LOCUS       NM_001414743            7551 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus myosin VIIA (Myo7a), transcript variant 1, mRNA.
ACCESSION   NM_001414743 XM_006229743
VERSION     NM_001414743.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7551)
  AUTHORS   Wen,Q., Wu,S., Lee,W.M., Wong,C.K.C., Lui,W.Y., Silvestrini,B. and
            Cheng,C.Y.
  TITLE     Myosin VIIa Supports Spermatid/Organelle Transport and Cell
            Adhesion During Spermatogenesis in the Rat Testis
  JOURNAL   Endocrinology 160 (3), 484-503 (2019)
   PUBMED   30649248
  REMARK    GeneRIF: crucial to support cellular transport and adhesion during
            spermatogenesis
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7551)
  AUTHORS   Morgan,C.P., Krey,J.F., Grati,M., Zhao,B., Fallen,S.,
            Kannan-Sundhari,A., Liu,X.Z., Choi,D., Muller,U. and
            Barr-Gillespie,P.G.
  TITLE     PDZD7-MYO7A complex identified in enriched stereocilia membranes
  JOURNAL   Elife 5, e18312 (2016)
   PUBMED   27525485
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7551)
  AUTHORS   Lelli,A., Michel,V., Boutet de Monvel,J., Cortese,M.,
            Bosch-Grau,M., Aghaie,A., Perfettini,I., Dupont,T., Avan,P.,
            El-Amraoui,A. and Petit,C.
  TITLE     Class III myosins shape the auditory hair bundles by limiting
            microvilli and stereocilia growth
  JOURNAL   J Cell Biol 212 (2), 231-244 (2016)
   PUBMED   26754646
REFERENCE   4  (bases 1 to 7551)
  AUTHORS   Li,W., Wu,J., Yang,J., Sun,S., Chai,R., Chen,Z.Y. and Li,H.
  TITLE     Notch inhibition induces mitotically generated hair cells in
            mammalian cochleae via activating the Wnt pathway
  JOURNAL   Proc Natl Acad Sci U S A 112 (1), 166-171 (2015)
   PUBMED   25535395
REFERENCE   5  (bases 1 to 7551)
  AUTHORS   Ben-Salem,S., Rehm,H.L., Willems,P.J., Tamimi,Z.A., Ayadi,H.,
            Ali,B.R. and Al-Gazali,L.
  TITLE     Analysis of two Arab families reveals additional support for a
            DFNB2 nonsyndromic phenotype of MYO7A
  JOURNAL   Mol Biol Rep 41 (1), 193-200 (2014)
   PUBMED   24194196
REFERENCE   6  (bases 1 to 7551)
  AUTHORS   Hasson,T., Heintzelman,M.B., Santos-Sacchi,J., Corey,D.P. and
            Mooseker,M.S.
  TITLE     Expression in cochlea and retina of myosin VIIa, the gene product
            defective in Usher syndrome type 1B
  JOURNAL   Proc Natl Acad Sci U S A 92 (21), 9815-9819 (1995)
   PUBMED   7568224
REFERENCE   7  (bases 1 to 7551)
  AUTHORS   Gibson,F., Walsh,J., Mburu,P., Varela,A., Brown,K.A., Antonio,M.,
            Beisel,K.W., Steel,K.P. and Brown,S.D.
  TITLE     A type VII myosin encoded by the mouse deafness gene shaker-1
  JOURNAL   Nature 374 (6517), 62-64 (1995)
   PUBMED   7870172
REFERENCE   8  (bases 1 to 7551)
  AUTHORS   Weil,D., Blanchard,S., Kaplan,J., Guilford,P., Gibson,F., Walsh,J.,
            Mburu,P., Varela,A., Levilliers,J., Weston,M.D. et al.
  TITLE     Defective myosin VIIA gene responsible for Usher syndrome type 1B
  JOURNAL   Nature 374 (6517), 60-61 (1995)
   PUBMED   7870171
REFERENCE   9  (bases 1 to 7551)
  AUTHORS   Shnerson,A., Lenoir,M., van de Water,T.R. and Pujol,R.
  TITLE     The pattern of sensorineural degeneration in the cochlea of the
            deaf shaker-1 mouse: ultrastructural observations
  JOURNAL   Brain Res 285 (3), 305-315 (1983)
   PUBMED   6627025
REFERENCE   10 (bases 1 to 7551)
  AUTHORS   Deol,M.S. and Green,M.C.
