LOCUS       NM_001414232            8567 bp    mRNA    linear   ROD 18-FEB-2024
DEFINITION  Rattus norvegicus myocardin (Myocd), transcript variant 1, mRNA.
ACCESSION   NM_001414232 XM_006246582
VERSION     NM_001414232.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8567)
  AUTHORS   Dong,K., Shen,J., He,X., Hu,G., Wang,L., Osman,I., Bunting,K.M.,
            Dixon-Melvin,R., Zheng,Z., Xin,H., Xiang,M., Vazdarjanova,A.,
            Fulton,D.J.R. and Zhou,J.
  TITLE     CARMN Is an Evolutionarily Conserved Smooth Muscle Cell-Specific
            LncRNA That Maintains Contractile Phenotype by Binding Myocardin
  JOURNAL   Circulation 144 (23), 1856-1875 (2021)
   PUBMED   34694145
  REMARK    GeneRIF: CARMN Is an Evolutionarily Conserved Smooth Muscle
            Cell-Specific LncRNA That Maintains Contractile Phenotype by
            Binding Myocardin.
REFERENCE   2  (bases 1 to 8567)
  AUTHORS   Xia,X.D., Yu,X.H., Chen,L.Y., Xie,S.L., Feng,Y.G., Yang,R.Z.,
            Zhao,Z.W., Li,H., Wang,G. and Tang,C.K.
  TITLE     Myocardin suppression increases lipid retention and atherosclerosis
            via downregulation of ABCA1 in vascular smooth muscle cells
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1866 (4), 158824 (2021)
   PUBMED   33035679
REFERENCE   3  (bases 1 to 8567)
  AUTHORS   Shi,Z., Ren,M. and Rockey,D.C.
  TITLE     Myocardin and myocardin-related transcription factor-A
            synergistically mediate actin cytoskeletal-dependent inhibition of
            liver fibrogenesis
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 318 (3), G504-G517 (2020)
   PUBMED   31928221
  REMARK    GeneRIF: Myocardin and myocardin-related transcription factor-A
            (MRTF-A) are upregulated in activated hepatic stellate cells and
            are closely associated with robustly increased actin cytoskeleton
            remodeling.
            Erratum:[Am J Physiol Gastrointest Liver Physiol. 2020 Nov
            1;319(5):G637. PMID: 33141606]
REFERENCE   4  (bases 1 to 8567)
  AUTHORS   Houweling,A.C., Beaman,G.M., Postma,A.V., Gainous,T.B.,
            Lichtenbelt,K.D., Brancati,F., Lopes,F.M., van der Made,I.,
            Polstra,A.M., Robinson,M.L., Wright,K.D., Ellingford,J.M.,
            Jackson,A.R., Overwater,E., Genesio,R., Romano,S., Camerota,L.,
            D'Angelo,E., Meijers-Heijboer,E.J., Christoffels,V.M., McHugh,K.M.,
            Black,B.L., Newman,W.G., Woolf,A.S. and Creemers,E.E.
  TITLE     Loss-of-function variants in myocardin cause congenital megabladder
            in humans and mice
  JOURNAL   J Clin Invest 129 (12), 5374-5380 (2019)
   PUBMED   31513549
REFERENCE   5  (bases 1 to 8567)
  AUTHORS   Huang,C., Zhang,W. and Zhu,Y.
  TITLE     Drug-eluting stent specifically designed to target vascular smooth
            muscle cell phenotypic modulation attenuated restenosis through the
            YAP pathway
  JOURNAL   Am J Physiol Heart Circ Physiol 317 (3), H541-H551 (2019)
   PUBMED   31298560
REFERENCE   6  (bases 1 to 8567)
  AUTHORS   Yoshida,T., Sinha,S., Dandre,F., Wamhoff,B.R., Hoofnagle,M.H.,
            Kremer,B.E., Wang,D.Z., Olson,E.N. and Owens,G.K.
