LOCUS       NP_062197               1043 aa            linear   ROD 03-APR-2024
DEFINITION  unconventional myosin-Ia [Rattus norvegicus].
ACCESSION   NP_062197 XP_001056742 XP_238479
VERSION     NP_062197.1
DBSOURCE    REFSEQ: accession NM_019324.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1043)
  AUTHORS   Revenu,C., Ubelmann,F., Hurbain,I., El-Marjou,F., Dingli,F.,
            Loew,D., Delacour,D., Gilet,J., Brot-Laroche,E., Rivero,F.,
            Louvard,D. and Robine,S.
  TITLE     A new role for the architecture of microvillar actin bundles in
            apical retention of membrane proteins
  JOURNAL   Mol Biol Cell 23 (2), 324-336 (2012)
   PUBMED   22114352
REFERENCE   2  (residues 1 to 1043)
  AUTHORS   Benesh,A.E., Nambiar,R., McConnell,R.E., Mao,S., Tabb,D.L. and
            Tyska,M.J.
  TITLE     Differential localization and dynamics of class I myosins in the
            enterocyte microvillus
  JOURNAL   Mol Biol Cell 21 (6), 970-978 (2010)
   PUBMED   20089841
REFERENCE   3  (residues 1 to 1043)
  AUTHORS   Tyska,M.J., Mackey,A.T., Huang,J.D., Copeland,N.G., Jenkins,N.A.
            and Mooseker,M.S.
  TITLE     Myosin-1a is critical for normal brush border structure and
            composition
  JOURNAL   Mol Biol Cell 16 (5), 2443-2457 (2005)
   PUBMED   15758024
REFERENCE   4  (residues 1 to 1043)
  AUTHORS   Tyska,M.J. and Mooseker,M.S.
  TITLE     A role for myosin-1A in the localization of a brush border
            disaccharidase
  JOURNAL   J Cell Biol 165 (3), 395-405 (2004)
   PUBMED   15138292
REFERENCE   5  (residues 1 to 1043)
  AUTHORS   Donaudy,F., Ferrara,A., Esposito,L., Hertzano,R., Ben-David,O.,
            Bell,R.E., Melchionda,S., Zelante,L., Avraham,K.B. and Gasparini,P.
  TITLE     Multiple mutations of MYO1A, a cochlear-expressed gene, in
            sensorineural hearing loss
  JOURNAL   Am J Hum Genet 72 (6), 1571-1577 (2003)
   PUBMED   12736868
REFERENCE   6  (residues 1 to 1043)
  AUTHORS   Skowron,J.F. and Mooseker,M.S.
  TITLE     Cloning and characterization of mouse brush border myosin-I in
            adult and embryonic intestine
  JOURNAL   J Exp Zool 283 (3), 242-257 (1999)
   PUBMED   9933937
REFERENCE   7  (residues 1 to 1043)
  AUTHORS   Skowron,J.F., Bement,W.M. and Mooseker,M.S.
  TITLE     Human brush border myosin-I and myosin-Ic expression in human
            intestine and Caco-2BBe cells
  JOURNAL   Cell Motil Cytoskeleton 41 (4), 308-324 (1998)
   PUBMED   9858156
REFERENCE   8  (residues 1 to 1043)
  AUTHORS   Durrbach,A., Collins,K., Matsudaira,P., Louvard,D. and Coudrier,E.
  TITLE     Brush border myosin-I truncated in the motor domain impairs the
            distribution and the function of endocytic compartments in an
            hepatoma cell line
  JOURNAL   Proc Natl Acad Sci U S A 93 (14), 7053-7058 (1996)
   PUBMED   8692943
REFERENCE   9  (residues 1 to 1043)
  AUTHORS   Lewis,A.K. and Bridgman,P.C.
  TITLE     Mammalian myosin I alpha is concentrated near the plasma membrane
            in nerve growth cones
  JOURNAL   Cell Motil Cytoskeleton 33 (2), 130-150 (1996)
   PUBMED   8635202
REFERENCE   10 (residues 1 to 1043)
  AUTHORS   Balish,M.F. and Coluccio,L.M.