  TITLE     Cattanach's translocation as a tool for studying the action of the
            shaker-1 gene in the mouse
  JOURNAL   J Exp Zool 170 (3), 301-309 (1969)
   PUBMED   5795329
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Dec 12, 2022 this sequence version replaced XM_006229743.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.2667.1,
                                           SRR26360186.1881739.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-471               JAXUCZ010000001.1  161818107-161818577 c
            472-585             JAXUCZ010000001.1  161813145-161813258 c
            586-738             JAXUCZ010000001.1  161808677-161808829 c
            739-923             JAXUCZ010000001.1  161803555-161803739 c
            924-1045            JAXUCZ010000001.1  161803005-161803126 c
            1046-1188           JAXUCZ010000001.1  161802782-161802924 c
            1189-1302           JAXUCZ010000001.1  161802493-161802606 c
            1303-1456           JAXUCZ010000001.1  161800947-161801100 c
            1457-1533           JAXUCZ010000001.1  161799991-161800067 c
            1534-1653           JAXUCZ010000001.1  161799617-161799736 c
            1654-1796           JAXUCZ010000001.1  161798845-161798987 c
            1797-2007           JAXUCZ010000001.1  161797981-161798191 c
            2008-2143           JAXUCZ010000001.1  161797406-161797541 c
            2144-2250           JAXUCZ010000001.1  161794993-161795099 c
            2251-2388           JAXUCZ010000001.1  161788804-161788941 c
            2389-2547           JAXUCZ010000001.1  161786894-161787052 c
            2548-2640           JAXUCZ010000001.1  161786497-161786589 c
            2641-2735           JAXUCZ010000001.1  161784413-161784507 c
            2736-2820           JAXUCZ010000001.1  161783200-161783284 c
            2821-3039           JAXUCZ010000001.1  161782471-161782689 c
            3040-3147           JAXUCZ010000001.1  161782020-161782127 c
            3148-3357           JAXUCZ010000001.1  161780779-161780988 c
            3358-3561           JAXUCZ010000001.1  161780169-161780372 c
            3562-3738           JAXUCZ010000001.1  161779770-161779946 c
            3739-3828           JAXUCZ010000001.1  161779203-161779292 c
            3829-3956           JAXUCZ010000001.1  161778174-161778301 c
            3957-4083           JAXUCZ010000001.1  161776256-161776382 c
            4084-4203           JAXUCZ010000001.1  161775585-161775704 c
            4204-4377           JAXUCZ010000001.1  161775033-161775206 c
            4378-4605           JAXUCZ010000001.1  161774110-161774337 c
            4606-4776           JAXUCZ010000001.1  161772769-161772939 c
            4777-4894           JAXUCZ010000001.1  161770572-161770689 c
            4895-5021           JAXUCZ010000001.1  161769722-161769848 c
            5022-5191           JAXUCZ010000001.1  161768978-161769147 c
            5192-5382           JAXUCZ010000001.1  161768126-161768316 c
            5383-5507           JAXUCZ010000001.1  161767490-161767614 c
            5508-5665           JAXUCZ010000001.1  161766957-161767114 c
            5666-5819           JAXUCZ010000001.1  161765982-161766135 c
            5820-5975           JAXUCZ010000001.1  161762020-161762175 c
            5976-6081           JAXUCZ010000001.1  161761468-161761573 c
            6082-6195           JAXUCZ010000001.1  161760595-161760708 c
            6196-6283           JAXUCZ010000001.1  161759789-161759876 c
