LOCUS       NM_001135017             992 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus myosin light chain 12A (Myl12a), mRNA.
ACCESSION   NM_001135017
VERSION     NM_001135017.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 992)
  AUTHORS   Toepfer,C.N., Sikkel,M.B., Caorsi,V., Vydyanath,A., Torre,I.,
            Copeland,O., Lyon,A.R., Marston,S.B., Luther,P.K., Macleod,K.T.,
            West,T.G. and Ferenczi,M.A.
  TITLE     A post-MI power struggle: adaptations in cardiac power occur at the
            sarcomere level alongside MyBP-C and RLC phosphorylation
  JOURNAL   Am J Physiol Heart Circ Physiol 311 (2), H465-H475 (2016)
   PUBMED   27233767
  REMARK    GeneRIF: Phosphorylation of myosin regulatory light chain (RLC)
            increased and remained elevated post-MI, while phosphorylation of
            myosin binding protein-C (MyBP-C) was initially depressed but then
            increased as the hearts became decompensated.
REFERENCE   2  (bases 1 to 992)
  AUTHORS   Kiyomitsu,T. and Cheeseman,I.M.
  TITLE     Cortical dynein and asymmetric membrane elongation coordinately
            position the spindle in anaphase
  JOURNAL   Cell 154 (2), 391-402 (2013)
   PUBMED   23870127
  REMARK    Erratum:[Cell. 2013 Sep 12;154(6):1401]
REFERENCE   3  (bases 1 to 992)
  AUTHORS   Frobel,J., Cadeddu,R.P., Hartwig,S., Bruns,I., Wilk,C.M.,
            Kundgen,A., Fischer,J.C., Schroeder,T., Steidl,U.G., Germing,U.,
            Lehr,S., Haas,R. and Czibere,A.
  TITLE     Platelet proteome analysis reveals integrin-dependent aggregation
            defects in patients with myelodysplastic syndromes
  JOURNAL   Mol Cell Proteomics 12 (5), 1272-1280 (2013)
   PUBMED   23382103
REFERENCE   4  (bases 1 to 992)
  AUTHORS   Park,I., Han,C., Jin,S., Lee,B., Choi,H., Kwon,J.T., Kim,D.,
            Kim,J., Lifirsu,E., Park,W.J., Park,Z.Y., Kim,D.H. and Cho,C.
  TITLE     Myosin regulatory light chains are required to maintain the
            stability of myosin II and cellular integrity
  JOURNAL   Biochem J 434 (1), 171-180 (2011)
   PUBMED   21126233
REFERENCE   5  (bases 1 to 992)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   6  (bases 1 to 992)
  AUTHORS   Noda,Y., Horikawa,S., Katayama,Y. and Sasaki,S.
  TITLE     Identification of a multiprotein 'motor' complex binding to water
            channel aquaporin-2
  JOURNAL   Biochem Biophys Res Commun 330 (4), 1041-1047 (2005)
   PUBMED   15823548
REFERENCE   7  (bases 1 to 992)
  AUTHORS   Wang,Y. and Chantler,P.D.
  TITLE     Functional analysis of individual brain myosin II isoforms through
            hybrid formation
  JOURNAL   FEBS Lett 348 (3), 244-248 (1994)
   PUBMED   8034049
REFERENCE   8  (bases 1 to 992)
  AUTHORS   Feinstein,D.L., Durand,M. and Milner,R.J.
  TITLE     Expression of myosin regulatory light chains in rat brain:
            characterization of a novel isoform
  JOURNAL   Brain Res Mol Brain Res 10 (2), 97-105 (1991)
   PUBMED   1649372
REFERENCE   9  (bases 1 to 992)
  AUTHORS   Grant,J.W., Taubman,M.B., Church,S.L., Johnson,R.L. and
            Nadal-Ginard,B.
  TITLE     Mammalian nonsarcomeric myosin regulatory light chains are encoded
            by two differentially regulated and linked genes
  JOURNAL   J Cell Biol 111 (3), 1127-1135 (1990)
   PUBMED   2391362
  REMARK    Erratum:[J Cell Biol 1990 Nov;111(5 Pt 1):2207]
REFERENCE   10 (bases 1 to 992)
  AUTHORS   Taubman,M.B., Grant,J.W. and Nadal-Ginard,B.
