LOCUS       NM_019324               3332 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus myosin IA (Myo1a), mRNA.
ACCESSION   NM_019324 XM_001056742 XM_238479
VERSION     NM_019324.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3332)
  AUTHORS   Revenu,C., Ubelmann,F., Hurbain,I., El-Marjou,F., Dingli,F.,
            Loew,D., Delacour,D., Gilet,J., Brot-Laroche,E., Rivero,F.,
            Louvard,D. and Robine,S.
  TITLE     A new role for the architecture of microvillar actin bundles in
            apical retention of membrane proteins
  JOURNAL   Mol Biol Cell 23 (2), 324-336 (2012)
   PUBMED   22114352
REFERENCE   2  (bases 1 to 3332)
  AUTHORS   Benesh,A.E., Nambiar,R., McConnell,R.E., Mao,S., Tabb,D.L. and
            Tyska,M.J.
  TITLE     Differential localization and dynamics of class I myosins in the
            enterocyte microvillus
  JOURNAL   Mol Biol Cell 21 (6), 970-978 (2010)
   PUBMED   20089841
REFERENCE   3  (bases 1 to 3332)
  AUTHORS   Tyska,M.J., Mackey,A.T., Huang,J.D., Copeland,N.G., Jenkins,N.A.
            and Mooseker,M.S.
  TITLE     Myosin-1a is critical for normal brush border structure and
            composition
  JOURNAL   Mol Biol Cell 16 (5), 2443-2457 (2005)
   PUBMED   15758024
REFERENCE   4  (bases 1 to 3332)
  AUTHORS   Tyska,M.J. and Mooseker,M.S.
  TITLE     A role for myosin-1A in the localization of a brush border
            disaccharidase
  JOURNAL   J Cell Biol 165 (3), 395-405 (2004)
   PUBMED   15138292
REFERENCE   5  (bases 1 to 3332)
  AUTHORS   Donaudy,F., Ferrara,A., Esposito,L., Hertzano,R., Ben-David,O.,
            Bell,R.E., Melchionda,S., Zelante,L., Avraham,K.B. and Gasparini,P.
  TITLE     Multiple mutations of MYO1A, a cochlear-expressed gene, in
            sensorineural hearing loss
  JOURNAL   Am J Hum Genet 72 (6), 1571-1577 (2003)
   PUBMED   12736868
REFERENCE   6  (bases 1 to 3332)
  AUTHORS   Skowron,J.F. and Mooseker,M.S.
  TITLE     Cloning and characterization of mouse brush border myosin-I in
            adult and embryonic intestine
  JOURNAL   J Exp Zool 283 (3), 242-257 (1999)
   PUBMED   9933937
REFERENCE   7  (bases 1 to 3332)
  AUTHORS   Skowron,J.F., Bement,W.M. and Mooseker,M.S.
  TITLE     Human brush border myosin-I and myosin-Ic expression in human
            intestine and Caco-2BBe cells
  JOURNAL   Cell Motil Cytoskeleton 41 (4), 308-324 (1998)
   PUBMED   9858156
REFERENCE   8  (bases 1 to 3332)
  AUTHORS   Durrbach,A., Collins,K., Matsudaira,P., Louvard,D. and Coudrier,E.
  TITLE     Brush border myosin-I truncated in the motor domain impairs the
            distribution and the function of endocytic compartments in an
            hepatoma cell line
  JOURNAL   Proc Natl Acad Sci U S A 93 (14), 7053-7058 (1996)
   PUBMED   8692943
REFERENCE   9  (bases 1 to 3332)
  AUTHORS   Lewis,A.K. and Bridgman,P.C.
  TITLE     Mammalian myosin I alpha is concentrated near the plasma membrane
            in nerve growth cones
  JOURNAL   Cell Motil Cytoskeleton 33 (2), 130-150 (1996)
   PUBMED   8635202
REFERENCE   10 (bases 1 to 3332)
  AUTHORS   Balish,M.F. and Coluccio,L.M.