            6284-6390           JAXUCZ010000001.1  161759516-161759622 c
            6391-6576           JAXUCZ010000001.1  161758523-161758708 c
            6577-6693           JAXUCZ010000001.1  161758005-161758121 c
            6694-6777           JAXUCZ010000001.1  161757164-161757247 c
            6778-6897           JAXUCZ010000001.1  161756231-161756350 c
            6898-7551           JAXUCZ010000001.1  161755110-161755763 c
FEATURES             Location/Qualifiers
     source          1..7551
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..7551
                     /gene="Myo7a"
                     /note="myosin VIIA"
                     /db_xref="GeneID:266714"
                     /db_xref="RGD:628830"
     exon            1..471
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     CDS             271..6987
                     /gene="Myo7a"
                     /note="isoform 1 is encoded by transcript variant 1;
                     myosin-VIIa; myosin VIIA (Usher syndrome 1B (autosomal
                     recessive, severe)); unconventional myosin-VIIa"
                     /codon_start=1
                     /product="unconventional myosin-VIIa isoform 1"
                     /protein_id="NP_001401672.1"
                     /db_xref="GeneID:266714"
                     /db_xref="RGD:628830"
                     /translation="MDKRRKKRKEVRREEGREADRLEGWSRRLEGIMDGQWPLAQGSA
                     SAGAWYLILFGYKNTEALPSSYKGDYVWMDLKSGQEFDVPIGAMVKLCESGQIQVVDD
                     EGNEHWISPQNATHIKPMHPTSVHGVEDMIRLGDLNEAGILRNLLIRYRDHLIYTYTG
                     SILVAVNPYQLLSIYSSEHIRQYTNKKIGEMPPHIFAIADNCYFNMKRNNRDQCCIIS
                     GESGAGKTESTKLILQFLAAISGQHSWIEQQVLEATPILEAFGNAKTIRNDNSSRFGK
                     YIDIHFNKRGAIEGAKIEQYLLEKSRVCRQAPDERNYHVFYCMLEGMNEEEKKKLGLG
                     QAADYNYLAMGNCITCEGRVDSQEYANIRSAMKVLMFTDTENWEILKLLAAILHMGNL
                     QYEARTFENLDACEVLFSPSLATAASHLEVNPPDLMSCLTSRTLITRGETVSTPLSRE
                     QALDVRDAFVKGIYGRLFVWIVEKINAAIYKPPSQEVTNSRRSIGLLDIFGFENFTVN
                     SFEQLCINFANEHLQQFFVRHVFKLEQEEYDLESIDWLHIEFTDNQEALDMIANRPMN
                     VISLIDEESKFPKGTDATMLHKLNSQHRLNANYVPPKNSHETQFGINHFAGIVYYESQ
                     GFLEKNRDTLHGDIIQLVHSSRNKFVKQIFQADVAMGAETRKRSPTLSSQFKRSLELL
                     MRTLGACQPFFVRCIKPNEFKKPMLFDRHLCVRQLRYSGMMETIRIRHAGYPIRYSFV
                     EFVERYRVLLPGVKPAYKQDDLQGTCQRMAEAVLGTHDDWQIGKTKIFLKDHHDMLLE
                     VERDKAITDRVILLQKVIRGFKDRSNFLRLKSAATLIQRHWRGHHCRKNYELIRLGFL
                     RLQALHRSRKLHKQYRLARQRIIKFQARCRAYLVRRAFRHRLWAVITVQAYARGMIAR
                     RLHRRLRVEYWRRLEAERMRLAEEEKLRKEMSAKKAKEEAERKHQERLAQLAREDAER
                     ELKEKEEARRKKELLQQMERARHEPINHSDMVDKMFGFLGTSSGLPGQEGQAPSGFED
                     LERGRREMVEEDVDAALPLPDEDEEDLSEYKFAKFAATYFQGTTTHSYTRRPLKQPLL
                     YHDDEGDQLAALAVWITILRFMGDLPEPKYHTAMSDGSEKIPVMTKIYETLGKKTYKR
                     ELQALQGEGEAQLSEGQKKTSVKHKLVHLTLKKKSKLTEEVTKRLHDGESMVQGNSML
                     EDRPTSNLEKLHFIIGNGILRPALRDEIYCQISKQLTHNPSKSSYARGWILVSLCVGC
                     FAPSEKFVKYLRNFIHGGPPGYAPYCEERLRRTFVNGTRTQPPSWLELQATKSKKPIM
                     LPVTFMDGTTKTLLADSATTAKELCNALADKISLKDRFGFSLYIALFDKVSSLGSGSD
                     HVMDAISQCEQYAKEQGAQERNAPWRLFFRKEVFTPWHNPSEDNVATNLIYQQVVRGV
                     KFGEYRCEKEDDLAELASQQYFVDYGSEMILERLLSLVPTYIPDREITPLKNLEKWAQ
