LOCUS       NM_001399243            1138 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus myozenin 2 (Myoz2), transcript variant 1, mRNA.
ACCESSION   NM_001399243 XM_006233264
VERSION     NM_001399243.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1138)
  AUTHORS   Shenkman,B.S. and Lomonosova,Y.N.
  TITLE     Expression of calsarcin isoforms and myosin phenotype stabilization
            in transitional unloaded muscle
  JOURNAL   Dokl Biochem Biophys 459, 214-216 (2014)
   PUBMED   25559982
  REMARK    GeneRIF: Results suggest that under weightlessness conditions, in
            some muscle fibers a decrease in the calsarcin--1 expression can
            cause intensification of the calcineurin pathway and thereby
            stabilize their slow phenotype
REFERENCE   2  (bases 1 to 1138)
  AUTHORS   Gallego-Delgado,J., Lazaro,A., Osende,J.I., Esteban,V.,
            Barderas,M.G., Gomez-Guerrero,C., Vega,R., Vivanco,F. and Egido,J.
  TITLE     Proteomic analysis of early left ventricular hypertrophy secondary
            to hypertension: modulation by antihypertensive therapies
  JOURNAL   J Am Soc Nephrol 17 (12 Suppl 3), S159-S164 (2006)
   PUBMED   17130255
  REMARK    GeneRIF: In proteomic study of left ventricular hypertrophy, three
            altered protein spots corresponded to two unique proteins that were
            identified as Calsarcin-1 (CS-1) and ubiquinone biosynthesis
            protein COQ7 homolog.
REFERENCE   3  (bases 1 to 1138)
  AUTHORS   Heineke,J., Ruetten,H., Willenbockel,C., Gross,S.C., Naguib,M.,
            Schaefer,A., Kempf,T., Hilfiker-Kleiner,D., Caroni,P., Kraft,T.,
            Kaiser,R.A., Molkentin,J.D., Drexler,H. and Wollert,K.C.
  TITLE     Attenuation of cardiac remodeling after myocardial infarction by
            muscle LIM protein-calcineurin signaling at the sarcomeric Z-disc
  JOURNAL   Proc Natl Acad Sci U S A 102 (5), 1655-1660 (2005)
   PUBMED   15665106
REFERENCE   4  (bases 1 to 1138)
  AUTHORS   Hayashi,T., Arimura,T., Itoh-Satoh,M., Ueda,K., Hohda,S.,
            Inagaki,N., Takahashi,M., Hori,H., Yasunami,M., Nishi,H., Koga,Y.,
            Nakamura,H., Matsuzaki,M., Choi,B.Y., Bae,S.W., You,C.W., Han,K.H.,
            Park,J.E., Knoll,R., Hoshijima,M., Chien,K.R. and Kimura,A.
  TITLE     Tcap gene mutations in hypertrophic cardiomyopathy and dilated
            cardiomyopathy
  JOURNAL   J Am Coll Cardiol 44 (11), 2192-2201 (2004)
   PUBMED   15582318
REFERENCE   5  (bases 1 to 1138)
  AUTHORS   Frey,N., Barrientos,T., Shelton,J.M., Frank,D., Rutten,H.,
            Gehring,D., Kuhn,C., Lutz,M., Rothermel,B., Bassel-Duby,R.,
            Richardson,J.A., Katus,H.A., Hill,J.A. and Olson,E.N.
  TITLE     Mice lacking calsarcin-1 are sensitized to calcineurin signaling
            and show accelerated cardiomyopathy in response to pathological
            biomechanical stress
  JOURNAL   Nat Med 10 (12), 1336-1343 (2004)
   PUBMED   15543153
REFERENCE   6  (bases 1 to 1138)
  AUTHORS   Frey,N., Richardson,J.A. and Olson,E.N.