  TITLE     Myocardin is a key regulator of CArG-dependent transcription of
            multiple smooth muscle marker genes
  JOURNAL   Circ Res 92 (8), 856-864 (2003)
   PUBMED   12663482
REFERENCE   7  (bases 1 to 8567)
  AUTHORS   Du,K.L., Ip,H.S., Li,J., Chen,M., Dandre,F., Yu,W., Lu,M.M.,
            Owens,G.K. and Parmacek,M.S.
  TITLE     Myocardin is a critical serum response factor cofactor in the
            transcriptional program regulating smooth muscle cell
            differentiation
  JOURNAL   Mol Cell Biol 23 (7), 2425-2437 (2003)
   PUBMED   12640126
REFERENCE   8  (bases 1 to 8567)
  AUTHORS   Chen,J., Kitchen,C.M., Streb,J.W. and Miano,J.M.
  TITLE     Myocardin: a component of a molecular switch for smooth muscle
            differentiation
  JOURNAL   J Mol Cell Cardiol 34 (10), 1345-1356 (2002)
   PUBMED   12392995
  REMARK    GeneRIF: myocardin is an important component of a molecular switch
            for the SMC differentiation program
REFERENCE   9  (bases 1 to 8567)
  AUTHORS   Firulli,A.B.
  TITLE     Another hat for myocardin
  JOURNAL   J Mol Cell Cardiol 34 (10), 1293-1296 (2002)
   PUBMED   12392987
REFERENCE   10 (bases 1 to 8567)
  AUTHORS   Wang,D., Chang,P.S., Wang,Z., Sutherland,L., Richardson,J.A.,
            Small,E., Krieg,P.A. and Olson,E.N.
  TITLE     Activation of cardiac gene expression by myocardin, a
            transcriptional cofactor for serum response factor
  JOURNAL   Cell 105 (7), 851-862 (2001)
   PUBMED   11439182
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000220.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001414232.2.
            
            On Nov 16, 2022 this sequence version replaced XM_006246582.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5756307, SAMEA5760383
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-352               JACYVU010000220.1  6752189-6752540     c
            353-418             JACYVU010000220.1  6716707-6716772     c
            419-474             JACYVU010000220.1  6707109-6707164     c
            475-550             JACYVU010000220.1  6705441-6705516     c
            551-712             JACYVU010000220.1  6702283-6702444     c
            713-888             JACYVU010000220.1  6688140-6688315     c
            889-1014            JACYVU010000220.1  6684977-6685102     c
            1015-1304           JACYVU010000220.1  6681910-6682199     c
            1305-1458           JACYVU010000220.1  6680929-6681082     c
            1459-2355           JACYVU010000220.1  6674305-6675201     c
            2356-2499           JACYVU010000220.1  6672091-6672234     c
            2500-2628           JACYVU010000220.1  6670973-6671101     c
            2629-2686           JACYVU010000220.1  6668509-6668566     c
            2687-8567           JACYVU010000220.1  6658077-6663957     c
FEATURES             Location/Qualifiers
     source          1..8567
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..8567
                     /gene="Myocd"
