LOCUS       NM_017083               6081 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus myosin Vb (Myo5b), mRNA.
ACCESSION   NM_017083 XM_017600853
VERSION     NM_017083.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6081)
  AUTHORS   Ji,H.H., Yao,L.L., Liu,C. and Li,X.D.
  TITLE     Regulation of Myosin-5b by Rab11a and the Rab11 family interacting
            protein 2
  JOURNAL   Biosci Rep 39 (1) (2019)
   PUBMED   30545898
  REMARK    GeneRIF: Which bridges Myo5b and the membrane-bound Rab11a.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6081)
  AUTHORS   Ultanir,S.K., Yadav,S., Hertz,N.T., Oses-Prieto,J.A., Claxton,S.,
            Burlingame,A.L., Shokat,K.M., Jan,L.Y. and Jan,Y.N.
  TITLE     MST3 kinase phosphorylates TAO1/2 to enable Myosin Va function in
            promoting spine synapse development
  JOURNAL   Neuron 84 (5), 968-982 (2014)
   PUBMED   25456499
REFERENCE   3  (bases 1 to 6081)
  AUTHORS   Schumacher-Bass,S.M., Vesely,E.D., Zhang,L., Ryland,K.E.,
            McEwen,D.P., Chan,P.J., Frasier,C.R., McIntyre,J.C., Shaw,R.M. and
            Martens,J.R.
  TITLE     Role for myosin-V motor proteins in the selective delivery of Kv
            channel isoforms to the membrane surface of cardiac myocytes
  JOURNAL   Circ Res 114 (6), 982-992 (2014)
   PUBMED   24508725
REFERENCE   4  (bases 1 to 6081)
  AUTHORS   Satoh,T.
  TITLE     Rho GTPases in insulin-stimulated glucose uptake
  JOURNAL   Small GTPases 5, e28102 (2014)
   PUBMED   24613967
  REMARK    Review article
REFERENCE   5  (bases 1 to 6081)
  AUTHORS   Liu,Y., Xu,X.H., Chen,Q., Wang,T., Deng,C.Y., Song,B.L., Du,J.L.
            and Luo,Z.G.
  TITLE     Myosin Vb controls biogenesis of post-Golgi Rab10 carriers during
            axon development
  JOURNAL   Nat Commun 4, 2005 (2013)
   PUBMED   23770993
  REMARK    GeneRIF: Rab10 interaction with myosin Vb (MYO5B) determines the
            formation of Rab10 carriers and is important for axon development.
REFERENCE   6  (bases 1 to 6081)
  AUTHORS   Swiatecka-Urban,A., Talebian,L., Kanno,E., Moreau-Marquis,S.,
            Coutermarsh,B., Hansen,K., Karlson,K.H., Barnaby,R., Cheney,R.E.,
            Langford,G.M., Fukuda,M. and Stanton,B.A.
  TITLE     Myosin Vb is required for trafficking of the cystic fibrosis
            transmembrane conductance regulator in Rab11a-specific apical
            recycling endosomes in polarized human airway epithelial cells
  JOURNAL   J Biol Chem 282 (32), 23725-23736 (2007)
   PUBMED   17462998
REFERENCE   7  (bases 1 to 6081)
  AUTHORS   Nedvetsky,P.I., Stefan,E., Frische,S., Santamaria,K., Wiesner,B.,
            Valenti,G., Hammer,J.A. 3rd, Nielsen,S., Goldenring,J.R.,
            Rosenthal,W. and Klussmann,E.
  TITLE     A Role of myosin Vb and Rab11-FIP2 in the aquaporin-2 shuttle
  JOURNAL   Traffic 8 (2), 110-123 (2007)
   PUBMED   17156409
REFERENCE   8  (bases 1 to 6081)
  AUTHORS   Lise,M.F., Wong,T.P., Trinh,A., Hines,R.M., Liu,L., Kang,R.,
            Hines,D.J., Lu,J., Goldenring,J.R., Wang,Y.T. and El-Husseini,A.
  TITLE     Involvement of myosin Vb in glutamate receptor trafficking
  JOURNAL   J Biol Chem 281 (6), 3669-3678 (2006)
   PUBMED   16338934
  REMARK    GeneRIF: myosin Vb has a role in in glutamate receptor GluR1
            trafficking
REFERENCE   9  (bases 1 to 6081)
  AUTHORS   Provance,D.W. Jr., Gourley,C.R., Silan,C.M., Cameron,L.C.,
            Shokat,K.M., Goldenring,J.R., Shah,K., Gillespie,P.G. and
            Mercer,J.A.
