LOCUS       NM_001368817            5201 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus myopalladin (Mypn), mRNA.
ACCESSION   NM_001368817 XM_006256374
VERSION     NM_001368817.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5201)
  AUTHORS   Miyatake,S., Mitsuhashi,S., Hayashi,Y.K., Purevjav,E.,
            Nishikawa,A., Koshimizu,E., Suzuki,M., Yatabe,K., Tanaka,Y.,
            Ogata,K., Kuru,S., Shiina,M., Tsurusaki,Y., Nakashima,M.,
            Mizuguchi,T., Miyake,N., Saitsu,H., Ogata,K., Kawai,M., Towbin,J.,
            Nonaka,I., Nishino,I. and Matsumoto,N.
  TITLE     Biallelic Mutations in MYPN, Encoding Myopalladin, Are Associated
            with Childhood-Onset, Slowly Progressive Nemaline Myopathy
  JOURNAL   Am J Hum Genet 100 (1), 169-178 (2017)
   PUBMED   28017374
REFERENCE   2  (bases 1 to 5201)
  AUTHORS   Bang,M.L., Mudry,R.E., McElhinny,A.S., Trombitas,K., Geach,A.J.,
            Yamasaki,R., Sorimachi,H., Granzier,H., Gregorio,C.C. and Labeit,S.
  TITLE     Myopalladin, a novel 145-kilodalton sarcomeric protein with
            multiple roles in Z-disc and I-band protein assemblies
  JOURNAL   J Cell Biol 153 (2), 413-427 (2001)
   PUBMED   11309420
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Feb 28, 2019 this sequence version replaced XM_006256374.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments. This transcript is inferred from
            orthologous data and is based on the mouse transcript, NM_182992.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.59813.1,
                                           SRR26643296.39809.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-250               JAXUCZ010000020.1  25435554-25435803
            251-1132            JAXUCZ010000020.1  25446490-25447371
            1133-1308           JAXUCZ010000020.1  25469446-25469621
            1309-1360           JAXUCZ010000020.1  25471756-25471807
            1361-1457           JAXUCZ010000020.1  25475186-25475282
            1458-1529           JAXUCZ010000020.1  25476399-25476470
            1530-1671           JAXUCZ010000020.1  25485786-25485927
            1672-1695           JAXUCZ010000020.1  25488470-25488493
            1696-1812           JAXUCZ010000020.1  25490479-25490595
            1813-2185           JAXUCZ010000020.1  25492666-25493038
            2186-2773           JAXUCZ010000020.1  25500666-25501253
            2774-2912           JAXUCZ010000020.1  25501883-25502021
            2913-3134           JAXUCZ010000020.1  25507273-25507494
            3135-3284           JAXUCZ010000020.1  25509306-25509455
            3285-3367           JAXUCZ010000020.1  25511267-25511349
            3368-3494           JAXUCZ010000020.1  25512650-25512776
            3495-3702           JAXUCZ010000020.1  25514050-25514257
            3703-3868           JAXUCZ010000020.1  25516840-25517005
            3869-4002           JAXUCZ010000020.1  25518663-25518796
            4003-5201           JAXUCZ010000020.1  25519951-25521149
FEATURES             Location/Qualifiers
     source          1..5201
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p11"
     gene            1..5201
                     /gene="Mypn"
                     /note="myopalladin"
                     /db_xref="GeneID:309760"
                     /db_xref="RGD:1308510"
     exon            1..250
                     /gene="Mypn"
                     /inference="alignment:Splign:2.1.0"
     exon            251..1132
                     /gene="Mypn"
                     /inference="alignment:Splign:2.1.0"
