LOCUS       NM_134335              12148 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus myosin IXA (Myo9a), mRNA.
ACCESSION   NM_134335
VERSION     NM_134335.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 12148)
  AUTHORS   O'Connor,E., Topf,A., Muller,J.S., Cox,D., Evangelista,T.,
            Colomer,J., Abicht,A., Senderek,J., Hasselmann,O., Yaramis,A.,
            Laval,S.H. and Lochmuller,H.
  TITLE     Identification of mutations in the MYO9A gene in patients with
            congenital myasthenic syndrome
  JOURNAL   Brain 139 (Pt 8), 2143-2153 (2016)
   PUBMED   27259756
REFERENCE   2  (bases 1 to 12148)
  AUTHORS   Folci,A., Murru,L., Vezzoli,E., Ponzoni,L., Gerosa,L., Moretto,E.,
            Longo,F., Zapata,J., Braida,D., Pistillo,F., Bahler,M.,
            Francolini,M., Sala,M. and Bassani,S.
  TITLE     Myosin IXa Binds AMPAR and Regulates Synaptic Structure, LTP, and
            Cognitive Function
  JOURNAL   Front Mol Neurosci 9, 1 (2016)
   PUBMED   26834556
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 12148)
  AUTHORS   Elbediwy,A., Zihni,C., Terry,S.J., Clark,P., Matter,K. and
            Balda,M.S.
  TITLE     Epithelial junction formation requires confinement of Cdc42
            activity by a novel SH3BP1 complex
  JOURNAL   J Cell Biol 198 (4), 677-693 (2012)
   PUBMED   22891260
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 10, 2021 this sequence version replaced NM_134335.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ001713.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-332               JAXUCZ010000008.1  69045014-69045345
            333-1243            JAXUCZ010000008.1  69083452-69084362
            1244-1338           JAXUCZ010000008.1  69087396-69087490
            1339-1401           JAXUCZ010000008.1  69091544-69091606
            1402-1501           JAXUCZ010000008.1  69095507-69095606
            1502-1558           JAXUCZ010000008.1  69097153-69097209
            1559-1656           JAXUCZ010000008.1  69107627-69107724
            1657-1783           JAXUCZ010000008.1  69110118-69110244
            1784-1873           JAXUCZ010000008.1  69114222-69114311
            1874-1990           JAXUCZ010000008.1  69116801-69116917
            1991-2125           JAXUCZ010000008.1  69120932-69121066
            2126-2247           JAXUCZ010000008.1  69130569-69130690
            2248-2389           JAXUCZ010000008.1  69142152-69142293
            2390-2585           JAXUCZ010000008.1  69148059-69148254
            2586-2705           JAXUCZ010000008.1  69152840-69152959
            2706-2781           JAXUCZ010000008.1  69157544-69157619
            2782-2928           JAXUCZ010000008.1  69163036-69163182
            2929-2968           JAXUCZ010000008.1  69164460-69164499
            2969-3091           JAXUCZ010000008.1  69167649-69167771
            3092-3172           JAXUCZ010000008.1  69168969-69169049
            3173-3283           JAXUCZ010000008.1  69172009-69172119
            3284-3406           JAXUCZ010000008.1  69173452-69173574
            3407-3556           JAXUCZ010000008.1  69175807-69175956
            3557-3876           JAXUCZ010000008.1  69178283-69178602
            3877-5457           JAXUCZ010000008.1  69179251-69180831
            5458-5539           JAXUCZ010000008.1  69183282-69183363
            5540-5752           JAXUCZ010000008.1  69183870-69184082
            5753-5865           JAXUCZ010000008.1  69195015-69195127