  TITLE     Chemical-genetic inhibition of a sensitized mutant myosin Vb
            demonstrates a role in peripheral-pericentriolar membrane traffic
  JOURNAL   Proc Natl Acad Sci U S A 101 (7), 1868-1873 (2004)
   PUBMED   14766983
  REMARK    GeneRIF: myosin Vb functions in traffic between peripheral and
            pericentrosomal compartments
REFERENCE   10 (bases 1 to 6081)
  AUTHORS   Zhao,L.P., Koslovsky,J.S., Reinhard,J., Bahler,M., Witt,A.E.,
            Provance,D.W. Jr. and Mercer,J.A.
  TITLE     Cloning and characterization of myr 6, an unconventional myosin of
            the dilute/myosin-V family
  JOURNAL   Proc Natl Acad Sci U S A 93 (20), 10826-10831 (1996)
   PUBMED   8855265
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On or before Nov 30, 2020 this sequence version replaced
            XM_017600853.1, NM_017083.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               JAXUCZ010000018.1  70313976-70314172
            198-308             JAXUCZ010000018.1  70435286-70435396
            309-480             JAXUCZ010000018.1  70440844-70441015
            481-625             JAXUCZ010000018.1  70443191-70443335
            626-782             JAXUCZ010000018.1  70473131-70473287
            783-926             JAXUCZ010000018.1  70481959-70482102
            927-1008            JAXUCZ010000018.1  70483518-70483599
            1009-1116           JAXUCZ010000018.1  70489457-70489564
            1117-1226           JAXUCZ010000018.1  70492950-70493059
            1227-1492           JAXUCZ010000018.1  70497971-70498236
            1493-1574           JAXUCZ010000018.1  70509014-70509095
            1575-1715           JAXUCZ010000018.1  70509520-70509660
            1716-1838           JAXUCZ010000018.1  70518260-70518382
            1839-1922           JAXUCZ010000018.1  70519301-70519384
            1923-2078           JAXUCZ010000018.1  70533369-70533524
            2079-2176           JAXUCZ010000018.1  70534184-70534281
            2177-2263           JAXUCZ010000018.1  70539450-70539536
            2264-2378           JAXUCZ010000018.1  70551960-70552074
            2379-2590           JAXUCZ010000018.1  70554653-70554864
            2591-2747           JAXUCZ010000018.1  70557123-70557279
            2748-2987           JAXUCZ010000018.1  70557948-70558187
            2988-3221           JAXUCZ010000018.1  70564828-70565061
            3222-3306           JAXUCZ010000018.1  70571000-70571084
            3307-3440           JAXUCZ010000018.1  70572210-70572343
            3441-3563           JAXUCZ010000018.1  70573350-70573472
            3564-3701           JAXUCZ010000018.1  70574413-70574550
            3702-3767           JAXUCZ010000018.1  70578296-70578361
            3768-4007           JAXUCZ010000018.1  70580674-70580913
            4008-4108           JAXUCZ010000018.1  70581918-70582018
            4109-4186           JAXUCZ010000018.1  70586979-70587056
            4187-4385           JAXUCZ010000018.1  70589720-70589918
            4386-4479           JAXUCZ010000018.1  70591944-70592037
            4480-4623           JAXUCZ010000018.1  70594052-70594195
            4624-4775           JAXUCZ010000018.1  70598152-70598303
            4776-4865           JAXUCZ010000018.1  70600159-70600248
            4866-5016           JAXUCZ010000018.1  70602558-70602708
            5017-5302           JAXUCZ010000018.1  70603947-70604232
            5303-5477           JAXUCZ010000018.1  70605124-70605298
