LOCUS       NM_001100485            6026 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus myosin heavy chain 8 (Myh8), mRNA.
ACCESSION   NM_001100485 XM_001078049
VERSION     NM_001100485.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6026)
  AUTHORS   Stern-Straeter,J., Bonaterra,G.A., Kassner,S.S., Zugel,S.,
            Hormann,K., Kinscherf,R. and Goessler,U.R.
  TITLE     Characterization of human myoblast differentiation for
            tissue-engineering purposes by quantitative gene expression
            analysis
  JOURNAL   J Tissue Eng Regen Med 5 (8), e197-e206 (2011)
   PUBMED   21370490
REFERENCE   2  (bases 1 to 6026)
  AUTHORS   Toydemir,R.M., Chen,H., Proud,V.K., Martin,R., van Bokhoven,H.,
            Hamel,B.C., Tuerlings,J.H., Stratakis,C.A., Jorde,L.B. and
            Bamshad,M.J.
  TITLE     Trismus-pseudocamptodactyly syndrome is caused by recurrent
            mutation of MYH8
  JOURNAL   Am J Med Genet A 140 (22), 2387-2393 (2006)
   PUBMED   17041932
REFERENCE   3  (bases 1 to 6026)
  AUTHORS   Veugelers,M., Bressan,M., McDermott,D.A., Weremowicz,S.,
            Morton,C.C., Mabry,C.C., Lefaivre,J.F., Zunamon,A., Destree,A.,
            Chaudron,J.M. and Basson,C.T.
  TITLE     Mutation of perinatal myosin heavy chain associated with a Carney
            complex variant
  JOURNAL   N Engl J Med 351 (5), 460-469 (2004)
   PUBMED   15282353
REFERENCE   4  (bases 1 to 6026)
  AUTHORS   Smith,T.H. and Miller,J.B.
  TITLE     Distinct myogenic programs of embryonic and fetal mouse muscle
            cells: expression of the perinatal myosin heavy chain isoform in
            vitro
  JOURNAL   Dev Biol 149 (1), 16-26 (1992)
   PUBMED   1728586
REFERENCE   5  (bases 1 to 6026)
  AUTHORS   Schiaffino,S., Gorza,L., Dones,I., Cornelio,F. and Sartore,S.
  TITLE     Fetal myosin immunoreactivity in human dystrophic muscle
  JOURNAL   Muscle Nerve 9 (1), 51-58 (1986)
   PUBMED   3513005
REFERENCE   6  (bases 1 to 6026)
  AUTHORS   Periasamy,M., Wieczorek,D.F. and Nadal-Ginard,B.
  TITLE     Characterization of a developmentally regulated perinatal myosin
            heavy-chain gene expressed in skeletal muscle
  JOURNAL   J Biol Chem 259 (21), 13573-13578 (1984)
   PUBMED   6149224
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CH473948.1.
            
            On Dec 25, 2009 this sequence version replaced XM_001078049.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760384,
                              SAMN06621351 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..6026
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..6026
                     /gene="Myh8"
                     /note="myosin heavy chain 8"
                     /db_xref="GeneID:252942"
                     /db_xref="RGD:620356"
     exon            1..42
                     /gene="Myh8"
                     /inference="alignment:Splign:2.1.0"
     exon            43..282
                     /gene="Myh8"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..5886
                     /gene="Myh8"
                     /note="gene_id=rCG34493.1 transcript_id=rCT34493.1
                     protein_id=rCP44498.1; myHC-perinatal; myosin heavy chain,
                     skeletal muscle, perinatal; myosin, heavy polypeptide 8,
                     skeletal muscle, perinatal; myosin, heavy chain 8,
                     skeletal muscle, perinatal"
                     /codon_start=1
                     /product="myosin-8"
                     /protein_id="NP_001093955.1"
                     /db_xref="GeneID:252942"
                     /db_xref="RGD:620356"
