LOCUS       NM_173101               4258 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus myosin IE (Myo1e), mRNA.
ACCESSION   NM_173101 XM_001055455
VERSION     NM_173101.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4258)
  AUTHORS   Revenu,C., Ubelmann,F., Hurbain,I., El-Marjou,F., Dingli,F.,
            Loew,D., Delacour,D., Gilet,J., Brot-Laroche,E., Rivero,F.,
            Louvard,D. and Robine,S.
  TITLE     A new role for the architecture of microvillar actin bundles in
            apical retention of membrane proteins
  JOURNAL   Mol Biol Cell 23 (2), 324-336 (2012)
   PUBMED   22114352
REFERENCE   2  (bases 1 to 4258)
  AUTHORS   Feeser,E.A., Ignacio,C.M., Krendel,M. and Ostap,E.M.
  TITLE     Myo1e binds anionic phospholipids with high affinity
  JOURNAL   Biochemistry 49 (43), 9353-9360 (2010)
   PUBMED   20860408
REFERENCE   3  (bases 1 to 4258)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   4  (bases 1 to 4258)
  AUTHORS   Benesh,A.E., Nambiar,R., McConnell,R.E., Mao,S., Tabb,D.L. and
            Tyska,M.J.
  TITLE     Differential localization and dynamics of class I myosins in the
            enterocyte microvillus
  JOURNAL   Mol Biol Cell 21 (6), 970-978 (2010)
   PUBMED   20089841
REFERENCE   5  (bases 1 to 4258)
  AUTHORS   Krendel,M., Kim,S.V., Willinger,T., Wang,T., Kashgarian,M.,
            Flavell,R.A. and Mooseker,M.S.
  TITLE     Disruption of Myosin 1e promotes podocyte injury
  JOURNAL   J Am Soc Nephrol 20 (1), 86-94 (2009)
   PUBMED   19005011
REFERENCE   6  (bases 1 to 4258)
  AUTHORS   Schmahl,J., Raymond,C.S. and Soriano,P.
  TITLE     PDGF signaling specificity is mediated through multiple immediate
            early genes
  JOURNAL   Nat Genet 39 (1), 52-60 (2007)
   PUBMED   17143286
REFERENCE   7  (bases 1 to 4258)
  AUTHORS   Dumont,R.A., Zhao,Y.D., Holt,J.R., Bahler,M. and Gillespie,P.G.
  TITLE     Myosin-I isozymes in neonatal rodent auditory and vestibular
            epithelia
  JOURNAL   J Assoc Res Otolaryngol 3 (4), 375-389 (2002)
   PUBMED   12486594
  REMARK    GeneRIF: Myo1e found in hair cells of auditory and vestibular
            epithelia; enriched in cuticular plate, actin meshwork that anchors
            stereocilia.
REFERENCE   8  (bases 1 to 4258)
  AUTHORS   El Mezgueldi,M., Tang,N., Rosenfeld,S.S. and Ostap,E.M.
  TITLE     The kinetic mechanism of Myo1e (human myosin-IC)
  JOURNAL   J Biol Chem 277 (24), 21514-21521 (2002)
   PUBMED   11940582
REFERENCE   9  (bases 1 to 4258)
  AUTHORS   Huber,L.A., Fialka,I., Paiha,K., Hunziker,W., Sacks,D.B.,
            Bahler,M., Way,M., Gagescu,R. and Gruenberg,J.
  TITLE     Both calmodulin and the unconventional myosin Myr4 regulate
            membrane trafficking along the recycling pathway of MDCK cells
  JOURNAL   Traffic 1 (6), 494-503 (2000)
   PUBMED   11208135
REFERENCE   10 (bases 1 to 4258)
  AUTHORS   Stoffler,H.E., Ruppert,C., Reinhard,J. and Bahler,M.