            5478-5558           JAXUCZ010000018.1  70606687-70606767
            5559-6081           JAXUCZ010000018.1  70613396-70613918
FEATURES             Location/Qualifiers
     source          1..6081
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..6081
                     /gene="Myo5b"
                     /gene_synonym="Myr6"
                     /note="myosin Vb"
                     /db_xref="GeneID:25132"
                     /db_xref="RGD:621347"
     exon            1..197
                     /gene="Myo5b"
                     /gene_synonym="Myr6"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..5711
                     /gene="Myo5b"
                     /gene_synonym="Myr6"
                     /note="myosin 5B; myosin heavy chain myr 6; Myosin of the
                     dilute-myosin-V family"
                     /codon_start=1
                     /product="unconventional myosin-Vb"
                     /protein_id="NP_058779.2"
                     /db_xref="GeneID:25132"
                     /db_xref="RGD:621347"
                     /translation="MSYSELYSRYTRVWIPDPDEVWRSAELTKDYKDGDESLQLRLED
                     DTILDYPIDVQNNQVPFLRNPDILVGENDLTALSHLHEPAVLHNLKVRFLESNHIYTY
                     CGIVLVAINPYEQLPIYGQDVIYAYSGQNMGDMDPHIFAVAEEAYKQMARDEKNQSII
                     VSGESGAGKTVSAKYAMRYFATVGGSASDTNIEEKVLASSPIMEAIGNAKTTRNDNSS
                     RFGKYIEIGFDKKYHIIGANMRTYLLEKSRVVFQADDERNYHIFYQLCAAASLPEFKE
                     LALTCAEDFFYTAHGGNTTIEGVDDAEDFEKTRQALTLLGVRESHQISIFKIIASILH
                     LGSVEIQAERDGDSCSISPQDEHLSNFCRLLGIEHSQMEHWLCHRKLVTTSETYVKTM
                     SLQQVVNARNALAKHIYAQLFSWIVEHINKALQTSLKQHSFIGVLDIYGFETFEINSF
                     EQFCINYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDFYDNQPCIDLIEAKLGILD
                     LLDEECKVPKGTDQNWAQKLYERHSNSQHFQKPRMSNTAFIVIHFADKVEYLSDGFLE
                     KNRDTVYEEQINILKASKFPLVADLFRDDKDSVPATNTAKSRSSSKINVRSSRPLMKA
                     PNKEHKKSVGYQFRTSLNLLMETLNATTPHYVRCIKPNDEKLPFHFDPKRAVQQLRAC
                     GVLETIRISAAGYPSRWTYHDFFNRYRVLMKKRELANTTDKKNICKSVLESLIKDPDK
                     FQFGRTKIFFRAGQVAYLEKLRADKFREATIMIQKTVRGWLQRVKYRRLRAATLTLQR
                     FCRGYLARRLTEHLRRTRAAIVFQKQYRMLKARRAYCRVRRAAVIIQSYTRAMCVRRS
                     YRQVLTEHKATIIQKYARGWMARRHFQRQRDAAIVIQCAFRRLKARQALKALKIEARS
                     AEHLKRLNVGMENKVVQLQRKIDDQNKEFKTLSEQLSAVTSTHAMEVEKLKKELARYQ
                     QNQEADPSLQLQEEVQSLRTELQKAHSERRVLEDTHNRENGELRKRVADLEHENALLK
                     DEKEHLNNQILRQSKAESSQSSVEENLLIKKELEEERSRYQNLVKEYSQLEQRYENLR
                     DEQQTPGHRKNPSNQSSLESDSNYPSISTSEIGDTEDALQQVEEIGIEKAAMDMTVFL
                     KLQKRVRELEQERKKLQVQLEKEQQDSKKVQVEQQNNGLDVDQDADIAYNSLKRQELE
                     SENKKLKNDLNELRKAVADQAMQDNSTHSSPDSYSLLLNQLKLANEELEVRKEEVLIL
                     RTQIMNADQRRLSGKNMEPNINARTSWPNSEKHVDQEDAIEAYHGVCQTNSQTEDWGY
                     LNEDGELGLAYQGLKQVARLLEAQLQAQNLKHEEEVEHLKAQVEAMKEEMDKQQQTFC
                     QTLLLSPEAQVEFGVQQEISRLTNENLDFKELVEKLEKNEKKLKKQLKIYMKKVQDLE
                     AAQALAQSDRRHHELTRQVTVQRKEKDFQGMLEYHKEDEALLIRNLVTDLKPQMLSGT
                     VPCLPAYILYMCIRHADYTNDDLKVHSLLSSTINGIKKVLKKHNEDFEMTSFWLSNTC
                     RLLHCLKQYSGDEGFMTQNTAKQNEHCLKNFDLTEYRQVLSDLSIQIYQQLIKIAEGL
                     LQPMIVSAMLENESIQGLSGVRPTGYRKRSSSMVDGENSYCLEAIIRQMNFFHTVLCD
                     QGLDPEIILQVFKQLFYMINAVTLNNLLLRKDACSWSTGMQLRYNISQLEEWLRGKNL
