LOCUS       NM_030865               2052 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus myocilin (Myoc), mRNA.
ACCESSION   NM_030865 XM_346449
VERSION     NM_030865.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2052)
  AUTHORS   Milewska,M., Domoradzki,T., Majewska,A., Blaszczyk,M., Gajewska,M.,
            Hulanicka,M., Ciecierska,A. and Grzelkowska-Kowalczyk,K.
  TITLE     Interleukin-8 enhances myocilin expression, Akt-FoxO3 signaling and
            myogenic differentiation in rat skeletal muscle cells
  JOURNAL   J Cell Physiol 234 (11), 19675-19690 (2019)
   PUBMED   30945300
  REMARK    GeneRIF: IL-8 increased myocilin expression, Akt phosphorylation,
            FoxO3 dispersion throughout the cytoplasm, and reduced FoxO3 level.
            IL-8 decreased the expression of atrogin and MuRF1 and increased
            myotube length and diameter.
REFERENCE   2  (bases 1 to 2052)
  AUTHORS   Waryah,A.M., Narsani,A.K., Sheikh,S.A., Shaikh,H. and Shahani,M.Y.
  TITLE     The novel heterozygous Thr377Arg MYOC mutation causes severe
            Juvenile Open Angle Glaucoma in a large Pakistani family
  JOURNAL   Gene 528 (2), 356-359 (2013)
   PUBMED   23886590
REFERENCE   3  (bases 1 to 2052)
  AUTHORS   Anholt,R.R. and Carbone,M.A.
  TITLE     A molecular mechanism for glaucoma: endoplasmic reticulum stress
            and the unfolded protein response
  JOURNAL   Trends Mol Med 19 (10), 586-593 (2013)
   PUBMED   23876925
  REMARK    Review article
REFERENCE   4  (bases 1 to 2052)
  AUTHORS   Kwon,H.S., Johnson,T.V., Joe,M.K., Abu-Asab,M., Zhang,J., Chan,C.C.
            and Tomarev,S.I.
  TITLE     Myocilin mediates myelination in the peripheral nervous system
            through ErbB2/3 signaling
  JOURNAL   J Biol Chem 288 (37), 26357-26371 (2013)
   PUBMED   23897819
REFERENCE   5  (bases 1 to 2052)
  AUTHORS   Kwon,H.S., Johnson,T.V. and Tomarev,S.I.
  TITLE     Myocilin stimulates osteogenic differentiation of mesenchymal stem
            cells through mitogen-activated protein kinase signaling
  JOURNAL   J Biol Chem 288 (23), 16882-16894 (2013)
   PUBMED   23629661
  REMARK    GeneRIF: Myocilin also stimulated osteogenic differentiation of
            wild-type MSCs, which was associated with activation of the p38,
            Erk1/2, and JNK MAP kinase signaling pathways
REFERENCE   6  (bases 1 to 2052)
  AUTHORS   Taguchi,M., Kanno,H., Kubota,R., Miwa,S., Shishiba,Y. and Ozawa,Y.
  TITLE     Molecular cloning and expression profile of rat myocilin
  JOURNAL   Mol Genet Metab 70 (1), 75-80 (2000)
   PUBMED   10833334
REFERENCE   7  (bases 1 to 2052)
  AUTHORS   Fingert,J.H., Heon,E., Liebmann,J.M., Yamamoto,T., Craig,J.E.,
            Rait,J., Kawase,K., Hoh,S.T., Buys,Y.M., Dickinson,J., Hockey,R.R.,
            Williams-Lyn,D., Trope,G., Kitazawa,Y., Ritch,R., Mackey,D.A.,
            Alward,W.L., Sheffield,V.C. and Stone,E.M.
  TITLE     Analysis of myocilin mutations in 1703 glaucoma patients from five
            different populations
  JOURNAL   Hum Mol Genet 8 (5), 899-905 (1999)
   PUBMED   10196380
REFERENCE   8  (bases 1 to 2052)
  AUTHORS   Wiggs,J.L., Allingham,R.R., Vollrath,D., Jones,K.H., De La Paz,M.,
            Kern,J., Patterson,K., Babb,V.L., Del Bono,E.A., Broomer,B.W.,
            Pericak-Vance,M.A. and Haines,J.L.