  TITLE     A novel mammalian myosin I from rat with an SH3 domain localizes to
            Con A-inducible, F-actin-rich structures at cell-cell contacts
  JOURNAL   J Cell Biol 129 (3), 819-830 (1995)
   PUBMED   7730414
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 27, 2020 this sequence version replaced NM_173101.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X74815.1, SRR26643284.11459.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-290               JAXUCZ010000008.1  79768828-79769117
            291-434             JAXUCZ010000008.1  79848270-79848413
            435-524             JAXUCZ010000008.1  79859788-79859877
            525-619             JAXUCZ010000008.1  79864190-79864284
            620-707             JAXUCZ010000008.1  79878009-79878096
            708-797             JAXUCZ010000008.1  79881429-79881518
            798-929             JAXUCZ010000008.1  79883697-79883828
            930-1064            JAXUCZ010000008.1  79886122-79886256
            1065-1197           JAXUCZ010000008.1  79888609-79888741
            1198-1394           JAXUCZ010000008.1  79896144-79896340
            1395-1475           JAXUCZ010000008.1  79897409-79897489
            1476-1562           JAXUCZ010000008.1  79898846-79898932
            1563-1649           JAXUCZ010000008.1  79901419-79901505
            1650-1817           JAXUCZ010000008.1  79902093-79902260
            1818-1903           JAXUCZ010000008.1  79903285-79903370
            1904-1985           JAXUCZ010000008.1  79907134-79907215
            1986-2092           JAXUCZ010000008.1  79913936-79914042
            2093-2191           JAXUCZ010000008.1  79920600-79920698
            2192-2336           JAXUCZ010000008.1  79923933-79924077
            2337-2451           JAXUCZ010000008.1  79929439-79929553
            2452-2621           JAXUCZ010000008.1  79930224-79930393
            2622-2767           JAXUCZ010000008.1  79932110-79932255
            2768-2914           JAXUCZ010000008.1  79938130-79938276
            2915-3072           JAXUCZ010000008.1  79939815-79939972
            3073-3162           JAXUCZ010000008.1  79940325-79940414
            3163-3364           JAXUCZ010000008.1  79944787-79944988
            3365-3534           JAXUCZ010000008.1  79957061-79957230
            3535-4258           JAXUCZ010000008.1  79960004-79960727
FEATURES             Location/Qualifiers
     source          1..4258
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..4258
                     /gene="Myo1e"
                     /gene_synonym="Myr3; MYR5"
                     /note="myosin IE"
                     /db_xref="GeneID:25484"
                     /db_xref="RGD:3144"
     exon            1..290
                     /gene="Myo1e"
                     /gene_synonym="Myr3; MYR5"
                     /inference="alignment:Splign:2.1.0"
     CDS             288..3611
                     /gene="Myo1e"
                     /gene_synonym="Myr3; MYR5"
                     /note="myosin-Ie; myosin heavy chain myr 3; Unconventional
                     myosin from rat 5; unconventional myosin 1E"
                     /codon_start=1
                     /product="unconventional myosin-Ie"
                     /protein_id="NP_775124.1"
                     /db_xref="GeneID:25484"
                     /db_xref="RGD:3144"
                     /translation="MGSKGAYRYHWQSHNVKHSGVDDMVLLSKITESSIVENLKKRYM
                     DDYIFTYIGSVLISVNPFKQMPYFGEKEIEMYQGAAQYENPPHIYALADSMYRNMIID