     CDS             252..4172
                     /gene="Mypn"
                     /codon_start=1
                     /product="myopalladin"
                     /protein_id="NP_001355746.1"
                     /db_xref="GeneID:309760"
                     /db_xref="RGD:1308510"
                     /translation="MQDDSIEASTSISQLLRESYLAETRHRGDNERSRAEPSSNPFHF
                     SSPGAAEGGGPEDLPDLSAFLSQEELDESVNLARLAINHDPLERVDESQTRKRLSSDQ
                     KPSFEPAFLQDSSRGLASSKDSPPETKRPQYSSETQSKKVFLNKAADFIEELSSLFKA
                     HSSKRIRPRACKNHKSKTESPNKVVQENSPTFSDLTERRERTSVPIPIPADSRDNELN
                     HAIEQREAKRREAELAAVEAAAGDSTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEG
                     SRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSC
                     FASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSATIPPTVQ
                     AQPRVSTIQQCQSPTNYLQGLNGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPS
                     PKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKY
                     GTVSSIAQLAVRGNEDISDNETLHSDNSTTNPAATEQQPSPPNPQPPPEEQPPKPKLE
                     GVLVNHNEPRSSSRIGLRVHFNLPEDDKDTEASSGCGMANTSQTRPDSFPERFNGQEA
                     RISEPSSPVKEPPPVLAKPKLDSTQLQQLHNQVLLEQLQLHNTSPSSPKESPFNTSIL
                     NSAPPTVTISSKQVKSPAPQTFNLARPKHFFPASSTSTATVSPSSSPVFTLSNTPQTI
                     QRTVSKESLLMTHPSTQGRSPGGLSIQNEPAPPSPAEPAVPTVSYSITSGNQFQPHCV
                     SPTPVSPTGRIQNPVAFLSSVLPSLPSIPPTNAMGLPKSAPSVPPQGLMKKTTKTPQA
                     VSDDYIRETKNSVILDLGKKVNFSDVRSHQQEYKISSFEQRLMNEIEFRLERTPVDES
                     DDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKVYWFKDGKQIS
                     KRNEHCKMRRDGDGTCSLHIESTHGDDDGNYTIMAANPQGRISCSGHLMVQGFPIRNR
                     LSPAGQSHRGRSRMQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPP
                     ELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYTCVATNKTGQNSFSLE
                     LTVVAKEVKKAPVILEKLQNSGVPEGHPVRLEGRVIGMPPPVFYWKKDNETIPFTRER
                     ISMHQDTTGYVCLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYAQWHQQIPTPIS
                     IRPSGSRYGSLTSKGLDIFSAFSSMESTMMYSCTSRSVVESDEL"
     exon            1133..1308
                     /gene="Mypn"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1360
                     /gene="Mypn"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1457
                     /gene="Mypn"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1529
                     /gene="Mypn"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1671
                     /gene="Mypn"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1695
                     /gene="Mypn"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1812
                     /gene="Mypn"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..2185
                     /gene="Mypn"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2773
                     /gene="Mypn"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..2912
                     /gene="Mypn"
                     /inference="alignment:Splign:2.1.0"
     exon            2913..3134
                     /gene="Mypn"
                     /inference="alignment:Splign:2.1.0"
     exon            3135..3284
                     /gene="Mypn"
                     /inference="alignment:Splign:2.1.0"
     exon            3285..3367
                     /gene="Mypn"
                     /inference="alignment:Splign:2.1.0"
     exon            3368..3494