  TITLE     Prevalence of mutations in TIGR/Myocilin in patients with adult and
            juvenile primary open-angle glaucoma
  JOURNAL   Am J Hum Genet 63 (5), 1549-1552 (1998)
   PUBMED   9792882
REFERENCE   9  (bases 1 to 2052)
  AUTHORS   Alward,W.L., Fingert,J.H., Coote,M.A., Johnson,A.T., Lerner,S.F.,
            Junqua,D., Durcan,F.J., McCartney,P.J., Mackey,D.A., Sheffield,V.C.
            and Stone,E.M.
  TITLE     Clinical features associated with mutations in the chromosome 1
            open-angle glaucoma gene (GLC1A)
  JOURNAL   N Engl J Med 338 (15), 1022-1027 (1998)
   PUBMED   9535666
REFERENCE   10 (bases 1 to 2052)
  AUTHORS   Stone,E.M., Fingert,J.H., Alward,W.L., Nguyen,T.D., Polansky,J.R.,
            Sunden,S.L., Nishimura,D., Clark,A.F., Nystuen,A., Nichols,B.E.,
            Mackey,D.A., Ritch,R., Kalenak,J.W., Craven,E.R. and Sheffield,V.C.
  TITLE     Identification of a gene that causes primary open angle glaucoma
  JOURNAL   Science 275 (5300), 668-670 (1997)
   PUBMED   9005853
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Nov 26, 2020 this sequence version replaced NM_030865.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF093567.1, AB019393.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-676               JAXUCZ010000013.1  77509963-77510638
            677-799             JAXUCZ010000013.1  77517633-77517755
            800-2052            JAXUCZ010000013.1  77519109-77520361
FEATURES             Location/Qualifiers
     source          1..2052
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q22"
     gene            1..2052
                     /gene="Myoc"
                     /gene_synonym="Tigr"
                     /note="myocilin"
                     /db_xref="GeneID:81523"
                     /db_xref="RGD:620430"
     exon            1..676
                     /gene="Myoc"
                     /gene_synonym="Tigr"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1584
                     /gene="Myoc"
                     /gene_synonym="Tigr"
                     /note="trabecular meshwork-induced glucocorticoid response
                     protein; myocilin, trabecular meshwork inducible
                     glucocorticoid response"
                     /codon_start=1
                     /product="myocilin precursor"
                     /protein_id="NP_110492.2"
                     /db_xref="GeneID:81523"
                     /db_xref="RGD:620430"
                     /translation="MPSCAYCCSCGPKMPALQLLFLACLVWGMGARTAQFRKANDRSG
                     RCQYTFTVASPSESSCPREDQAMSAIQDLQRDSSIQHADLESTKARVRSLESLLHQMT
                     SGGVTGTQEVQEGLQGQLGALRRERDQLETQTRDLEVAYNNLLRDKSALEEEKRQLEQ
                     ENKDLARRLEGSSQEVARLRRGQCPSTHHPSQDMLPGSREVSQWNLDTLAFQELKSEL
                     TEVPASQILKNQSGHPRSKEGDKGCGVLMWVGEPVTLRTAETITGKYGVWMRDPKPTH
                     PYTQETTWRIDTVGTGIRQVFEYSQISQFEQGYPSKVHVLPQALESTGAVVYAGSLYF
                     QGAESRTVLRYELNTETVKAEKEIPGAGYHGQFPYAWGGYTDIDLAVDESGLWVIYST