                     QQSGAVQTMEPLIQAAQLLQLKKKTQEDAEAICSLCTSLSTQQIVKILNLYTPLNEFE
                     ERVTVSFIRTIQAQLQERSDPQQLLLDSKHMFPVLFPFNPSALTMDSIHIPACLNLEF
                     LNEV"
     exon            198..308
                     /gene="Myo5b"
                     /gene_synonym="Myr6"
                     /inference="alignment:Splign:2.1.0"
     exon            309..480
                     /gene="Myo5b"
                     /gene_synonym="Myr6"
                     /inference="alignment:Splign:2.1.0"
     exon            481..625
                     /gene="Myo5b"
                     /gene_synonym="Myr6"
                     /inference="alignment:Splign:2.1.0"
     exon            626..782
                     /gene="Myo5b"
                     /gene_synonym="Myr6"
                     /inference="alignment:Splign:2.1.0"
     exon            783..926
                     /gene="Myo5b"
                     /gene_synonym="Myr6"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1008
                     /gene="Myo5b"
                     /gene_synonym="Myr6"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1116
                     /gene="Myo5b"
                     /gene_synonym="Myr6"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1226
                     /gene="Myo5b"
                     /gene_synonym="Myr6"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1492
                     /gene="Myo5b"
                     /gene_synonym="Myr6"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1574
                     /gene="Myo5b"
                     /gene_synonym="Myr6"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1715
                     /gene="Myo5b"
                     /gene_synonym="Myr6"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1838
                     /gene="Myo5b"
                     /gene_synonym="Myr6"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..1922
                     /gene="Myo5b"
                     /gene_synonym="Myr6"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..2078
                     /gene="Myo5b"
                     /gene_synonym="Myr6"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..2176
                     /gene="Myo5b"
                     /gene_synonym="Myr6"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2263
                     /gene="Myo5b"
                     /gene_synonym="Myr6"
                     /inference="alignment:Splign:2.1.0"
     exon            2264..2378
                     /gene="Myo5b"
                     /gene_synonym="Myr6"
                     /inference="alignment:Splign:2.1.0"
     exon            2379..2590
                     /gene="Myo5b"
                     /gene_synonym="Myr6"
                     /inference="alignment:Splign:2.1.0"
     exon            2591..2747
                     /gene="Myo5b"
                     /gene_synonym="Myr6"
                     /inference="alignment:Splign:2.1.0"
     exon            2748..2987
                     /gene="Myo5b"
                     /gene_synonym="Myr6"
                     /inference="alignment:Splign:2.1.0"
     exon            2988..3221
                     /gene="Myo5b"
                     /gene_synonym="Myr6"
                     /inference="alignment:Splign:2.1.0"
     exon            3222..3306
                     /gene="Myo5b"
                     /gene_synonym="Myr6"
                     /inference="alignment:Splign:2.1.0"
     exon            3307..3440