            5866-6008           JAXUCZ010000008.1  69202476-69202618
            6009-6232           JAXUCZ010000008.1  69207541-69207764
            6233-6349           JAXUCZ010000008.1  69208190-69208306
            6350-6538           JAXUCZ010000008.1  69208626-69208814
            6539-6586           JAXUCZ010000008.1  69209673-69209720
            6587-6698           JAXUCZ010000008.1  69214269-69214380
            6699-6760           JAXUCZ010000008.1  69216827-69216888
            6761-6953           JAXUCZ010000008.1  69226519-69226711
            6954-7082           JAXUCZ010000008.1  69228006-69228134
            7083-7188           JAXUCZ010000008.1  69228440-69228545
            7189-7320           JAXUCZ010000008.1  69229659-69229790
            7321-7444           JAXUCZ010000008.1  69230640-69230763
            7445-7498           JAXUCZ010000008.1  69232539-69232592
            7499-7701           JAXUCZ010000008.1  69241484-69241686
            7702-7823           JAXUCZ010000008.1  69243069-69243190
            7824-12148          JAXUCZ010000008.1  69243770-69248094
FEATURES             Location/Qualifiers
     source          1..12148
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..12148
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /note="myosin IXA"
                     /db_xref="GeneID:171296"
                     /db_xref="RGD:621395"
     exon            1..332
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
     exon            333..1243
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
     CDS             404..8284
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /note="myosin-IXa; unconventional myosin-9a"
                     /codon_start=1
                     /product="unconventional myosin-IXa"
                     /protein_id="NP_599162.2"
                     /db_xref="GeneID:171296"
                     /db_xref="RGD:621395"
                     /translation="MNVSDGGRRRFEDNEHTLRIYPGTISEGTIYCPIPARKNSTAAE
                     VIDSLINRLHLDKTKCYVLAEVKEFGGEEWILNPTDCPVQRMMLWPRMALENRLSGED
                     YRFLLREKNLDGSIHYGSLQSWLRVTEERRRMMERGFLPQPQQKDFDDLCSLPDLNEK
                     TLLENLRNRFKHEKIYTYVGSILIAINPFKFLPIYNPKYVKMYDNHQLGKLEPHIYAV
                     ADVAYHAMLQRKKNQCIVISGESGSGKTQSTNFLIHHLTALSQKGFASGVEQIILGAG
                     PVLEAFGNAKTAHNNNSSRFGKFIQVNYQETGTVLGAYVEKYLLEKSRLVYQEHNERN
                     YHVFYYLLAGASEEERLAFHLKQPEEYHFLNQITKKPLRQSWDDYCYDSEPDCFTVEG
                     EDLRHDFERLQLAMEMVGFLPKTRRQIFSLLSAILHLGNISYKKKTYRDDSIDICNPE
                     VLPIVSELLEVKEEMLFEALVTRKTVTVGEKLILPYKLAEAVTVRNSMAKSLYSALFD
                     WIVFRINHALLNSKDLEKDTKTLSIGVLDIFGFEDYENNSFEQFCINFANERLQHYFN
                     QHIFKLEQEEYRTEGISWHNIDYIDNTCCINLISKKPTGLLHLLDEESNFPQATNQTL
                     LDKFKHQHEENSYIEFPAVMEPAFIIKHYAGKVKYGVKDFREKNTDHMRPDIVALLRS
                     SRNAFVSGMTGIDPVAVFRWAVLRAFFRAVVAFREAGKRHIQRKSGHDDTTPCTILKS
                     MDSFSFLQHPVHQRSLEILQRCKEEKYSITRKNPRTPLSDLQGMNTLNEKNQHDTFDI
                     AWNVRTGIRQSRLPTNNTSLLDKDGIFANSASSKLLERAHGILTRNKNFRSKPVLPKH
                     LLEVNSLKHLTRLTLQDRITKSLLHLHKKKKPPSISAQFQVSLSKLMETLDQAEPYFV
                     KCIRSNAEKLPLRFSDALVLRQLRYTGMLETVRIRQSGYSSKYSFQDFVSHFHVLLPQ
                     HIIPSKFNIQDFFRKININPDNYQVGKTMVFLKEHERQHLQDLLHQEVLRRIILLQRW
                     FRVLLSRQQFLHLRQASVIIQRFWRNYLNQKQVRNAAVEKDAFIMASAASLLQASWRA