                     EENRGAIVLSKLNPENLELESTWETNIRKQSVANAFVICGILYTVSSYSSVHATINFA
                     YDTNTGISKTLTIPFKNRYKYSSMVDYNPLERKLFAWDNFNMVTYDIKLSEM"
     exon            677..799
                     /gene="Myoc"
                     /gene_synonym="Tigr"
                     /inference="alignment:Splign:2.1.0"
     exon            800..2052
                     /gene="Myoc"
                     /gene_synonym="Tigr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagccagcag ggccacccat ccagacacct tgcagcagag ccttctagaa gaagcctcac
       61 ccagccttca taccgatgcc ctcctgtgca tactgctgca gctgcggtcc caagatgcca
      121 gctctccagc tgctgtttct ggcctgcctg gtatggggaa tgggggccag gacagcacag
      181 ttccgaaagg ccaacgatcg gagtggtcga tgccagtaca ccttcactgt ggccagcccc
      241 agtgaatcta gctgcccaag ggaggaccag gccatgtcag ccatccagga ccttcagaga
      301 gatagcagca tccagcatgc agacctagag tccaccaagg cccgggtcag atccctggag
      361 agtctcctcc accagatgac ctcaggcgga gttactggga cccaggaggt ccaggagggg
      421 ctacaaggcc agctgggtgc cctgaggaga gagcgggacc agctggagac ccaaaccagg
      481 gatctggagg tagcctataa caatctcctg agagacaaat cagctttgga ggaagagaag
      541 aggcagctgg aacaagagaa taaagatttg gccaggaggc tagaaggcag cagccaggag
      601 gtagcaaggc tgaggagagg ccagtgtccc tcaacccacc acccctctca ggacatgttg
      661 ccaggctcca gggaagtctc tcagtggaat ttggacacgt tggctttcca ggaactgaag
      721 tcagaactaa cagaggttcc tgcttcccaa atcttgaaga atcaatctgg tcatcccagg
      781 agcaaagagg gagacaaagg atgtggagtg ctaatgtggg taggagagcc agtcaccctg
      841 aggacagctg agacaatcac tggaaagtat ggagtatgga tgagagaccc caagcccact
      901 cacccctaca cccaggagac cacttggagg attgacacgg ttggcacagg catccgccag
      961 gtgtttgagt acagtcagat aagccagttc gagcagggct atccttcaaa ggtccatgtg
     1021 ctcccccagg cactggaaag cacaggtgct gtggtgtatg cagggagcct gtatttccag
     1081 ggtgctgagt ccagaactgt gctcaggtat gaactgaaca cagaaacagt gaaggcagag
     1141 aaggaaattc ctggagctgg ctaccatgga cagttcccat acgcatgggg tggctacaca
     1201 gacatagact tagctgtgga tgagagtggc ctctgggtca tctatagcac agaggaaaac
     1261 agaggagcca tagtcctctc caaattgaac ccagagaacc tggaacttga gagtacctgg
     1321 gagaccaaca tccgtaagca gtctgtggct aatgcctttg ttatctgtgg catcttgtac
     1381 acggtgagca gctactcttc agtccatgca accatcaact ttgcctatga cactaacact
     1441 gggatcagca agaccctgac catcccattc aagaatcgct acaaatacag cagcatggtc
     1501 gactacaacc ccctggagag gaaactcttt gcctgggaca acttcaacat ggtcacctat
     1561 gatatcaagc tctcagagat gtgaggagcc tctatcccta ccagagaagg cagaaaaagg
     1621 gggaagttcc aggctcccag gtgaagcagc tgcaagagga ggcagccaga tgctgggggc
     1681 ttctgcttct caagattttg tttgtccagg tcaatacctc ggggcttgta cagttgcata
     1741 tattctgctc tcttctgtca gctttcaaag gggtgttcat cttttaaaaa tcatatagtg
     1801 tagcagtcca gagaaaaact agaagtgttg tttcctcatg aaaccattgc ttttgcaagc
     1861 tgtatggtta ctacaaacct tgagaggcag caacagttct accaagagga gggagataac
     1921 ggggaggggg tgaccaccac tcctgtggtt agaactgctc ctgcagtatt tactccagtt
     1981 tctaaggcta cagatatagc atgtacatta aaccctttgc cctgtgaaat aaagttatct
     2041 tacacgacgt ta
//
