LOCUS       NM_017240               5923 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus myosin heavy chain 7 (Myh7), mRNA.
ACCESSION   NM_017240
VERSION     NM_017240.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5923)
  AUTHORS   Forini,F., Nicolini,G., Kusmic,C., D'Aurizio,R., Mercatanti,A.,
            Iervasi,G. and Pitto,L.
  TITLE     T3 Critically Affects the Mhrt/Brg1 Axis to Regulate the Cardiac
            MHC Switch: Role of an Epigenetic Cross-Talk
  JOURNAL   Cells 9 (10), 2155 (2020)
   PUBMED   32987653
  REMARK    GeneRIF: T3 Critically Affects the Mhrt/Brg1 Axis to Regulate the
            Cardiac MHC Switch: Role of an Epigenetic Cross-Talk.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5923)
  AUTHORS   Guo,Z., Lu,J., Li,J., Wang,P., Li,Z., Zhong,Y., Guo,K., Wang,J.,
            Ye,J. and Liu,P.
  TITLE     JMJD3 inhibition protects against isoproterenol-induced cardiac
            hypertrophy by suppressing beta-MHC expression
  JOURNAL   Mol Cell Endocrinol 477, 1-14 (2018)
   PUBMED   29753027
  REMARK    GeneRIF: JMJD3 may be a key epigenetic regulator of beta-MHC
            expression in cardiomyocytes and a potential therapeutic target for
            cardiac hypertrophy.
REFERENCE   3  (bases 1 to 5923)
  AUTHORS   Tomita-Mitchell,A., Stamm,K.D., Mahnke,D.K., Kim,M.S.,
            Hidestrand,P.M., Liang,H.L., Goetsch,M.A., Hidestrand,M.,
            Simpson,P., Pelech,A.N., Tweddell,J.S., Benson,D.W., Lough,J.W. and
            Mitchell,M.E.
  TITLE     Impact of MYH6 variants in hypoplastic left heart syndrome
  JOURNAL   Physiol Genomics 48 (12), 912-921 (2016)
   PUBMED   27789736
REFERENCE   4  (bases 1 to 5923)
  AUTHORS   Ji,Y.X., Zhang,P., Zhang,X.J., Zhao,Y.C., Deng,K.Q., Jiang,X.,
            Wang,P.X., Huang,Z. and Li,H.
  TITLE     The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac
            hypertrophy via TAK1-dependent signalling
  JOURNAL   Nat Commun 7, 11267 (2016)
   PUBMED   27249171
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5923)
  AUTHORS   Zhang,Y., Si,Y. and Ma,N.
  TITLE     Meis1 promotes poly (rC)-binding protein 2 expression and inhibits
            angiotensin II-induced cardiomyocyte hypertrophy
  JOURNAL   IUBMB Life 68 (1), 13-22 (2016)
   PUBMED   26597775
REFERENCE   6  (bases 1 to 5923)
  AUTHORS   O'Neill,L., Holbrook,N.J., Fargnoli,J. and Lakatta,E.G.
  TITLE     Progressive changes from young adult age to senescence in mRNA for
            rat cardiac myosin heavy chain genes
  JOURNAL   Cardioscience 2 (1), 1-5 (1991)
   PUBMED   1888877
REFERENCE   7  (bases 1 to 5923)
  AUTHORS   Schuyler,G.T. and Yarbrough,L.R.
  TITLE     Changes in myosin and creatine kinase mRNA levels with cardiac
            hypertrophy and hypothyroidism
  JOURNAL   Basic Res Cardiol 85 (5), 481-494 (1990)
   PUBMED   1703406
REFERENCE   8  (bases 1 to 5923)
  AUTHORS   McNally,E.M., Kraft,R., Bravo-Zehnder,M., Taylor,D.A. and
            Leinwand,L.A.
  TITLE     Full-length rat alpha and beta cardiac myosin heavy chain
            sequences. Comparisons suggest a molecular basis for functional
            differences
  JOURNAL   J Mol Biol 210 (3), 665-671 (1989)
   PUBMED   2614840
REFERENCE   9  (bases 1 to 5923)
  AUTHORS   Kraft,R., Bravo-Zehnder,M., Taylor,D.A. and Leinwand,L.A.