                     HLERQRYLELRAAAVIIQQRWRELCRRRHRAATCIQSRWRGYRQSKKYKEQRNKIILL
                     QSIYRGFRARQRYKALKEERLKETKLEHGLAQIKTCGPLEIQGSDPSEWEDRSFANRV
                     KAIEECKSVIESNRISRESSMDFSKESPDKQQERGRSQSGTDLQGDVIVRQRPKSLED
                     LHQKKVGRAKRESRRMRELEQAIFSLELLKVRSLGGMSPSEERRWSTELMPEGLQSPQ
                     GTPDSESSQGSLELLTCDENQKSKPESLILDDGELKISSPSTFTNPKFDSQNNALSAS
                     SETSSTFSGKGASSDSEHLKNGTAEEKLVYSSQPITCKSQLRDSFVSSSLPTFFYIPH
                     QEPLKTSSQLDTSIQRNKLPERETTLKTTLTLDINREARKCQFSGQVTPLNPDSSCTV
                     LKKLEKLNIEKEKRQKQLQQQNEKEMMEQIRQQTDILEKERKAFKTIEQSRTEASLLA
                     PSFYQSRQKVERPSSLHIQNTPSKGEAGVLGSPSALATKDSPSIHLPPKDRPVTLFFE
                     RKGSPCQSRTVKELTKTERMGTQHDAACRLSNNRNTEREHFKSTHSYSHRSDDPSREG
                     SSRPIFFTPKDNVITPLVHSGNPQVHKQDEPAWKSKLAGPGQREVARPAHKKKARMAR
                     TRSDFLTRGTFADGEGDTEEDDYDDIIEPLLSLDQASHSELGPVSSLGQASHSDSEMT
                     SQRFSSVDEQARLHKAMSQGEITKLAGRQKSSDLDIRPQRAKMRFWAKGKQGEKKTTR
                     VKPAPQSEVSSLFAGSDVTPVHPFSDELTQYHPTPPLSPELPGSCRKEFKENKEPSPK
                     AKRKRGVKISSVALDSMHWQNDSVQIIASANDLKSMDEFLLKKMNDLDNEDSKKDTLV
                     DVVFKKALKEFRQNIFSSYSSALAMDDGKSIRYKDLYALFEQILEKTMRFEQRDWNES
                     PVRVWVNTFKVFLDEYMNEFKTLDSTAPKVLKTERKKRRKKETDLVEEHNGHMFKATQ
                     YSIPTYCEYCSSLIWIMDRASVCKLCKYACHKKCCLKTTAKCSKKYDPELSSRQFGVE
                     LSRLTSEDRAVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDAESVNL
                     DDYNIHVIASVFKQWLRDLPNPLMTFELYEEFLRAMGLQERKETIRGVYSVIDQLSRT
                     HLSTLERLIFHLVRIALQEDTNRMSANALAIVFAPCILRCPDTTDPLQSVQDISKTTT
                     CVELIVVEQMNKYKARLKDISSLEFAENKAKTRLSLIRRSMKPVLIAVRFMSITRSSV
                     SGKGRLHRGSHPNPSSPVIVRLPSMSDVPEETLTSETAMDTDVTDQQQAAMQQEEKVL
                     TEQIENLQKEKEELTFEMLVLEPRASDDEALESEASIGTADSLENLNMDPEERSLALS
                     SLKAAGKSEPSSKFRKQLRKQPDSLDSVSSSVSSCLSNTTSSHGTRKRFQIYSKSPFY
                     RAASACEAQGMEGPLGQAKSLEDRPQFISRGTFNPEKGKQKLKNVKNSPQKTKETPEG
                     TVSSGRKKTVDSDCSSTQQLPLFGNNEFMV"
     exon            1244..1338
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1401
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1501
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1558
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1656
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1783
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1873
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..1990
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2125
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2247
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..2389
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2585
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
     exon            2586..2705
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
     exon            2706..2781
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
     exon            2782..2928
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
     exon            2929..2968
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
     exon            2969..3091
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
     exon            3092..3172
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
     exon            3173..3283
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
     exon            3284..3406
