LOCUS       NM_012605                662 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus myosin light chain 11 (Myl11), mRNA.
ACCESSION   NM_012605
VERSION     NM_012605.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 662)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   2  (bases 1 to 662)
  AUTHORS   Wang,Y., Szczesna-Cordary,D., Craig,R., Diaz-Perez,Z., Guzman,G.,
            Miller,T. and Potter,J.D.
  TITLE     Fast skeletal muscle regulatory light chain is required for fast
            and slow skeletal muscle development
  JOURNAL   FASEB J 21 (9), 2205-2214 (2007)
   PUBMED   17356007
  REMARK    Erratum:[FASEB J. 2007 Aug;21(10):2633]
REFERENCE   3  (bases 1 to 662)
  AUTHORS   Liu,X., Lindberg,R., Xiao,B.G., Steffensen,K.R., Leppert,D.,
            Link,H. and Huang,Y.M.
  TITLE     CD24 and myosin light polypeptide 2 are involved in prevention of
            experimental autoimmune encephalomyelitis by myelin basic
            protein-pulsed dendritic cells
  JOURNAL   J Neuroimmunol 172 (1-2), 137-144 (2006)
   PUBMED   16380169
REFERENCE   4  (bases 1 to 662)
  AUTHORS   Leszczynski,J.K. and Esser,K.A.
  TITLE     The MEF2 site is necessary for induction of the myosin light chain
            2 slow promoter in overloaded regenerating plantaris muscle
  JOURNAL   Life Sci 73 (25), 3265-3276 (2003)
   PUBMED   14561531
  REMARK    GeneRIF: results demonstrate that the -270MLC2s promoter contains
            the elements necessary for expression of MLC2s in regenerating
            overloaded plantaris muscle
REFERENCE   5  (bases 1 to 662)
  AUTHORS   Andersen,P.S., Havndrup,O., Bundgaard,H., Moolman-Smook,J.C.,
            Larsen,L.A., Mogensen,J., Brink,P.A., Borglum,A.D., Corfield,V.A.,
            Kjeldsen,K., Vuust,J. and Christiansen,M.
  TITLE     Myosin light chain mutations in familial hypertrophic
            cardiomyopathy: phenotypic presentation and frequency in Danish and
            South African populations
  JOURNAL   J Med Genet 38 (12), E43 (2001)
   PUBMED   11748309
REFERENCE   6  (bases 1 to 662)
  AUTHORS   Flavigny,J., Richard,P., Isnard,R., Carrier,L., Charron,P.,
            Bonne,G., Forissier,J.F., Desnos,M., Dubourg,O., Komajda,M.,
            Schwartz,K. and Hainque,B.
  TITLE     Identification of two novel mutations in the ventricular regulatory
            myosin light chain gene (MYL2) associated with familial and
            classical forms of hypertrophic cardiomyopathy
  JOURNAL   J Mol Med (Berl) 76 (3-4), 208-214 (1998)
   PUBMED   9535554
REFERENCE   7  (bases 1 to 662)
  AUTHORS   Nudel,U., Calvo,J.M., Shani,M. and Levy,Z.
  TITLE     The nucleotide sequence of a rat myosin light chain 2 gene
  JOURNAL   Nucleic Acids Res 12 (18), 7175-7186 (1984)
   PUBMED   6091059
REFERENCE   8  (bases 1 to 662)
  AUTHORS   Garfinkel,L.I., Periasamy,M. and Nadal-Ginard,B.
  TITLE     Cloning and characterization of cDNA sequences corresponding to
            myosin light chains 1, 2, and 3, troponin-C, troponin-T,
            alpha-tropomyosin, and alpha-actin
  JOURNAL   J Biol Chem 257 (18), 11078-11086 (1982)
   PUBMED   6179945
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB770854.1, BI278596.1 and JAXUCZ010000001.1.