  TITLE     Identification of brush border myosin-I in liver and testis
  JOURNAL   Biochem Biophys Res Commun 211 (1), 331-339 (1995)
   PUBMED   7779104
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On or before Aug 18, 2012 this sequence version replaced
            XM_238479.6, XM_001056742.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.30284.1,
                                           SRR26643291.20482.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               JAXUCZ010000007.1  65428258-65428390
            134-249             JAXUCZ010000007.1  65428481-65428596
            250-344             JAXUCZ010000007.1  65428812-65428906
            345-449             JAXUCZ010000007.1  65429494-65429598
            450-496             JAXUCZ010000007.1  65429823-65429869
            497-560             JAXUCZ010000007.1  65430104-65430167
            561-659             JAXUCZ010000007.1  65430339-65430437
            660-763             JAXUCZ010000007.1  65432709-65432812
            764-911             JAXUCZ010000007.1  65432929-65433076
            912-1030            JAXUCZ010000007.1  65433422-65433540
            1031-1117           JAXUCZ010000007.1  65433620-65433706
            1118-1183           JAXUCZ010000007.1  65435075-65435140
            1184-1288           JAXUCZ010000007.1  65435248-65435352
            1289-1351           JAXUCZ010000007.1  65436187-65436249
            1352-1552           JAXUCZ010000007.1  65436446-65436646
            1553-1779           JAXUCZ010000007.1  65436800-65437026
            1780-1980           JAXUCZ010000007.1  65437330-65437530
            1981-2074           JAXUCZ010000007.1  65437678-65437771
            2075-2224           JAXUCZ010000007.1  65438054-65438203
            2225-2293           JAXUCZ010000007.1  65438320-65438388
            2294-2368           JAXUCZ010000007.1  65438828-65438902
            2369-2503           JAXUCZ010000007.1  65440847-65440981
            2504-2610           JAXUCZ010000007.1  65441553-65441659
            2611-2743           JAXUCZ010000007.1  65441912-65442044
            2744-2896           JAXUCZ010000007.1  65442145-65442297
            2897-3024           JAXUCZ010000007.1  65442463-65442590
            3025-3332           JAXUCZ010000007.1  65442906-65443213
FEATURES             Location/Qualifiers
     source          1..3332
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..3332
                     /gene="Myo1a"
                     /gene_synonym="BBMI; MIHC; Myh1; Myhl"
                     /note="myosin IA"
                     /db_xref="GeneID:299509"
                     /db_xref="RGD:3135"
     exon            1..133
                     /gene="Myo1a"
                     /gene_synonym="BBMI; MIHC; Myh1; Myhl"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..3151
                     /gene="Myo1a"
                     /gene_synonym="BBMI; MIHC; Myh1; Myhl"
                     /note="myosin-Ia; brush border myosin I; BBM-I; myosin I
                     heavy chain; myosin, heavy polypeptide-like (110kD);
                     myosin heavy polypeptide 1 skeletal muscle adult"
                     /codon_start=1
                     /product="unconventional myosin-Ia"
                     /protein_id="NP_062197.1"
                     /db_xref="GeneID:299509"
                     /db_xref="RGD:3135"
                     /translation="MPLLEGSVGVEDLILLEPLDEESLIKNLQLRYEKKEIYTYIGNV
                     VISMNPYQQLPIYGPEFIAKYRDYTFYELKPHIYALANVAYQSLKDRDRDQCILITGE
                     SGAGKTEASKLVMSYVAAVCGKGEQVNSVKEQLLQSNPVLEAFGNAKTIRNDNSSRFG
                     KYMDIEFDFKGSPLGGVITNYLLEKSRVVKQLKGERNFHIFYQLLAGADTQLLKALKL
                     EEDARGYAYLNGEVSRVNGMDDASNFRAVQNAMAVIGFSEEEIRQVLEVTALVLKLGN
                     VKLADEFQANGLPASGVCDGKGIQEIGEMMGLNSAELEKALCSRTMETGKEKVVTVLN
                     VIQAQYARDALAKNIYSRLFDWIVNRINESIKVGTGEKRKVMGVLDIYGFEILEDNSF
                     EQFVINYCNEKLQQVFIELTLKEEQEEYKREGIPWTKVEYFDNGIICDLIEHSQRGIL
                     AMLDEECLRPGVVSDTTFLAKLNQLFSKHSHYESKVTQNAQRQYDRTMGLSCFRICHY
                     AGKVTYNVTSFIDKNNDLLFRDLSQTMWKAQHPLLHSLFPEGNPKEASLKRPPTAGTQ
                     FKNSVAILMKNLYSKNPNYIRCIKPNDQQQQGRFTSELVMVQARYLGLLENVRVRRAG
                     YAFRQAYKPFLERYRLLSRSTWPRWNGEDREGVEKVLGSLILSSEELAYGRTKIFIRS