  TITLE     Complete nucleotide sequence of full length cDNA for rat beta
            cardiac myosin heavy chain
  JOURNAL   Nucleic Acids Res 17 (18), 7529-7530 (1989)
   PUBMED   2798112
REFERENCE   10 (bases 1 to 5923)
  AUTHORS   Izumo,S., Lompre,A.M., Matsuoka,R., Koren,G., Schwartz,K.,
            Nadal-Ginard,B. and Mahdavi,V.
  TITLE     Myosin heavy chain messenger RNA and protein isoform transitions
            during cardiac hypertrophy. Interaction between hemodynamic and
            thyroid hormone-induced signals
  JOURNAL   J Clin Invest 79 (3), 970-977 (1987)
   PUBMED   2950137
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X15939.1.
            
            On Feb 21, 2013 this sequence version replaced NM_017240.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X15939.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN11044071
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5923              X15939.1           3-5925
FEATURES             Location/Qualifiers
     source          1..5923
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p13"
     gene            1..5923
                     /gene="Myh7"
                     /gene_synonym="Bmyo; myHC-beta; myHC-slow; Myhcb"
                     /note="myosin heavy chain 7"
                     /db_xref="GeneID:29557"
                     /db_xref="RGD:62030"
     exon            1..209
                     /gene="Myh7"
                     /gene_synonym="Bmyo; myHC-beta; myHC-slow; Myhcb"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..5816
                     /gene="Myh7"
                     /gene_synonym="Bmyo; myHC-beta; myHC-slow; Myhcb"
                     /note="myosin heavy chain, cardiac muscle, fetal; beta
                     myosin heavy chain; myosin, heavy polypeptide 7, cardiac
                     muscle, beta; myosin heavy chain, polypeptide 7; myosin
                     heavy chain polypeptide 7 cardiac muscle fetal; myosin,
                     heavy chain 7, cardiac muscle, beta"
                     /codon_start=1
                     /product="myosin-7"
                     /protein_id="NP_058936.1"
                     /db_xref="GeneID:29557"
                     /db_xref="RGD:62030"
                     /translation="MADREMAAFGAGAPFLRKSEKERLEAQTRPFDLKKDVFVPDDKE
                     EFVKAKIVSREGGKVTAETENGKTVTVKEDQVMQQNPPKFDKIEDMAMLTFLHEPAVL
                     YNLKERYASWMIYTYSGLFCVTVNPYKWLPVYNAQVVAAYRGKKRSEAPPHIFSISDN
                     AYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQTPGKGTLED
                     QIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQ
                     LKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFFSQGETTVASIDDSEEHMATDS
                     AFDVLGFTPEEKNSIYKLTGAIMHFGNMKFKQKQREEQAEPDGTEEADKSAYLMGLNS
                     ADLLKGLCHPRVKVGNEYVTKGQNVQQVAYAIGALAKSVYEKMFNWMVTRINATLETK
                     QPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEW
                     TFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKP
                     RNIKGKQEAHFSLIHYAGTVDYNILGWLQKNKDPLNETVVGLYQKSSLKLLSNLFANY
                     AGADAPVDKGKGKAKKGSSFQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPG
                     VMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDSRK
                     GAEKLLGSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQAQSRGVLSR
                     MEFKKLLERRDSLLIIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAETEKEMANMKEEF
                     GRVKDALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQ
