LOCUS       NP_001401672            2238 aa            linear   ROD 30-MAR-2024
DEFINITION  unconventional myosin-VIIa isoform 1 [Rattus norvegicus].
ACCESSION   NP_001401672 XP_006229805
VERSION     NP_001401672.1
DBSOURCE    REFSEQ: accession NM_001414743.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 2238)
  AUTHORS   Wen,Q., Wu,S., Lee,W.M., Wong,C.K.C., Lui,W.Y., Silvestrini,B. and
            Cheng,C.Y.
  TITLE     Myosin VIIa Supports Spermatid/Organelle Transport and Cell
            Adhesion During Spermatogenesis in the Rat Testis
  JOURNAL   Endocrinology 160 (3), 484-503 (2019)
   PUBMED   30649248
  REMARK    GeneRIF: crucial to support cellular transport and adhesion during
            spermatogenesis
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 2238)
  AUTHORS   Morgan,C.P., Krey,J.F., Grati,M., Zhao,B., Fallen,S.,
            Kannan-Sundhari,A., Liu,X.Z., Choi,D., Muller,U. and
            Barr-Gillespie,P.G.
  TITLE     PDZD7-MYO7A complex identified in enriched stereocilia membranes
  JOURNAL   Elife 5, e18312 (2016)
   PUBMED   27525485
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 2238)
  AUTHORS   Lelli,A., Michel,V., Boutet de Monvel,J., Cortese,M.,
            Bosch-Grau,M., Aghaie,A., Perfettini,I., Dupont,T., Avan,P.,
            El-Amraoui,A. and Petit,C.
  TITLE     Class III myosins shape the auditory hair bundles by limiting
            microvilli and stereocilia growth
  JOURNAL   J Cell Biol 212 (2), 231-244 (2016)
   PUBMED   26754646
REFERENCE   4  (residues 1 to 2238)
  AUTHORS   Li,W., Wu,J., Yang,J., Sun,S., Chai,R., Chen,Z.Y. and Li,H.
  TITLE     Notch inhibition induces mitotically generated hair cells in
            mammalian cochleae via activating the Wnt pathway
  JOURNAL   Proc Natl Acad Sci U S A 112 (1), 166-171 (2015)
   PUBMED   25535395
REFERENCE   5  (residues 1 to 2238)
  AUTHORS   Ben-Salem,S., Rehm,H.L., Willems,P.J., Tamimi,Z.A., Ayadi,H.,
            Ali,B.R. and Al-Gazali,L.
  TITLE     Analysis of two Arab families reveals additional support for a
            DFNB2 nonsyndromic phenotype of MYO7A
  JOURNAL   Mol Biol Rep 41 (1), 193-200 (2014)
   PUBMED   24194196
REFERENCE   6  (residues 1 to 2238)
  AUTHORS   Hasson,T., Heintzelman,M.B., Santos-Sacchi,J., Corey,D.P. and
            Mooseker,M.S.
  TITLE     Expression in cochlea and retina of myosin VIIa, the gene product
            defective in Usher syndrome type 1B
  JOURNAL   Proc Natl Acad Sci U S A 92 (21), 9815-9819 (1995)
   PUBMED   7568224
REFERENCE   7  (residues 1 to 2238)
  AUTHORS   Gibson,F., Walsh,J., Mburu,P., Varela,A., Brown,K.A., Antonio,M.,
            Beisel,K.W., Steel,K.P. and Brown,S.D.
  TITLE     A type VII myosin encoded by the mouse deafness gene shaker-1
  JOURNAL   Nature 374 (6517), 62-64 (1995)
   PUBMED   7870172
REFERENCE   8  (residues 1 to 2238)
  AUTHORS   Weil,D., Blanchard,S., Kaplan,J., Guilford,P., Gibson,F., Walsh,J.,
            Mburu,P., Varela,A., Levilliers,J., Weston,M.D. et al.
  TITLE     Defective myosin VIIA gene responsible for Usher syndrome type 1B
  JOURNAL   Nature 374 (6517), 60-61 (1995)
   PUBMED   7870171
REFERENCE   9  (residues 1 to 2238)
  AUTHORS   Shnerson,A., Lenoir,M., van de Water,T.R. and Pujol,R.
  TITLE     The pattern of sensorineural degeneration in the cochlea of the
            deaf shaker-1 mouse: ultrastructural observations
  JOURNAL   Brain Res 285 (3), 305-315 (1983)
   PUBMED   6627025
REFERENCE   10 (residues 1 to 2238)
  AUTHORS   Deol,M.S. and Green,M.C.