                     PKTLFYLEEQRRLRLQQLATLIQKVYRGWRCRTHYQQMRKSQILISAWFRGNKQKKHY
                     GKIRSSVLLIQAFVRGWKARKNYRKYFRSGAAITLANFIYQSITQKFLLNLKKNLPST
                     KVLDNTWPAAPYRCFNTANQELQHLFYQWKCKKYRDQLSPKQVQTLREKLCASELFKG
                     KKASYLQSVPVPFRGDYVGLQGNPKLQRLKGREEGPVLVADTVKKVNRGNGKTSSRIL
                     LLTKGHVILTDAKKSQAQIVIKLEDVAGVSVTSLEDGLFSLHLSEMSSAASKGDILLI
                     SDHLVELLTKMYQAVLDATQRQLPVTVTEKFSVRFKEGSVAVKVTQGPQGSGNRKLTC
                     KKKGSSSMEVTVR"
     exon            134..249
                     /gene="Myo1a"
                     /gene_synonym="BBMI; MIHC; Myh1; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            250..344
                     /gene="Myo1a"
                     /gene_synonym="BBMI; MIHC; Myh1; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            345..449
                     /gene="Myo1a"
                     /gene_synonym="BBMI; MIHC; Myh1; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            450..496
                     /gene="Myo1a"
                     /gene_synonym="BBMI; MIHC; Myh1; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            497..560
                     /gene="Myo1a"
                     /gene_synonym="BBMI; MIHC; Myh1; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            561..659
                     /gene="Myo1a"
                     /gene_synonym="BBMI; MIHC; Myh1; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            660..763
                     /gene="Myo1a"
                     /gene_synonym="BBMI; MIHC; Myh1; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            764..911
                     /gene="Myo1a"
                     /gene_synonym="BBMI; MIHC; Myh1; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1030
                     /gene="Myo1a"
                     /gene_synonym="BBMI; MIHC; Myh1; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1117
                     /gene="Myo1a"
                     /gene_synonym="BBMI; MIHC; Myh1; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1183
                     /gene="Myo1a"
                     /gene_synonym="BBMI; MIHC; Myh1; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1288
                     /gene="Myo1a"
                     /gene_synonym="BBMI; MIHC; Myh1; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1351
                     /gene="Myo1a"
                     /gene_synonym="BBMI; MIHC; Myh1; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1552
                     /gene="Myo1a"
                     /gene_synonym="BBMI; MIHC; Myh1; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1779
                     /gene="Myo1a"
                     /gene_synonym="BBMI; MIHC; Myh1; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1980
                     /gene="Myo1a"
                     /gene_synonym="BBMI; MIHC; Myh1; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2074
                     /gene="Myo1a"
                     /gene_synonym="BBMI; MIHC; Myh1; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2224
                     /gene="Myo1a"
                     /gene_synonym="BBMI; MIHC; Myh1; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..2293
                     /gene="Myo1a"
                     /gene_synonym="BBMI; MIHC; Myh1; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            2294..2368
                     /gene="Myo1a"
                     /gene_synonym="BBMI; MIHC; Myh1; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            2369..2503
                     /gene="Myo1a"
                     /gene_synonym="BBMI; MIHC; Myh1; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            2504..2610
                     /gene="Myo1a"
                     /gene_synonym="BBMI; MIHC; Myh1; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            2611..2743
                     /gene="Myo1a"
                     /gene_synonym="BBMI; MIHC; Myh1; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            2744..2896
                     /gene="Myo1a"
                     /gene_synonym="BBMI; MIHC; Myh1; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            2897..3024
                     /gene="Myo1a"
                     /gene_synonym="BBMI; MIHC; Myh1; Myhl"
                     /inference="alignment:Splign:2.1.0"
