LOCUS       NM_053986               3609 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus myosin Ib (Myo1b), mRNA.
ACCESSION   NM_053986 XM_346851
VERSION     NM_053986.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3609)
  AUTHORS   Telek,E., Karadi,K., Kardos,J., Kengyel,A., Fekete,Z., Halasz,H.,
            Nyitrai,M., Bugyi,B. and Lukacs,A.
  TITLE     The C-terminal tail extension of myosin 16 acts as a molten
            globule, including intrinsically disordered regions, and interacts
            with the N-terminal ankyrin
  JOURNAL   J Biol Chem 297 (1), 100716 (2021)
   PUBMED   33930467
  REMARK    GeneRIF: The C-terminal tail extension of myosin 16 acts as a
            molten globule, including intrinsically disordered regions, and
            interacts with the N-terminal ankyrin.
REFERENCE   2  (bases 1 to 3609)
  AUTHORS   Tokuo,H., Komaba,S. and Coluccio,L.M.
  TITLE     In pancreatic beta-cells myosin 1b regulates glucose-stimulated
            insulin secretion by modulating an early step in insulin granule
            trafficking from the Golgi
  JOURNAL   Mol Biol Cell 32 (12), 1210-1220 (2021)
   PUBMED   33826361
  REMARK    GeneRIF: In pancreatic beta-cells myosin 1b regulates
            glucose-stimulated insulin secretion by modulating an early step in
            insulin granule trafficking from the Golgi.
REFERENCE   3  (bases 1 to 3609)
  AUTHORS   Kittelberger,N., Breunig,M., Martin,R., Knolker,H.J. and Miklavc,P.
  TITLE     The role of myosin 1c and myosin 1b in surfactant exocytosis
  JOURNAL   J Cell Sci 129 (8), 1685-1696 (2016)
   PUBMED   26940917
  REMARK    GeneRIF: expression of myosin 1b constructs influenced secretory
            vesicle compression rate in alveolar type II cells
REFERENCE   4  (bases 1 to 3609)
  AUTHORS   Prosperi,M.T., Lepine,P., Dingli,F., Paul-Gilloteaux,P., Martin,R.,
            Loew,D., Knolker,H.J. and Coudrier,E.
  TITLE     Myosin 1b functions as an effector of EphB signaling to control
            cell repulsion
  JOURNAL   J Cell Biol 210 (2), 347-361 (2015)
   PUBMED   26195670
REFERENCE   5  (bases 1 to 3609)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3609)
  AUTHORS   Bose,A., Guilherme,A., Robida,S.I., Nicoloro,S.M., Zhou,Q.L.,
            Jiang,Z.Y., Pomerleau,D.P. and Czech,M.P.
  TITLE     Glucose transporter recycling in response to insulin is facilitated
            by myosin Myo1c
  JOURNAL   Nature 420 (6917), 821-824 (2002)
   PUBMED   12490950
REFERENCE   7  (bases 1 to 3609)
  AUTHORS   Dumont,R.A., Zhao,Y.D., Holt,J.R., Bahler,M. and Gillespie,P.G.
  TITLE     Myosin-I isozymes in neonatal rodent auditory and vestibular
            epithelia
  JOURNAL   J Assoc Res Otolaryngol 3 (4), 375-389 (2002)
   PUBMED   12486594
REFERENCE   8  (bases 1 to 3609)
  AUTHORS   Boyd-White,J., Srirangam,A., Goheen,M.P. and Wagner,M.C.
  TITLE     Ischemia disrupts myosin I beta in renal tubules
  JOURNAL   Am J Physiol Cell Physiol 281 (4), C1326-C1335 (2001)
   PUBMED   11546671
REFERENCE   9  (bases 1 to 3609)
  AUTHORS   Huber,L.A., Fialka,I., Paiha,K., Hunziker,W., Sacks,D.B.,
            Bahler,M., Way,M., Gagescu,R. and Gruenberg,J.
