LOCUS       NM_017115               1448 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus myogenin (Myog), mRNA.
ACCESSION   NM_017115
VERSION     NM_017115.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1448)
  AUTHORS   Bi,J., Jing,H., Zhou,C., Gao,P., Han,F., Li,G. and Zhang,S.
  TITLE     Regulation of skeletal myogenesis in C2C12 cells through modulation
            of Pax7, MyoD, and myogenin via different low-frequency
            electromagnetic field energies
  JOURNAL   Technol Health Care 30 (S1), 371-382 (2022)
   PUBMED   35124612
  REMARK    GeneRIF: Regulation of skeletal myogenesis in C2C12 cells through
            modulation of Pax7, MyoD, and myogenin via different low-frequency
            electromagnetic field energies.
REFERENCE   2  (bases 1 to 1448)
  AUTHORS   Alves,A.N., Ribeiro,B.G., Fernandes,K.P., Souza,N.H., Rocha,L.A.,
            Nunes,F.D., Bussadori,S.K. and Mesquita-Ferrari,R.A.
  TITLE     Comparative effects of low-level laser therapy pre- and post-injury
            on mRNA expression of MyoD, myogenin, and IL-6 during the skeletal
            muscle repair
  JOURNAL   Lasers Med Sci 31 (4), 679-685 (2016)
   PUBMED   26914683
  REMARK    GeneRIF: low-level laser therapy (LLLT) administered following
            muscle injury modulates the mRNA expression of MyoD and myogenin.
            Moreover, the both forms of LLLT administration were able to
            modulate the mRNA expression of IL-6 during the muscle repair
            process.
REFERENCE   3  (bases 1 to 1448)
  AUTHORS   Liu,S.T., Huang,S.M., Ho,C.L., Yen,L.C., Huang,C.J., Lin,W.S. and
            Chan,J.Y.
  TITLE     The regulatory mechanisms of myogenin expression in
            doxorubicin-treated rat cardiomyocytes
  JOURNAL   Oncotarget 6 (35), 37443-37457 (2015)
   PUBMED   26452256
  REMARK    GeneRIF: Suggest that myogenin is the target for
            doxorubicin-induced cardio-toxicity.
REFERENCE   4  (bases 1 to 1448)
  AUTHORS   Takahashi,T., Friedmacher,F., Takahashi,H., Hofmann,A.D. and
            Puri,P.
  TITLE     Myogenin gene expression is not altered in the developing diaphragm
            of nitrofen-induced congenital diaphragmatic hernia
  JOURNAL   Pediatr Surg Int 30 (9), 901-906 (2014)
   PUBMED   25056796
  REMARK    GeneRIF: Myogenin, which is expressed in MPCs, belongs to a family
            of basic helix-loop-helix transcription factors that activate
            skeletal muscle differentiation and thus plays a key role in fetal
            diaphragmatic development and muscularization.
REFERENCE   5  (bases 1 to 1448)
  AUTHORS   Millay,D.P., Sutherland,L.B., Bassel-Duby,R. and Olson,E.N.
  TITLE     Myomaker is essential for muscle regeneration
  JOURNAL   Genes Dev 28 (15), 1641-1646 (2014)
   PUBMED   25085416
REFERENCE   6  (bases 1 to 1448)
  AUTHORS   Hasty,P., Bradley,A., Morris,J.H., Edmondson,D.G., Venuti,J.M.,
            Olson,E.N. and Klein,W.H.
  TITLE     Muscle deficiency and neonatal death in mice with a targeted
            mutation in the myogenin gene
  JOURNAL   Nature 364 (6437), 501-506 (1993)
   PUBMED   8393145
REFERENCE   7  (bases 1 to 1448)
  AUTHORS   Arnold,H.H., Gerharz,C.D., Gabbert,H.E. and Salminen,A.
  TITLE     Retinoic acid induces myogenin synthesis and myogenic
            differentiation in the rat rhabdomyosarcoma cell line BA-Han-1C
  JOURNAL   J Cell Biol 118 (4), 877-887 (1992)
   PUBMED   1323566
REFERENCE   8  (bases 1 to 1448)
  AUTHORS   Asher,O., Fuchs,S., Zuk,D., Rapaport,D. and Buonanno,A.
  TITLE     Changes in the expression of mRNAs for myogenic factors and other
            muscle-specific proteins in experimental autoimmune myasthenia
            gravis
  JOURNAL   FEBS Lett 299 (1), 15-18 (1992)
   PUBMED   1312030
REFERENCE   9  (bases 1 to 1448)
  AUTHORS   Florini,J.R. and Ewton,D.Z.
  TITLE     Highly specific inhibition of IGF-I-stimulated differentiation by
            an antisense oligodeoxyribonucleotide to myogenin mRNA. No effects
            on other actions of IGF-T
  JOURNAL   J Biol Chem 265 (23), 13435-13437 (1990)
   PUBMED   1696254
REFERENCE   10 (bases 1 to 1448)
  AUTHORS   Wright,W.E., Sassoon,D.A. and Lin,V.K.
