LOCUS       NM_001077656             991 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus myosin, light chain 1 (Myl1), transcript variant
            1f, mRNA.
ACCESSION   NM_001077656
VERSION     NM_001077656.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 991)
  AUTHORS   Kim,J.H., Graber,T.G., Liu,H., Asakura,A. and Thompson,L.V.
  TITLE     Increasing myosin light chain 3f (MLC3f) protects against a decline
            in contractile velocity
  JOURNAL   PLoS One 14 (4), e0214982 (2019)
   PUBMED   30964931
  REMARK    GeneRIF: these results indicate that rAd-MLC3f injection rescues
            hindlimb unloading-induced decline in Vo in MHC type IIB single
            muscle fibers.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 991)
  AUTHORS   Ravenscroft,G., Zaharieva,I.T., Bortolotti,C.A., Lambrughi,M.,
            Pignataro,M., Borsari,M., Sewry,C.A., Phadke,R., Haliloglu,G.,
            Ong,R., Goullee,H., Whyte,T., Consortium,U.K., Manzur,A., Talim,B.,
            Kaya,U., Osborn,D.P.S., Forrest,A.R.R., Laing,N.G. and Muntoni,F.
  TITLE     Bi-allelic mutations in MYL1 cause a severe congenital myopathy
  JOURNAL   Hum Mol Genet 27 (24), 4263-4272 (2018)
   PUBMED   30215711
REFERENCE   3  (bases 1 to 991)
  AUTHORS   Kosla,J., Pankova,D., Plachy,J., Tolde,O., Bicanova,K., Dvorak,M.,
            Rosel,D. and Brabek,J.
  TITLE     Metastasis of aggressive amoeboid sarcoma cells is dependent on
            Rho/ROCK/MLC signaling
  JOURNAL   Cell Commun Signal 11, 51 (2013)
   PUBMED   23899007
  REMARK    GeneRIF: Metastasis of aggressive amoeboid sarcoma cells is
            dependent on Rho/ROCK/MLC signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 991)
  AUTHORS   Polewicz,D., Cadete,V.J., Doroszko,A., Hunter,B.E., Sawicka,J.,
            Szczesna-Cordary,D., Light,P.E. and Sawicki,G.
  TITLE     Ischemia induced peroxynitrite dependent modifications of
            cardiomyocyte MLC1 increases its degradation by MMP-2 leading to
            contractile dysfunction
  JOURNAL   J Cell Mol Med 15 (5), 1136-1147 (2011)
   PUBMED   20518849
  REMARK    GeneRIF: Mass spectrometry analysis of ischemic rat cardiomyocyte
            MLC1 showed nitration of tyrosines 78 and 190
REFERENCE   5  (bases 1 to 991)
  AUTHORS   Zhong,S. and Thompson,L.V.
  TITLE     The roles of myosin ATPase activity and myosin light chain relative
            content in the slowing of type IIB fibers with hindlimb unweighting
            in rats
  JOURNAL   Am J Physiol Cell Physiol 293 (2), C723-C728 (2007)
   PUBMED   17494635
  REMARK    GeneRIF: Slowing of shortening velocity in tyep IIb fibers with
            hindlimb unloading involves a increase in the amount of MLC1-f.
REFERENCE   6  (bases 1 to 991)
  AUTHORS   Larsson,L. and Moss,R.L.
  TITLE     Maximum velocity of shortening in relation to myosin isoform
            composition in single fibres from human skeletal muscles
  JOURNAL   J Physiol 472, 595-614 (1993)
   PUBMED   8145163
REFERENCE   7  (bases 1 to 991)
  AUTHORS   Strehler,E.E., Periasamy,M., Strehler-Page,M.A. and Nadal-Ginard,B.
  TITLE     Myosin light-chain 1 and 3 gene has two structurally distinct and
            differentially regulated promoters evolving at different rates
  JOURNAL   Mol Cell Biol 5 (11), 3168-3182 (1985)
   PUBMED   3018505
REFERENCE   8  (bases 1 to 991)
  AUTHORS   Periasamy,M., Strehler,E.E., Garfinkel,L.I., Gubits,R.M.,
            Ruiz-Opazo,N. and Nadal-Ginard,B.
  TITLE     Fast skeletal muscle myosin light chains 1 and 3 are produced from
            a single gene by a combined process of differential RNA
            transcription and splicing
  JOURNAL   J Biol Chem 259 (21), 13595-13604 (1984)
   PUBMED   6092382
REFERENCE   9  (bases 1 to 991)
  AUTHORS   Garfinkel,L.I., Periasamy,M. and Nadal-Ginard,B.
  TITLE     Cloning and characterization of cDNA sequences corresponding to
            myosin light chains 1, 2, and 3, troponin-C, troponin-T,
            alpha-tropomyosin, and alpha-actin
  JOURNAL   J Biol Chem 257 (18), 11078-11086 (1982)
   PUBMED   6179945
REFERENCE   10 (bases 1 to 991)
  AUTHORS   Housley,C.