                     /gene="Mypn"
                     /inference="alignment:Splign:2.1.0"
     exon            3495..3702
                     /gene="Mypn"
                     /inference="alignment:Splign:2.1.0"
     exon            3703..3868
                     /gene="Mypn"
                     /inference="alignment:Splign:2.1.0"
     exon            3869..4002
                     /gene="Mypn"
                     /inference="alignment:Splign:2.1.0"
     exon            4003..5201
                     /gene="Mypn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgtgagctg acaaatgctc tggccgtggt ggtgaccgcg gtggtgacag tggcccagct
       61 tctaacagcc atcctcacca aactacggtt aactcctcgc tctctatgga cggccactct
      121 ctctttccaa gggcgtgaag aatttcccct ttctccagtg ttttcttcaa aaacttctct
      181 gtggataact gtcatcgcag aagcttgcct gggttggaca tcctcatctg ggtcaccaaa
      241 gaaaagaaag catgcaagac gacagcatag aggcatctac ttccatctct cagctcctga
      301 gagaaagcta tctggctgaa accagacatc gcggggacaa tgagcggagt cgagcagagc
      361 cctcctccaa ccctttccat ttcagcagtc ctggggctgc agaaggagga ggcccggagg
      421 accttccgga tctttctgcc ttcctgagcc aagaggagtt agatgaaagt gtcaacctgg
      481 caaggctagc catcaaccac gaccccttgg agagggtgga tgaatctcag acgaggaagc
      541 gtctgtcttc tgaccagaag ccaagcttcg aacccgcctt cctccaggac agctcccgag
      601 gtcttgccag ctccaaagac agccccccgg agaccaagag gccacagtac agttctgaaa
      661 cccagtccaa gaaagtcttc ctgaacaagg ctgccgactt catcgaagag ctctcctccc
      721 ttttcaaggc tcacagctcc aagaggatca gacctcgggc ctgcaaaaac cacaagagca
      781 aaacggaatc cccaaacaaa gttgtgcaag aaaacagccc gactttctca gatctgacgg
      841 aaaggcgcga gagaacatcg gtccccatcc ccatccctgc agatagcagg gataacgaac
      901 tgaaccatgc cattgaacag cgggaagcca agaggcggga agccgagctg gcagcggtgg
      961 aggctgcggc tggagatagc accccgggtt cttcaccttc gtccctatac tacgaagagc
     1021 ctctggggca gcctccccgc ttcacacaaa agttacggag cagagaagta ccggaaggaa
     1081 gccgagtcca gttggattgt atagtggtag gaattccacc gccccaagta aggtggtatt
     1141 gtgaaggcaa ggaacttgaa aactccccag acatccacat cgtacaggca ggaaaccttc
     1201 actcactcac catcgccgaa gccttcgaag aggacacagg tcgatattca tgctttgctt
     1261 ccaacattta tgggacagat tcaacttccg ctgagattta catagaagga gtctcttcct
     1321 ctgactcaga aggggaccct aacaaagaag agatgaatcg aatccagaag ccaaatgagg
     1381 tgtcctcacc tcctaccacc tctgcaacca ttcctccaac agtacaagcc cagcccagag
     1441 tgtccaccat tcagcagtgt cagagtccta ccaactattt gcaaggcctg aacgggaaac
     1501 ccatcattgc agcaccagtg tttacgaaga tgctgcagaa cttgtcagcc tctgaggggc
     1561 agctggttgt ctttgagtgc agagtgaaag gggccccgtc tccgaaagtc gagtggtaca
     1621 gagaaggaac cttaatcgaa gactccccag acttcaggat cttacaaaag aaaccccgat
     1681 ccatggcaga accagaggag atctgcacat tagtcatcgc tgaggtgttt gcagaagact
     1741 caggatgctt cacgtgcacg gcaagcaaca agtacggcac ggtgtctagc atcgcacagc
     1801 tggctgtgag aggaaatgaa gacatcagtg ataatgagac tcttcactca gacaactcaa
     1861 ccaccaaccc agctgcaact gagcaacagc cctccccacc caacccccag cctcctccgg
     1921 aggagcagcc ccccaaaccc aaacttgagg gggtcctggt gaaccataat gagcctcggt
     1981 ctagctccag gattgggcta cgggtgcact tcaatctgcc tgaagacgac aaagatactg
     2041 aggcatcctc tgggtgtggc atggccaaca ccagccagac taggccggat tccttccctg
     2101 agaggttcaa tgggcaggaa gccagaatct cagagccttc ctcacctgtc aaggagcccc
     2161 ctccagtcct ggccaaacca aaacttgact ccactcagtt acaacagctt cataaccaag
     2221 tgttgctgga acagctacaa ctgcataaca catctccttc atcacccaag gaatctcctt
     2281 tcaacacgag tatcttgaac tccgctcccc caacagtaac catttccagc aagcaagtga
     2341 agagtcctgc accacagaca tttaacttag cccggccgaa gcatttcttc cctgcctcaa