                     LAIAAHKKGIYAQRRTDAQKVKQDVVNYARFKWPLLFSRFYEAYKFSGPPLPKSDVIV
                     AVNWTGVYFVDEQEQVLLELSFPEIMAVSSSRGAKLMAPSFTLATIKGDEYTFTSSNA
                     EDIRDLVVTFLEGLRKRSKYVVALQDNPNPAGEESGFLSFAKGDLIILDHDTGEQVMN
                     SGWANGINERTKQRGDFPTDCVYVMPTVTLPPREIVALVTMTPDQRQDVVRLLQLRTA
                     EPEVRTKPYTLEEFSYDYFRSPPKHTLSRVMVSKARGKDRLWSHTREPLKQALLKKIV
                     GSEELSQEACMSFIAVLKYMGDYPSKRTRSVNELTDQIFEWAVKAEPLKDEAYVQILK
                     QLTDNHIRYSEEKGWELLWLCTGLFPPSNILLPHVQRFLQSRKHCPLAIDCLQRLQKA
                     LRNGSRKYPPHLVEVEAIQHKTTQIFHKVYFPDDTDEAFEVESSTKAKDFCQNIASRL
                     LLKSSEGFSLFVKIADKVISVPENDFFFDFVRHLTDWIKKARPIKDGIVPSLTYQVFF
                     MKKLWTTTVPGKDPMADSIFHYYQELPKYLRGYHKCTREEVLQLGALIYRVKFEEDKS
                     YFPSIPKLLRELVPQDLIRQVSPDDWKRSIVAYFNKHAGKSKEEAKLAFLKLIFKWPT
                     FGSAFFEVKQTTEPNFPEILLIAINKYGISLIDPRTKDILTTHPFTKISNWSSGNTYF
                     HITIGNLVRGSKLLCETSLGYKMDDLLTSYISQMLTAMSKQRNSRSGR"
     exon            472..585
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            586..738
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            739..923
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1045
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1188
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1302
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1456
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1533
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1653
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1796
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..2007
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..2143
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..2250
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..2388
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            2389..2547
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            2548..2640
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            2641..2735
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            2736..2820
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            2821..3039
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            3040..3147
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            3148..3357
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            3358..3561
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            3562..3738
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            3739..3828
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            3829..3956
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            3957..4083
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            4084..4203
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            4204..4377
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            4378..4605
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            4606..4776
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            4777..4894
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            4895..5021
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            5022..5191
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            5192..5382
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            5383..5507
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            5508..5665