                     /translation="MSTGSDAEMAIFGEAAPYLRKSEKERIEAQNKPFDAKTSVFVAE
                     PKESYVKSVIQSKEGGKVTVKTESGATLTVKEDQVFPMNPPKYDKIEDMAMMTHLHEP
                     GVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSI
                     SDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGEKKKEESGKMQGT
                     LEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRV
                     TFQLKAERSYHIFYQITSNKKPELIEMLLITTNPYDYAFVSQGEITVPSIDDQEELMA
                     TDSAIDILGFSPEEKVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLQS
                     LNSADLLKALCYPRVKVGNEYVTKGQTVQQVYNAVGALAKAVYEKMFLWMVTRINQQL
                     DTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEG
                     IEWTFIDFGMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNF
                     QKPKPTKGKAEAHFSLIHYAGTVDYNITGWLDKNKDPLNDTVVGLYQKSAMKTLASLF
                     STYASAEADGGAKKGAKKKGSSFQTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETK
                     TPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVLNASAIPEGQFID
                     SKKASEKLLGSIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDEKLAQIITRTQAVCRGY
                     LMRVEYQKMLLRRESIFCIQYNIRAFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMK
                     EEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKN
                     KIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKH
                     ATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKTKL
                     EQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEF
                     EISNLISKIEDEQAVEIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSREL
                     EEISERLEEAGGATSAQVELNKKRETEFQKLRRDLEEATLQHEATSAALRKKHADSMA
                     ELGEQIDNLQRVKQKLEKEKSELKMEIDDLSSNAEAIAKAKGNLEKMCRTLEDQVSEL
                     KSKEEEQQRLINELTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKR
                     QLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKY
                     ETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVE
                     RTNAACAALDKKQRNFDKVLSEWRQKYEETQAELESCQKESRTLSTELFKVKNAYEES
                     LDQLETLRRENKNLQQEISDLTEQIAEGGKHIHELEKIKKQVEQEKCEIQAALEEAEA
                     SLEHEEGKILRIQLELNQVKSEIDRKIAEKDEEIDQLKRNHIRVVETMQSTLDAEIRS
                     RNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKDTQLHLDDALRGQE
                     DLKEQLAIVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSL
                     INTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLER
                     MKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKG
                     LRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLAKFR
                     KLQHELEEAEERADIAESQVNKLRVKSREVHTKISAE"
     exon            283..426
                     /gene="Myh8"
                     /inference="alignment:Splign:2.1.0"
     exon            427..583
                     /gene="Myh8"
                     /inference="alignment:Splign:2.1.0"
     exon            584..611
                     /gene="Myh8"
                     /inference="alignment:Splign:2.1.0"
     exon            612..720
                     /gene="Myh8"
                     /inference="alignment:Splign:2.1.0"
     exon            721..813
                     /gene="Myh8"
                     /inference="alignment:Splign:2.1.0"
     exon            814..877
                     /gene="Myh8"
                     /inference="alignment:Splign:2.1.0"
     exon            878..976
                     /gene="Myh8"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1080