                     LEAKVKEMTERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATE
                     NKVKNLTEEMAGLDEIIVKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQ
                     VDDLEGSLDQDKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELN
                     ALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEI
                     SERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELG
                     EQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSK
                     AEETQRSVNDLTRQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLE
                     EEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETD
                     AIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSN
                     AAAAALDKKQRNFDKILVEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEH
                     LETFKRENKNLQEEISDLTEQLGSTGKSIHELEKIRKQLEAEKLELQSALEEAEASLE
                     HEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNE
                     ALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLK
                     ENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQ
                     KKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKN
                     NMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRK
                     SERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQ
                     HELDEAEERADIAESQVNKLRAKSRDIGAKGLNEE"
     exon            210..353
                     /gene="Myh7"
                     /gene_synonym="Bmyo; myHC-beta; myHC-slow; Myhcb"
                     /inference="alignment:Splign:2.1.0"
     exon            354..510
                     /gene="Myh7"
                     /gene_synonym="Bmyo; myHC-beta; myHC-slow; Myhcb"
                     /inference="alignment:Splign:2.1.0"
     exon            511..538
                     /gene="Myh7"
                     /gene_synonym="Bmyo; myHC-beta; myHC-slow; Myhcb"
                     /inference="alignment:Splign:2.1.0"
     exon            539..647
                     /gene="Myh7"
                     /gene_synonym="Bmyo; myHC-beta; myHC-slow; Myhcb"
                     /inference="alignment:Splign:2.1.0"
     exon            648..740
                     /gene="Myh7"
                     /gene_synonym="Bmyo; myHC-beta; myHC-slow; Myhcb"
                     /inference="alignment:Splign:2.1.0"
     exon            741..804
                     /gene="Myh7"
                     /gene_synonym="Bmyo; myHC-beta; myHC-slow; Myhcb"
                     /inference="alignment:Splign:2.1.0"
     exon            805..903
                     /gene="Myh7"
                     /gene_synonym="Bmyo; myHC-beta; myHC-slow; Myhcb"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1007
                     /gene="Myh7"
                     /gene_synonym="Bmyo; myHC-beta; myHC-slow; Myhcb"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1146
                     /gene="Myh7"
                     /gene_synonym="Bmyo; myHC-beta; myHC-slow; Myhcb"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1265
                     /gene="Myh7"
                     /gene_synonym="Bmyo; myHC-beta; myHC-slow; Myhcb"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1415
                     /gene="Myh7"
                     /gene_synonym="Bmyo; myHC-beta; myHC-slow; Myhcb"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1586
                     /gene="Myh7"
                     /gene_synonym="Bmyo; myHC-beta; myHC-slow; Myhcb"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1896
                     /gene="Myh7"
