LOCUS       NM_012606                928 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus myosin light chain 3 (Myl3), mRNA.
ACCESSION   NM_012606
VERSION     NM_012606.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 928)
  AUTHORS   Dogra,A., Kour,D., Gour,A., Bhardwaj,M., Bag,S., Dhiman,S.K.,
            Kumar,A., Singh,G. and Nandi,U.
  TITLE     Ameliorating effect of rutin against diclofenac-induced cardiac
            injury in rats with underlying function of FABP3, MYL3, and ANP
  JOURNAL   Drug Chem Toxicol 46 (3), 597-608 (2023)
   PUBMED   35509154
  REMARK    GeneRIF: Ameliorating effect of rutin against diclofenac-induced
            cardiac injury in rats with underlying function of FABP3, MYL3, and
            ANP.
REFERENCE   2  (bases 1 to 928)
  AUTHORS   Zhong,S. and Thompson,L.V.
  TITLE     The roles of myosin ATPase activity and myosin light chain relative
            content in the slowing of type IIB fibers with hindlimb unweighting
            in rats
  JOURNAL   Am J Physiol Cell Physiol 293 (2), C723-C728 (2007)
   PUBMED   17494635
  REMARK    GeneRIF: Slowing of shortening velocity in type IIb fibers with
            hindlimb unloading involves a decrease in the relative amount of
            Myl3.
REFERENCE   3  (bases 1 to 928)
  AUTHORS   Morita,H., Larson,M.G., Barr,S.C., Vasan,R.S., O'Donnell,C.J.,
            Hirschhorn,J.N., Levy,D., Corey,D., Seidman,C.E., Seidman,J.G. and
            Benjamin,E.J.
  TITLE     Single-gene mutations and increased left ventricular wall thickness
            in the community: the Framingham Heart Study
  JOURNAL   Circulation 113 (23), 2697-2705 (2006)
   PUBMED   16754800
REFERENCE   4  (bases 1 to 928)
  AUTHORS   Haase,H., Dobbernack,G., Tunnemann,G., Karczewski,P., Cardoso,C.,
            Petzhold,D., Schlegel,W.P., Lutter,S., Pierschalek,P., Behlke,J.
            and Morano,I.
  TITLE     Minigenes encoding N-terminal domains of human cardiac myosin light
            chain-1 improve heart function of transgenic rats
  JOURNAL   FASEB J 20 (7), 865-873 (2006)
   PUBMED   16675844
REFERENCE   5  (bases 1 to 928)
  AUTHORS   Yamashita,H., Sugiura,S., Fujita,H., Yasuda,Si., Nagai,R.,
            Saeki,Y., Sunagawa,K. and Sugi,H.
  TITLE     Myosin light chain isoforms modify force-generating ability of
            cardiac myosin by changing the kinetics of actin-myosin interaction
  JOURNAL   Cardiovasc Res 60 (3), 580-588 (2003)
   PUBMED   14659803
REFERENCE   6  (bases 1 to 928)
  AUTHORS   Harada,A., Furuta,B., Takeuchi,K., Itakura,M., Takahashi,M. and
            Umeda,M.
  TITLE     Nadrin, a novel neuron-specific GTPase-activating protein involved
            in regulated exocytosis
  JOURNAL   J Biol Chem 275 (47), 36885-36891 (2000)
   PUBMED   10967100
REFERENCE   7  (bases 1 to 928)
  AUTHORS   Poetter,K., Jiang,H., Hassanzadeh,S., Master,S.R., Chang,A.,
            Dalakas,M.C., Rayment,I., Sellers,J.R., Fananapazir,L. and
            Epstein,N.D.
  TITLE     Mutations in either the essential or regulatory light chains of
            myosin are associated with a rare myopathy in human heart and
            skeletal muscle
  JOURNAL   Nat Genet 13 (1), 63-69 (1996)
   PUBMED   8673105
REFERENCE   8  (bases 1 to 928)
  AUTHORS   Brand,T., Milting,H., Zippel,M. and Jockusch,H.
  TITLE     Differential synthesis by cultured atrial and ventricular rat
            cardiac myocytes of myosin light chain isoforms
  JOURNAL   FEBS Lett 283 (2), 289-290 (1991)
   PUBMED   2044768
  REMARK    Erratum:[FEBS Lett 1991 Sep 2;289(1):127]
REFERENCE   9  (bases 1 to 928)
  AUTHORS   Periasamy,M., Wadgaonkar,R., Kumar,C., Martin,B.J. and
            Siddiqui,M.A.