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
     exon            3407..3556
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
     exon            3557..3876
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
     exon            3877..5457
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
     exon            5458..5539
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
     exon            5540..5752
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
     exon            5753..5865
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
     exon            5866..6008
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
     exon            6009..6232
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
     exon            6233..6349
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
     exon            6350..6538
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
     exon            6539..6586
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
     exon            6587..6698
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
     exon            6699..6760
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
     exon            6761..6953
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
     exon            6954..7082
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
     exon            7083..7188
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
     exon            7189..7320
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
     exon            7321..7444
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
     exon            7445..7498
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
     exon            7499..7701
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
     exon            7702..7823
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
     exon            7824..12148
                     /gene="Myo9a"
                     /gene_synonym="myr 7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcaggacag ggagggactg cggcggagat acgggtccca cgggcaagag cagagaccgc
       61 gatttaggcg gccgttccaa cgcgtgctct ctgggcgggg tgcggcgggg gatgtgccta
      121 cccaggccgg gcggagtctc tctgacaggg cgggggatgc gcggccgccg ctctctcgga
      181 ccctgaggcg gctgggccca ccctcgagga accatcctac ccccggcggc cttggcctct
      241 gctttctccg gcctgaccct ggaaaccgag gcggggaagc ggataccgcc gaagaggaag
      301 gggctgtggt ggccaccgcg gcgcagccag agttcttttg ccaagaaaat ggtttgccca
      361 gtcctgaaca catactgtcc tttctgatgg gacaagatcc aatatgaatg taagtgatgg
      421 aggaagacga cgctttgagg ataatgaaca cacattgcga atatatcctg ggacaatttc
      481 agaaggaaca atttactgtc caattcctgc cagaaaaaac tccacagctg ctgaggtgat
      541 tgactccctt ataaacagac ttcacctaga caagacaaaa tgctacgttt tagcagaggt
      601 aaaggaattt ggtggagaag aatggattct caatccaacc gactgtccag ttcagcgaat
      661 gatgctgtgg ccccgaatgg ctttggaaaa tcgcctaagt ggggaggact atcgctttct
      721 tctgagagaa aaaaacctcg atggatcaat tcattatggt agcctccagt catggctacg
      781 ggtaaccgaa gaacgccgaa ggatgatgga gcggggtttt cttccacagc ctcaacagaa
      841 agactttgat gatttatgta gcttgcctga tttgaatgag aaaactctct tagaaaacct
      901 acggaatcgc tttaagcatg aaaaaattta tacttatgtt ggcagtattc taatagctat
      961 taatccattc aaatttcttc ctatttataa ccccaaatat gtcaaaatgt atgataacca
     1021 ccagctggga aaacttgaac cccacatata tgctgtggcg gatgttgctt atcatgccat
     1081 gcttcagcgc aaaaagaatc agtgtattgt gatttcagga gagagtggtt ctgggaagac