  TITLE     Myogenin, a factor regulating myogenesis, has a domain homologous
            to MyoD
  JOURNAL   Cell 56 (4), 607-617 (1989)
   PUBMED   2537150
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from JAXUCZ010000013.1.
            
            On Nov 27, 2020 this sequence version replaced NM_017115.2.
            
            Summary: This gene belongs to the myogenic factor subfamily of the
            basic helix-loop-helix (BHLH) family of transcription factors. The
            protein encoded by this gene is a muscle-specific skeletal
            myogenin, which acts in concert with other family members to
            regulate myogenesis. The protein plays an essential role in the
            conversion of undifferentiated cells to myoblasts and functional
            skeletal muscle. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M24393.1, SRR26643296.31595.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-504               JAXUCZ010000013.1  48297476-48297979
            505-586             JAXUCZ010000013.1  48298568-48298649
            587-1448            JAXUCZ010000013.1  48299204-48300065
FEATURES             Location/Qualifiers
     source          1..1448
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..1448
                     /gene="Myog"
                     /note="myogenin"
                     /db_xref="GeneID:29148"
                     /db_xref="RGD:620432"
     exon            1..504
                     /gene="Myog"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..708
                     /gene="Myog"
                     /codon_start=1
                     /product="myogenin"
                     /protein_id="NP_058811.2"
                     /db_xref="GeneID:29148"
                     /db_xref="RGD:620432"
                     /translation="MELYETSPYFYQEPHFYDGENYLPVHLQGFEPPGYERTELSLSP
                     EARGPLEEKGLGTPEHCPGQCLPWACKVCKRKSVSVDRRRAATLREKRRLKKVNEAFE
                     ALKRSTLLNPNQRLPKVEILRSAIQYIERLQALLSSLNQEERDLRYRGGGGPQPVVPS
                     ECNSHSASCSPEWGNALEFGPNPGDHLLAADPTGAHNLHSLTSIVDSITVEDMSVTFP
                     DETMPN"
     exon            505..586
                     /gene="Myog"
                     /inference="alignment:Splign:2.1.0"
     exon            587..1448
                     /gene="Myog"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggccagtgga aggaacaagt cttttccgac ctgatggagc tgtatgaaac atccccctat
       61 ttctaccagg agccccactt ctatgacggg gaaaactacc ttcctgtcca ccttcagggc
      121 ttcgagcccc cgggctatga gcggaccgag ctcagcttaa gcccggaagc ccgagggccc
      181 ctagaagaaa agggactggg gacccctgag cattgtccag gccagtgcct gccctgggcg
      241 tgtaaggtgt gtaagaggaa gtctgtgtct gtggaccggc ggagggcagc cacactgagg
      301 gagaagcgca ggctcaagaa agtgaatgag gccttcgagg ctctgaagag aagcaccctg
      361 ctcaacccca accagcggct gcctaaggtg gagatcctgc gcagtgccat ccagtacatt
      421 gagcgcctac aggccttgct cagctccctc aaccaggagg agcgcgatct ccgctaccga
      481 ggcgggggcg ggccccagcc ggtggtaccc agtgaatgca actcccacag cgcctcctgc
      541 agtccggagt ggggcaatgc actggagttt ggtcccaacc caggagatca tttgctcgca
      601 gctgacccta caggtgccca caacctgcac tcccttacgt ccatcgtgga cagcatcacg
      661 gtggaggata tgtctgtcac cttcccagat gaaaccatgc ccaactgaga ttgtctgcca
      721 ggctgggtgt gcatgggagc ccctgagttg gtgtcagacg ccaccacttc tgcagcaggg
      781 gccttttaag tggggctgtc ctggtgccca gaaaacagcc ctgggctgcc acaagccaga
      841 ctacccaccg tccattcaca taagactaac acccagccca gcaagggaat ttaactgact
      901 ccttaaagca gagagtatcc ccttccaagg agagaaagat ggagtccaga gagccccctt
      961 gttaatgccc ctcaacgggg caaactcagg agcttccttt ttttttttct tcataatgcg
     1021 cctctaattc caccccccaa atgagacagt ttgagagaca gtgagtgccc cgaccgggac
     1081 aagtgtgcac atctgttcga ctctcttcct gatgccagtg gctgggctgg gcctgccctg
     1141 agatgagaga gaagggaggg aacgataggg ttccaaagtc tctggggggc aagcatttgc
     1201 agtggatatt gggaaccttc cagtgctttg tgtattgttt attgttgtgt gtgttgtttg
     1261 taaagctgtc atctgaccaa ggtctcctgt gctgatgcca gggacaggca gggaaggggg
     1321 tgggggctct tggggtgact tcttttgtta actaagcatt gtgtggtttt gccaattttt
     1381 tttgtaattt ttttgctaac ttatttggat ttcctttttt aaaaaatgaa taaagaccgg
     1441 ttgctatc
//