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            5666..5819
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            5820..5975
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            5976..6081
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            6082..6195
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            6196..6283
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            6284..6390
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            6391..6576
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            6577..6693
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            6694..6777
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            6778..6897
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
     exon            6898..7551
                     /gene="Myo7a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acccttataa gaacagggtc cttgagtgtg gaaagggttg gtggctgcag gacggtgcct
       61 agagtaggat ggtgaggtcc tgagcccctg aggcagagac tgggttgtgt gggtagaagg
      121 aggtgctggt ctggcctgac tgccctgagc tgcctgtggc ttctgagtat cctcctggtt
      181 ctcccattct tcccagcccc tgctccccgc tggtgttttc taaaggagca gttgggtttc
      241 tagggttcca gaccagaagg gttgtatgaa atggataaga gaagaaaaaa gagaaaagag
      301 gttagaagag aggagggcag agaagcagac aggctggaag ggtggagcag gaggctagag
      361 ggcatcatgg atggacagtg gcctctggct cagggctctg catcggctgg agcctggtac
      421 ctcatcttgt ttggatacaa gaacacagaa gctctgccaa gctcctacaa gggggactac
      481 gtgtggatgg acctgaagtc gggccaggag ttcgatgtgc ccatcggggc catggtaaag
      541 ctctgtgagt ctgggcagat ccaggtggtg gatgatgaag gcaatgaaca ctggatttcc
      601 cctcaaaatg ccacgcacat caagccaatg caccccacat cggtgcatgg tgtggaggac
      661 atgatccgcc tgggggatct caacgaggca ggcattcttc gaaaccttct cattcgctac
      721 cgggaccatc tcatctacac atacacgggt tccatcctgg tggccgtgaa cccctaccag
      781 ctgctgtcca tctactcgtc agagcacatc cgccagtata ccaacaagaa gataggggag
      841 atgccccccc acatctttgc cattgccgac aattgctact tcaacatgaa acgcaacaac
      901 cgggaccagt gctgtatcat cagcggggaa tcaggagctg gcaagacaga gagcacaaag
      961 ctgatcctgc agttcctggc ggctatcagt ggacagcact catggatcga gcagcaggtg
     1021 ctggaggcca ccccgatcct ggaagcattt gggaatgcca agaccatccg caatgacaac
     1081 tccagccgct ttggcaagta cattgacatc cactttaaca agcgtggtgc cattgagggc
     1141 gcaaaaatag agcagtacct gctggagaag tcacgagtct gccgccaggc ccctgatgag
     1201 aggaactatc acgtgttcta ctgtatgctg gagggcatga atgaggagga gaagaagaag
     1261 ctaggcctag gccaggccgc tgactacaac tatttggcaa tgggtaactg catcacctgt
     1321 gagggccgtg tggacagtca ggagtatgcc aacatccgct cagccatgaa ggtgctcatg
     1381 ttcacagaca cggagaactg ggagatcttg aagcttctgg ccgccatcct acacatgggc
     1441 aatctgcagt acgaggcccg tacgtttgag aacttggatg cgtgcgaagt cctcttctcc
     1501 ccatcgctgg ccacggcagc ttctcatctc gaggtgaatc ccccagacct gatgagctgc
     1561 ctcaccagcc gcaccctcat cacccgtggg gaaacggtct ccacccctct cagcagggag
     1621 caggcgctgg atgtgcgaga tgcctttgtc aagggcatct atgggcggct ctttgtatgg
     1681 attgtggaga agatcaatgc agcaatctac aaaccaccct ctcaggaagt gacgaactct
     1741 cgccggtcca tcggtctcct ggacatcttt gggtttgaga acttcaccgt gaacagcttt
     1801 gagcagctct gcattaactt tgccaatgag cacctgcagc agtttttcgt gcgacacgtg
     1861 ttcaagttgg agcaggagga gtatgacttg gagagcattg actggctgca catcgagttc
     1921 actgacaacc aggaggccct ggacatgatc gccaaccggc ctatgaacgt catctccctc
     1981 attgacgaag agagcaagtt ccccaagggc acggatgcca ccatgctgca taagttgaac