     1141 tcaaagcaca aactttctta ttcatcacct tactgccctc agccagaaag gatttgccag
     1201 tggagtagaa cagattattc ttggagctgg accagtactt gaggcctttg gaaatgcaaa
     1261 gacagctcat aataacaatt caagtcgttt tggcaagttt attcaagtaa attaccaaga
     1321 aacaggcact gtacttgggg cctatgttga aaaatatctt ctggaaaaat ctagacttgt
     1381 ttatcaagag cataatgaac ggaactatca tgtattctat tacctccttg caggagcaag
     1441 tgaagaagag aggttagcat tccaccttaa gcagcctgag gagtatcatt ttctcaacca
     1501 gataacaaag aaacccctca gacagagctg ggatgattat tgctatgatt ctgagccgga
     1561 ttgcttcaca gtggagggag aagatttgag gcatgatttt gaacgcttac aattggccat
     1621 ggaaatggta ggatttcttc ccaagacacg aagacagatt ttctcactgc tctcagcaat
     1681 actacatttg ggtaatatct catataaaaa gaagacctat cgagatgact ctattgatat
     1741 ctgtaatcct gaagtactgc ctattgtctc agaattacta gaagttaaag aagagatgct
     1801 atttgaagca ttggttacaa ggaagacggt gacagtgggt gaaaagctta ttttaccata
     1861 taaactggca gaggctgtga cagtgagaaa ctccatggct aaatctttat atagtgctct
     1921 gtttgactgg atagtgtttc gtattaatca tgcacttctg aatagtaaag atttggaaaa
     1981 agatactaag actttgtcca ttggtgtact tgatattttt gggtttgaag attatgaaaa
     2041 caatagtttt gaacagttct gtattaattt tgctaatgaa cgtttacagc actactttaa
     2101 tcagcatatc tttaagttgg agcaagagga atatagaact gaaggtatca gttggcacaa
     2161 cattgattat attgataata cttgttgtat aaatcttatt agcaaaaaac caacaggact
     2221 gctccacctt ttggatgaag aaagcaactt tccacaggct acaaatcaaa cattacttga
     2281 caagtttaaa catcaacatg aagagaattc ttacattgaa tttccagctg taatggagcc
     2341 tgcttttatc ataaaacatt acgctggaaa agtaaaatat ggagtaaagg attttcggga
     2401 aaaaaataca gatcatatgc gtccagacat tgtggctctt ctgagaagta gcaggaatgc
     2461 ttttgtttct gggatgactg gcattgatcc cgtagctgtt ttccgatggg cagttctccg
     2521 agcatttttt agagctgtgg ttgctttcag ggaagctggg aaaagacata ttcagagaaa
     2581 aagtggacat gatgatacaa caccatgtac aattttgaaa agtatggata gttttagctt
     2641 tctccaacac ccagtccacc agaggagctt agagattctg cagaggtgca aggaagagaa
     2701 gtacagtata acccggaaaa acccaagaac acctctttct gatcttcaag gcatgaacac
     2761 tctgaatgaa aaaaatcaac atgatacatt tgatattgcc tggaatgtca gaactggaat
     2821 tcgccaaagc agactaccaa ctaacaatac ttccttgctt gataaagatg ggatatttgc
     2881 taattcagca agcagcaaac tcctggaaag agctcatgga attctcacga gaaacaaaaa
     2941 tttcaggtca aaacctgttc ttccaaagca cttgctggag gtaaattctt tgaaacatct
     3001 gaccagactg acccttcagg atcgaattac caaatctctt cttcatttgc ataagaagaa
     3061 gaaacctccc agtatcagcg cccagtttca ggtctcctta agcaagctga tggagacact
     3121 tgatcaagca gaaccatatt ttgtaaaatg cattcgctca aatgctgaaa agctgccctt
     3181 aagattcagt gatgccttgg tactaagaca gcttcggtac actgggatgc tggagacagt
     3241 tagaattcgc caatctggat atagctccaa atattctttc caggattttg tgagccactt
     3301 tcatgtactt cttccccaac atattatccc atcaaaattt aacattcaag atttcttcag
     3361 aaaaataaat atcaatcctg ataattatca agttggaaaa accatggtgt tcctaaagga
     3421 gcatgaacga cagcacttac aggatctgct tcatcaggaa gtgcttcgca gaatcatact
     3481 gctgcagcgg tggttcaggg tcttgctctc taggcagcag ttccttcact tgagacaggc
     3541 gtctgttatt attcagcgat tctggaggaa ctatctaaat cagaagcaag ttagaaatgc
     3601 ggctgtggag aaagatgctt tcatcatggc tagtgcagct tcccttcttc aagcgtcctg
     3661 gcgtgctcac ttagagaggc agcggtactt ggagttacga gctgcagctg tcattatcca
     3721 gcagagatgg agggaactct gtaggcgtag acacagggct gctacctgta tacagtcaag
     3781 atggaggggc tacaggcaaa gtaagaagta caaagaacaa aggaataaaa ttatcctgtt
     3841 acagtcaata tatagaggat tcagagcacg acaaagatat aaggctttaa aagaggaaag