  TITLE     Both calmodulin and the unconventional myosin Myr4 regulate
            membrane trafficking along the recycling pathway of MDCK cells
  JOURNAL   Traffic 1 (6), 494-503 (2000)
   PUBMED   11208135
REFERENCE   10 (bases 1 to 3609)
  AUTHORS   Ruppert,C., Kroschewski,R. and Bahler,M.
  TITLE     Identification, characterization and cloning of myr 1, a mammalian
            myosin-I
  JOURNAL   J Cell Biol 120 (6), 1393-1403 (1993)
   PUBMED   8449985
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            [WARNING] On Jul 30, 2024 this sequence was replaced by
            NM_053986.3.
            
            On Nov 27, 2020 this sequence version replaced NM_053986.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X68199.1, SRR26643298.48760.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               JAXUCZ010000009.1  57182062-57182192
            132-275             JAXUCZ010000009.1  57217577-57217720
            276-391             JAXUCZ010000009.1  57234906-57235021
            392-486             JAXUCZ010000009.1  57261168-57261262
            487-591             JAXUCZ010000009.1  57271264-57271368
            592-638             JAXUCZ010000009.1  57275746-57275792
            639-702             JAXUCZ010000009.1  57281181-57281244
            703-801             JAXUCZ010000009.1  57291548-57291646
            802-905             JAXUCZ010000009.1  57294445-57294548
            906-1053            JAXUCZ010000009.1  57295921-57296068
            1054-1172           JAXUCZ010000009.1  57296343-57296461
            1173-1259           JAXUCZ010000009.1  57302372-57302458
            1260-1325           JAXUCZ010000009.1  57303070-57303135
            1326-1430           JAXUCZ010000009.1  57311358-57311462
            1431-1493           JAXUCZ010000009.1  57313820-57313882
            1494-1694           JAXUCZ010000009.1  57316117-57316317
            1695-1921           JAXUCZ010000009.1  57317390-57317616
            1922-2122           JAXUCZ010000009.1  57318879-57319079
            2123-2216           JAXUCZ010000009.1  57320882-57320975
            2217-2366           JAXUCZ010000009.1  57321730-57321879
            2367-2435           JAXUCZ010000009.1  57324199-57324267
            2436-2522           JAXUCZ010000009.1  57325926-57326012
            2523-2609           JAXUCZ010000009.1  57326256-57326342
            2610-2696           JAXUCZ010000009.1  57327944-57328030
            2697-2771           JAXUCZ010000009.1  57330871-57330945
            2772-2906           JAXUCZ010000009.1  57332158-57332292
            2907-3013           JAXUCZ010000009.1  57334487-57334593
            3014-3146           JAXUCZ010000009.1  57336670-57336802
            3147-3299           JAXUCZ010000009.1  57337482-57337634
            3300-3427           JAXUCZ010000009.1  57338947-57339074
            3428-3609           JAXUCZ010000009.1  57342579-57342760
FEATURES             Location/Qualifiers
     source          1..3609
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q22"
     gene            1..3609
                     /gene="Myo1b"
                     /gene_synonym="Myr1"
                     /note="myosin Ib"
                     /db_xref="GeneID:117057"
                     /db_xref="RGD:70994"
     exon            1..131
                     /gene="Myo1b"
                     /gene_synonym="Myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            132..275
                     /gene="Myo1b"