     2041 tcacagcaca ggctcaatgc caactacgtc ccacccaaga acagccatga gacccagttt
     2101 ggaatcaacc actttgcggg cattgtctac tatgagagtc aaggcttcct ggagaagaac
     2161 agagacaccc tgcatgggga catcatccag ctggtccact cttcccggaa caagtttgta
     2221 aagcagattt tccaggccga cgttgctatg ggtgcagaga ccaggaagcg ctcgcctaca
     2281 ctcagcagcc agttcaagcg gtctctggag ctgctgatgc gcacactggg cgcctgccag
     2341 cccttctttg tacgatgcat caaacccaat gagttcaaga agcccatgct cttcgaccgg
     2401 cacctgtgtg tacgccagct gcgctattcg ggcatgatgg agactatccg catccgccac
     2461 gcaggctacc ccattcgcta cagctttgtg gagtttgtgg agcgctaccg cgtgctgctg
     2521 cctggggtga aaccagcata caagcaggat gacctccaag ggacatgcca gcgcatggct
     2581 gaggccgtgc tgggcactca cgatgactgg cagattggca aaaccaagat ctttctgaag
     2641 gaccaccatg acatgttgct ggaggtggag cgggacaagg ccatcacaga cagagtcatt
     2701 ctcctccaga aggtcatccg gggcttcaaa gacaggtcca acttcctgag attgaagagt
     2761 gcagccacac tgatccagag gcattggcgg ggccaccact gtaggaaaaa ctatgagctg
     2821 attcgtcttg gcttcctgcg gttgcaggcc ctgcaccgct cccggaaact gcacaaacag
     2881 taccgcctgg ccagacagcg cataataaag ttccaggccc gctgccgggc ctacctggtg
     2941 cgcagggcct tccgccaccg cctctgggcc gtgatcaccg tgcaggccta tgcccggggc
     3001 atgattgcgc gccggctaca ccggcgcctc cgagttgagt actggcggcg ccttgaggca
     3061 gagaggatgc ggctggcaga ggaggagaag ctaagaaagg agatgagtgc caagaaggcc
     3121 aaggaggagg cggagcgcaa gcatcaggag cgcctggccc agctagcccg cgaggatgca
     3181 gagcgggaac tgaaggagaa ggaagaggct cggcggaaga aggagctgtt acagcagatg
     3241 gagagggccc gccatgagcc tatcaaccac tcagatatgg tggacaagat gtttggcttc
     3301 ctggggactt caagtggcct gccaggccag gagggccagg cacctagtgg ctttgaggac
     3361 ctggagcgag ggcggaggga gatggtggaa gaggatgtcg atgctgccct gcccctgcct
     3421 gacgaggatg aggaggacct ttctgagtac aaattcgcca aatttgctgc cacctacttc
     3481 cagggcacaa ccacacactc ctacacccgg aggcccctca agcagccact gctctaccac
     3541 gatgatgagg gtgaccagct ggcggcactg gctgtctgga tcaccatcct ccggttcatg
     3601 ggggacctcc cagagcccaa gtaccacaca gccatgagcg atggcagtga gaagatccct
     3661 gtgatgacta agatctatga gaccctgggc aagaagacat acaagaggga gctgcaggcc
     3721 ctgcagggcg agggcgaggc ccagctctct gaggggcaga agaagaccag tgtgaaacac
     3781 aagttggtac acttgacact gaagaagaag tccaaactca cagaagaggt gaccaagagg
     3841 ctgcatgatg gggagtccat ggtacagggc aacagcatgc tggaggaccg gcccacctca
     3901 aatctagaga agctgcactt catcattggc aacggtatcc tgcgacctgc actgcgggat
     3961 gagatttact gccagatcag caagcaactc acacacaacc catccaagag cagctatgcc
     4021 aggggctgga tccttgtgtc tctgtgtgtg ggatgcttcg ccccttctga gaagtttgtt
     4081 aagtacctac ggaacttcat ccatggaggc ccacccggct atgcccccta ctgtgaggag
     4141 cgcctgagaa ggacctttgt caatggaact cggacacagc cacccagttg gctggaactg
     4201 caggccacca agtccaagaa gcccatcatg ttgcccgtga ccttcatgga cgggaccact
     4261 aagaccctgc tagcagattc agcaaccaca gccaaggaac tatgcaatgc tctggctgac
     4321 aagatctcac tcaaggaccg ctttggcttc tccctctaca ttgctctgtt cgataaggta
     4381 tcctccctgg gcagtggcag tgaccacgtc atggacgcaa tctcccagtg cgagcagtat
     4441 gccaaggagc agggtgcaca ggagcgcaac gccccctgga ggctcttctt cagaaaggag
     4501 gtcttcacac cctggcacaa cccctcggag gacaacgtgg ccaccaacct catctaccag
     4561 caggtggtgc gaggagtcaa gtttggggag tacaggtgtg agaaggagga tgacctggcc
     4621 gagttggcct cccagcagta ctttgtggac tatggttctg agatgattct ggagcgtctg
     4681 ctgagcctcg tgcccactta cattcctgac cgtgagatca caccgctaaa gaatcttgag
     4741 aagtgggcac agctggctat tgctgcccac aagaagggaa tttatgccca gaggagaact