                     /gene="Myh8"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1219
                     /gene="Myh8"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1338
                     /gene="Myh8"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1488
                     /gene="Myh8"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1659
                     /gene="Myh8"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1969
                     /gene="Myh8"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2037
                     /gene="Myh8"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2125
                     /gene="Myh8"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2243
                     /gene="Myh8"
                     /inference="alignment:Splign:2.1.0"
     exon            2244..2367
                     /gene="Myh8"
                     /inference="alignment:Splign:2.1.0"
     exon            2368..2504
                     /gene="Myh8"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2760
                     /gene="Myh8"
                     /inference="alignment:Splign:2.1.0"
     exon            2761..3003
                     /gene="Myh8"
                     /inference="alignment:Splign:2.1.0"
     exon            3004..3180
                     /gene="Myh8"
                     /inference="alignment:Splign:2.1.0"
     exon            3181..3326
                     /gene="Myh8"
                     /inference="alignment:Splign:2.1.0"
     exon            3327..3417
                     /gene="Myh8"
                     /inference="alignment:Splign:2.1.0"
     exon            3418..3807
                     /gene="Myh8"
                     /inference="alignment:Splign:2.1.0"
     exon            3808..3934
                     /gene="Myh8"
                     /inference="alignment:Splign:2.1.0"
     exon            3935..4053
                     /gene="Myh8"
                     /inference="alignment:Splign:2.1.0"
     exon            4054..4250
                     /gene="Myh8"
                     /inference="alignment:Splign:2.1.0"
     exon            4251..4434
                     /gene="Myh8"
                     /inference="alignment:Splign:2.1.0"
     exon            4435..4600
                     /gene="Myh8"
                     /inference="alignment:Splign:2.1.0"
     exon            4601..4725
                     /gene="Myh8"
                     /inference="alignment:Splign:2.1.0"
     exon            4726..5034
                     /gene="Myh8"
                     /inference="alignment:Splign:2.1.0"
     exon            5035..5238
                     /gene="Myh8"
                     /inference="alignment:Splign:2.1.0"
     exon            5239..5364
                     /gene="Myh8"
                     /inference="alignment:Splign:2.1.0"
     exon            5365..5535
                     /gene="Myh8"
                     /inference="alignment:Splign:2.1.0"
     exon            5536..5640
                     /gene="Myh8"
                     /inference="alignment:Splign:2.1.0"
     exon            5641..5736
                     /gene="Myh8"
                     /inference="alignment:Splign:2.1.0"
     exon            5737..6026
                     /gene="Myh8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcaggacag tcgtgactac attttcatcc agagccccat aggccgacac ctcggctaag
       61 taagtagcag ccatgagtac gggttcggac gcggagatgg ctatttttgg cgaagctgct
      121 ccttacctcc gaaaatcgga gaaggagcgg attgaggccc aaaacaagcc ctttgatgcc
      181 aaaacatctg tctttgtggc ggagcccaag gagtcctatg tgaagagcgt catacaaagc