  TITLE     Cloning and characterization of mammalian myosin regulatory light
            chain (RLC) cDNA: the RLC gene is expressed in smooth, sarcomeric,
            and nonmuscle tissues
  JOURNAL   J Cell Biol 104 (6), 1505-1513 (1987)
   PUBMED   3584239
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            EV767772.1, X05566.1 and BQ207032.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ217399.1, FQ229140.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                EV767772.1         31-88
            59-687              X05566.1           1-629
            688-992             BQ207032.1         1-305               c
FEATURES             Location/Qualifiers
     source          1..992
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q38"
     gene            1..992
                     /gene="Myl12a"
                     /gene_synonym="RGD1309537; Rlc-a"
                     /note="myosin light chain 12A"
                     /db_xref="GeneID:501203"
                     /db_xref="RGD:1309537"
     exon            1..112
                     /gene="Myl12a"
                     /gene_synonym="RGD1309537; Rlc-a"
                     /inference="alignment:Splign:2.1.0"
     exon            113..311
                     /gene="Myl12a"
                     /gene_synonym="RGD1309537; Rlc-a"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..646
                     /gene="Myl12a"
                     /gene_synonym="RGD1309537; Rlc-a"
                     /note="myosin RLC-A; myosin, light chain 12A, regulatory,
                     non-sarcomeric"
                     /codon_start=1
                     /product="myosin regulatory light chain RLC-A"
                     /protein_id="NP_001128489.1"
                     /db_xref="GeneID:501203"
                     /db_xref="RGD:1309537"
                     /translation="MSSKRAKTKTTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQN
                     RDGFIDKEDLHDMLASMGKNPTDEYLDAMMNEAPGPINFTMFLTMFGEKLNGTDPEDV
                     IRNAFACFDEEAIGTIQEDYLRELLTTMGDRFTDEEVDELYREAPIDKKGNFNYIEFT
                     RILKHGAKDKDD"
     exon            312..473
                     /gene="Myl12a"
                     /gene_synonym="RGD1309537; Rlc-a"
                     /inference="alignment:Splign:2.1.0"
     exon            474..975
                     /gene="Myl12a"
                     /gene_synonym="RGD1309537; Rlc-a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcggaggc cggaagtggc cgttcttggg cggctggaaa gttagaaagt ttgtgagggc
       61 ggcggcaaag cttcgcagag acgctcactc ttggttctcg cggctgagca gggatttaac
      121 cgccaccatg tcgagcaaaa gagcgaagac caagaccacc aagaagcgcc ctcagcgcgc
      181 aacgtccaac gtgttcgcca tgtttgacca gtcccagatc caggagttca aagaggcctt
      241 caacatgatc gaccagaacc gggacggctt catcgacaag gaggacctgc acgatatgct
      301 ggcttcaatg ggaaaaaatc caactgatga atacctggac gccatgatga atgaggcccc
      361 gggccccatc aatttcacca tgttcctcac catgtttgga gaaaagctga acggcaccga
      421 ccctgaggac gtcatcagaa atgccttcgc ttgcttcgat gaggaagcaa tcggcaccat
      481 ccaggaggat tacctgaggg agctgctcac caccatgggc gaccgcttca cagatgagga
      541 agtggatgag ctgtacaggg aggcccccat cgacaaaaag gggaatttca actacatcga
      601 gttcacgcgc atcctcaagc acggagcgaa agacaaagat gactgaagag ctgtggcttc
      661 cagccaaatg tccctgttgc cattggggta tttctgagat tttcctcctg gagccggtcg
      721 catgcccttg cttttctgcc ttttgctttc cttgttttgt atttattctc agccactttg
      781 ggccacgtgt acctttatca tcagactgga aacgggactt tctgtcattg ttcgatgaga
      841 acgtaaggta atttaactta cagacagtct tgtcccttgt aataactgca gccacagagt
      901 cagtatattt tttcagagaa agttatccac tcaatttttt ctgaatgata attaaacttt
      961 ctgataaaat acttaaaaaa aaaaaaaaaa aa
//