     3901 gctgaaagaa acaaaactag agcatggatt ggcgcagatc aagacatgtg gacctctaga
     3961 aatccagggt tcagaccctt ctgagtggga ggatcgttcc tttgccaaca gagtgaaagc
     4021 catagaagaa tgtaaatctg tgatagagag taatcgaatt agccgggaga gttcaatgga
     4081 cttctcaaag gagtctccag acaagcaaca ggagagaggc aggagccaaa gtggtacaga
     4141 tttacagggg gatgtgattg taagacagag gcccaagtca ttggaagatc tacatcagaa
     4201 aaaagtaggt cgggccaaaa gagaaagtcg gagaatgaga gaattagaac aagctatatt
     4261 tagcttagaa ttgctcaaag tccgttctct tggtggcatg tctccttcag aggaacgtag
     4321 atggtctaca gaattgatgc ctgaaggcct tcaatctcca cagggtacac ctgatagtga
     4381 gagctctcaa gggagcttag aacttttaac ctgtgatgag aaccaaaaga gcaaaccaga
     4441 gtccctcatt ttagatgatg gagaattgaa aatttcatca cccagtacat ttaccaatcc
     4501 aaaatttgat tcacaaaata atgccctcag tgcctcaagt gagacaagct ctacgttttc
     4561 tggaaaagga gcatcctctg actcagagca tttgaagaat ggaactgcag aggaaaagct
     4621 tgtctatagt tctcaaccca tcacttgtaa atctcagctg agagactctt ttgtttcaag
     4681 tagtctgcct acattttttt atattcctca tcaagaacct ctgaaaacaa gctcccaact
     4741 agatacaagt atccaaagaa acaaactacc agaaagagaa accactttga agacaactct
     4801 tactctggat attaacagag aagccaggaa gtgtcagttt tcaggtcagg tgactccttt
     4861 gaatccagat tcttcatgta ctgtgcttaa gaagctagaa aagctgaata ttgaaaagga
     4921 gaaaaggcaa aagcagttac agcagcagaa tgaaaaagaa atgatggaac agattcgtca
     4981 gcagacagat attttagaga aggaacgcaa ggctttcaag acaattgaac agtcacgaac
     5041 tgaggcctct ctcttggcac catcctttta ccagtcaaga caaaaagtag agaggccatc
     5101 ttctctgcat atccaaaata ctccaagtaa gggagaagct ggtgtactag gttccccatc
     5161 agctcttgcc acaaaagata gtccctccat tcatttaccc ccaaaagacc gacctgttac
     5221 cctgttcttt gaaagaaaag gaagcccatg ccaatctaga actgtcaagg aattaaccaa
     5281 gacagaaaga atgggtaccc aacatgatgc tgcctgtaga ctctccaata atcgcaatac
     5341 agaaagagaa cactttaagt caactcactc ttacagccac agatctgatg acccttccag
     5401 agagggaagt tcgagaccta ttttcttcac accaaaagac aatgtgatta ctccccttgt
     5461 acacagtgga aatcctcaag tccacaaaca agatgaacca gcttggaaat ctaagttagc
     5521 agggcctggg caacgagagg ttgccagacc ggcccataaa aagaaagctc gaatggcgcg
     5581 gacgcgctcc gatttcttga ctagaggtac ttttgccgat ggggaggggg atacagagga
     5641 agatgattac gatgacatta ttgagcccct tctctccctt gaccaagctt ctcactctga
     5701 gctagggcct gtatccagcc tgggtcaggc ctctcacagt gactccgaaa tgacgtcaca
     5761 acgattttct tcagttgatg aacaagcaag gcttcataag gctatgtctc aaggagagat
     5821 tacaaaattg gcaggacgac agaagtcttc agatttggac ataagacccc agagagcgaa
     5881 gatgagattc tgggccaaag ggaaacaagg agagaagaag actactagag taaaacctgc
     5941 tccccagtcg gaggtctcat cactctttgc tggctcagat gtgacacctg ttcatccatt
     6001 ttctgatgag ttaactcagt accacccaac acctcctttg agtccagaac tgcccgggag
     6061 ttgtcgaaaa gagttcaaag agaataagga accatcgcca aaggcaaaac gcaagagagg
     6121 tgtgaaaatc agcagtgtgg ccttggactc tatgcactgg caaaatgact ctgtccaaat
     6181 catagcaagt gccaacgatt taaaaagtat ggatgagttt cttctgaaaa agatgaatga
     6241 cctagataat gaagacagca agaaggatac attagtggat gttgtattta aaaaagccct
     6301 caaagaattt cggcaaaata tcttcagctc ttactcgtct gcactggcga tggatgatgg
     6361 gaaaagcata cgctataaag atctgtatgc gctatttgaa cagatcctgg aaaagaccat
     6421 gaggtttgag caacgtgatt ggaatgaatc tccagtgaga gtttgggtta acacttttaa
     6481 ggtgttttta gatgaataca tgaatgaatt caagactttg gatagcacag ccccaaaggt
     6541 gcttaaaaca gaaagaaaga aaaggaggaa aaaggaaact gatttggtgg aagagcacaa
     6601 tggccacatg tttaaggcca cccagtacag catccctacc tactgtgaat actgttcttc