                     /gene="Myo5b"
                     /gene_synonym="Myr6"
                     /inference="alignment:Splign:2.1.0"
     exon            3441..3563
                     /gene="Myo5b"
                     /gene_synonym="Myr6"
                     /inference="alignment:Splign:2.1.0"
     exon            3564..3701
                     /gene="Myo5b"
                     /gene_synonym="Myr6"
                     /inference="alignment:Splign:2.1.0"
     exon            3702..3767
                     /gene="Myo5b"
                     /gene_synonym="Myr6"
                     /inference="alignment:Splign:2.1.0"
     exon            3768..4007
                     /gene="Myo5b"
                     /gene_synonym="Myr6"
                     /inference="alignment:Splign:2.1.0"
     exon            4008..4108
                     /gene="Myo5b"
                     /gene_synonym="Myr6"
                     /inference="alignment:Splign:2.1.0"
     exon            4109..4186
                     /gene="Myo5b"
                     /gene_synonym="Myr6"
                     /inference="alignment:Splign:2.1.0"
     exon            4187..4385
                     /gene="Myo5b"
                     /gene_synonym="Myr6"
                     /inference="alignment:Splign:2.1.0"
     exon            4386..4479
                     /gene="Myo5b"
                     /gene_synonym="Myr6"
                     /inference="alignment:Splign:2.1.0"
     exon            4480..4623
                     /gene="Myo5b"
                     /gene_synonym="Myr6"
                     /inference="alignment:Splign:2.1.0"
     exon            4624..4775
                     /gene="Myo5b"
                     /gene_synonym="Myr6"
                     /inference="alignment:Splign:2.1.0"
     exon            4776..4865
                     /gene="Myo5b"
                     /gene_synonym="Myr6"
                     /inference="alignment:Splign:2.1.0"
     exon            4866..5016
                     /gene="Myo5b"
                     /gene_synonym="Myr6"
                     /inference="alignment:Splign:2.1.0"
     exon            5017..5302
                     /gene="Myo5b"
                     /gene_synonym="Myr6"
                     /inference="alignment:Splign:2.1.0"
     exon            5303..5477
                     /gene="Myo5b"
                     /gene_synonym="Myr6"
                     /inference="alignment:Splign:2.1.0"
     exon            5478..5558
                     /gene="Myo5b"
                     /gene_synonym="Myr6"
                     /inference="alignment:Splign:2.1.0"
     exon            5559..6081
                     /gene="Myo5b"
                     /gene_synonym="Myr6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgggtcgg tccacccgag aaaggggcgc ggaggaactg ggaccgaccc gggaagactg
       61 cgccagaggt gcacggagat cgcgcgggga gcgaggagcc gggcctcggc gctcagcccg
      121 gatccagcgt cccgcgaagc acccggggct ccggcccggc ccgcggggtc atgtcgtaca
      181 gcgagctcta cagccggtac acgagggtct ggatccccga cccagatgag gtgtggcgct
      241 cggctgaact aaccaaggac tacaaagatg gggatgagag cctacaactc agactggaag
      301 atgacacaat tctggattac ccaatcgatg tccaaaataa ccaggtgcca ttcttgcgga
      361 atccagatat cttagtagga gaaaacgacc tcactgcact cagccatctc cacgagcccg
      421 cagttctgca taacttaaag gtccgtttcc tggagtctaa ccacatctac acttactgtg
      481 gaattgtgct tgttgccatt aatccctatg agcagctgcc aatctacggg caggatgtca
