1501 ttcatgctgg tggtggctct ccaggcacat gcacagaacc agaactacac actggcagcc
     1561 cagatctcag agcgcatcat tgttcgggcc tctaacccag gccagtttga aagtgacagt
     1621 gacgtgctat ggcaacgggc acagctgcca gacaccgtct tccaccatgg ccgtgtgggc
     1681 atcaacaccg accggccaga tgaggcactg gttgtccacg ggaacgtcaa ggtgatgggg
     1741 tcgctcatgc acccttcaga tttgcgggcc aaggagcatg tgcaggaggt ggacaccact
     1801 gaacagctga agaggatctc tcggatgcgg ctggtacact acagatacaa gcctgagttc
     1861 gctgctagtg caggcattga agctaccgca ccggagacag gtgtcatcgc ccaggaagtg
     1921 aaggagatcc tgccggaagc tgtgaaggac acgggggatg tagtctttgc caatgggaaa
     1981 accatagaga acttccttgt agtgaacaag gagcggatct tcatggagaa cgtgggggct
     2041 gtgaaggagt tgtgcaagct gacagacaac ctggagactc gcattgatga gctggagcgc
     2101 tggagccaca agctggctaa gctgcggcgt ctcgacagcc tcaagtcaac tggcagctcg
     2161 ggcgcgttca gccatgcggg gagccagttt agccgggcag gcagtgtccc tcacaaaaag
     2221 aggcccccta aactggccaa taagtcatca ccagtggtcc cagatcaggc ctgcatcagt
     2281 cagcgctttc tgcaaggaac tatcattgct ctggtggtgg tcatggcctt cagcgtggtg
     2341 tccatgtcca cactatatgt gctgagcctg cgctctgaag aggacctggt ggatgctgac
     2401 ggctctcttg ccgtgtccac ttcctgtctt ctggccctgc tccggcccca ggaccctggg
     2461 gggagtgtgg ccgtgtgccc atgcaggtcc agccagagct ttgggaccac acagctccga
     2521 cagtcctcta tgaccactgg actaccaggc acacagccgt ctttgctgct ggttaccagt
     2581 tcagcctcag gtcccgctct ccgtgccttg gacctgtgct ccagccagcc ctgccccatt
     2641 gtctgctgct ctactcccgt ctccagtcct gctacagacc ccagccttgg ccccattgtt
     2701 actcctactc caagtcccag ccctagcccc aaccctaacc ccaagcactc aggccctggc
     2761 cagatggccc ctctgccagt caccaacatc agagccaaat cctggggcat ttcagctaat
     2821 ggcatcagct attccaaaca tcccaagagc ctggaacctc tagccagtcc tgtggtcccc
     2881 tttcctggag ggcagagcaa gaccaaaaac agccccagct tcagtctcca aagtcgcgcc
     2941 cgcagaggag ccccacaacc cagcccaagc cctgcccagt tcactcagac ccagggccag
     3001 ctagacccag tgccatccct gacctccatc cagctgctgg agaattccat gcccatcacc
     3061 tcccagtact gtgtgccaga ggatgcctgc aggcttggaa acttcaccta ccacatccct
     3121 gtcagcagca gcacaccact gcacctcagc ctgaccctgc agatgaattc ctccacccct
     3181 gtgtccgtgg tactgtgcag cctgatttcg aaggaggagc cctgtgagga gggaggcttt
     3241 ttgcagacgc tccacagcca tcaggacacc cagggcacct ctcaccagtg gccagtaacc
     3301 atcctgtcct tccgtgaatt cacataccac ttccgggtgg cattgctggg tcaggccgac
     3361 tgcagctcag aggccgccgt tcagccggcc acagactact acttccactt ctaccgcctg
     3421 tgtgactgag ctgcctccca aggcactgcc acagccggga ctggggtccc tgggccctca
     3481 acactggata caaatgtgtt acactggagc ctgctgcagg ccagctctct gctcttcact
     3541 gcctcccttg attggagact ggaagtcctt acactggagt tgctgggcca actgttcacc
     3601 ctcacacagc acagagaggg ctagaggggg cagcctcctg gcttttcctt ctggctatct
     3661 ccttggaaca ccacaggact aattcatggc tgtttagtca tggttcctgg agggctggct
     3721 tgcccactcc cactctccct gccttccctt ctgagctgtg gtggagcgaa gacccacagc
     3781 agttggacct ggacctctaa cacctggctg gaccccatga gtccatgcag agttaataac
     3841 tcacccttta tgctgttccc aggagggaca gcttggtagt aacttcctgg ggtttgactg
     3901 ttacactaga cctggatttc taagctttaa gtgtggttgg tttcaggagt tttccctggg
     3961 acagcttagt tcctaagaat tcctgaggta gtcagggctg ccctgaatag ctggagaagc
     4021 tgaccttgtg ccttaagtct actagtgcct gatggaaccc accctcgtag ggctgaacca
     4081 gtggggctga caggccatgg acccttgaac ctggagtacc ctggaaggag tggctccctg
     4141 tgagctccca agatctgttc ctgggagttt cccacactca tgatggagtg ggtgacgagc
     4201 agaggagcag gaatccctgc aagcagtaga caggtttcca ctggaaggtg aacgcagaga
     4261 acgtttatta atgatgtaat tactgaatgc acttaaagca cggtaccaag gagcagggta
     4321 gagcggggaa gccgagtggg cctcagcatg gaaggacact agcagacagg actcccagtt
     4381 cctctctcct ggcttgggtc catgcccagt gggtctcatc tctgcctctt ccaccccgag
     4441 gaaaggagtg gtgggtttaa gaaattttac tcaagtggca acgtcagcat ttcctggtag
     4501 cacctacagc attccgattg catgcaggct cctggaagga gtgtgccaat catttaccgc
     4561 atgccctggg ttcagcagtg ggaaagggaa taatgctctt gggaaaccag gccctacttt
     4621 tccagcctcc cattctgagc tctacatggg aggcatctct atcgggagct gagtttggga
     4681 agcctatgaa ctgtgggtcc tgccaaggac ctcaaagcac ttaccctcag ggtagggaca
     4741 cagcagggat gccctgcctc caggctttct ccccagcttg gctccattcc tccgttctgc
     4801 catcacaact ccccacatca ggtcacgctt gccttctgac cttgttctgt tctcccacaa
     4861 ggtcgtcctg cccacggtac cttaagagtg cccagcctca ctgctttagt ggcatgctgg
     4921 ggctccctta caagagaggc aagtgttcct caactgtggc ccctcagtcc ttaactggaa
     4981 agtgaccctc ttctaccccc tggagtccat ctggacacag ccagcccgag gcccactggc
     5041 agctgcctgc tcgcatgcct gggaagaggt cctcagtgag ttggggccaa acttgggctc
     5101 caagctgctt gagggggtcg accttggacc aaagttgcct taagccccaa atgtagaagg
     5161 gcttagggga aggtgtaagg gccacaggct ggaagctgac agcctagctg gcactccctt
     5221 cctctcttcc ttctgctgtt cctatagcca ctgggctaat ctccccctcg ctttaagctg
     5281 tatatagggc ccgcagcaca gatccctgcc catgctgtac cccttagcag cctgcgtgtt
     5341 catagagcgt ctcccttctg gttaactccc ttttctccat ggctctgact cctatttatc
     5401 atgtactcac tctgactctg aggaaggcag ggaggtgcca cccagcctac ttgcttcctg
     5461 tcccccaaat ggtcctcttc gtaagtgaat agacatataa ataaatgtat aaatacggct
     5521 ttgtatctgc a
//
