LOCUS       NP_059039                172 aa            linear   ROD 03-APR-2024
DEFINITION  myosin regulatory light chain 12B [Rattus norvegicus].
ACCESSION   NP_059039 XP_346860
VERSION     NP_059039.2
DBSOURCE    REFSEQ: accession NM_017343.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 172)
  AUTHORS   Toepfer,C.N., Sikkel,M.B., Caorsi,V., Vydyanath,A., Torre,I.,
            Copeland,O., Lyon,A.R., Marston,S.B., Luther,P.K., Macleod,K.T.,
            West,T.G. and Ferenczi,M.A.
  TITLE     A post-MI power struggle: adaptations in cardiac power occur at the
            sarcomere level alongside MyBP-C and RLC phosphorylation
  JOURNAL   Am J Physiol Heart Circ Physiol 311 (2), H465-H475 (2016)
   PUBMED   27233767
  REMARK    GeneRIF: Phosphorylation of myosin regulatory light chain (RLC)
            increased and remained elevated post-MI, while phosphorylation of
            myosin binding protein-C (MyBP-C) was initially depressed but then
            increased as the hearts became decompensated.
REFERENCE   2  (residues 1 to 172)
  AUTHORS   Lu,Z., Ma,X.N., Zhang,H.M., Ji,H.H., Ding,H., Zhang,J., Luo,D.,
            Sun,Y. and Li,X.D.
  TITLE     Mouse myosin-19 is a plus-end-directed, high-duty ratio molecular
            motor
  JOURNAL   J Biol Chem 289 (26), 18535-18548 (2014)
   PUBMED   24825904
REFERENCE   3  (residues 1 to 172)
  AUTHORS   Kiyomitsu,T. and Cheeseman,I.M.
  TITLE     Cortical dynein and asymmetric membrane elongation coordinately
            position the spindle in anaphase
  JOURNAL   Cell 154 (2), 391-402 (2013)
   PUBMED   23870127
  REMARK    Erratum:[Cell. 2013 Sep 12;154(6):1401]
REFERENCE   4  (residues 1 to 172)
  AUTHORS   Sutherland,C. and Walsh,M.P.
  TITLE     Myosin regulatory light chain diphosphorylation slows relaxation of
            arterial smooth muscle
  JOURNAL   J Biol Chem 287 (29), 24064-24076 (2012)
   PUBMED   22661704
  REMARK    GeneRIF: Findings conclude that phosphorylation at Thr(18)
            decreases the rates of LC(20) dephosphorylation and smooth muscle
            relaxation compared with LC(20) phosphorylated exclusively at
            Ser(19).
REFERENCE   5  (residues 1 to 172)
  AUTHORS   Revenu,C., Ubelmann,F., Hurbain,I., El-Marjou,F., Dingli,F.,
            Loew,D., Delacour,D., Gilet,J., Brot-Laroche,E., Rivero,F.,
            Louvard,D. and Robine,S.
  TITLE     A new role for the architecture of microvillar actin bundles in
            apical retention of membrane proteins
  JOURNAL   Mol Biol Cell 23 (2), 324-336 (2012)
   PUBMED   22114352
REFERENCE   6  (residues 1 to 172)
  AUTHORS   Wang,Y. and Chantler,P.D.
  TITLE     Functional analysis of individual brain myosin II isoforms through
            hybrid formation
  JOURNAL   FEBS Lett 348 (3), 244-248 (1994)
   PUBMED   8034049
REFERENCE   7  (residues 1 to 172)
  AUTHORS   Ozaki,T., Asai,T. and Sakiyama,S.
  TITLE     Molecular cloning of a unique complementary DNA of rat myosin
            regulatory light chain and its elevated expression in
            v-src-transformed rat culture cell lines
  JOURNAL   Cell Growth Differ 4 (11), 939-945 (1993)
   PUBMED   8297799
REFERENCE   8  (residues 1 to 172)
  AUTHORS   Feinstein,D.L., Durand,M. and Milner,R.J.
  TITLE     Expression of myosin regulatory light chains in rat brain:
            characterization of a novel isoform
  JOURNAL   Brain Res Mol Brain Res 10 (2), 97-105 (1991)
   PUBMED   1649372
REFERENCE   9  (residues 1 to 172)
  AUTHORS   Grant,J.W., Taubman,M.B., Church,S.L., Johnson,R.L. and
            Nadal-Ginard,B.
  TITLE     Mammalian nonsarcomeric myosin regulatory light chains are encoded
            by two differentially regulated and linked genes
  JOURNAL   J Cell Biol 111 (3), 1127-1135 (1990)
   PUBMED   2391362
  REMARK    Erratum:[J Cell Biol 1990 Nov;111(5 Pt 1):2207]
REFERENCE   10 (residues 1 to 172)
  AUTHORS   Taubman,M.B., Grant,J.W. and Nadal-Ginard,B.
  TITLE     Cloning and characterization of mammalian myosin regulatory light
            chain (RLC) cDNA: the RLC gene is expressed in smooth, sarcomeric,
            and nonmuscle tissues
  JOURNAL   J Cell Biol 104 (6), 1505-1513 (1987)
   PUBMED   3584239
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF977112.1, BC060577.1, EV769828.1 and CO405920.1.
            
            On Sep 17, 2008 this sequence version replaced NP_059039.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ118700.1, FQ229195.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00155333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..172
                     /organism="Rattus norvegicus"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q38"
     Protein         1..172
                     /product="myosin regulatory light chain 12B"
                     /note="myosin regulatory light chain-B; MLC-2; MLC20;
                     myosin RLC-B; myosin regulatory light chain 20 kDa; myosin
                     regulatory light chain MRLC2; myosin, light chain 12B,
                     regulatory; myosin light chain, regulatory B"
                     /calculated_mol_wt=19648
     Region          1..20
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P18666.3)"
     Site            19
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by MLCK and ZIPK/DAPK3.
                     /evidence=ECO:0000269|PubMed:11384979; propagated from
                     UniProtKB/Swiss-Prot (P18666.3)"
     Site            20
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MLCK and ZIPK/DAPK3.
                     /evidence=ECO:0000269|PubMed:11384979; propagated from
                     UniProtKB/Swiss-Prot (P18666.3)"
     Region          25..163
                     /region_name="PTZ00184"
                     /note="calmodulin; Provisional"
                     /db_xref="CDD:185504"
     CDS             1..172
                     /gene="Myl12b"
                     /gene_synonym="Mrlc2; Mrlcb; Mylc2b"
                     /coded_by="NM_017343.2:101..619"
                     /db_xref="GeneID:50685"
                     /db_xref="RGD:628855"
ORIGIN      
        1 msskkaktkt tkkrpqrats nvfamfdqsq iqefkeafnm idqnrdgfid kedlhdmlas
       61 lgknptdayl dammneapgp inftmfltmf geklngtdpe dvirnafacf deeatgtiqe
      121 dylrellttm gdrftdeevd elyreapidk kgnfnyieft rilkhgakdk dd
//