                     RENQCVIISGESGAGKTVAAKYIMSYVSRVSGGGPKVQHVKDIILQSNPLLEAFGNAK
                     TVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNPGERSFHIFYQLIEG
                     ASPEQKQSLGITSMDYYYYLSLSGSYKVDDIDDKRDFQETLHAMNVIGIFSEEQTLVL
                     QIVAGILHLGNINFKEVGNYAAVESEEFLAFPAYLLGINQDRLKEKLTSRQMDSKWGG
                     KSESIHVTLNVEQACYTRDALAKALHARVFDFLVDSINKAMEKDHEEYNIGVLDIYGF
                     EIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIEYFNNKIVCDLI
                     ESKVNPPGIMSILDDVCATMHAVGEGADQTLLQKLQMQIGSHEHFNSWNQGFIIHHYA
                     GKVSYDMDGFCERNRDVLFMDLIELMQSSELPFIKSLFPENLQADKKGRPTTAGSKIK
                     KQANDLVSTLMKCTPHYIRCIKPNETKKPKDWEESRVKHQVEYLGLKENIRVRRAGYA
                     YRRVFQKFLQRYAILTKATWPVWRGDEKQGVLHLLQSVNMDSDQFQLGRSKVFIKAPE
                     SLFLLEEMRERKYDGYARVIQKTWRKFVARKKYVQMREDASDLLLNKKERRRNSINRN
                     FIGDYIGMEEHPELQQFVGKREKIDFADIVTKYDRRFKGVKRDLLLTPKCLYLIGREK
                     VKQGPDKGLVKEVLKRKIEVERILSVSLSTMQDDIFILHEQEYDSLLESVFKTEFLSL
                     LTKRYEEKTQKQLPLKFSNTLELKLKKENWGPWSAGGSRQVQFYQGFGDLAILKPSNK
                     VLQVSIGPGLPKNARPTRRNTVSSRGYSGGTNNNYPMRAAPAPPGCHRNGLTRNQFVH
                     PPRASGNQRSNQKSLYTSMARPPLPRQQSTGSDRLSQTPESLDFLKVPDQGAAGVRRQ
                     TTSRPPPAGGRPKPQPKPKPQVPQCKALYAYDAQDTDELSFNANDVIDIIKEDPSGWW
                     TGRLRGKQGLFPNNYVTKI"
     exon            291..434
                     /gene="Myo1e"
                     /gene_synonym="Myr3; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            435..524
                     /gene="Myo1e"
                     /gene_synonym="Myr3; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            525..619
                     /gene="Myo1e"
                     /gene_synonym="Myr3; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            620..707
                     /gene="Myo1e"
                     /gene_synonym="Myr3; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            708..797
                     /gene="Myo1e"
                     /gene_synonym="Myr3; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            798..929
                     /gene="Myo1e"
                     /gene_synonym="Myr3; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1064
                     /gene="Myo1e"
                     /gene_synonym="Myr3; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1197
                     /gene="Myo1e"
                     /gene_synonym="Myr3; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1394
                     /gene="Myo1e"
                     /gene_synonym="Myr3; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1475
                     /gene="Myo1e"
                     /gene_synonym="Myr3; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1562
                     /gene="Myo1e"
                     /gene_synonym="Myr3; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1649
                     /gene="Myo1e"
                     /gene_synonym="Myr3; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1817
                     /gene="Myo1e"
                     /gene_synonym="Myr3; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..1903
                     /gene="Myo1e"
                     /gene_synonym="Myr3; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..1985
                     /gene="Myo1e"
                     /gene_synonym="Myr3; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2092
                     /gene="Myo1e"