  TITLE     Characterization of a rat myosin alkali light chain gene expressed
            in ventricular and slow twitch skeletal muscles
  JOURNAL   Nucleic Acids Res 17 (19), 7723-7734 (1989)
   PUBMED   2798124
REFERENCE   10 (bases 1 to 928)
  AUTHORS   McNally,E.M., Buttrick,P.M. and Leinwand,L.A.
  TITLE     Ventricular myosin light chain 1 is developmentally regulated and
            does not change in hypertension
  JOURNAL   Nucleic Acids Res 17 (7), 2753-2767 (1989)
   PUBMED   2717409
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081832.1.
            
            On Jan 26, 2008 this sequence version replaced NM_012606.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081832.1, FQ216255.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132287, SAMD00132293
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..928
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..928
                     /gene="Myl3"
                     /gene_synonym="MLClV; Mylc1v; rVMLC1"
                     /note="myosin light chain 3"
                     /db_xref="GeneID:24585"
                     /db_xref="RGD:3142"
     exon            1..196
                     /gene="Myl3"
                     /gene_synonym="MLClV; Mylc1v; rVMLC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..655
                     /gene="Myl3"
                     /gene_synonym="MLClV; Mylc1v; rVMLC1"
                     /note="MLC1SB; ventricular/slow twitch myosin alkali light
                     chain; Myosin light chain 3, alkali, cardiac ventricles;
                     ventricular, skeletal, slow; myosin, light polypeptide 3;
                     ventricular myosin light chain 1; myosin alkali light
                     chain 1, ventricular; myosin, light chain 3, alkali;
                     ventricular, skeletal, slow"
                     /codon_start=1
                     /product="myosin light chain 3"
                     /protein_id="NP_036738.1"
                     /db_xref="GeneID:24585"
                     /db_xref="RGD:3142"
                     /translation="MAPKKPEPKKDDAKTAAPKAAPAPAAAPAAAPEPERPKEAEFDA
                     SKIKIEFTPEQIEEFKEAFQLFDRTPKGEMKITYGQCGDVLRALGQNPTQAEVLRVLG
                     KPKQEELNSKMMDFETFLPMLQHISKNKDTGTYEDFVEGLRVFDKEGNGTVMGAELRH
                     VLATLGERLTEDEVEKLMAGQEDSNGCINYEAFVKHIMAS"
     exon            197..224
                     /gene="Myl3"
                     /gene_synonym="MLClV; Mylc1v; rVMLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            225..374
                     /gene="Myl3"
                     /gene_synonym="MLClV; Mylc1v; rVMLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            375..548
                     /gene="Myl3"
                     /gene_synonym="MLClV; Mylc1v; rVMLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            549..626
                     /gene="Myl3"
                     /gene_synonym="MLClV; Mylc1v; rVMLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            627..664
                     /gene="Myl3"
                     /gene_synonym="MLClV; Mylc1v; rVMLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            665..902
                     /gene="Myl3"
                     /gene_synonym="MLClV; Mylc1v; rVMLC1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctatctcact ctcttctctc cttcttcccg cctctctgtg attacagctc caatggcccc
       61 caaaaagcca gagcccaaga aggacgatgc caaaaccgct gcccccaaag cagctccggc
      121 ccctgcggct gcacctgcgg ctgcacctga gcccgaacgc cctaaggaag cagagtttga
      181 tgcctccaag attaagattg agttcacgcc tgaacagatt gaagagttca aggaggcctt
      241 ccaactgttt gaccgcacac ctaagggcga gatgaagatc acgtacgggc agtgtgggga
      301 tgtcctgcgg gctctgggac agaatcctac ccaggcagag gtgctccgcg tcttggggaa
      361 gcccaaacag gaagagctca actccaagat gatggatttt gaaacattcc tgcccatgct
      421 gcagcacatc tccaagaaca aagacacggg cacatatgag gacttcgtgg aggggctgcg
      481 ggtcttcgac aaggagggca acggaactgt tatgggtgca gagctccgtc atgtgctggc
      541 cacgctgggt gagaggctga cagaagacga ggtagagaaa ctgatggctg gtcaagaaga
      601 ctccaatggc tgcatcaact atgaagcatt tgtgaagcac atcatggcca gctgagcctc
      661 tcaggaagcc cagggcaggc caagctgggg acatgccatc tcccaaccat aatgctgaca
      721 ccatgtctgg agcttcggga aggaaaggag tgtcccagac tccagcacat ggtcgcagat
      781 cactccgtgt gcggtggtcc tccctggccc ctgctaggat gtgcttgcct acccgtggta
      841 ccctttctgt ctccaccctg cggccttatg aataaatgat ttccttcctt ctgctctctc
      901 tcaaaaaaaa aaaaaaaaaa aaaaaaaa
//