     2401 gcacttccac agcaactgtg tccccatcca gctccccagt gttcacgttg agcaatactc
     2461 ctcaaacaat tcagaggaca gtcagcaaag aaagcctctt aatgactcac ccctccacac
     2521 aaggcagatc tccaggcggg ctctccatcc aaaatgagcc agctcctcca agcccagcag
     2581 agccagcagt gccaacagtc tcctattcca tcaccagtgg aaaccagttt cagcctcact
     2641 gtgtatcccc aactcctgtc tctcctaccg gtcggattca gaacccagtg gctttcctta
     2701 gctctgttct gccttctctc ccttccattc cacccaccaa tgccatgggg ctgcctaaaa
     2761 gtgcaccatc tgtaccaccc cagggtctga tgaagaaaac cacaaagacc cctcaagcag
     2821 tgagtgacga ttacatccga gagacaaaga actcggtgat tctagacttg gggaagaaag
     2881 tgaatttcag tgatgtcaga tcacaccagc aggaatataa aatttccagc tttgagcaga
     2941 ggctgatgaa cgagatagag ttccgcctgg agcgtacccc tgttgacgaa tctgatgacg
     3001 agatacagca tgacgaaatc cccacgggca agtgcatcgc tcccatcttt gacaaaagac
     3061 tcaagcactt ccgggttact gaaggctctc cagtgacctt cacctgcaaa attgttggga
     3121 tacctgttcc aaaggtttat tggttcaaag acgggaagca gatttctaag agaaatgagc
     3181 actgtaaaat gaggagagac ggggacggga cctgctctct gcacattgag tccacccacg
     3241 gcgatgacga cggcaactac accatcatgg ccgccaaccc ccaggggaga atcagctgtt
     3301 ctggccactt gatggtacag ggttttccca ttcgaaaccg actcagccct gccggtcagt
     3361 ctcacagagg aaggtccaga atgcaagaaa gagacaaaga gcctctgcag gagcgctttt
     3421 tccgaccaca tttcctgcag gcccctgggg atatggtggc tcatgagggt cgcctctgta
     3481 gactggactg caaggtgagt ggcttaccac ccccggagct gacatggctg ctcaatggac
     3541 aacctgtgct accagatgcc tcccacaaga tgctggtcag agagactgga gtccactctc
     3601 tgctcatcga ccctctcacc caacgagatg cagggaccta tacatgtgtg gcaacaaaca
     3661 aaaccgggca gaattccttc agtttggagc tcactgtggt agccaaagag gtaaagaagg
     3721 cgcccgtgat cctagagaaa ctccagaaca gcggcgttcc cgagggccac cccgtgcgac
     3781 tagagggcag agtcataggc atgcccccgc ctgtgttcta ctggaagaaa gacaacgaga
     3841 ctatcccgtt cactagagag aggatcagca tgcaccagga tacaacaggc tatgtctgcc
     3901 tcctcattca gccagccaag aaatccgatg cggggtggta cacgctgtca gccaagaatg
     3961 aagccggcat cgtgtcatgc acagctaggt tggatatata tgctcagtgg caccagcaaa
     4021 tcccaacacc tatatccatc cggcccagcg gcagccgcta cgggtctctc accagcaaag
     4081 gacttgacat cttctctgcc ttctcctcta tggaaagcac aatgatgtac tcctgcactt
     4141 ctcggagtgt ggtggagagc gatgaacttt aaggatgtcc gggtgcctgc tgtgagagag
     4201 tggactgtgg gggaggggaa ggaagactga cgacatgcag tggtttccaa acaactggat
     4261 ttgaatgagt ttccatcctg ctggacccat ggcaagaagt gttttaagtg agttggctga
     4321 gggaaagatg tcaggctgtg tatcttaaag ataccagtag acaacatacc caaaccaaag
     4381 ataaccacac cactgctacc acagcttttg gtggggggta gggagctagc atgctccccc
     4441 acctggtatg ctagggaccc taggcccaag taggagcaat caggagccac agccagggct
     4501 gaaagaagtt agcaacttta ggatagaggc aaaggcgggg agctcattgc cacctttcat
     4561 gggttacatc catatcagcc atcctggtaa atccattaaa tgaactccct cttaatctta
     4621 gaggatcttg ctataggcac cccccatccc cgaagcgaca aaacactttg cattatctat
     4681 catacctgtg gagtcacgtg ataagccaaa atgtgcctga gatttaaaga aaccaaaaaa
     4741 caaaagcaag agtttattag acagtcagat ttcccactct gcttgttttg tggtcaaaac
     4801 aaggctccca ccagcctatc agtgccattt taggcagaaa gccacaccca cctccatccc
     4861 tagtgcctag atgggtactg agcacaatgg agaccttcga aacacatctg ctgggtaatg
     4921 actcctagat cattcagttt ctaccgttct tagctagtcc aaacatggcc ccgggaatgg
     4981 ttgtcacagc agtctgctgc aggcaagcca gggctgtgaa ctggaaatgt ctgttgtcat
     5041 ttcccttcac tcaaatctcg ggtgtcctct ctgtgccagg tgcccctcag ctggcatcct
     5101 tctcaagtgg ctttagtaat ttcttagaaa ggcttgaaac ttcctttgtt tcaaggcaag
     5161 gatttccagt atagaaataa attcatttac tcaaaacaaa a
//