     6661 cttgatatgg ataatggaca gagcctctgt ttgcaaattg tgtaagtacg cttgccataa
     6721 gaagtgctgt ctgaaaacca cagccaagtg ttctaagaag tatgatccag agctgtcatc
     6781 tcggcaattt ggggttgagc tgtcccgtct gactagtgaa gaccgagctg ttcctttagt
     6841 ggtagagaag ctcataaact acattgaaat gcatggactt tatacagagg gtatttaccg
     6901 aaagtctggt tcaactaata aaatcaagga gcttcgacaa ggtctagata cagatgctga
     6961 aagtgtaaac ctagatgact ataacataca tgtcattgca agtgtattca aacaatggct
     7021 tcgtgatttg cccaatccac tcatgacttt tgaactctat gaagaattcc ttcgagctat
     7081 gggccttcag gaaagaaagg agacaatccg tggtgtgtac tctgtaattg atcagctctc
     7141 ccggactcac ctcagtacac tggaacgcct tatctttcat ctagttagga ttgctctaca
     7201 ggaagacact aatagaatgt ctgctaatgc tttggccatc gtgtttgcac cttgcattct
     7261 ccgttgccct gacactactg acccactaca aagtgttcaa gatatcagta agactaccac
     7321 atgtgtggaa ctgatagttg tagaacaaat gaataaatac aaggctcgtc tcaaagacat
     7381 cagtagcctg gaatttgctg aaaataaagc aaagaccaga ctatcactga ttcgtagatc
     7441 aatgaaacct gtcctaattg cagttagatt tatgagcatt acccgcagtt cagtctcggg
     7501 aaaggggcgt ctacatcgag gaagccatcc aaatccatcc tcccctgtta tagtccgatt
     7561 gccttccatg tctgatgtcc cagaagagac cttgactagt gagacagcca tggacactga
     7621 cgtcacagac cagcagcaag cagcaatgca gcaggaggag aaagtactga ctgagcagat
     7681 tgagaaccta cagaaagaaa aggaagaact aacatttgag atgcttgtat tggagcctcg
     7741 tgcctctgat gatgaagccc ttgagtctga ggcttctatt gggactgctg atagcttgga
     7801 aaatttgaat atggatcctg aagagagaag cttagccctt agctccctga aagcagctgg
     7861 caagtctgag ccttcaagca agtttcgaaa gcagctaaga aagcagccag actctttgga
     7921 ctcagtcagc tcctccgttt cttcatgtct atcaaacact acatcatctc atggcactag
     7981 aaagcgattt cagatttatt ccaagtctcc attttaccga gctgcctcag cttgtgaggc
     8041 ccagggaatg gaaggaccac taggccaagc caaatcccta gaagacaggc ctcagttcat
     8101 cagcagagga accttcaacc ctgaaaaggg caaacaaaaa ctaaagaatg tgaaaaactc
     8161 acctcagaaa accaaagaga ccccagaggg gacggtttca tctggccgaa agaaaactgt
     8221 ggactcagac tgcagctcca cacagcaact accactgttt ggaaataatg agtttatggt
     8281 ctaaatggac agaaatgtct ccacatctca tctttggggc ctcttctggt caccttgttt
     8341 gtaacagtca gtcctaatgg tcctaccttg tcttcagctg acagtttgtg tgctggaaca
     8401 ctgcacttct ggcaaaagtg gcctctttga agtttgctag ggatgggcca gctgtgcctt
     8461 ggctgctgta tttgatttga gattccacta aacaaagcca cctgagacct gggtgatttt
     8521 ggccaacagt agttgcttct tgcccaccta tttttccctt tccacagata gttattgaac
     8581 tagggggcta ctgtgatcct gagaaatgct ctcatttcta gcatttaaag accaccatac
     8641 aaacttctgt taaccacgaa agcaaaacct tttgtgtttg tattgggata gttagaaact
     8701 gttatagaat ataaaatttc cccaaggact tataagcaaa acgcctaagc cctctctttt
     8761 aaatttaatt acaaaatatt cgatgttata ttttggaaac aaactgattc cattaagccc
     8821 agagtgactc agccatctga taatattgtg aagagaccgt actttgtctc ttgttgatat
     8881 ttggtattac aatcagtgct ggtttaactc ctggttaagt cctgcaaatg ttatttcatg
     8941 ggataaagtt cagtagccat actgtactag tatgccctga tttttagatc agactcctct
     9001 aggtttttgt ttgtgatgtc acaggacaca tttagataat tcctaaatgt gaaggcatcg
     9061 tcctgattga tccaggcttt tcttttttta tagactaaac tgaagactgt atccgagcct
     9121 attcatctgc tggtggagta ccaccataga tgtgaccgtt tcatcacttc tctacgagta
     9181 ctcgcgtaca actttgcatg agtgttatag aaaaagacgc caaaagaaat ttagaaagtt
     9241 ttaatatgat ctatttaatt gttgtcttct ttttctcaga ccatcagtat tagatgaaaa
     9301 aaaaatcaag gactacttga agctattttt gttaatattc ttgctcctga agtttactgt
     9361 aaatacacat gtatagtatg cctagttctt tttaacccta tgcttccccc tattcccatg