                     /gene_synonym="Mycd"
                     /note="myocardin"
                     /db_xref="GeneID:246297"
                     /db_xref="RGD:631347"
     exon            1..352
                     /gene="Myocd"
                     /gene_synonym="Mycd"
                     /inference="alignment:Splign:2.1.0"
     CDS             298..3258
                     /gene="Myocd"
                     /gene_synonym="Mycd"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription factor myocardin"
                     /codon_start=1
                     /product="myocardin isoform 1"
                     /protein_id="NP_001401161.1"
                     /db_xref="GeneID:246297"
                     /db_xref="RGD:631347"
                     /translation="MTLLGSEHSLLIRRKFRSVLQLRLQQRRTQEQLANQGLIPPLKS
                     PTEFHDPRKKLDSAKTEDSLRRKVRNRSDRASLVNMHILQASTAERSIPTAQMKLKRA
                     RLADDLNEKIALRPGPLELVEKNILPMDSSVKEAIKGTEVSLSKAADAFAFEDDSSRD
                     GLSPDQARSEDPQGSGGSTPDIKSTEAPLAGPLDTIQDLTPGSESDKNDTASQLSNQS
                     DSGKQVLGPLSTPIPVHTAVKSKSLGDSKNRHKKPKDPKPKVKKLKYHQYIPPDQKAE
                     KSPPPMDSAYARLLQQQQLFLQLQILSQQQQQQQQQQQQQQQQQQQQRFSYPGMHQAH
                     LKEPNEQMTRNPNSSSTPLNNTPLSPVKNSLSGQTGVSSLKPGPLPPNLDDLKVSELR
                     QQLRIRGLPVSGTKTALVDRLRPFQDCAGNPVPNFGDITTVTFPVTPNTLPSYQSSPS
                     GFYHFGSTSSSPPISPASSDLSAAGSLPDTFTDASPGFGLHASPVPACTDESLLSSLN
                     GGSGPSEPDGLDSEKDKMLVEKQKVINQLTWKLRQEQRQVEELRMQLQKQKSGCNDQK
                     PLPFLATTIKQEDVSSCPFAAQQASGKGQGHSSDSPPPACETAQLLPHCVESSGQTHV
                     LSSTFLSPQCSPQHSPLGTLKSPQHISLPPSPNNHYFLASSSGAQRENHGVSSPNSSQ
                     GCAQNSGAHEGHPPSFSPPSSSLHQPFSGTQADSSHSSGLNPCPKSPVIHPKMTGLQS
                     SDKVGPTFSIPSPTFPKSSPTVPEITQPPSYEDAVKQQMTRSQQMDELLDVLIESGEM
                     PADAREDHSCLQKIPKIPGSSCSPTTILPKSSASFEQASSGGQISFDHYATDSEEHLE
                     VLLNSHSPIGKVSDVTLLKIGSEEPPFDGIMDGFPGKAAEDLFSAHELLPGPLSPMHT
                     QLSPPSVDSSGLQLSFTESPWETMEWLDLTPPSSTPGFSNLTSSGPSIFNIDFLDVTD
                     LNLNSPMDLHLQQW"
     exon            353..418
                     /gene="Myocd"
                     /gene_synonym="Mycd"
                     /inference="alignment:Splign:2.1.0"
     exon            419..474
                     /gene="Myocd"
                     /gene_synonym="Mycd"
                     /inference="alignment:Splign:2.1.0"
     exon            475..550
                     /gene="Myocd"
                     /gene_synonym="Mycd"
                     /inference="alignment:Splign:2.1.0"
     exon            551..712
                     /gene="Myocd"
                     /gene_synonym="Mycd"
                     /inference="alignment:Splign:2.1.0"
     exon            713..888
                     /gene="Myocd"
                     /gene_synonym="Mycd"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1014
                     /gene="Myocd"