            
            On Oct 17, 2007 this sequence version replaced NM_012605.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ224781.1, FQ217368.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-397               CB770854.1         11-407
            398-558             BI278596.1         106-266             c
            559-270518738       JAXUCZ010000001.1  1-270518180
            270518739-270518794 BI278596.1         49-104              c
            270518795-270518841 BI278596.1         1-47                c
FEATURES             Location/Qualifiers
     source          1..662
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..662
                     /gene="Myl11"
                     /gene_synonym="MLC2; Myl2; Mylpf; Myolc1"
                     /note="myosin light chain 11"
                     /db_xref="GeneID:24584"
                     /db_xref="RGD:3141"
     exon            1..44
                     /gene="Myl11"
                     /gene_synonym="MLC2; Myl2; Mylpf; Myolc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..551
                     /gene="Myl11"
                     /gene_synonym="MLC2; Myl2; Mylpf; Myolc1"
                     /note="G2; DTNB; MLC-2; fast skeletal myosin light chain
                     2; Myosin, light polypeptide 2, alkali; ventricular,
                     skeletal, slow; myosin light chain, phosphorylatable, fast
                     skeletal muscle"
                     /codon_start=1
                     /product="myosin regulatory light chain 11"
                     /protein_id="NP_036737.1"
                     /db_xref="GeneID:24584"
                     /db_xref="RGD:3141"
                     /translation="MAPKKAKRRAAAEGSSNVFSMFDQTQIQEFKEAFTVIDQNRDGI
                     IDKEDLRDTFAAMGRLNVKNEELDAMMKEASGPINFTVFLTMFGEKLKGADPEDVITG
                     AFKVLDPEGKGTIKKQFLEELLTTQCDRFSQEEIKNMWAAFPPDVGGNVDYKNICYVI
                     THGDAKDQE"
     exon            45..137
                     /gene="Myl11"
                     /gene_synonym="MLC2; Myl2; Mylpf; Myolc1"
                     /inference="alignment:Splign:2.1.0"
     exon            138..213
                     /gene="Myl11"
                     /gene_synonym="MLC2; Myl2; Mylpf; Myolc1"
                     /inference="alignment:Splign:2.1.0"
     exon            214..318
                     /gene="Myl11"
                     /gene_synonym="MLC2; Myl2; Mylpf; Myolc1"
                     /inference="alignment:Splign:2.1.0"
     exon            319..397
                     /gene="Myl11"
                     /gene_synonym="MLC2; Myl2; Mylpf; Myolc1"
                     /inference="alignment:Splign:2.1.0"
     exon            398..446
                     /gene="Myl11"
                     /gene_synonym="MLC2; Myl2; Mylpf; Myolc1"
                     /inference="alignment:Splign:2.1.0"
     exon            447..645
                     /gene="Myl11"
                     /gene_synonym="MLC2; Myl2; Mylpf; Myolc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccatctgga gctactgcct tgccctcaga ggatctaaga catggcaccc aagaaggcca
       61 agagaagggc agcagcagaa gggagctcca atgttttctc catgtttgac cagactcaga
      121 tccaggagtt caaggaggct ttcactgtaa ttgatcagaa cagggatggc attattgaca
      181 aggaggatct tcgggacacc tttgcggcca tgggccgtct caatgtgaag aatgaggaac
      241 tcgacgccat gatgaaggaa gccagtgggc ctatcaactt cactgtcttc ctgaccatgt
      301 ttggggagaa gctgaagggt gcggaccccg aggatgtgat cactggagcc ttcaaggtcc
      361 tggacccaga agggaagggc accatcaaaa agcaattctt ggaggagctg cttaccacgc
      421 agtgcgaccg attttcccag gaggagatca agaatatgtg ggcagccttc cctccagatg
      481 tgggcggcaa cgtggactac aagaacatct gctatgtcat cacacacggt gacgctaagg
      541 accaggaata ggggacccaa ggtctcagaa gacccagata ggcttgtagc cgcaccaact
      601 ctcaccctga ccccccaata aaagtcaact ggtctttgtt tcttaaaaaa aaaaaaaaaa
      661 aa
//