                     /gene_synonym="Myr3; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2191
                     /gene="Myo1e"
                     /gene_synonym="Myr3; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..2336
                     /gene="Myo1e"
                     /gene_synonym="Myr3; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..2451
                     /gene="Myo1e"
                     /gene_synonym="Myr3; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            2452..2621
                     /gene="Myo1e"
                     /gene_synonym="Myr3; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            2622..2767
                     /gene="Myo1e"
                     /gene_synonym="Myr3; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            2768..2914
                     /gene="Myo1e"
                     /gene_synonym="Myr3; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            2915..3072
                     /gene="Myo1e"
                     /gene_synonym="Myr3; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            3073..3162
                     /gene="Myo1e"
                     /gene_synonym="Myr3; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            3163..3364
                     /gene="Myo1e"
                     /gene_synonym="Myr3; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            3365..3534
                     /gene="Myo1e"
                     /gene_synonym="Myr3; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            3535..4258
                     /gene="Myo1e"
                     /gene_synonym="Myr3; MYR5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacaggcagt cctgcagagc gcatcagggt gcatctctag acagttgggg atcgccaggt
       61 cggagtgtgc accgggtctg ctaagttttg ccttcaccca gagtcttgga tcccgcctgg
      121 atggagtccc ttctgggttt ccattggctc ctgtgagtgc ttgggtgtct ggagattgtt
      181 ttttggcgaa ggggaacaac ttttgaagtt cgcccaggag accgcgttcc aaccctagtg
      241 cctaggcagc cggacccggc gggggcgcga ccgcggcggg agtcaccatg ggcagcaaag
      301 gcgcctaccg gtaccattgg cagagccaca atgtcaagca cagtggtgtg gacgacatgg
      361 tactactctc caagatcaca gagagctcca tcgtagagaa cctgaagaag agatacatgg
      421 acgactatat ttttacatat atagggtctg tcttaatctc tgtcaaccct ttcaagcaaa
      481 tgccatattt tggagaaaaa gagattgaaa tgtaccaagg agcggcccag tatgagaacc
      541 cacctcatat ctatgccctt gcagacagta tgtacagaaa catgatcatc gacagagaga
      601 accagtgtgt catcatcagt ggtgaaagtg gtgctggaaa gacagtagct gccaagtaca
      661 tcatgagcta cgtctccaga gtgtccggag gaggccccaa ggtccagcat gtcaaggaca
      721 tcatccttca gtccaaccca ctcctggagg ccttcgggaa tgccaagaca gtccgcaaca
      781 acaactccag ccgatttgga aaatactttg aaatccagtt cagtccaggt ggggaaccag
      841 atggtggcaa gatctccaac ttccttctgg aaaagtccag agtggtgatg aggaacccgg
      901 gagaacggag cttccacata ttctaccagc tcatcgaggg cgcctctcca gagcagaagc
      961 aaagccttgg tatcaccagc atggactact attattacct gagcctctca gggtcataca
     1021 aggttgatga cattgatgac aagcgggatt tccaggaaac cctgcacgcc atgaatgtga
     1081 ttgggatctt ctcagaggag cagactctcg tgctgcagat tgtggctgga attctccact
     1141 tgggaaacat caacttcaag gaagtgggca actatgcggc cgtggagagc gaagaatttt
     1201 tggcttttcc tgcgtatctg ctgggtataa accaagaccg gttaaaagag aagctgacga
     1261 gccggcagat ggacagtaag tggggaggaa agtcagagtc catccatgtg accctcaatg
     1321 tggagcaggc ctgctacacc agggatgccc tcgccaaggc cctgcacgcg cgagtctttg
     1381 atttcttggt ggattccatc aataaagcta tggagaagga ccacgaggag tacaacattg
