LOCUS       NM_001109495             795 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Rattus norvegicus myosin, light chain 4 (Myl4), mRNA.
ACCESSION   NM_001109495 XM_001081553
VERSION     NM_001109495.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 795)
  AUTHORS   Zhong,Y., Tang,K., Nattel,S., Zhai,M., Gong,S., Yu,Q., Zeng,Y.,
            E,G., Maimaitiaili,N., Wang,J., Xu,Y., Peng,W. and Li,H.
  TITLE     Myosin light-chain 4 gene-transfer attenuates atrial fibrosis while
            correcting autophagic flux dysregulation
  JOURNAL   Redox Biol 60, 102606 (2023)
   PUBMED   36645977
  REMARK    GeneRIF: Myosin light-chain 4 gene-transfer attenuates atrial
            fibrosis while correcting autophagic flux dysregulation.
REFERENCE   2  (bases 1 to 795)
  AUTHORS   Peng,W., Li,M., Li,H., Tang,K., Zhuang,J., Zhang,J., Xiao,J.,
            Jiang,H., Li,D., Yu,Y., Sham,P.C., Nattel,S. and Xu,Y.
  TITLE     Dysfunction of Myosin Light-Chain 4 (MYL4) Leads to Heritable
            Atrial Cardiomyopathy With Electrical, Contractile, and Structural
            Components: Evidence From Genetically-Engineered Rats
  JOURNAL   J Am Heart Assoc 6 (11), e007030 (2017)
   PUBMED   29080865
  REMARK    GeneRIF: Loss-of-function MYL4 gene variants cause progressive
            atrial cardiomyopathy in genetically modified rats.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 795)
  AUTHORS   Haase,H., Dobbernack,G., Tunnemann,G., Karczewski,P., Cardoso,C.,
            Petzhold,D., Schlegel,W.P., Lutter,S., Pierschalek,P., Behlke,J.
            and Morano,I.
  TITLE     Minigenes encoding N-terminal domains of human cardiac myosin light
            chain-1 improve heart function of transgenic rats
  JOURNAL   FASEB J 20 (7), 865-873 (2006)
   PUBMED   16675844
REFERENCE   4  (bases 1 to 795)
  AUTHORS   Abdelaziz,A.I., Segaric,J., Bartsch,H., Petzhold,D., Schlegel,W.P.,
            Kott,M., Seefeldt,I., Klose,J., Bader,M., Haase,H. and Morano,I.
  TITLE     Functional characterization of the human atrial essential myosin
            light chain (hALC-1) in a transgenic rat model
  JOURNAL   J Mol Med (Berl) 82 (4), 265-274 (2004)
   PUBMED   14985854
REFERENCE   5  (bases 1 to 795)
  AUTHORS   Timson,D.J., Trayer,H.R. and Trayer,I.P.
  TITLE     The N-terminus of A1-type myosin essential light chains binds actin
            and modulates myosin motor function
  JOURNAL   Eur J Biochem 255 (3), 654-662 (1998)
   PUBMED   9738905
REFERENCE   6  (bases 1 to 795)
  AUTHORS   Morano,I. and Haase,H.
  TITLE     Different actin affinities of human cardiac essential myosin light
            chain isoforms
  JOURNAL   FEBS Lett 408 (1), 71-74 (1997)
   PUBMED   9180271
REFERENCE   7  (bases 1 to 795)
  AUTHORS   Rovner,A.S., McNally,E.M. and Leinwand,L.A.
  TITLE     Complete cDNA sequence of rat atrial myosin light chain 1: patterns
            of expression during development and with hypertension
  JOURNAL   Nucleic Acids Res 18 (6), 1581-1586 (1990)
   PUBMED   2326197
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On Oct 4, 2007 this sequence version replaced XM_001081553.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: FN805610.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA5760383, SAMEA5760384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..795
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..795
                     /gene="Myl4"
                     /note="myosin, light chain 4"
                     /db_xref="GeneID:688228"
                     /db_xref="RGD:1591197"
     exon            1..193
                     /gene="Myl4"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..652
                     /gene="Myl4"
                     /codon_start=1
                     /product="myosin light chain 4"
                     /protein_id="NP_001102965.1"
                     /db_xref="GeneID:688228"
                     /db_xref="RGD:1591197"
                     /translation="MPPKKPEPKKETAKAAAAPAPAPAPAPEPLRDSAFDPKSVKIDF
                     SADQIEEFKEAFSLFDRTPTGEMKITYGQCGDVLRALGQNPTNAEVLRVLGKPKPEEM
                     NSKTLDFEMFLPILQHISRNKEQGTYEDFVEGLRVFDKESNGTVMGAELRHVLATLGE
                     KMSEAEVEQLLTGQEDANGCINYEAFVKHVMSG"
     exon            194..221
                     /gene="Myl4"
                     /inference="alignment:Splign:2.1.0"
     exon            222..371
                     /gene="Myl4"
                     /inference="alignment:Splign:2.1.0"
     exon            372..545
                     /gene="Myl4"
                     /inference="alignment:Splign:2.1.0"
     exon            546..623
                     /gene="Myl4"
                     /inference="alignment:Splign:2.1.0"
     exon            624..667
                     /gene="Myl4"
                     /inference="alignment:Splign:2.1.0"
     exon            668..795
                     /gene="Myl4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccatcttcct ctcaggagcc acctttcctc agtttttagg tcccacgtcc actggagatc
       61 ctaaggcagc atgcctccca agaagcctga gcccaagaag gagactgcca aggcagccgc
      121 agcccctgcc ccagctcctg ccccagctcc cgagcccctc agggactctg cctttgatcc
      181 caagagtgtg aagatagact tcagtgccga ccagatcgaa gaattcaaag aggccttttc
      241 attgtttgac cggactccaa ctggagagat gaaaatcacc tatgggcagt gtggggacgt
      301 gctgcgggcc ctgggccaga accccaccaa cgcagaggtg ctgcgagttt tgggcaaacc
      361 caagcctgaa gagatgaatt ccaagacact ggacttcgag atgttcctgc ccatcctgca
      421 gcacatctcc cgcaacaagg agcagggcac ctatgaggac ttcgtggagg ggctgcgggt
      481 ctttgacaaa gaaagcaacg gcacagtcat gggcgccgag cttcggcatg tcctcgccac
      541 cctgggagag aagatgagcg aggctgaggt ggagcagctg ttgactgggc aggaggatgc
      601 caacggatgc atcaactatg aagcctttgt caagcatgtc atgtccgggt aaagacattt
      661 ctccaaggtg cttggccccg cgtgagtaag ggagagagcc atggtggttg ttacggagca
      721 ctggactcat actggcctcg cagacccacg gcctcccctg taaataaaga agcccagtgt
      781 ggagtctcac caatc
//