                     /gene_synonym="Bmyo; myHC-beta; myHC-slow; Myhcb"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..1964
                     /gene="Myh7"
                     /gene_synonym="Bmyo; myHC-beta; myHC-slow; Myhcb"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2052
                     /gene="Myh7"
                     /gene_synonym="Bmyo; myHC-beta; myHC-slow; Myhcb"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..2170
                     /gene="Myh7"
                     /gene_synonym="Bmyo; myHC-beta; myHC-slow; Myhcb"
                     /inference="alignment:Splign:2.1.0"
     exon            2171..2294
                     /gene="Myh7"
                     /gene_synonym="Bmyo; myHC-beta; myHC-slow; Myhcb"
                     /inference="alignment:Splign:2.1.0"
     exon            2295..2431
                     /gene="Myh7"
                     /gene_synonym="Bmyo; myHC-beta; myHC-slow; Myhcb"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..2687
                     /gene="Myh7"
                     /gene_synonym="Bmyo; myHC-beta; myHC-slow; Myhcb"
                     /inference="alignment:Splign:2.1.0"
     exon            2688..2930
                     /gene="Myh7"
                     /gene_synonym="Bmyo; myHC-beta; myHC-slow; Myhcb"
                     /inference="alignment:Splign:2.1.0"
     exon            2931..3107
                     /gene="Myh7"
                     /gene_synonym="Bmyo; myHC-beta; myHC-slow; Myhcb"
                     /inference="alignment:Splign:2.1.0"
     exon            3108..3253
                     /gene="Myh7"
                     /gene_synonym="Bmyo; myHC-beta; myHC-slow; Myhcb"
                     /inference="alignment:Splign:2.1.0"
     exon            3254..3344
                     /gene="Myh7"
                     /gene_synonym="Bmyo; myHC-beta; myHC-slow; Myhcb"
                     /inference="alignment:Splign:2.1.0"
     exon            3345..3734
                     /gene="Myh7"
                     /gene_synonym="Bmyo; myHC-beta; myHC-slow; Myhcb"
                     /inference="alignment:Splign:2.1.0"
     exon            3735..3861
                     /gene="Myh7"
                     /gene_synonym="Bmyo; myHC-beta; myHC-slow; Myhcb"
                     /inference="alignment:Splign:2.1.0"
     exon            3862..3980
                     /gene="Myh7"
                     /gene_synonym="Bmyo; myHC-beta; myHC-slow; Myhcb"
                     /inference="alignment:Splign:2.1.0"
     exon            3981..4177
                     /gene="Myh7"
                     /gene_synonym="Bmyo; myHC-beta; myHC-slow; Myhcb"
                     /inference="alignment:Splign:2.1.0"
     exon            4178..4361
                     /gene="Myh7"
                     /gene_synonym="Bmyo; myHC-beta; myHC-slow; Myhcb"
                     /inference="alignment:Splign:2.1.0"
     exon            4362..4527
                     /gene="Myh7"
                     /gene_synonym="Bmyo; myHC-beta; myHC-slow; Myhcb"
                     /inference="alignment:Splign:2.1.0"
     exon            4528..4652
                     /gene="Myh7"
                     /gene_synonym="Bmyo; myHC-beta; myHC-slow; Myhcb"
                     /inference="alignment:Splign:2.1.0"
     exon            4653..4961
                     /gene="Myh7"
                     /gene_synonym="Bmyo; myHC-beta; myHC-slow; Myhcb"
                     /inference="alignment:Splign:2.1.0"
     exon            4962..5165
                     /gene="Myh7"
                     /gene_synonym="Bmyo; myHC-beta; myHC-slow; Myhcb"