                     /gene_synonym="Mycd"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1304
                     /gene="Myocd"
                     /gene_synonym="Mycd"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1458
                     /gene="Myocd"
                     /gene_synonym="Mycd"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..2355
                     /gene="Myocd"
                     /gene_synonym="Mycd"
                     /inference="alignment:Splign:2.1.0"
     exon            2356..2499
                     /gene="Myocd"
                     /gene_synonym="Mycd"
                     /inference="alignment:Splign:2.1.0"
     exon            2500..2628
                     /gene="Myocd"
                     /gene_synonym="Mycd"
                     /inference="alignment:Splign:2.1.0"
     exon            2629..2686
                     /gene="Myocd"
                     /gene_synonym="Mycd"
                     /inference="alignment:Splign:2.1.0"
     exon            2687..8567
                     /gene="Myocd"
                     /gene_synonym="Mycd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaccgctggc agcctatgac atcagtcagg aacgcctagg atgcggctgt tcctggccac
       61 cctcagagga ggagggtcct gcctgctggg agttaattag cctcgcaagc ggcgaggggg
      121 gaggcgccag ttttctgggg acactggcgg ccactgtgtg tcctcctgcc caagggagct
      181 ccccaagagt tggatgaatt ctgggtcgtt agctgctgtc ctctgggctc cctggagcca
      241 atttctggtg gaaagcgggg cgtctggcca gcgaccagcg gcttgctgag actcaccatg
      301 acactcctgg ggtctgaaca ctctttgctg attagaagga agttccgatc agtcttacag
      361 ttacggcttc aacagagaag gacccaggag cagctggcta accaaggctt aataccaccc
      421 ctgaaaagtc caactgagtt ccatgacccg aggaaaaaac tggatagtgc caagactgaa
      481 gactctctga ggcgcaaggt cagaaacaga tcggaccgtg ccagcctggt taatatgcac
      541 attctccaag cctccacggc agaaagatcc attccaactg ctcagatgaa gctgaagaga
      601 gcccgccttg cagatgacct caacgagaag attgctctcc gcccagggcc cttggaactg
      661 gtggagaaga acattctgcc tatggattct tccgtgaaag aggctataaa aggtactgag
      721 gtgagcctct ccaaagcagc agatgcattt gcctttgaag atgacagcag cagggatggg
      781 ctttccccag atcaggctcg gagcgaggat ccccagggct ctggaggatc aaccccagac
      841 atcaaatcca ctgaggctcc tctggctggc cctctggaca caatccagga tctcactcct
      901 ggctcagaaa gtgacaagaa cgatacagcc tcccagctga gcaaccagtc agactctggg
      961 aagcaggtgc ttggccctct cagcaccccg atccctgtgc acactgcggt aaagtccaag
     1021 tctttgggtg atagtaagaa ccgccacaaa aagcccaaag accccaaacc aaaggtgaag
     1081 aagctcaaat accaccagta catccccccg gaccagaagg cagagaaatc ccctcccccc
     1141 atggactctg cctatgctcg gctgcttcag caacagcagc tattcctgca gctacagatc
     1201 ctcagccagc agcaacagca gcagcaacag cagcaacagc agcagcagca acagcagcaa
     1261 cagcaacggt tcagctaccc tgggatgcac caagcacacc tcaaagagcc aaatgaacag
     1321 atgaccagaa atccgaattc ttcctcaaca ccactgaaca ataccccgct gtcccctgtc
     1381 aaaaatagcc tttctggaca aactggtgtt tcttctctca aaccaggccc ccttccacca