  TITLE     Identification of brush border myosin-I in liver and testis
  JOURNAL   Biochem Biophys Res Commun 211 (1), 331-339 (1995)
   PUBMED   7779104
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On or before Aug 18, 2012 this sequence version replaced
            XP_238479.6, XP_001056742.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.30284.1,
                                           SRR26643291.20482.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1043
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     Protein         1..1043
                     /product="unconventional myosin-Ia"
                     /note="myosin-Ia; brush border myosin I; BBM-I; myosin I
                     heavy chain; myosin, heavy polypeptide-like (110kD);
                     myosin heavy polypeptide 1 skeletal muscle adult"
                     /calculated_mol_wt=118717
     Region          22..681
                     /region_name="MYSc_Myo1"
                     /note="class I myosin, motor domain; cd01378"
                     /db_xref="CDD:276829"
     Site            order(49..52,57,101..108,148..158,380..385)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:276829"
     Site            order(49..52,57)
                     /site_type="other"
                     /note="purine-binding loop"
                     /db_xref="CDD:276829"
     Site            101..108
                     /site_type="other"
                     /note="P-loop"
                     /db_xref="CDD:276829"
     Site            148..158
                     /site_type="other"
                     /note="switch I region"
                     /db_xref="CDD:276829"
     Site            380..385
                     /site_type="other"
                     /note="switch II region"
                     /db_xref="CDD:276829"
     Site            order(409..420,423..430,432)
                     /site_type="other"
                     /note="relay loop"
                     /db_xref="CDD:276829"
     Site            613..623
                     /site_type="other"
                     /note="SH1 helix"
                     /db_xref="CDD:276829"
     Site            order(625..651,668..681)
                     /site_type="other"
                     /note="converter subdomain"
                     /db_xref="CDD:276829"
     Region          742..764
                     /region_name="IQ"
                     /note="Calmodulin-binding motif; smart00015"
                     /db_xref="CDD:197470"
     Region          847..1042
                     /region_name="Myosin_TH1"
                     /note="Unconventional myosin tail, actin- and
                     lipid-binding; pfam06017"
                     /db_xref="CDD:461801"
     CDS             1..1043
                     /gene="Myo1a"
                     /gene_synonym="BBMI; MIHC; Myh1; Myhl"
                     /coded_by="NM_019324.1:20..3151"
                     /db_xref="GeneID:299509"
                     /db_xref="RGD:3135"
ORIGIN      
        1 mpllegsvgv edlillepld eesliknlql ryekkeiyty ignvvismnp yqqlpiygpe
       61 fiakyrdytf yelkphiyal anvayqslkd rdrdqcilit gesgagktea sklvmsyvaa
      121 vcgkgeqvns vkeqllqsnp vleafgnakt irndnssrfg kymdiefdfk gsplggvitn
      181 ylleksrvvk qlkgernfhi fyqllagadt qllkalklee dargyaylng evsrvngmdd
      241 asnfravqna mavigfseee irqvlevtal vlklgnvkla defqanglpa sgvcdgkgiq
      301 eigemmglns aelekalcsr tmetgkekvv tvlnviqaqy ardalakniy srlfdwivnr
      361 inesikvgtg ekrkvmgvld iygfeiledn sfeqfvinyc neklqqvfie ltlkeeqeey
      421 kregipwtkv eyfdngiicd liehsqrgil amldeeclrp gvvsdttfla klnqlfskhs
      481 hyeskvtqna qrqydrtmgl scfrichyag kvtynvtsfi dknndllfrd lsqtmwkaqh
      541 pllhslfpeg npkeaslkrp ptagtqfkns vailmknlys knpnyircik pndqqqqgrf
      601 tselvmvqar ylgllenvrv rragyafrqa ykpfleryrl lsrstwprwn gedregvekv
      661 lgslilssee laygrtkifi rspktlfyle eqrrlrlqql atliqkvyrg wrcrthyqqm
      721 rksqilisaw frgnkqkkhy gkirssvlli qafvrgwkar knyrkyfrsg aaitlanfiy
      781 qsitqkflln lkknlpstkv ldntwpaapy rcfntanqel qhlfyqwkck kyrdqlspkq
      841 vqtlreklca selfkgkkas ylqsvpvpfr gdyvglqgnp klqrlkgree gpvlvadtvk
      901 kvnrgngkts srillltkgh viltdakksq aqivikledv agvsvtsled glfslhlsem
      961 ssaaskgdil lisdhlvell tkmyqavlda tqrqlpvtvt ekfsvrfkeg svavkvtqgp
     1021 qgsgnrkltc kkkgsssmev tvr
//