                     /inference="alignment:Splign:2.1.0"
     exon            5166..5291
                     /gene="Myh7"
                     /gene_synonym="Bmyo; myHC-beta; myHC-slow; Myhcb"
                     /inference="alignment:Splign:2.1.0"
     exon            5292..5567
                     /gene="Myh7"
                     /gene_synonym="Bmyo; myHC-beta; myHC-slow; Myhcb"
                     /inference="alignment:Splign:2.1.0"
     exon            5568..5663
                     /gene="Myh7"
                     /gene_synonym="Bmyo; myHC-beta; myHC-slow; Myhcb"
                     /inference="alignment:Splign:2.1.0"
     exon            5664..5798
                     /gene="Myh7"
                     /gene_synonym="Bmyo; myHC-beta; myHC-slow; Myhcb"
                     /inference="alignment:Splign:2.1.0"
     exon            5799..5923
                     /gene="Myh7"
                     /gene_synonym="Bmyo; myHC-beta; myHC-slow; Myhcb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcagtcat ggcggatcga gagatggctg catttggggc cggagccccc ttcctgcgaa
       61 aatctgagaa ggagcggctg gaggcgcaga ccaggccctt tgacctcaag aaagatgttt
      121 ttgtgcctga tgacaaagaa gagtttgtca aggccaagat cgtgtctcga gagggtggca
      181 aagtcaccgc tgagacagag aatggcaaga cggtgactgt gaaggaggac caggtgatgc
      241 agcagaaccc tcccaagttc gacaagatcg aggacatggc catgctgacc ttcctgcacg
      301 agccggctgt gctctacaat ctcaaggaga ggtacgcttc ctggatgatc tacacctact
      361 caggcctctt ctgtgtcacc gtcaacccct ataagtggct gccagtgtac aatgcgcaag
      421 tggtagctgc ctaccggggc aagaagagga gcgaggctcc accccacatc ttctccatct
      481 ctgacaacgc ctatcagtac atgctgacag atcgggagaa ccagtccatc ctcatcaccg
      541 gagaatccgg agctggtaag accgtcaaca ccaagagggt catccaatat tttgctgtta
      601 ttgctgccat tggggaccgc agcaagaagg accagacccc aggcaagggc accttggaag
      661 atcaaatcat ccaagccaac cccgctctgg aggcctttgg caatgccaag acagttcgga
      721 atgataactc ctcccgattt gggaaattca ttcgaatcca ttttggggca acaggaaagt
      781 tggcatctgc agatatagag acctaccttc tggaaaaatc cagagttatt ttccagctga
      841 aagcagaaag agattatcac attttctacc aaatcctgtc taataaaaag cctgagcttc
      901 tagacatgct gctgatcacc aacaacccct acgattatgc gttcttctcc cagggagaga
      961 cgactgtggc ctcaatagat gactctgaag agcacatggc caccgatagc gcctttgatg
     1021 tgctgggctt cactccagaa gagaagaact ccatttacaa gctgacaggc gccatcatgc
     1081 actttggaaa catgaagttc aaacagaagc agagggagga gcaggcagag ccagacggca
     1141 cggaagaagc tgacaagtca gcctacctca tgggactgaa ctcggctgac ctgctcaagg
     1201 ggttgtgcca ccctcgagtc aaagtgggca acgagtatgt caccaaaggg cagaatgtcc
     1261 agcaggtggc atatgccatc ggggcactgg ccaagtcagt gtacgagaag atgttcaact
     1321 ggatggtgac acgcatcaac gcaaccctgg agaccaagca gccacgccag tacttcatag
     1381 gtgtcctgga catcgccggc tttgagatct ttgatttcaa cagctttgag cagctgtgca
     1441 tcaacttcac caatgagaag ctgcagcagt tcttcaacca ccacatgttc gtgctggagc
     1501 aggaggagta caagaaggaa ggcatcgagt ggacgtttat tgacttcggc atggacctgc
     1561 aggcctgcat cgacctcatc gagaagccca tgggcatcat gtccatcctg gaggaggagt
     1621 gcatgttccc caaggccacg gacatgacct tcaaggccaa gctgtacgac aaccacctgg
     1681 gcaagtccaa caacttccag aagcctcgca atatcaaggg aaagcaggaa gcccacttct
     1741 ctctgatcca ctatgctggc accgtggact acaatatcct gggctggcta cagaagaaca
     1801 aggaccctct caatgagacg gtggtggggc tgtaccagaa gtcctccctc aagctcctaa
     1861 gtaatctgtt tgccaactat gctggagctg atgcacctgt agacaagggc aaaggcaaag
     1921 caaagaaagg ctcatccttt cagaccgtgt ccgcactgca cagggaaaat ctgaacaaac
     1981 ttatgacaaa cctgcgctcc acgcaccctc actttgtacg ctgcatcatc cccaatgaga
     2041 cgaagtctcc aggggtgatg gacaaccccc tggtcatgca ccagctgcga tgcaacggag