  TITLE     Calsarcins, a novel family of sarcomeric calcineurin-binding
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 97 (26), 14632-14637 (2000)
   PUBMED   11114196
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Jan 5, 2022 this sequence version replaced XM_006233264.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ216608.1, FQ215331.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760475 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               JAXUCZ010000002.1  213852631-213852778 c
            149-241             JAXUCZ010000002.1  213852021-213852113 c
            242-411             JAXUCZ010000002.1  213844250-213844419 c
            412-541             JAXUCZ010000002.1  213835637-213835766 c
            542-725             JAXUCZ010000002.1  213833355-213833538 c
            726-1138            JAXUCZ010000002.1  213826052-213826464 c
FEATURES             Location/Qualifiers
     source          1..1138
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..1138
                     /gene="Myoz2"
                     /note="myozenin 2"
                     /db_xref="GeneID:295426"
                     /db_xref="RGD:1307669"
     exon            1..148
                     /gene="Myoz2"
                     /inference="alignment:Splign:2.1.0"
     exon            149..241
                     /gene="Myoz2"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..960
                     /gene="Myoz2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     calsarcin-1"
                     /codon_start=1
                     /product="myozenin-2 isoform 1"
                     /protein_id="NP_001386172.1"
                     /db_xref="GeneID:295426"
                     /db_xref="RGD:1307669"
                     /translation="MLSHSAMVKQRKQQASAITKEIHGHDVDGMDLGKKVSVPRDIMI
                     EELSHFGNRGARLFKMRQRRSDKYTFENFQYETKAQINHNLAMQNGRIDGSNLEGGSQ
                     QAPSTPPNTPDPRSPPNPENIAPGYSGPLKEIPPERFNTTAVPKYYQSPWEQAIGDDP
                     ELLEALYPKLFKPEGKAELPDYRSFNRVATPFGGFEKASKMVKFKVPDFERLLLTDPR
                     FLAFANPLSGRRCFNRTPKGWISENIPVVITTEPAEDVTMPESDDL"
     exon            242..411
                     /gene="Myoz2"
                     /inference="alignment:Splign:2.1.0"
     exon            412..541
                     /gene="Myoz2"
                     /inference="alignment:Splign:2.1.0"
     exon            542..725
                     /gene="Myoz2"
                     /inference="alignment:Splign:2.1.0"
     exon            726..1138
                     /gene="Myoz2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcccctgtt tgagtcagat ctagggacca tgccgttcca ggttcaagga taaaacccat
       61 caggcccaac tgccatcatc ttccaccttc agtgccttcc tccacaattg ggattcaccc
      121 ctgctgaaaa gtgcagtctg acagcaaggg aacaaaaaac aaactatgct atcacacagt
      181 gccatggtga agcaaaggaa acagcaagca tcagccatca cgaaggaaat ccatggacac
      241 gatgtcgacg gcatggatct gggcaagaaa gttagcgtcc ccagagacat catgatagaa
      301 gaattgtccc atttcggtaa tcgcggtgcc agactgttta agatgcgtca aagaagatct
      361 gacaaataca cctttgaaaa tttccagtac gaaacaaaag cacaaatcaa tcacaatctt
      421 gccatgcaga atgggagaat tgacggaagt aacctggaag gtggttcaca gcaagctccc
      481 tcaactcctc ctaacacccc ggatccacga agccccccaa atccggagaa cattgcacca
      541 ggatattctg gacccctgaa ggaaattcct cctgaaagat ttaacacgac ggctgttcct
      601 aagtactacc agtctccctg ggagcaggcc attggcgacg atccagagct cctggaagct
      661 ttgtacccga aacttttcaa gcctgaagga aaggcagaac tgccagatta caggagcttt
      721 aacagagttg ccactccatt tggaggtttt gagaaagcat caaaaatggt taaattcaag
      781 gttccagact tcgaacgact gctgctaaca gatcccaggt ttttggcctt tgccaatcct
      841 ctttcgggca gacgatgctt taataggaca ccaaaggggt ggatatctga gaatattcct
      901 gtcgtgatca caactgagcc tgcagaagat gtcactatgc cagagtcaga tgacttgtga
      961 acgggaagcc aggcaggccg ccgagagctc tacacataaa agctgccgtc ggtcttctta
     1021 gcggcgaagc catttgagtg cctcgtcact gtggtcatcc aattgcggtt acacacattt
     1081 cattttgtgg cgttcaattt gaactgaaca attaaattct ggtttaagaa tctctcaa
//