     1441 gtgtcctgga catctatggc tttgaaatat ttcagaaaaa tggcttcgag cagttctgca
     1501 tcaatttcgt taatgaaaaa ttacagcaga tttttatcga gctgacgcta aaggccgagc
     1561 aggaagaata cgttcaggag gggataagat ggacacccat tgaatatttc aataataaaa
     1621 ttgtgtgtga cctcatagag agcaaagtca accctcctgg aattatgagc atcctggatg
     1681 acgtgtgtgc caccatgcat gctgtgggtg agggtgctga ccagacactg ctacagaagc
     1741 tccagatgca gatcgggagc catgagcact ttaacagctg gaaccaaggt ttcattattc
     1801 accactatgc tgggaaggtt tcctatgaca tggatggctt ctgtgaaagg aaccgggatg
     1861 tgctattcat ggacctgatt gagctcatgc agagcagtga gctgcctttt ataaagtctt
     1921 tatttcctga aaacctgcaa gccgacaaga aagggcgccc aacgactgca ggaagcaaaa
     1981 taaagaaaca agccaatgac ctcgtgagca ccctgatgaa atgtacaccc cactacattc
     2041 gctgcataaa accgaacgaa accaagaagc ccaaagactg ggaggagagc agagtgaagc
     2101 atcaagtgga gtacctgggt ctcaaggaaa acatccgagt gagaagggct ggttatgctt
     2161 atcggcgtgt cttccagaaa tttctacaga ggtatgccat tctgaccaaa gctacctggc
     2221 ctgtgtggag aggagatgag aaacaaggtg tcctccatct gctacagtct gtcaacatgg
     2281 acagcgacca gttccagctc gggaggagta aagtgttcat caaagccccg gagtctctat
     2341 ttcttctgga agagatgaga gagagaaagt atgatgggta cgcacgcgtg atacagaaaa
     2401 catggaggaa gtttgtggcc cgcaagaagt atgtccagat gagagaagac gcctcagacc
     2461 tgttgttgaa caagaaggag aggaggagaa acagcatcaa ccgaaacttc atcggggact
     2521 acatcgggat ggaggagcac ccggagctcc agcagtttgt gggcaagagg gagaagattg
     2581 actttgctga catagtcacc aagtatgaca ggaggttcaa gggtgtcaag cgagacctgc
     2641 tgctaacccc aaagtgcttg tacttaattg gaagggagaa ggtgaagcaa ggcccggaca
     2701 aaggtcttgt gaaggaagtc ctgaagcgga agatcgaggt ggaaaggatc ctgtccgtgt
     2761 ccctcagtac catgcaggat gacatcttca ttctccatga gcaagagtat gacagtttgc
     2821 ttgagtccgt ctttaaaaca gagttcctga gccttttaac aaagcgatat gaggaaaaaa
     2881 cccagaagca actacctctg aaattcagca atacccttga actgaagttg aaaaaggaga
     2941 actggggtcc ctggagtgct gggggctccc ggcaagtgca gttctaccaa ggcttcggtg
     3001 acctggccat cctcaagccc agcaacaaag tgctgcaggt cagcattgga cctgggctgc
     3061 ccaagaacgc ccgtcccacc agaagaaaca ctgtctcaag cagagggtat tctggtggaa
     3121 ctaacaacaa ttacccgatg agagccgccc ctgctccccc aggatgccat cgaaatggcc
     3181 tcaccagaaa ccagtttgtg catcctcccc gtgcctctgg aaaccagagg tccaatcaga
     3241 aaagcctata cacctctatg gcccgcccac ccttgccaag gcaacagtcc acaggctcag
     3301 accgattgtc tcagacaccg gagagcctgg atttcctcaa ggtcccggac cagggtgctg
     3361 ctggagtccg aagacaaacg accagccggc ctcccccagc aggcggcaga ccaaagcctc
     3421 agcccaagcc taagcctcag gtgccgcagt gcaaggctct gtatgcctac gatgctcagg
     3481 acacagacga actcagcttc aatgccaatg acgtcatcga tattattaag gaagatcctt
     3541 ctggctggtg gacgggtaga ctacgaggca agcagggcct gtttcctaac aactatgtca
     3601 ccaagatctg aggcgcccag aaattgtcat gcaggcagag gagctccaga cgtggactgg
     3661 ggaggggact ttttggggac tccccttctg atccacaatg agcaactgct actccaaggt
     3721 ctgaagctat tctggtacct tccccatgga agacgcagaa aagcttggga tgggaacaag
     3781 gagtttcact ccgtaaatga tcctaaaagg tagtctagtt cccaggagcg ccaaaacaac
     3841 cacccactaa gatttattta ttgtatttaa atctggtgaa agcagcaggg gctgctgggt
     3901 gtctatcccg cagcctccag cgcactcacc aagcccaggg gacagcaggt ggtgactatg
     3961 acaagtgcct ttagttgaag agcacgtttc attcattcct ctcttccata cctgatacat
     4021 tcctttctgc taaccctcct tcagggagga cccaccctct gcaggctgga cttggtgtga
     4081 acaggcactc acctgtcaat gccaagggca ggccgtcctt ccaagcccat gggagccagg
     4141 gccactaaga ctgctggtgg ggaggaagtt gggtgctggg ctgactgatg gtcttgcttt
     4201 cccttggtct ttgcttgtaa tgtggctggc ccatgttggt tttatgttta atgttgtg
//
