LOCUS       NM_001106148            2206 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus myotilin (Myot), mRNA.
ACCESSION   NM_001106148 XM_001053135 XM_001053210 XM_214563
VERSION     NM_001106148.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2206)
  AUTHORS   von Nandelstadh,P., Ismail,M., Gardin,C., Suila,H., Zara,I.,
            Belgrano,A., Valle,G., Carpen,O. and Faulkner,G.
  TITLE     A class III PDZ binding motif in the myotilin and FATZ families
            binds enigma family proteins: a common link for Z-disc myopathies
  JOURNAL   Mol Cell Biol 29 (3), 822-834 (2009)
   PUBMED   19047374
REFERENCE   2  (bases 1 to 2206)
  AUTHORS   Hauser,M.A., Horrigan,S.K., Salmikangas,P., Torian,U.M.,
            Viles,K.D., Dancel,R., Tim,R.W., Taivainen,A., Bartoloni,L.,
            Gilchrist,J.M., Stajich,J.M., Gaskell,P.C., Gilbert,J.R.,
            Vance,J.M., Pericak-Vance,M.A., Carpen,O., Westbrook,C.A. and
            Speer,M.C.
  TITLE     Myotilin is mutated in limb girdle muscular dystrophy 1A
  JOURNAL   Hum Mol Genet 9 (14), 2141-2147 (2000)
   PUBMED   10958653
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474178.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001053135.1, XM_001053210.1, XM_214563.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760384,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2206
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..2206
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="myotilin"
                     /db_xref="GeneID:291605"
                     /db_xref="RGD:1310569"
     exon            1..85
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /inference="alignment:Splign:2.1.0"
     exon            86..623
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /inference="alignment:Splign:2.1.0"
     CDS             271..1761
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /note="titin immunoglobulin domain protein (myotilin)"
                     /codon_start=1
                     /product="myotilin"
                     /protein_id="NP_001099618.1"
                     /db_xref="GeneID:291605"
                     /db_xref="RGD:1310569"
                     /translation="MFNYERPKHFIQSQNPCGSGLQPPGPEVSSFPNQTKQSSIVIQP
                     RQCTEQRFSASSTVSSHITVSSSAYPASQQLAGPNPGQKVTATYNQSPASFLSSILPS
                     QPDYSNSKIPSTVDSNYQQSSVHQPVNAVSSQAAGAKPTPRTPDHEIQGSKEALIQDL
                     ERKLKCKDTLLHNGNQRLTYEEKMARRLLGPQNAAAVFQAQNSDVQDSSQHNPEHARL
                     QVPTSQVRSRSSSRADANDQDAIQEKFYPPRFIQVPENMSIEEGRFCRMDFKVSGLPA
                     PDVSWYLNGRLVQSDELHKMIVSEKGFHSLIFEVVRASDAGPYACVARNRAGEATFTV
                     QLDVLAKEHKRAPMFIYKPQSKKVFEGESVKLECQISAIPPPKLFWKRNNEMVQFNTD
                     RISLYHDNAGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTPPAPK
                     QLRVRPTFSKYLALNGKGLDVKQAFNPEGEFQRLAAQSGLYESEEL"
     exon            624..798
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /inference="alignment:Splign:2.1.0"
     exon            799..900
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /inference="alignment:Splign:2.1.0"
     exon            901..947
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1080
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1288
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1454
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1588
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..2206
                     /gene="Myot"
                     /gene_synonym="Ttid"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagccacac gatcctgagc aaggagatgc ttcttccttc tcttcagtag tgggttgaga
       61 caagctggcc ccttctgagc taaggaaaca atatccttca agagaaaccc accaacatca
      121 ggagtacagt gttctagaga tctcagcaag gagggccaga ctaaggtttc ttctgacttg
      181 ctgcaacctt ctgtaattcc aggcttgcca ccccacggtc aggagtctat ccttctggga
      241 gcaaatccat cttccatata ccagctaagc atgtttaact acgaacgtcc aaaacacttc
      301 atccagtccc aaaatccatg tggctccggg ctgcagcctc caggacctga agtctccagc
      361 ttccctaacc agaccaaaca gtcttccatc gtcatccagc ctcgccaatg caccgagcag
      421 agattttctg cttcctccac agtgagctct cacatcaccg tgtcttcctc tgcttatcct
      481 gcttcccagc agctggctgg ccccaacccc ggtcagaagg ttactgctac ctataaccag
      541 tccccagcca gcttcctcag ttctatatta ccgtctcagc ctgattacag taacagtaaa
      601 atcccatcca ctgtggactc caactatcaa caatcctcag ttcaccaacc tgtaaatgcc
      661 gtgtcatccc aagctgcagg tgctaagccc actccaagga ctcctgacca cgaaatccaa
      721 ggatcaaaag aagcattgat tcaagatttg gaaagaaagc tgaaatgcaa agacaccctt
      781 cttcataatg gaaaccaaag actgacctat gaggagaaga tggctcgcag gttgttagga
      841 ccgcagaatg ctgctgctgt gtttcaagct caaaacagtg acgtccaaga ttcgtcacag
      901 cataacccag aacatgcacg gctgcaagtt cccacatcac aagtaagaag tagatcgtcc
      961 tccagagcag acgcaaatga ccaggatgcc atccaggaga agttttaccc accacgcttc
     1021 attcaagtgc cagaaaatat gtccatcgaa gaaggaagat tctgcagaat ggactttaaa
     1081 gtgagtggac tgccagcccc tgatgtgtca tggtatctaa acgggagact ggtgcaatca
     1141 gatgagttgc acaaaatgat agtgtcagag aagggtttcc actccctcat ctttgaagtg
     1201 gtcagagcat cagatgcagg gccatatgca tgtgtagcca gaaacagagc tggagaagcc
     1261 accttcacag tgcagctgga tgttctggca aaagagcaca aaagagcacc gatgtttatc
     1321 tacaaaccac agagcaaaaa ggtttttgag ggagaatcag tgaagttaga gtgccagatc
     1381 tcagctatcc ctccaccaaa gcttttctgg aaaagaaaca acgaaatggt tcagttcaac
     1441 actgaccgga taagcttata tcatgataat gctggaagag taactttact gataaaagat
     1501 gtaaacaaga aggatgctgg gtggtataca gtgtcagcag tcaatgaagc tggcgtgacc
     1561 acgtgtaaca caagattaga tgtcacagcc cgtccaaacc aaactccccc agctcctaag
     1621 caactgcgtg ttcgaccaac tttcagcaaa tatttagccc taaatgggaa aggtttggat
     1681 gtgaaacaag ctttcaaccc tgaaggagag tttcagcgtc tggcagctca atccggactc
     1741 tatgaaagtg aagaacttta ataactttgc ccacagggaa aacagagctt cactcctcca
     1801 atggatctga taacattgtg aaaaaaaatc catggttgta ttaacagatt gtgactttac
     1861 ttaggtcata tactaactcc catttagaat gttattcacc ctctgactct ggcacaacgt
     1921 gtctattcct ctgacctgtg aagccggcag taaactaagt aaatgagttt gtattataag
     1981 agactgtttt aagatacagt gtcttaacac tgaagtcatg cacatttaac aactatgagt
     2041 tatgaaccag aaacttttta aatgccacta attcttgcag taaagtgtat gggtattgcc
     2101 taacagactt tatttacctg ttttctctta taggaatact aacatggtat agattatctg
     2161 agtgttccac aatttcatgt caaaagagaa taaaattcaa gtagtt
//