     exon            3025..3332
                     /gene="Myo1a"
                     /gene_synonym="BBMI; MIHC; Myh1; Myhl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaccctctag cctcttgaca tgcctctcct ggaaggttcc gtgggggtgg aggatctcat
       61 cctcctggag cctctggatg aggagtctct gatcaagaac ctccaacttc gttatgagaa
      121 aaaagagatt tatacgtaca ttgggaatgt ggtgatctcc atgaacccct accagcagct
      181 tcctatctat ggcccagagt ttattgccaa ataccgggac tataccttct atgagctgaa
      241 gccccacatc tatgctttgg caaacgtggc ctaccagtcg ctgaaggatc gggaccggga
      301 ccagtgtatc ctgatcactg gcgagagtgg agctggcaag actgaggcta gtaagctagt
      361 gatgtcctat gtggctgctg tctgtgggaa aggggagcag gtgaactcgg tgaaggagca
      421 gctgcttcag tcaaacccag tgctggaagc atttggcaat gccaagacca tccgcaatga
      481 caactcctct cgatttggaa aatacatgga catcgagttt gacttcaaag ggtcccccct
      541 tggaggtgtc attaccaact atctgcttga gaagtccaga gtggtgaagc aactcaaagg
      601 ggaaaggaac ttccatatct tctatcagct gctggctgga gcagacacac agctgctgaa
      661 ggccctaaag cttgaggaag atgcacgtgg ctatgcctac cttaatgggg aggtgtccag
      721 ggtgaacggt atggatgatg cctccaactt cagggctgtg cagaacgcaa tggcagtgat
      781 tgggttctca gaggaggaga ttagacaagt gctggaggtg acagccctgg tactgaagct
      841 gggcaatgtg aagctggcag atgaattcca ggccaacggg cttccagcca gtggtgtctg
      901 tgatgggaaa ggtattcagg agattgggga gatgatgggt ttgaactctg cagaactaga
      961 gaaagctttg tgctcaagaa ccatggagac aggcaaagag aaggtggtca cggtgctgaa
     1021 cgtcatccag gctcagtatg ctcgggatgc cctggccaag aatatttaca gccgcctctt
     1081 cgactggata gtgaatcgca tcaacgagag catcaaggtg ggcactgggg agaagaggaa
     1141 ggttatgggg gtcctggata tctacggctt tgagatactg gaggataaca gctttgagca
     1201 gttcgtgatc aactactgca atgaaaaact acagcaggtg tttatagaac tgaccttgaa
     1261 ggaagaacag gaggaatata agagagaagg cataccatgg acaaaggtgg agtactttga
     1321 caacggcatc atctgtgacc tcattgaaca tagtcagcga ggcatcctgg ccatgctgga
     1381 tgaggagtgc ctgagacctg gggtggtcag tgacaccact tttctagcaa agttgaacca
     1441 gcttttctcc aagcacagtc actacgagag taaagtcacc cagaatgctc agcgccaata
     1501 cgaccgcacc atgggcctca gctgcttccg catctgccac tatgcgggca aggtgacata
     1561 caacgtgacc agtttcatcg acaagaataa cgacctactc ttccgagacc tatcccagac
     1621 aatgtggaag gcccagcatc ccctcctcca ctccctgttc ccagagggga atcccaagga
     1681 agcatctctc aaacggcccc cgactgctgg gacccagttt aagaattcgg tggccatact
     1741 catgaagaac ctgtattcta agaacccgaa ctacatcagg tgcataaagc ccaatgacca
     1801 gcagcagcaa ggcaggttca cctcagaact ggttatggtc caggctcgat acctggggct
     1861 gctggagaat gttcgggtgc gcagggctgg ctacgccttc cgccaggcct ataagccttt
     1921 cctggagagg taccgattgc tgagccggag cacgtggccg cgctggaatg gggaagaccg
     1981 ggaaggtgtg gagaaggtcc tggggtctct gattttgtca tcagaggagc tggcctatgg
     2041 gaggacaaag atcttcatca gaagccccaa gactcttttc tacctggaag aacaaaggcg
     2101 cctgaggctt cagcagctgg ccaccctcat ccagaaggtt taccggggct ggcgttgtcg
     2161 gacccactac cagcagatgc ggaagagtca gatcctcatc tcggcttggt ttcggggcaa
     2221 caagcaaaag aagcactatg ggaagatccg gtcatcagta ctgctgatcc aggctttcgt
     2281 gaggggctgg aaggcccgca agaactatcg aaaatacttc cggtcaggcg ccgccatcac
     2341 tttggcaaat tttatctacc agagcataac ccagaaattc ctcttgaatc tgaagaagaa
     2401 tttgccatcc accaaagtgt tggacaacac gtggccagct gccccttaca ggtgcttcaa
     2461 cacagccaat caggaactgc agcacctctt ctaccagtgg aagtgcaaga agtaccgaga
     2521 tcagctgtcc ccgaagcagg tgcagacact gagggaaaag ctctgtgcca gcgaactgtt
     2581 taagggcaag aaggcttcct acctccagag cgtgcctgtc cctttccgtg gtgattacgt
     2641 cggcctgcag gggaacccca agctgcagag actgaagggc agggaggaag ggcctgtcct
     2701 ggtggcagac accgtgaaga aggtcaaccg tggcaatggc aagacttctt cacggattct
     2761 cctcctgacc aaggggcatg tgattctcac agatgccaag aagtcccagg cccaaattgt
     2821 cattaagctg gaggatgtgg ctggggtgtc agtcaccagc ctcgaggacg ggctctttag
     2881 cttgcatctg agtgagatgt cgtcggcagc ctccaagggg gacatcctgc taatcagcga
     2941 ccacctggtt gaactgctga caaaaatgta ccaagcagtg ctggatgcca cacagaggca
     3001 gcttcctgtc actgtgactg agaagttctc agtgaggttc aaggagggca gtgtggctgt
     3061 caaggttacc cagggccccc aggggagtgg gaacagaaag ctgacttgca agaagaaggg
     3121 gagtagttct atggaggtga ctgtgcggtg agattgggac ctcctggaga cacagcttct
     3181 tcctctggag caaaacttgg agtcttactc ttctgaccat gaggtgtggg gcttagagat
     3241 gaagaaccct ggaagatgcc cctctgttcc cgggaccttc tagaattctt acccaaatgc
     3301 agcatcctcc cagcttcagc ccattaataa at
//