                     /gene_synonym="Myr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..3551
                     /gene="Myo1b"
                     /gene_synonym="Myr1"
                     /note="MMIa; MMI-alpha; myosin I alpha; myosin heavy chain
                     myr 1"
                     /codon_start=1
                     /product="unconventional myosin-Ib"
                     /protein_id="NP_446438.1"
                     /db_xref="GeneID:117057"
                     /db_xref="RGD:70994"
                     /translation="MAKKEVKSSLLDNMIGVGDTVLLEPLNEETFIDNLKKRFDHNEI
                     YTYIGSVVISVNPYRSLPIYSPEKVEDYRNRNFYELSPHIFALSDEAYRSLRDQDKDQ
                     CILITGESGAGKTEASKLVMSYVAAVCGKGAEVNQVKEQLLQSTPVLEAFGNAKTVRN
                     DNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSRVVKQPRGERNFHVFYQLLSGASEE
                     LLHKLKLERDFSRYNYLSLDSAKVNGVDDAANFRTVRNAMQIVGFSDPEAESVLEVVA
                     AVLKLGNIEFKPESRMNGLDESKIKDKNELKEICELTSIDQVVLERAFSFRTVEAKQE
                     KVSTTLNVAQAYYARDALAKNLYSRLFSWLVNRINESIKAQTKVRKKVMGVLDIYGFE
                     IFEDNSFEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNAIICDLIE
                     NNTNGILAMLDEECLRPGTVTDETFLEKLNQVCATHQHFESRMSKCSRFLNDTTLPHS
                     CFRIQHYAGKVLYQVEGFVDKNNDLLYRDLSQAMWKAGHALIKSLFPEGNPAKVNLKR
                     PPTAGSQFKASVATLMKNLQTKNPNYIRCIKPNDKKAAHIFSESLVCHQIRYLGLLEN
                     VRVRRAGYAFRQAYEPCLERYKMLCKQTWPHWKGPARSGVEVLFNELEIPVEEYSFGR
                     SKIFIRNPRTLFQLEDLRKQRLEDLATLIQKIYRGWKCRTHFLLMKRSQVVIAAWYRR
                     YAQQKRYQQIKSSALVIQSYIRGWKARKILRELKHQKRCKEAATTIAAYWHGTQARKE
                     RRRLKDEARNKHAIAVIWAFWLGSKARRELKRLKEEARRKHAVAVIWAYWLGLKVRRE
                     YRKFFRANAGKKIYEFTLQRIVQKYLLEMKNKMPSLSPIDKNWPSRPYLFLDSTHKEL
                     KRIFHLWRCKKYRDQFTDQQKLIYEEKLEASELFKDKKALYPSSVGQPFQGAYLEINK
                     NPKYKKLKDAIEEKIIIAEVVNKINRANGKSTSRIFLLTNNNLLLADQKSGQIKSEVP
                     LVDVTKVSMSSQNDGFFAVHLKEGSEAASKGDFLFSSDHLIEMATKLYRTTLSQTKQK
                     LNIEISDEFLVQFRQDKVCVKFIQGNQKNGSVPTCKRKNNRLLEVAVP"
     exon            276..391
                     /gene="Myo1b"
                     /gene_synonym="Myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            392..486
                     /gene="Myo1b"
                     /gene_synonym="Myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            487..591
                     /gene="Myo1b"
                     /gene_synonym="Myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            592..638
                     /gene="Myo1b"
                     /gene_synonym="Myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            639..702
                     /gene="Myo1b"
                     /gene_synonym="Myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            703..801
                     /gene="Myo1b"
                     /gene_synonym="Myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            802..905
                     /gene="Myo1b"
                     /gene_synonym="Myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1053
                     /gene="Myo1b"
                     /gene_synonym="Myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1172
                     /gene="Myo1b"
                     /gene_synonym="Myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1259
                     /gene="Myo1b"
                     /gene_synonym="Myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1325
                     /gene="Myo1b"