     4801 gatgcccaga aggtcaaaca ggatgtggtc aattatgccc gtttcaagtg gcccttgctc
     4861 ttttccaggt tttatgaagc ctacaaattc tcaggccctc ccctccctaa gagtgacgtc
     4921 atcgtggctg tgaactggac gggcgtctac ttcgtggacg agcaggagca ggtgcttctg
     4981 gagctgtcct ttccggagat catggctgtg tccagcagta ggggagcaaa actgatggcc
     5041 cccagcttta cactggccac catcaaaggg gatgagtaca ccttcacatc tagcaatgct
     5101 gaggacatcc gtgacctggt ggtcaccttt ctggaggggc tccggaagag gtctaagtat
     5161 gtggtggcac tgcaggacaa tcccaaccct gctggtgagg agtcgggctt cctcagcttt
     5221 gccaagggag acctcatcat tctcgaccat gataccggcg agcaggtcat gaattcaggc
     5281 tgggccaatg gcatcaacga gagaaccaag cagcgtggag acttccccac cgactgtgtc
     5341 tacgtcatgc ccactgtcac cttgccaccc agggaaattg tggccctggt cactatgacc
     5401 ccagaccaga ggcaggatgt tgtccggctt ctgcagctgc gcacagcaga gccagaggtg
     5461 cgcaccaagc cctacacgct ggaggagttc tcctatgact acttcaggtc cccacccaag
     5521 cacacgctga gccgtgtcat ggtgtccaag gcccgaggga aggaccgact gtggagtcac
     5581 acacgagagc ccctcaagca ggccctgctc aagaagatcg tgggcagcga ggaactctcc
     5641 caggaagcct gcatgtcctt catagctgtg ctcaagtaca tgggtgacta cccatccaag
     5701 aggacacgct ctgtcaatga gctcactgac cagatcttcg agtgggcagt gaaggccgag
     5761 cccctcaaag atgaggccta cgtgcagatc ctgaagcagc tgactgacaa tcatatcagg
     5821 tacagcgaag agaagggttg ggagctgctg tggctgtgca caggcctctt cccacccagc
     5881 aacatcctcc tgcctcatgt tcagcgtttc ctgcagtccc gcaaacactg tcctcttgcc
     5941 attgactgcc tacaaaggct ccagaaagcc ctgagaaacg ggtcccggaa gtaccctcca
     6001 cacctggtgg aggtagaggc catccagcac aagactaccc agattttcca caaggtctac
     6061 ttccctgacg acacggatga ggcttttgag gtagagtcca gcaccaaggc caaggacttc
     6121 tgccagaaca tcgccagccg gctgctcctc aagtcttctg agggattcag cctttttgtc
     6181 aaaatcgcag ataaggtcat cagcgtccct gagaatgact tcttctttga ctttgttcga
     6241 cacctgacag actggataaa gaaggcacgg cccatcaagg atggaatcgt gccctcactg
     6301 acctaccagg tgttcttcat gaagaagctg tggaccacca ccgtgcctgg caaggacccc
     6361 atggccgact ccatattcca ctattaccag gaactgccca agtatctccg aggctaccac
     6421 aagtgcaccc gggaggaggt gctacagctg ggcgcgctca tctacagggt caagtttgag
     6481 gaggacaaat cctacttccc tagcatcccc aagttgctga gggagctggt gccccaggac
     6541 ctaatccggc aggtctcacc tgatgactgg aaacggtcta ttgtcgccta cttcaacaag
     6601 catgcaggga agtccaagga ggaggccaag ctggccttcc tcaagctcat cttcaagtgg
     6661 cccacctttg gatcagcctt ctttgaggtg aagcaaacga cagaaccaaa cttcccagag
     6721 attctcttaa ttgccatcaa caagtatggg atcagcctca tcgatcccag aaccaaggac
     6781 atcttgacta ctcacccctt caccaagatc tccaactgga gtagtggcaa cacctacttc
     6841 cacatcacca ttgggaactt ggtccgtggg agcaaactgc tctgtgagac atcactggga
     6901 tacaaaatgg atgatcttct gacttcctac atcagccaga tgctcactgc catgagcaaa
     6961 cagaggaact ccaggagcgg gaggtgaaca gtagaggaga tactggctca ggccttggcc
     7021 atccaggcag ggaggctgga ccgaccatat ccattgggca tctgacctgc ctgtcatgga
     7081 gtccagactt ttctgcatcc acctatggaa tctgggcttg ctgtcaccct acttcgttgt
     7141 ggccttcctg gtgtaagagc ctgtgctcct tgctcacctc ccctgattca gaacagctcc
     7201 gtcaagcaat gtcttttgag tttctgtaca tggatggaac aggggagtga aggacagttt
     7261 agctctctcc atacttggaa caaccaagct atttgtgcac tgaactgata ctctgaaacc
     7321 ctgactgggt tcagggtcct cagtactggt ctctccctta tgcactacca ctgaggactc
     7381 cttggaggac cccttcaata tcatctgctc cagggagccc cctagactac ctcctgagtc
     7441 tggacaaagt ctcctgattc taactgggtc acttctgtat gggacagtta tgtgctgggt
     7501 gtctgctaaa acttccctga ccaactgaga gcataaacca tgtgtcttat c
//