      541 tctatgccta cagtggccaa aatatgggcg acatggatcc ccacatcttt gctgtagcag
      601 aagaagccta caagcagatg gccagagatg aaaagaacca atccatcata gtcagcggag
      661 agtctggagc agggaagacc gtgtcagcca agtatgccat gcgctatttt gccacagttg
      721 ggggctcagc cagtgatacc aacatcgaag agaaggtcct ggcttccagt cccatcatgg
      781 aggccatcgg gaatgccaag acaactcgca acgacaatag cagccgattt gggaagtaca
      841 ttgagatcgg ctttgataaa aagtaccaca tcatcggggc caacatgagg acctatttgc
      901 tggagaagtc cagggtggtc tttcaggcgg atgatgagag gaactaccac atcttttacc
      961 agctctgtgc tgcggccagc cttcctgagt ttaaggagct cgcactaaca tgtgcagagg
     1021 actttttcta caccgcccat ggaggaaaca cgaccatcga gggtgtagat gatgcagagg
     1081 actttgagaa gacaagacaa gccctcacac tccttggagt tcgggagtcc catcaaatca
     1141 gcatctttaa gataattgct tctatcttgc accttggaag tgtggagatc caggccgagc
     1201 gggatgggga ctcctgcagc atatcgcccc aggacgaaca cctgagcaac ttctgccgcc
     1261 tgctaggaat agagcacagt cagatggagc actggctgtg tcatcggaag ctggtcacca
     1321 cctccgagac ctacgtcaag accatgtccc tgcagcaagt ggtcaacgca cgcaatgcct
     1381 tggccaagca catctatgcc cagctgttct cctggattgt ggagcacatc aacaaggccc
     1441 tgcaaacctc ccttaaacaa cactccttca tcggggtcct ggatatttat gggtttgaga
     1501 ccttcgagat taatagcttc gagcagtttt gtatcaacta tgccaacgaa aagctccagc
     1561 aacagttcaa ctcgcatgtg ttcaagctgg agcaagaaga gtatatgaag gagcagatcc
     1621 cgtggacctt gattgacttc tatgataacc aaccgtgcat agacctcata gaagccaagc
     1681 tgggtatcct ggacctgttg gatgaggagt gtaaggtccc caaaggaact gatcagaact
     1741 gggctcagaa actctatgaa cggcactcca acagtcaaca cttccagaaa ccacgcatgt
     1801 ccaacacggc cttcattgtc atccactttg cagacaaggt ggaatacctt tcagatggtt
     1861 ttctggagaa aaacagggac acggtatatg aagaacagat caacatcctg aaagccagca
     1921 agtttccact agtggctgat ttgttccgtg atgacaagga ctctgttcct gccaccaaca
     1981 cagctaagag tcggtcatct tcaaagatca atgttcgttc ttccagaccc ctcatgaagg
     2041 cccccaacaa ggagcacaag aaatccgtgg gctaccagtt ccgcacttcc ctaaacctgc
     2101 ttatggagac tctgaatgcc acaacgccac actacgttcg atgcatcaag cccaacgacg
     2161 aaaagctccc cttccacttc gacccaaaga gagctgtgca gcagctcaga gcctgcggcg
     2221 tgttggagac cattcggatc agcgcggcag gctacccgtc caggtggacc taccatgact
     2281 tcttcaaccg gtatcgggtg ttgatgaaga agagagagct tgccaacacc accgacaaga
     2341 agaatatctg caagtctgtc ctggagagtc tcatcaagga tccagacaag ttccagtttg
     2401 gccgcaccaa gatcttcttc cgggcaggtc aggtggccta cctggagaag cttcgggcag
     2461 acaagttccg ggaggccacc atcatgatcc aaaagacggt caggggctgg ctgcagagag
     2521 tgaagtaccg gaggctgaga gcagctacgc taaccctgca gagattctgc cgaggatact
     2581 tagcccgcag actgactgag cacttgagga gaacccgggc ggccatagtg ttccagaagc
     2641 agtaccgcat gctgaaggcc cgccgagcct actgcagggt ccgcagggct gcggtcatca
     2701 tccagtccta cacgagggcc atgtgtgtac gcagaagcta ccgccaggtc ctcacggagc
     2761 acaaagccac catcatccag aagtacgccc ggggctggat ggcacggaga cattttcagc
     2821 ggcagcggga tgcagccatt gtcatccagt gtgccttccg gaggctcaag gccaggcagg
     2881 cactgaaggc cctcaagatc gaggcccgtt ctgcagagca tctgaaacgc ctcaacgtgg
     2941 gcatggagaa caaagttgtc cagctgcagc ggaagattga tgaccagaac aaagagttca
     3001 agactctgtc agagcagttg tctgcagtta cctccaccca tgccatggag gtggagaagc
     3061 tgaagaagga gctggcgcgt taccagcaga accaggaggc tgaccccagc cttcagctgc
     3121 aggaggaggt acagagcctg cgcaccgaac tacagaaggc tcattcggag cgcagggtcc
     3181 tagaggatac tcacaacagg gagaatggtg aactgagaaa gcgagtcgca gacctggaac
     3241 atgaaaatgc actcttgaag gatgagaaag aacaccttaa caaccaaatc ctgcgccagt