     1441 aacctggatg atctcaaggt gtcagagtta agacaacagc ttcgaatccg gggcttgcca
     1501 gtgtcgggca ccaagacagc actggtggac cggcttcgac ccttccagga ttgtgctggc
     1561 aaccctgtgc ccaactttgg ggacatcaca actgtcacct ttcctgtcac gcccaacacc
     1621 ttgcccagtt atcagtcctc cccatcaggc ttctaccact ttggcagcac aagctccagc
     1681 ccgcccatct cccccgcctc atctgacttg tctgctgcag ggtccctgcc agacaccttc
     1741 accgatgcgt cacctggctt cggcctgcat gcatcgccgg tgcccgcctg tacggatgag
     1801 agtctgctga gcagcctgaa tgggggctcg ggcccctccg agcctgacgg gctagactct
     1861 gagaaggaca agatgctggt agagaagcaa aaggtgatca accagctcac ctggaagctg
     1921 cggcaagagc agcggcaggt ggaggagctg agaatgcaac tgcagaagca gaagagcggc
     1981 tgcaatgacc agaagccact gcccttcttg gccaccacca tcaagcagga agatgtctct
     2041 agctgtccct tcgcagccca gcaggcatct gggaagggac agggccacag ctccgacagt
     2101 ccccctccgg cctgtgagac tgctcagctg ctgcctcact gtgtggagtc ctcaggtcaa
     2161 acccatgtac tctcctccac atttctcagc ccccagtgct cccctcagca ctcccccctg
     2221 gggaccctga agagcccgca acacatcagc ctgcccccat cgcctaacaa ccattacttc
     2281 ctggcttcct cctctggggc tcagagagag aaccatgggg tgtcttcacc caacagcagc
     2341 caagggtgtg cacagaactc aggggcacat gaaggtcatc ctcctagctt ctctccccca
     2401 tcttccagcc tccatcagcc tttctctggc acccaagcag acagcagtca cagttctggg
     2461 ctcaaccctt gtcccaaaag cccagttatt catccaaaga tgactggttt acaatcttct
     2521 gacaaggtgg ggccaacgtt ttcaattcca tccccaactt ttcctaagtc gagtccaaca
     2581 gttccggaga taacccagcc cccatcctac gaagatgcag tgaaacagca aatgactcgg
     2641 agtcagcaga tggatgaact cctggatgtc ctcattgaaa gtggagaaat gccagcggat
     2701 gccagggaag atcattcatg tcttcaaaaa atcccaaaga tacctgggtc ctcctgcagc
     2761 ccaaccacca tcctccccaa gtcctcggct tcctttgaac aggcatcttc gggaggccag
     2821 atctccttcg atcactatgc caccgacagt gaggaacacc tggaagtctt attgaattct
     2881 cacagcccca ttgggaaggt gagcgatgtt accctcctca aaatcggaag cgaggagcct
     2941 ccttttgatg ggatcatgga tggcttccca gggaaggctg cggaagatct cttcagtgct
     3001 catgagctct tgcctgggcc gctctcccct atgcatacac agttgtcacc tccttctgtg
     3061 gacagcagtg gtctgcagct gagcttcacg gaatctcctt gggaaacaat ggaatggctg
     3121 gacctcactc cacctagttc cacaccaggc ttcagcaacc tcacctccag cgggcccagc
     3181 attttcaaca tcgattttct ggatgtcacg gatctcaatt tgaattcccc tatggacctc
     3241 cacttacagc agtggtaaac acctgaggta caagtgttat gagagctcag taggaattcc
     3301 atgggggaga gcacacaacc agaaatgtgt gatccaaaag ataaagggga gaaaaatggg
     3361 gagaaaaaaa aacgggatgg aggtttctgt gacaatcaac cggaacagga gtcagtcatt
     3421 aaaatatgtg taatgtaata tcaataactg ttaataactt cggtgatgca ttcgaaatgt
     3481 gccttgttgg agtaagagtg ccaaagatgt ctttttcacc gccttagctc ataccagtac
     3541 ctttttagcc cacagtctgt ctcaggcatt actgggacgt aagttcacac tatatagtct
     3601 gtctcaggca ttatcgggac atagactgac accattagct tttgttatga atttactaaa
     3661 ctttctgtgc aaggagaaca aatcctcctc aaggagcaca gggaagtccc tcaactattc
     3721 cggaagccat cctatgcctg aggcaacccc atcccgcccc ctccccacac acctgtgtgt
     3781 ccttctaact ttcagaagag cagggcctat ttcagccaat agagttctta aggcagaata
