LOCUS       NP_001101457            1438 aa            linear   ROD 29-MAR-2024
DEFINITION  myomesin-3 isoform 1 [Rattus norvegicus].
ACCESSION   NP_001101457 XP_001068470 XP_003750108 XP_233562
VERSION     NP_001101457.2
DBSOURCE    REFSEQ: accession NM_001107987.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1438)
  AUTHORS   du Puy,L., Beqqali,A., van Tol,H.T., Monshouwer-Kloots,J.,
            Passier,R., Haagsman,H.P. and Roelen,B.A.
  TITLE     Sarcosin (Krp1) in skeletal muscle differentiation: gene expression
            profiling and knockdown experiments
  JOURNAL   Int J Dev Biol 56 (4), 301-309 (2012)
   PUBMED   22562206
REFERENCE   2  (residues 1 to 1438)
  AUTHORS   Beqqali,A., Monshouwer-Kloots,J., Monteiro,R., Welling,M.,
            Bakkers,J., Ehler,E., Verkleij,A., Mummery,C. and Passier,R.
  TITLE     CHAP is a newly identified Z-disc protein essential for heart and
            skeletal muscle function
  JOURNAL   J Cell Sci 123 (Pt 7), 1141-1150 (2010)
   PUBMED   20215401
REFERENCE   3  (residues 1 to 1438)
  AUTHORS   Schoenauer,R., Lange,S., Hirschy,A., Ehler,E., Perriard,J.C. and
            Agarkova,I.
  TITLE     Myomesin 3, a novel structural component of the M-band in striated
            muscle
  JOURNAL   J Mol Biol 376 (2), 338-351 (2008)
   PUBMED   18177667
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1 and FQ126179.1.
            
            On or before Aug 15, 2019 this sequence version replaced
            XP_003750108.1, NP_001101457.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments. This variant is based on
            transcript alignments from orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.23765.1,
                                           SRR26643296.16396.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1438
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     Protein         1..1438
                     /product="myomesin-3 isoform 1"
                     /note="myomesin family, member 3"
                     /calculated_mol_wt=161971
     Region          154..248
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          171..175
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          184..188
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          213..217
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          227..232
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          240..243
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          272..363
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          304..308
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          329..333
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          343..348
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          356..359
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          374..460
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(374,440,455)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          <437..>709
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain [General function
                     prediction only]; COG3401"
                     /db_xref="CDD:442628"
     Site            order(456..457,459..460)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          702..792
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(702,768,783)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Site            order(784..785,787..788)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          804..893
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(804,870,885)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Site            order(886..887,889..890)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1127..1207
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          1138..1142
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          1152..1156
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          1174..1178
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1188..1193
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1201..1204
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          1336..1426
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          1354..1358
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          1367..1371
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          1392..1396
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          1406..1411
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          1419..1422
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..1438
                     /gene="Myom3"
                     /coded_by="NM_001107987.2:103..4419"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:313625"
                     /db_xref="RGD:1310060"
ORIGIN      
        1 mtlphspgsa gepqasqtvq vhrlehkhee eqkeerehsl rmgssvqrrt yrsseeeqqf
       61 spedyalaaa laltassels weaklrrqtt rveleergqk rigfgndler memaflrtqr
      121 llrqrrdwka lrqrteqkvl eakelielcs grgpwfwipl rshavweytt vlltctiqgs
      181 fpfqvtwykd diqidprlfp agkyritnny glltleirrc tvedsatytv lvknafgqas
      241 sfakvlirty lgkdagfdse ifkrsmfgpt veftsvlkpi faqekepfsl tclfsddvle
      301 aeeriqwfrd grllrsstrr qilyadrqas vkvscayked egfytirvss pfgpqeqsay
      361 vfirdaaaek pgapgsplnv rclnvhrdcl tltwvppsdt rgstitgysi elcqgdseew
      421 vpclktpggt crcpiqglie gqsyrfrvra iskagtslps kasaavvmgd ydtvqkktei
      481 pfdlgrkiti skndfedavt ipsaptnvha seirdtyavl sweephprgr apltytleks
      541 vigsgtweai ssetpikspr falldlekgk syvfrvraln qygmsdpsep sepitlkgkp
      601 atlpppaqvq sfrntqtsvs ltwepvdggs ellgyyiysr eagasewqtv nnkpiqdtkf
      661 tvpglrtgke yefcirsvse agvgessavt qpirvkqala tpsapydfal lncgknemvi
      721 gwkppkrrgg gkilgyyvdq hdseeldwhp vshqpnpsrv ckvtnlhegh fyefraramn
      781 wagigelsap sslfeckewt mpepgppydv raseiqatsv mlqwepplyi gagpvtgyrv
      841 sfqeigseew kpvtpdatsd thlrvsdlqp gkqymfrvqa mnsaglgqps vptdpvlled
      901 kpdaheievg vdeegqiyla feapeapdfp efqwskdykg ppdpqrvevk deinkskvil
      961 kepdlqdlgv ysvvvtdade dtsashtlte eelnklkkls heirnpvikl isgwnvdile
     1021 qgevrlwlev eklspaaelh lifnekeifs spnrkinfdr ekglveviiq qlseddkgsy
     1081 taqlqdgkak nqitlalvdd dfdkllrkad akrrdwkrkq gpyfqdpltw kvtedcqvll
     1141 tckvtntkke trfqwlfqkk eaprgqyspq tgdgslciee fskedqglyr avvsderged
     1201 dtvldltgea ldavltelgr isalsatplk iqgteegirl fskvkyynvd ymktawfhkd
     1261 krlesgdrvr agttldeiwl hildpkdsdk gkytleitag kevcqlsadl sgqafddala
     1321 ehqrlkalav ieknrakvvr glpdvatime dktlcltcvi sgdpspeisw lkndqpvsfl
     1381 dryhmevkgt evtitidkvt sedsgrygif vknkygsetg qvtisvfkhg eepkelkk
//