     3301 caaaagctga atcttcacag agctctgtgg aggaaaacct gctgattaag aaggaactgg
     3361 aggaggaacg gtcccggtac cagaacctcg tgaaggagta ctcccagctg gagcagagat
     3421 atgagaacct tcgggacgag cagcaaactc caggccacag gaagaaccca tcaaatcaaa
     3481 gtagcttaga atctgactcc aattacccct ccatttccac ctcagaaatc ggagacaccg
     3541 aggatgccct acagcaggtg gaggagattg gtatagagaa ggcagccatg gacatgactg
     3601 tcttcttgaa gctgcagaag agagtgcggg aacttgagca ggagaggaag aagctgcagg
     3661 tgcagctaga aaaggaacaa caggacagca agaaagtgca ggtagaacaa caaaacaatg
     3721 gcctagatgt ggaccaggat gcagatatag cctacaatag tctgaagaga caagagctcg
     3781 agtcagagaa caagaagctg aagaatgatc tgaatgagct gcggaaggct gtagccgacc
     3841 aagccatgca ggataactcc actcatagct cccccgacag ctacagcctc ctactgaacc
     3901 agctcaagct ggccaacgag gagctggagg tccgcaaaga ggaggtgctg atcctcagga
     3961 cccagatcat gaatgctgac cagcgcagac tgtccggcaa gaacatggag ccgaacatca
     4021 atgccagaac aagttggccc aacagcgaga agcacgtgga ccaggaagat gccattgagg
     4081 cctatcacgg ggtctgccag acaaacagcc agactgagga ttggggatat ttgaatgaag
     4141 atggagaact cggcttggct taccaaggcc taaagcaagt cgccaggttg ctggaggccc
     4201 agctgcaggc ccagaacctg aagcatgagg aggaggtgga gcatctcaag gcccaggtgg
     4261 aggccatgaa ggaggagatg gacaaacagc agcagacctt ctgccagact ctgctgctct
     4321 ccccagaggc ccaggtagaa tttggtgtcc agcaggagat atcccggctg accaatgaga
     4381 acctggactt taaggagttg gtggaaaagc tggagaagaa tgagaagaag ctgaaaaagc
     4441 agctgaagat ttacatgaag aaggtccagg acttagaagc tgcccaggca ttggcacaga
     4501 gtgacaggag gcaccatgaa ctcacaagac aggtcacggt ccaacgaaaa gagaaggact
     4561 tccaaggcat gctggagtac cacaaagagg acgaggcact ccttatccgg aacctggtga
     4621 cagacctgaa gccccagatg ctgtcgggca ccgtgccctg tctgcctgca tacatactct
     4681 acatgtgcat caggcacgcg gactacacca acgatgacct caaggtgcac tcgttgctga
     4741 gctccaccat caatggcatt aagaaagtcc tcaagaagca caatgaggac tttgagatga
     4801 cgtcattctg gttatccaac acctgccgcc tccttcactg tttgaagcag tacagtgggg
     4861 atgagggttt catgacacag aacacggcga agcagaatga gcactgtctc aagaactttg
     4921 acctcactga ataccgtcag gtgctaagtg acctttccat tcagatctat cagcaactca
     4981 ttaaaattgc tgagggcctg ctacagccta tgatagtttc tgccatgctg gaaaatgaga
     5041 gtatccaggg gctgtcaggg gtgaggccaa ctggctaccg gaagcgctcg tccagcatgg
     5101 tggacggaga aaattcgtat tgcctggagg ccatcatccg ccagatgaat ttctttcata
     5161 cagtcctgtg tgaccagggc ctggaccctg agattatcct gcaggtgttc aaacagcttt
     5221 tctacatgat caatgcggtg actcttaaca acctactcct gcggaaagat gcctgctcct
     5281 ggagcaccgg catgcaactc aggtacaaca taagtcaact cgaagagtgg cttcggggaa
     5341 aaaaccttca gcagagtgga gcggttcaga ccatggagcc cttgatccag gcagcccaac
     5401 tccttcagct gaagaagaag acccaggagg atgctgaggc catctgctct ctgtgtacct
     5461 ccctcagcac ccagcagatt gtcaaaattt taaacctcta cactcccttg aatgaatttg
     5521 aagaacgggt gacagtgtcc tttatacgaa caatccaggc tcagctacaa gagaggagtg
     5581 acccccagca gctactgctg gactccaaac acatgtttcc tgttctgttt ccatttaatc
     5641 catctgctct gaccatggac tcaatccaca tcccggcctg tctcaatctg gagttcctca
     5701 atgaagtctg aggatgcgtt gtttccaagg caagcgagaa ggaagtgcgt gctgtcggct
     5761 gaaggagtgc taggtctgtt aaatatgccc agcgtagatc aaaccatgtt agagacctgt
     5821 ggggagcact gaactaaaca gcggggtgca ctctggtcgt tagcttttgt acagactgct
     5881 cagaaaacac ctgaagtgag gacgattgtt gcagtggcac tttcaggtta aaccaagaca
     5941 cgtcagaacg gacggccgct gtgtagctcc agtcaccata caaagatgcc agttctacag
     6001 agtggaagtg cctagctttg agctgtgtat ataacttaag aatgttcaaa ctaagattat
     6061 attaaaaaca catgacataa a
//