  TITLE     Simplicity in materiel management
  JOURNAL   Dimens Health Serv 55 (1), 30-31 (1978)
   PUBMED   620885
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB809837.1, CR755322.1 and BI277595.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ214604.1, FQ214712.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-308               CB809837.1         74-381
            309-898             CR755322.1         132-721
            899-991             BI277595.1         1-93                c
FEATURES             Location/Qualifiers
     source          1..991
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q32"
     gene            1..991
                     /gene="Myl1"
                     /gene_synonym="Mcl3; MLC-f; Mlc1; Mlc3; MLC3-f; MLCf"
                     /note="myosin, light chain 1"
                     /db_xref="GeneID:56781"
                     /db_xref="RGD:1598796"
     exon            1..238
                     /gene="Myl1"
                     /gene_synonym="Mcl3; MLC-f; Mlc1; Mlc3; MLC3-f; MLCf"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..691
                     /gene="Myl1"
                     /gene_synonym="Mcl3; MLC-f; Mlc1; Mlc3; MLC3-f; MLCf"
                     /note="isoform 1f is encoded by transcript variant 1f;
                     fast myosin alkali light chain 3; fast myosin alkali light
                     chain 1; MLC1F; MLC3F; alkali myosin light chain 1; alkali
                     myosin light chain 3; MLC1/MLC3; MLC1F/MLC3F; myosin light
                     chain A1/A2; myosin light chain alkali 1/2; myosin, light
                     polypeptide 1"
                     /codon_start=1
                     /product="myosin light chain 1/3, skeletal muscle isoform
                     isoform 1f"
                     /protein_id="NP_001071124.1"
                     /db_xref="GeneID:56781"
                     /db_xref="RGD:1598796"
                     /translation="MAPKKDVKKPAAAAPAPAPAPAPAPAKPKEEKIDLSAIKIEFSK
                     EQQEEFKEAFLLFDRTGECKITLSQVGDVLRALGTNPTNAEVKKVLGNPSNEEMNAKK
                     IEFEQFLPMMQAISNNKDQGGYEDFVEGLRVFDKEGNGTVMGAELRHVLATLGEKMKE
                     EEVEALLAGQEDSNGCINYEAFVKHIMSV"
     exon            239..266
                     /gene="Myl1"
                     /gene_synonym="Mcl3; MLC-f; Mlc1; Mlc3; MLC3-f; MLCf"
                     /inference="alignment:Splign:2.1.0"
     exon            267..410
                     /gene="Myl1"
                     /gene_synonym="Mcl3; MLC-f; Mlc1; Mlc3; MLC3-f; MLCf"
                     /inference="alignment:Splign:2.1.0"
     exon            411..584
                     /gene="Myl1"
                     /gene_synonym="Mcl3; MLC-f; Mlc1; Mlc3; MLC3-f; MLCf"
                     /inference="alignment:Splign:2.1.0"
     exon            585..662
                     /gene="Myl1"
                     /gene_synonym="Mcl3; MLC-f; Mlc1; Mlc3; MLC3-f; MLCf"
                     /inference="alignment:Splign:2.1.0"
     exon            663..705
                     /gene="Myl1"
                     /gene_synonym="Mcl3; MLC-f; Mlc1; Mlc3; MLC3-f; MLCf"
                     /inference="alignment:Splign:2.1.0"
     exon            706..976
                     /gene="Myl1"
                     /gene_synonym="Mcl3; MLC-f; Mlc1; Mlc3; MLC3-f; MLCf"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggtccaccc tccagacgct gggctgcggg tcaagcgagc caccactgct cttccaagtg
       61 tcattttgac aggttcttct ggaggagatc cttcttttgt taacccatcg ttttaatcaa
      121 aatggcacca aagaaagacg tgaagaagcc cgctgctgct gctcctgccc cagccccggc
      181 cccggcccct gccccagcca aacctaaaga agaaaaaatc gatctgtctg ctattaagat
      241 cgagttctct aaggaacaac aggaggaatt caaggaggca tttctcctct tcgacagaac
      301 cggtgaatgc aagatcacct taagtcaggt gggcgacgtc ctccgggctc tgggcaccaa
      361 tcccacaaat gcagaagtca agaaggttct cgggaaccct agcaatgaag agatgaatgc
      421 taagaaaatc gagtttgaac agtttctgcc catgatgcaa gccatctcca acaacaagga
      481 ccagggaggc tatgaagatt tcgttgaggg tctgcgtgtc ttcgacaagg agggcaatgg
      541 caccgtcatg ggtgctgagc tccgccatgt cctcgccact ctgggagaga agatgaagga
      601 ggaggaggta gaagcattgc tggcgggcca ggaggactcc aatggctgca tcaactatga
      661 agcttttgtg aaacacatca tgtctgtcta aaaggagaat tcaagaacac agtgttgggg
      721 aagactggcc agaaagtcag ttcaagaaca cctatggcta actgtcaaca ccagcttgcc
      781 accacccgga agaacaaaca atctagacca ttctagattg aaggattccc tgaagtttta
      841 tcaaccttga gtttttcatg gcacacacat caggttgata atctcaagtc catgtaccac
      901 ctttatgatc tacttgggtc cacaacattc ataagagcac tacatcaata aacttggtca
      961 gtctggaaga ctcaaaaaaa aaaaaaaaaa a
//