     3841 atcagaatgg tcagagggac agaccaatca attcccagga gagcaactca gtgtccctca
     3901 acccccgaat ggtcccactg gactggcgat cactggcgac aactaactag cattatccag
     3961 aaatccaccc agaacacggt gctttttagc cagtagacca gttttttttt ttctgctacc
     4021 tctatgctca tcagtgatgc atagcaggtg agaaacttga atcacaacaa cttcatgctg
     4081 tggatggaga ctcctgaggc tctcaaatgc taccacctct agttccatag accagagata
     4141 gatgatcaga aaggcaactg gaggcccagg gagccgtact gggacaagta gaattggaga
     4201 aaatgccatt taacattccg ggaaagaaat accatggatt gctattacat gagcaacaca
     4261 cagggccaac ttccttttct tcttctttat ctttcttttc ttattgtaga cagagggaat
     4321 tcacctcagt ttattttcct ctcagtactt ttatttcaag atattaattc tttatgattc
     4381 ttttgctttt gattctctct ctctctctct ctctctctct ctctctctct ctcttactct
     4441 ccctctcttg gaaaggagag gtttcagctc taacaagcta ccgtattcct attaaagcca
     4501 cttttttaga acattaaagt ccaaactctc ttgctaaact cgttcttcac atgcacattg
     4561 actgcaaaca gaattcataa gaattccctt aggaagaaac tggggaagtg gcccattggt
     4621 cacaaagttc tttttttttt ttaactcttg tttgatttaa ggataatctt tggtttgtgt
     4681 tactctggag acattggaaa tcattagaga gtgaagataa atcagggggc catgtaaagt
     4741 agagaatgtg tcagtcagtt ttccaaatga gagcacaatt gcacaccata aacaacatga
     4801 gagtgaagga tcagagtctt ggggagtttt tcttgttgcc ctgtgtttgg tcagggcact
     4861 ggggactgag gaagacaaca cagattgccc gagtctctca gaggctactg tggcaccaat
     4921 tcaagtatta caatgttgca tgctgtagaa agtagctgtt gctgtttttt gttttgtttt
     4981 gtttcgtttt gttttaattt aagtcaccaa ggcactgttt tattcttttg taaaaaaaat
     5041 tcactgtgca cttatagaga aaataatcaa caatgttgtg aatttttgag aagttgtctt
     5101 ttttgataaa ccaaagattt agaaatcatt ccattgtcaa cttgtaaaaa aaaaaaaagt
     5161 ttgatcactg agtgtttttt ggtgactgct actctggaag ccaccagatc ttattgtagg
     5221 gaaggaaaca cagatatgca cacatatgta gttctatgcc tgtgtgtatg gggtatgtgt
     5281 atgcatacat gcacatgtgt atacaactgt gtgtgtgcac gcatatctga aaggtggcat
     5341 tcagagggcc tcaaaccctc agtccgctgt gaatgatgtg tggcctttct cactataagt
     5401 tgctgattga tcaacaagac tccacgttgc ctctctgtat gtgactaaag actccaaccc
     5461 aatgcccata gccacttgct gcaagtgaac aagctcctcc tggcaatgaa tatggatttg
     5521 agaggatcaa gcctggcagt gaattcggac acgataggac agagtggctt catcatcagt
     5581 agctgctaag gctagtgcct tctcttacag aagagtctaa agggagcacg aaacttgttc
     5641 tgacattcct tgatctgcaa tgcgcttgaa agggtctgcg tgataaactt ctcattgtgt
     5701 ttgttgcaac cggaaccaca gatccagagg caaagcttag catgaagatg aagctggggg
     5761 aaggaacctt attaccacat tccaaacatt gccctccgag gctgatgttt catttgagtc
     5821 tggatgaagc ttcctgctct tttttaggct ttggatgaac catgtatgct attccctcct
     5881 tgcttctttg gaaaacaaat ccatacagtg tcctgcctcc gagaccctca tctgagtgct
     5941 aataattttc cctttgggaa ttcctgtcag ggcgattggt tagacagctc tgtttttttt
     6001 ttttttccag ctagactgtg gggaactttt aaaaatagta ttcaaactga tacacacact
     6061 tcacactaga cgaaagggaa gatggctctg gtttgctagt gcaagccaat acagctagaa
     6121 tgggtccctg gattcttacc tcagtctgtt cctacggtct ccctaggcca tgtgtatgtg