                     /gene_synonym="Myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1430
                     /gene="Myo1b"
                     /gene_synonym="Myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1493
                     /gene="Myo1b"
                     /gene_synonym="Myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1694
                     /gene="Myo1b"
                     /gene_synonym="Myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1921
                     /gene="Myo1b"
                     /gene_synonym="Myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2122
                     /gene="Myo1b"
                     /gene_synonym="Myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2216
                     /gene="Myo1b"
                     /gene_synonym="Myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2366
                     /gene="Myo1b"
                     /gene_synonym="Myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2367..2435
                     /gene="Myo1b"
                     /gene_synonym="Myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2436..2522
                     /gene="Myo1b"
                     /gene_synonym="Myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2523..2609
                     /gene="Myo1b"
                     /gene_synonym="Myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2610..2696
                     /gene="Myo1b"
                     /gene_synonym="Myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2697..2771
                     /gene="Myo1b"
                     /gene_synonym="Myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2772..2906
                     /gene="Myo1b"
                     /gene_synonym="Myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2907..3013
                     /gene="Myo1b"
                     /gene_synonym="Myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            3014..3146
                     /gene="Myo1b"
                     /gene_synonym="Myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            3147..3299
                     /gene="Myo1b"
                     /gene_synonym="Myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            3300..3427
                     /gene="Myo1b"
                     /gene_synonym="Myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            3428..3609
                     /gene="Myo1b"
                     /gene_synonym="Myr1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcggctgag cggcgccgga tccctggcaa aactgtggca cgaaccccgc atcgggtcgg
       61 acccgcgttc cccaggcgcc ggccagcgag cagcacgcgg aggcggagcg gcagagcggt
      121 tgccgggcga gctggaaacc atggccaaga aggaggtaaa atcctcactt ctggacaata
      181 tgatcggcgt tggagatacg gttctcttgg agcctctcaa cgaggagaca ttcatcgaca
      241 acctgaagaa gcgcttcgat cacaatgaga tatatacata catcgggagt gtggttatat
      301 ctgttaaccc ctaccggtcc ttgcccattt attcaccaga gaaagtggaa gattacagaa
      361 atagaaactt ctatgaactg agccctcaca tctttgcttt gtcggatgaa gcatacagat
      421 ccctccgtga tcaagataaa gatcagtgca ttctcattac tggggagagt ggagcgggaa
      481 aaacagaggc cagcaagctt gtgatgtcct atgtcgctgc agtgtgtgga aaaggagcag
      541 aagttaatca ggtcaaggaa cagcttctcc agtccacccc tgtcctggaa gcttttggaa
      601 atgccaagac tgtaaggaat gacaattcat ccagattcgg caaatacatg gatattgaat
      661 ttgactttaa aggcgatccg ctgggaggag tgataagtaa ctatctttta gagaaatctc
      721 gtgttgttaa gcagccgaga ggtgaaagaa acttccatgt gttctatcag ctgctctcgg