      241 aaggaaggag ggaaagtgac cgttaagacg gaaagtggag caactctcac cgtcaaggaa
      301 gaccaagtct tccccatgaa ccctcccaaa tatgacaaga tcgaggacat ggccatgatg
      361 acccaccttc atgagcccgg ggtgctgtat aacctcaaag agcgttacgc agcctggatg
      421 atctacacct actcaggtct tttctgtgtc accgtcaacc cctacaagtg gctgccggtg
      481 tacaaccctg aagtggtggc ggcttacaga ggcaaaaagc gccaggaggc cccgccccac
      541 atcttctcca tctctgacaa cgcctaccag ttcatgttga cggatcgtga gaaccagtcc
      601 atcctgatca ccggagaatc tggggccggg aagactgtga acaccaagcg tgtcatccag
      661 tactttgcaa caattgcagt cactggggag aagaagaaag aggagtctgg caaaatgcag
      721 gggaccctgg aggatcaaat catcagtgcc aatcccttgc tggaggcctt tgggaatgcc
      781 aagactgtga gaaatgacaa ctcctctcgc tttggcaagt tcatcagaat ccacttcggt
      841 accacaggga aactggcatc tgctgatatc gaaacatatc ttctagagaa gtctagagtc
      901 actttccagc taaaggctga gagaagttac cacatttttt atcagattac ctccaataag
      961 aagccagagc taattgaaat gctcctgatc accaccaacc catacgacta cgcctttgtc
     1021 agtcaggggg agatcacagt gcccagcatt gatgatcaag aagagttgat ggccacagac
     1081 agtgccattg atatcctggg cttctcacct gaagagaaag tatccatcta taagctcacg
     1141 ggagctgtga tgcattatgg gaacatgaag ttcaagcaaa agcagcgtga ggagcaggct
     1201 gagccggatg gcactgaagt ggctgacaag gctgcctacc tccagtctct gaactctgct
     1261 gacctgctca aagccctctg ctaccccagg gtcaaggttg gcaatgagta cgtcaccaaa
     1321 ggccagacgg tgcaacaggt gtataatgca gtgggcgccc tggctaaagc tgtctatgag
     1381 aagatgttcc tgtggatggt cacccgcatc aaccagcagc tggacaccaa gcagcccagg
     1441 cagtacttca tcggggtctt ggacatcgct ggctttgaga tctttgactt caacagcctg
     1501 gagcagctgt gcatcaactt caccaacgag aaactgcaac agtttttcaa ccaccacatg
     1561 ttcgtgctgg agcaggagga gtacaagaag gaaggcatcg agtggacctt catcgacttc
     1621 gggatggacc tggcggcctg catcgagctc atcgagaagc cactgggtat cttctccatc
     1681 ctggaagagg agtgcatgtt ccccaaggcg acagacacct ccttcaagaa caagctgtat
     1741 gaccagcacc tgggaaaatc caacaacttc cagaagccca agcctaccaa aggcaaggcg
     1801 gaggcccact tctccctcat tcactatgcg ggcaccgtgg actacaacat cactggttgg
     1861 ctggacaaga acaaggaccc tttgaatgac accgtggtgg ggctgtacca gaagtcagca
     1921 atgaaaactc tggccagcct cttttccaca tacgccagtg ctgaagcaga tggtggtgca
     1981 aagaaaggag ctaagaagaa gggctcttct ttccaaaccg tgtcagccct tttcagggaa
     2041 aacttaaata aactgatgac caacctaaga agtacacacc ctcactttgt acggtgtatc
     2101 attcccaacg aaacgaaaac tcccggtgcc atggagcacg aactggtcct gcaccagctg
     2161 aggtgtaacg gggtgctgga aggcatccgc atctgcagga aggggttccc cagcaggatt
     2221 ctgtatgggg actttaagca gagatacaag gtgttaaatg caagtgctat tccagaggga
     2281 cagttcatcg acagcaagaa ggcctctgag aagcttctgg gctctattga tattgatcac
     2341 actcagtata aatttggaca caccaaggtt ttcttcaaag ctggtctcct gggtctcctg
     2401 gaagaaatga gagatgaaaa gctggcccag attataacaa gaacacaggc ggtctgtagg
     2461 ggatacctaa tgagagtcga gtaccagaaa atgctgctga gaagggagtc catcttctgc
     2521 atccagtaca acatccgcgc cttcatgaac gtcaagcact ggccctggat gaaactcttc
     2581 ttcaagatca agcccctgct gaagagcgct gagaccgaga aggagatggc caccatgaag
     2641 gaggagttcc agaaaaccaa ggacgagctc gccaagtcgg aggcaaagag gaaggagctg
     2701 gaggagaaaa tggtcacgct tctcaaagag aagaacgacc tgcagctcca ggttcaatct
     2761 gaagcagaca gcttggctga tgctgaggaa aggtgtgaac aattgattaa aaacaaaatc
     2821 cagctggagg ccaaaatcaa agaggtgact gagagagcgg aggatgagga ggagatcaat
     2881 gccgagctca cagccaagaa gaggaagctg gaggacgagt gctcagagct gaagaaggac
     2941 atcgatgacc ttgagctgac actggccaag gttgagaagg agaagcacgc cacggagaac
     3001 aaggtgaaaa acctcacaga ggagatggcg ggcctggacg aaaccatcgc caagctgacc
     3061 aaggagaaga aggccttgca ggaggcccac cagcagaccc tggatgacct gcaggcagag