  TITLE     Cattanach's translocation as a tool for studying the action of the
            shaker-1 gene in the mouse
  JOURNAL   J Exp Zool 170 (3), 301-309 (1969)
   PUBMED   5795329
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Dec 12, 2022 this sequence version replaced XP_006229805.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.2667.1,
                                           SRR26360186.1881739.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2238
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     Protein         1..2238
                     /product="unconventional myosin-VIIa isoform 1"
                     /note="myosin-VIIa; myosin VIIA (Usher syndrome 1B
                     (autosomal recessive, severe)); unconventional
                     myosin-VIIa"
                     /calculated_mol_wt=258083
     Region          140..790
                     /region_name="MYSc_Myo7"
                     /note="class VII myosin, motor domain; cd01381"
                     /db_xref="CDD:276832"
     Site            order(167..175,219..226,263..273,498..503)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276832"
     Site            167..175
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276832"
     Site            219..226
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276832"
     Site            263..273
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276832"
     Site            498..503
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276832"
     Site            527..550
                     /site_type="other"
                     /note="relay loop"
                     /db_xref="CDD:276832"
     Site            721..730
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276832"
     Site            order(733..758,778..790)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276832"
     Region          <835..>991
                     /region_name="DUF5401"
                     /note="Family of unknown function (DUF5401); pfam17380"
                     /db_xref="CDD:375164"
     Region          <918..>996
                     /region_name="MAP7"
                     /note="MAP7 (E-MAP-115) family; pfam05672"
                     /db_xref="CDD:461709"
     Region          1078..1314
                     /region_name="MyTH4"
                     /note="Domain in Myosin and Kinesin Tails; smart00139"
                     /db_xref="CDD:214535"
     Region          1318..1416
                     /region_name="FERM1_F1_Myosin-VII"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain 1, F1 sub-domain, found in Myosin-VIIa,
                     Myosin-VIIb, and similar proteins; cd17092"
                     /db_xref="CDD:340612"
     Region          1320..1535
                     /region_name="B41"
                     /note="Band 4.1 homologues; smart00295"
                     /db_xref="CDD:214604"
     Site            order(1368..1373,1378,1386,1408)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:340612"
     Region          1529..1627
                     /region_name="FERM_C1_MyoVII"
                     /note="FERM domain C-lobe, repeat 1, of Myosin VII
                     (MyoVII/Myo7); cd13198"
                     /db_xref="CDD:270019"
     Site            order(1529..1530,1534,1536,1551,1566)
                     /site_type="other"
                     /note="CEN1 peptide binding site [polypeptide binding]"
                     /db_xref="CDD:270019"
     Site            order(1539,1561,1563,1570)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270019"
     Site            1614..1625
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:270019"
     Region          1628..1692
                     /region_name="SH3_MYO7A"
                     /note="Src Homology 3 domain of Myosin VIIa and similar
                     proteins; cd11881"
                     /db_xref="CDD:212814"
     Site            order(1635,1637,1640,1647,1670..1671,1686,1688..1689)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212814"
     Region          1770..1919
                     /region_name="MyTH4"
                     /note="Domain in Myosin and Kinesin Tails; smart00139"
                     /db_xref="CDD:214535"
     Region          1924..2021