      781 gtgcctctga ggaactcctc cacaagctta aactggagcg ggatttcagc agatacaact
      841 atctgagtct ggactctgcc aaagtgaatg gtgtggacga cgctgccaat ttcagaactg
      901 tcaggaatgc catgcagatc gtgggctttt cggatcctga ggccgagtct gtcctggagg
      961 ttgtggcagc tgtcttgaaa ctggggaaca tcgagttcaa gcctgaatca cgaatgaacg
     1021 gtttggatga aagcaaaatc aaagacaaaa atgagttaaa agaaatttgt gagttgacca
     1081 gcatcgatca agtggtttta gaaagagcgt tcagtttccg aacggttgag gcgaagcagg
     1141 agaaagtttc aaccacattg aatgtggctc aggcttatta tgcccgtgat gccctggcta
     1201 aaaacctcta cagccggttg ttttcatggt tggtaaatcg aatcaacgaa agcattaagg
     1261 cacaaaccaa agtgagaaag aaggtcatgg gtgttctgga catttatggc tttgagatat
     1321 ttgaggacaa cagcttcgag cagttcatta ttaattattg taatgaaaag cttcaacaaa
     1381 tcttcattga actgaccctc aaagaagagc aagaggaata tattcgtgag gacatagaat
     1441 ggactcacat tgactacttc aacaatgcta tcatttgcga cctaatagaa aacaacacaa
     1501 acggaatctt ggccatgctg gatgaagagt gcctgagacc cggcactgtt acagatgaga
     1561 ccttcctgga aaagctgaac caagtctgtg ccacccacca gcacttcgag agcaggatga
     1621 gcaaatgttc ccgcttcctc aatgacacga ccctgcctca cagctgcttc agaatccagc
     1681 attatgctgg caaggtgcta taccaggtgg aagggtttgt tgacaagaac aatgaccttc
     1741 tgtaccgaga cctgtctcaa gccatgtgga aggctggcca tgccctcatc aagtctctgt
     1801 tccctgaagg gaatcctgca aaggtcaacc tgaaaaggcc tcctactgca gggtcccagt
     1861 tcaaggcgtc ggtggccacc ctgatgaaaa acctgcagac caagaacccg aactatatca
     1921 ggtgcatcaa gccgaacgat aaaaaggccg ctcacatttt cagtgagagt ctcgtgtgtc
     1981 atcagatccg gtacctgggt cttctggaga acgttcgagt gagacgggca ggctatgcct
     2041 tcaggcaggc ctatgaacct tgtctggaaa gatacaagat gctttgcaaa caaacatggc
     2101 ctcactggaa gggaccagca aggtctggtg tggaagttct gtttaatgag ctagagattc
     2161 ccgtggaaga gtactccttc ggtagatcca agatattcat ccgaaaccca aggacattat
     2221 tccaattaga agacctaagg aagcagcggc tggaggacct ggccactctc attcagaaga
     2281 tttatcgagg atggaaatgt cgtacacatt ttctgctcat gaaaagaagc caagtcgtga
     2341 ttgccgcctg gtacaggaga tacgcgcaac aaaagcgata tcagcagata aagagttcag
     2401 ccctggtgat tcagtcttac atccggggct ggaaggctag aaaaatcctg cgggagctga
     2461 agcatcagaa acgctgcaag gaggcagcca ccaccatcgc agcatactgg cacggcaccc
     2521 aggcgcgaaa ggagcggagg cggctgaagg acgaggctag gaataagcac gctattgcag
     2581 ttatttgggc tttctggctt ggatcgaagg cacgaaggga attgaaacgc ttgaaggagg
     2641 aggctaggcg taagcatgca gttgctgtca tttgggctta ctggcttgga ctgaaggtac
     2701 gaagggagta caggaaattc tttagagcaa atgctggaaa gaaaatctat gagtttacac
     2761 ttcaaagaat tgtgcaaaaa tacttgttgg aaatgaaaaa taaaatgcct tccttgtcac
     2821 caatagataa aaattggcca tcaagacctt acctattctt ggattcgact cacaaggagc
     2881 taaaaaggat cttccacttg tggaggtgta aaaaatacag ggatcaattc acagaccagc
     2941 agaaacttat ttatgaagag aagctggagg ccagtgaact cttcaaagac aagaaggctt
     3001 tatatccttc tagtgttggt cagccattcc aaggagctta cctggaaatc aacaagaacc
     3061 caaaatataa gaaactcaaa gatgccattg aagagaagat cattattgct gaggttgtga
     3121 acaaaatcaa ccgggctaat gggaagagta catctcggat tttcctctta acaaacaata
     3181 accttctcct tgctgaccaa aagtcggggc agatcaagtc cgaggtcccc ctggtggatg
     3241 tgactaaggt ctccatgagt tcacagaatg atggtttctt tgcagtacac ctcaaggagg
     3301 gttcagaagc agctagtaag ggtgactttc tcttcagcag tgaccacctg attgaaatgg
     3361 caaccaagtt gtatcgcacg actcttagcc aaactaaaca gaagctcaat atcgagattt
     3421 ccgatgagtt cctggtacag ttcagacagg acaaagtatg tgtgaagttt attcaaggca
     3481 accagaaaaa cgggagcgtg ccaacctgca aacgaaagaa caacaggctt cttgaagtcg
     3541 ctgtccctta agtgaggcct cctctctgtt ctcacggact tgtttcctcg taacagtgca
     3601 attttactt
//