     6181 tcctgtcttc atagcatagg taggagatgg gagataactg agaagattga tgaagacaga
     6241 tcaaatacgt ttcctcagct gtctcctact acagttttta agttctttta atcggtcttg
     6301 tggcaatgtg agctaagagg tgtgcagaga tgatcaccct tgggtttagc aatgttccta
     6361 gaacctcaaa tgaccacata gttagaggtc tgtaatattc ccatattaag gacagtcttg
     6421 gcagccattc ctattgtagt agctacaaga taacaggtcc ttctttatct aaaggtttcc
     6481 aaattctccc tatgcaagtt cttccagtaa actagggttt ggtaattatg cctgtgttct
     6541 aacagtgcta tcaagataat gggatggggg gatggcgaag tgaaggagaa aggaggaaaa
     6601 ggagggagag gaaaagaggg agtaagaaga tggggaggag aggaagaggg gccagaggaa
     6661 ggaaagaagg aaggaagggc gggagggaag aaatgagcga gagaaggaga aagggaggag
     6721 gcagggaagc aaaggtagga acagagaaaa ccatggccca acttcttgac ccaggaacct
     6781 cttggttcag ctatgatgtc atagtataac aagtgaaacc caagcatgga gacagcagct
     6841 ttccgagtga ttcccccccc cccccccccc cccgttaaca ggaatatcaa cacaccctct
     6901 atctggacag tccgaggctc taagcctgca gccttgtgcc tttcacaaac attagccggg
     6961 gacaacggtg actaaaacct actcccaagg ttttaaaata gttcttctta aaagttattt
     7021 atttcatatt caatcagctt tcctagagcc agtaaggctg tgaactccca catgacctgt
     7081 actgtctagg aggaggtggc cacttgctgc tccagagcac acagaccttt aggggttgat
     7141 ccagcatgga cattgactat ctgagggaat cactgctcct ctaagcaagg atgctgagag
     7201 cctctgagac cctccctgcc ctttgcactc aaatcctctg agcaatgatg aagggctcct
     7261 gatttttcca gaaatgggag tttttggttt tgctttctct ctctcctttt tcatgtaaaa
     7321 ctatcagcac acaagcttgt ctcttctcct aggctcacag aactgtctgc ctcttgttca
     7381 ttatttaaca ttcaggggag ttttggagtt ttttttaacc agacagagaa gccctttgga
     7441 aataaggaaa gttgtaaact tttttttcct gatcctaaat caccacagta agacatctgg
     7501 gcaaaaggga cagaagtgaa gcgggaggtg aatatccatg atgagtttct cttctttaag
     7561 agaaaagtat gcttctcccc agcccctcgc tgcatttccc acataaagtg tgctagggca
     7621 caatttgctg tcagatataa agaaaattag agtcccgaat agtctaacac aaacctgcag
     7681 ggaggttcag aggcaaatac ttccgagact tctctagaca gaggacaaca acagacatga
     7741 agagtcaggg tcctggaaaa agatggtccc atagtgatga gagcatgttc aggtgtgccc
     7801 ggaggtcctc actaggtgag gacaatctgt aaagaattgg tttcaagaca ggaaggaatc
     7861 caagaaggcc tttgtggctg tctgccaggg atattgttct aggatccact aaatccaata
     7921 agcatgagtg tactcccttc tgatcataag gaatcaatgg tactcccaca atcaaccccc
     7981 tgcagggcta accactgggt accatgatgg gcaccaggag gctgtgcttc ctctggatgg
     8041 tttagatggc ctcatgtgca aagaagcaca gtaaggagac ccacgaatgc tctttaaatg
     8101 ttttccaaag gagcaagact cacactgctc ccaaggctca gttccaatga ccttgtcaaa
     8161 aggaccaagg gcaaaggatt gctgggaaat caactctcgt tggaacacaa agcagtgttc
     8221 tggaaagatc aagacatcaa gcatggttct tccggcctct gtgtggtggt gttttcatat
     8281 tggtctcctt tgctcggtgt aatctgagag aaatgtggct cactgggaga gcaaagaagc
     8341 aatggctaaa ataccaaagt tggcatgtgt ccttttttaa agaaaaatgc atatattttt
     8401 aaataaaatg tttattttaa agagatgtaa acattttttt gaccagataa tgacgatgcc
     8461 tggctgtgat gttctttatg tgtattgctt cctgttctcc tctcagcagc tgaagaaggg
     8521 gtaccactgt gatccccatc ttccagataa agaaactgag gccaaga
//