                     /region_name="FERM2_F1_Myosin-VII"
                     /note="FERM (Four.1 protein, Ezrin, Radixin, Moesin)
                     domain 2, F1 sub-domain, found in Myosin-VIIa,
                     Myosin-VIIb, and similar proteins; cd17093"
                     /db_xref="CDD:340613"
     Region          1926..2138
                     /region_name="B41"
                     /note="Band 4.1 homologues; smart00295"
                     /db_xref="CDD:214604"
     Region          2134..2229
                     /region_name="FERM_C2_MyoVII"
                     /note="FERM domain C-lobe, repeat 2, of Myosin VII
                     (MyoVII, Myo7); cd13199"
                     /db_xref="CDD:270020"
     Site            order(2142,2163,2165,2171)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270020"
     Site            order(2175,2179..2182,2217,2221,2224..2225)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270020"
     Site            2217..2228
                     /site_type="other"
                     /note="putative actin binding site 2 [polypeptide
                     binding]"
                     /db_xref="CDD:270020"
     CDS             1..2238
                     /gene="Myo7a"
                     /coded_by="NM_001414743.1:271..6987"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:266714"
                     /db_xref="RGD:628830"
ORIGIN      
        1 mdkrrkkrke vrreegread rlegwsrrle gimdgqwpla qgsasagawy lilfgyknte
       61 alpssykgdy vwmdlksgqe fdvpigamvk lcesgqiqvv ddegnehwis pqnathikpm
      121 hptsvhgved mirlgdlnea gilrnlliry rdhliytytg silvavnpyq llsiyssehi
      181 rqytnkkige mpphifaiad ncyfnmkrnn rdqcciisge sgagktestk lilqflaais
      241 gqhswieqqv leatpileaf gnaktirndn ssrfgkyidi hfnkrgaieg akieqyllek
      301 srvcrqapde rnyhvfycml egmneeekkk lglgqaadyn ylamgncitc egrvdsqeya
      361 nirsamkvlm ftdtenweil kllaailhmg nlqyeartfe nldacevlfs pslataashl
      421 evnppdlmsc ltsrtlitrg etvstplsre qaldvrdafv kgiygrlfvw ivekinaaiy
      481 kppsqevtns rrsiglldif gfenftvnsf eqlcinfane hlqqffvrhv fkleqeeydl
      541 esidwlhief tdnqealdmi anrpmnvisl ideeskfpkg tdatmlhkln sqhrlnanyv
      601 ppknshetqf ginhfagivy yesqgflekn rdtlhgdiiq lvhssrnkfv kqifqadvam
      661 gaetrkrspt lssqfkrsle llmrtlgacq pffvrcikpn efkkpmlfdr hlcvrqlrys
      721 gmmetirirh agypirysfv efveryrvll pgvkpaykqd dlqgtcqrma eavlgthddw
      781 qigktkiflk dhhdmlleve rdkaitdrvi llqkvirgfk drsnflrlks aatliqrhwr
      841 ghhcrknyel irlgflrlqa lhrsrklhkq yrlarqriik fqarcraylv rrafrhrlwa
      901 vitvqayarg miarrlhrrl rveywrrlea ermrlaeeek lrkemsakka keeaerkhqe
      961 rlaqlareda erelkekeea rrkkellqqm erarhepinh sdmvdkmfgf lgtssglpgq
     1021 egqapsgfed lergrremve edvdaalplp dedeedlsey kfakfaatyf qgttthsytr
     1081 rplkqpllyh ddegdqlaal avwitilrfm gdlpepkyht amsdgsekip vmtkiyetlg
     1141 kktykrelqa lqgegeaqls egqkktsvkh klvhltlkkk sklteevtkr lhdgesmvqg
     1201 nsmledrpts nleklhfiig ngilrpalrd eiycqiskql thnpskssya rgwilvslcv
     1261 gcfapsekfv kylrnfihgg ppgyapycee rlrrtfvngt rtqppswlel qatkskkpim
     1321 lpvtfmdgtt ktlladsatt akelcnalad kislkdrfgf slyialfdkv sslgsgsdhv
     1381 mdaisqceqy akeqgaqern apwrlffrke vftpwhnpse dnvatnliyq qvvrgvkfge
     1441 yrcekeddla elasqqyfvd ygsemilerl lslvptyipd reitplknle kwaqlaiaah
     1501 kkgiyaqrrt daqkvkqdvv nyarfkwpll fsrfyeaykf sgpplpksdv ivavnwtgvy
     1561 fvdeqeqvll elsfpeimav sssrgaklma psftlatikg deytftssna edirdlvvtf
     1621 leglrkrsky vvalqdnpnp ageesgflsf akgdliildh dtgeqvmnsg wanginertk
     1681 qrgdfptdcv yvmptvtlpp reivalvtmt pdqrqdvvrl lqlrtaepev rtkpytleef
     1741 sydyfrsppk htlsrvmvsk argkdrlwsh treplkqall kkivgseels qeacmsfiav
     1801 lkymgdypsk rtrsvneltd qifewavkae plkdeayvqi lkqltdnhir yseekgwell
     1861 wlctglfpps nillphvqrf lqsrkhcpla idclqrlqka lrngsrkypp hlveveaiqh
     1921 kttqifhkvy fpddtdeafe vesstkakdf cqniasrlll kssegfslfv kiadkvisvp
     1981 endfffdfvr hltdwikkar pikdgivpsl tyqvffmkkl wtttvpgkdp madsifhyyq
     2041 elpkylrgyh kctreevlql galiyrvkfe edksyfpsip kllrelvpqd lirqvspddw
     2101 krsivayfnk hagkskeeak laflklifkw ptfgsaffev kqttepnfpe illiainkyg
     2161 islidprtkd iltthpftki snwssgntyf hitignlvrg skllcetslg ykmddlltsy
     2221 isqmltamsk qrnsrsgr
//