     3121 gaggacaaag tcaacaccct gaccaaagcc aaaaccaagc tcgaacagca agtggatgat
     3181 cttgaaggat cgctagagca agaaaagaag ctgaggatgg atctggaaag agccaagagg
     3241 aaactggagg gggacctgaa actggcccaa gagtccacaa tggacataga aaatgacaaa
     3301 cagcagctgg atgagaaact caaaaagaag gagtttgaaa tcagcaatct aataagcaaa
     3361 attgaagatg aacaagctgt ggaaatccag ttgcagaaga agatcaaaga gctgcaggcc
     3421 cgcatcgagg agctggagga ggaaatcgag gcagagcggg cctccagggc caaagcagag
     3481 aagcagcgct ctgacctctc ccgggaactg gaggagatca gcgagaggct ggaagaagcc
     3541 ggcggggcca catctgctca ggtggagttg aataagaagc gggaaacgga gttccagaag
     3601 cttcgcaggg acctggagga ggccaccctg cagcatgaag ccacatcagc cgctcttcgg
     3661 aagaagcacg cggacagtat ggcggagctc ggggagcaga tcgacaacct gcagcgggtg
     3721 aagcagaagc tggagaagga gaagagcgag ctgaagatgg agatcgacga ccttagcagt
     3781 aatgcagagg ccatcgccaa agccaaggga aaccttgaga agatgtgccg cactctggag
     3841 gaccaggtga gcgagctgaa gagcaaggag gaggagcagc agcggctcat caatgagctg
     3901 actgcacaga gagcacgcct gcagacagaa gcaggagagt attcccgaca gctggatgag
     3961 aaagatgctt tagtctctca gttgtcaagg agcaaacagg catccaccca gcagattgag
     4021 gagctgaagc gacagctcga ggaagaaacc aaggccaaga acgcgctggc ccacgccctg
     4081 cagtcctccc gccacgactg tgacctgctt cgggaacagt acgaggagga gcaggaaggc
     4141 aaagccgagc tgcagagggc gctgtccaag gccaacagcg aggtggccca gtggaggacc
     4201 aaatatgaga cggatgccat ccagcgcacg gaggagctgg aggaggccaa gaagaagctg
     4261 gctcagcgtc tgcaggcggc tgaggagcac gtagaagctg tgaacgccaa gtgtgcttcc
     4321 ctggagaaga caaagcagcg gctgcagaat gaggtggagg acctcatgct ggacgtagag
     4381 aggaccaacg ccgcgtgtgc tgccctggac aagaagcaga gaaacttcga caaggttcta
     4441 tcggaatgga gacagaagta tgaggaaact caggctgagc ttgagtcctg ccagaaggag
     4501 tcccgtactc tcagcacaga gctgttcaag gtgaagaacg cctatgagga gtctctggat
     4561 caactggaga cgctaaggag agagaacaag aatctacagc aggagatttc tgacctgacc
     4621 gagcagattg cagagggagg gaagcatatc cacgagctgg agaaaataaa gaagcaagtg
     4681 gaacaagaga agtgtgagat ccaggctgct ttagaggaag cagaggcatc tctggagcac
     4741 gaggagggaa agatcctgcg catccagctg gagctgaacc aagtcaagtc tgagatcgac
     4801 aggaagattg ctgagaagga tgaggagatc gaccagctga agagaaacca cattcgagtc
     4861 gtggagacga tgcagagcac gctggacgcc gagatcagga gcaggaacga cgctctgaga
     4921 gtcaagaaga agatggaggg cgacctcaat gagatggaaa tccagctgaa ccacgccaac
     4981 cgcttggctg ccgagagctt gaggaactac aggaacaccc aaggcatcct caaggacacc
     5041 cagttgcacc tggatgacgc tctccggggc caggaggacc tgaaggagca gttggcgatc
     5101 gtggagcgca gagccaacct gctgcaggct gagatcgagg agctgcgggc cactctggag
     5161 cagacggaga ggagcaggaa gattgcagag caggagctgc tggacgccag tgagcgcgtg
     5221 cagctcctcc acacccagaa cacgagcctc atcaacacca aaaagaagtt ggaaaatgat
     5281 gtttcacagc tgcagagtga agtggaggaa gtaattcaag agtcacgcaa tgcagaagag
     5341 aaggccaaga aagccattac tgacgccgcc atgatggcgg aggagctgaa gaaggagcag
     5401 gacaccagcg cccacctgga gcggatgaag aagaacctgg agcagacggt gaaggacctg
     5461 cagcaccgtc tggacgaggc tgagcagctg gcgctgaagg gcggcaagaa gcagatccag
     5521 aaactggagg ccagggtacg tgaacttgaa ggagaggttg agaatgaaca gaaacgtaat
     5581 gctgaggccg ttaaagggtt aaggaagcac gaaagaagag taaaggaact tacctaccag
     5641 accgaggagg accgcaagaa cgtgctgagg ctgcaggacc tggtggataa attacaggcg
     5701 aaggtgaaat cttacaagag acaagcagag gaggctgagg aacaatccaa cgtcaacctg
     5761 gccaagttcc gcaagctgca gcacgagctg gaggaagccg aggagcgggc agacatcgcc
     5821 gagtcccagg tcaacaagct gcgggtgaag agccgcgagg ttcacaccaa aatcagtgca
     5881 gagtaaacgc atcttgagga ggccgccaag tggctgaagg aaagcacaga atgtgctgcc
     5941 ttgggtcgct tgctgggtca cttgcctctc tgtgtttact tttctcccac tgctgactga
     6001 ataaaaacca caactcattg ataaat
//