     9421 gagtttcttc ctacagataa gaggccatta gacaagtggt gagacccatt caccctgggg
     9481 taagggataa ctaagggcat ctttctcatc actggtagtt tcctaagtta ccgtgttgga
     9541 agcatcatgt actagccatt gtgggagtag aactctggtt ttgctattta taatgttatg
     9601 tgaagtgaaa catgatacca tttcttaagt atgtgaaatg tttattttta aagtcactaa
     9661 atacattttg tctaactacc acatgcactg ttacaagaag agcctatacc atctataacc
     9721 tgaattttgg ttttcttctt cttttttttt tttttttttt gctttgaagt tatgaggata
     9781 gaagtctttt gtaaaggcag ggtctcctcc tacacagcac tgaacctcac gtcactgctg
     9841 cagcggcggc tctagacatg agacttggag catcattttg cacagtagct cgtggtagct
     9901 ggagttgtcc ctctccctgg tatgggttca gcattgagac acatgaagga agctttgaaa
     9961 atctctccta tgatgatggt cattcaataa atgttaactt ttatatccct tgagcattaa
    10021 caataagaat tttggaaact gttctaaagg aagccagagg ctgtgataag gtggggagct
    10081 cctttgggcc tttgtggcta cacagtctgt tttagtattt ggggaaagta gctgctatgg
    10141 gtggtaagtg ctgctctcta cttggctcaa aacaagttcc tttgtttcag aggaaaggcc
    10201 tggaacccag cacttgacgc acattcttcc acctaaagtt ttacagctca atttggtttt
    10261 tttgttgttg tttttttgtt tttgtttttg tttttaattt ctataaaata aatttggggc
    10321 tgagaaaaaa aataactacc tacataggtc actttgtagg aacaaagtaa tcaatattaa
    10381 agactttata atttttctca gggacctaaa acctgaattt gaataaagtt aaataaaaac
    10441 ttttttttcc agttgctaga tttgtggatt ttttaatcat tttaacaaga cgccaggatg
    10501 gggtcgggga aatccacaca atcgtaaaaa tgtctgggca aagtgtaggc cccctttgag
    10561 gaaaagaatg ctattgttct tgggttagca ggcacgattg gtctgataga gacaaagcca
    10621 taactcagta gtgtcagatg ctctgctcca tcagttctta tcagagcctc tgaatcacca
    10681 catagcaaca ctgttgcagt cactcctgat gcagatccac attgggttca ctattagact
    10741 ggccagctgc ttttcttcag tcttaaaatg caccaaagga aactctggca gcagcagaat
    10801 tcctcacatg tgaaacctgt gctccaaacc tgagagcatt ctagttactg catatacttc
    10861 tagtccacaa taactcctac atttttccta cccattaata tgtgtctgca gatgtgtatc
    10921 gtagaaaatg tagcagaagc aaatacattt tgcatcacag attgaagtaa attacagcaa
    10981 atgcaggcag gatttgggga ggtgatatgc ttagtttgca catatttgta cttcctgtca
    11041 tttcgtttat atgaccactc tgggtcatat acacaaacgg agatatgagt gttgctagga
    11101 gagacaaaag gatatgagtt cagggcatag ggcactaggg ccaactctca ggctttagaa
    11161 acctatcact cttactttgc atagggtgtg aaaactattc tgtgtctcac aatcgaagac
    11221 agcatcacag aagtgcgctg acatgaggtg atacatcgag gttgtattgt tccactttta
    11281 tgcctgtgag ctgttttttc aactgtaact aataagctag agagaaggaa ggattctcag
    11341 gcggtgaagc tgagagttgt aactagagga agaagttgtc cagatggctt tctcactcac
    11401 tttttaaaat tcttggtggg caaatagatg tgggccctgc attcttctac tgagtggtgt
    11461 gttatatgca cccacacact tgtgataact tctcagcact gtgccccaac accatgctgg
    11521 ccttagtagt aaaaaattta ggtatttgta gacctgactt tctgcatccc tagggtacta
    11581 gagaccacat ttctctggaa cattctcaca ttttggtgtt aagtgggtaa tctccagtgt
    11641 attagatctt actgatctcc tggtttaaac ttcaaatagc cctagtaatg ggtctgtcac
    11701 cttgtcaccc atccactctt aatgcctact tatcagccct cctaggtcat acaagagttg
    11761 cacctcttga accaagtatt tgtatttact gggggaaagg tatggactac agattagtat
    11821 tatattattt taatggattc aaagtaactt ataagtatgc tgagtgtaaa attttaaaat
    11881 actgtgtatt ataaaaggac acatcctgtg aaatatgcca ctttactgtt taagaatcta
    11941 taagaacgac ttaatcacag aacggattac attcccgatg aaatcagcag cactttgtaa
    12001 tttccttttt tttttttgga agggggcaag acatttgtat aaagtgcagt ttgtgtcact
    12061 cagattatgc actgtatagc tacacaaaag cagcctgctg aacaaatcac tcatggctca
    12121 ttaaagaaca aagcttccag aagtgcaa
//