     2101 tgctggaggg tatccgcatc tgtaggaagg gcttccccaa ccgcattctt tatggggact
     2161 tccggcagag gtatcgaatc ctgaacccag cagccatccc tgagggccaa ttcattgata
     2221 gccggaaagg ggctgagaag ctgctgggct ccctggacat tgaccacaac cagtacaagt
     2281 ttggccacac caaggtgttc ttcaaggcgg ggctgctggg gctgctggag gagatgcgag
     2341 atgagaggct gagccgcatc atcaccagaa tccaggccca gtcccgaggt gtactttcca
     2401 gaatggagtt taagaagctg ctggagcgca gagactccct gctgattatc cagtggaaca
     2461 tccgcgcctt catgggggtc aagaattggc cgtggatgaa gctctacttc aagatcaagc
     2521 cgctgctgaa gagcgcagag acagagaagg agatggccaa catgaaggag gagttcgggc
     2581 gagtcaaaga tgcactagag aagtctgagg ctcgccgcaa ggagctggag gagaagatgg
     2641 tgtccctgct gcaggagaag aatgacctgc agctccaagt gcaggcggaa caagacaacc
     2701 tggcagatgc cgaggagcgc tgcgaccagc tgatcaagaa caagatccag ctggaggcca
     2761 aggtgaagga gatgaccgag aggctggagg acgaggagga gatgaacgcc gagctcacgg
     2821 ccaagaagcg caaactggaa gacgagtgct cagagctcaa gagagatatc gatgacctgg
     2881 agctgaccct ggccaaggtg gagaaggaaa agcacgcaac agagaacaag gtgaaaaacc
     2941 tgacagagga gatggctggg ctggacgaga tcattgtcaa gctgaccaag gagaagaaag
     3001 ctctacaaga ggcccaccag caagccctag atgaccttca ggctgaggag gacaaggtca
     3061 acactctgac caaggccaag gtcaagctgg agcagcaagt ggatgatctg gagggatccc
     3121 tggatcagga caagaaggtg cgcatggacc tggagcgagc aaagcggaag ctggagggtg
     3181 acctgaagct gacccaggag agcatcatgg acctggagaa cgacaagcag cagttggatg
     3241 agcgactcaa aaagaaggac tttgagttaa atgcactcaa cgccaggatt gaggatgagc
     3301 aggccctggg cagccagctg cagaagaagc tcaaagagct tcaggcacgc atcgaggagc
     3361 tggaggagga gctggaggct gagcgcacag cccgggccaa ggtggagaag ctgcgctcag
     3421 acctgtcccg ggagctggag gagatcagtg agaggctaga ggaagccggt ggggccacat
     3481 ctgtgcagat agagatgaac aagaagcgcg aggccgagtt ccagaagatg cggcgggacc
     3541 tagaggaggc cacgctgcag catgaggcca cagctgcggc cctgcgcaag aaacacgcgg
     3601 acagcgtggc cgagctgggc gagcagatag acaatctaca gcgggtgaag cagaagctgg
     3661 agaaagagaa gagcgagttc aagctggagc tggatgacgt tacctccaac atggagcaga
     3721 tcatcaaggc caaggctaac ctggagaaga tgtgccggac cctggaggac cagatgaatg
     3781 aacaccggag caaggctgag gagacacagc gttctgtcaa tgacctcacc cgccagcggg
     3841 ccaagctgca gacagagaat ggggagctgt ccagacagct ggatgagaag gaggctctta
     3901 tctctcagct gacccgaggc aagctcacgt atacccagca gctggaggac ctcaagaggc
     3961 agctggagga ggaggtcaag gccaagaatg ccctggccca cgcactgcag tcagcccggc
     4021 atgattgcga cctgctgcgg gaacagtacg aggaggaaac agaagccaag gctgagctgc
     4081 agcgtgtcct gtccaaggcc aactcagagg tggcccagtg gaggaccaag tatgagacgg
     4141 acgccataca gaggacggag gagctggagg aagccaagaa gaagctggct cagaggcttc
     4201 aggatgctga ggaggcagtg gaggccgtca acgccaagtg ctcctcgctg gagaagacca
     4261 agcacaggct gcagaacgag atcgaggacc tgatggtgga tgtggagcgc tccaatgcgg
     4321 ccgccgcagc cctggacaag aagcagagga acttcgacaa gatcctggtt gagtggaagc
     4381 agaagtatga ggagtcccag tcagagctgg agtcttccca gaaggaggcg cgctccctga
     4441 gcacagagct cttcaagctg aagaatgcct atgaggagtc tctggagcac ctggagacct
     4501 tcaagcggga gaacaagaac ctccaggagg agatctcaga cctgactgaa cagctgggct
     4561 caactgggaa gagcatccac gagctggaga agatccgaaa gcaactggag gctgagaagc
     4621 tggagctgca gtcagccctg gaagaggctg aggcctccct ggagcatgag gagggcaaga
     4681 tcctccgagc ccagctggag ttcaaccaga tcaaggcaga gatcgaaagg aagctggcag
     4741 agaaggacga ggagatggag caggccaagc gcaaccacct gcgggtggtg gactccctgc
     4801 agacctccct ggatgccgag acgcgcagcc gcaacgaggc cctgcgggtg aagaagaaga
     4861 tggagggcga cctcaacgag atggagatcc agctcagtca tgccaaccgc atggctgctg
     4921 aggcccagaa acaagtgaag agcctccaga gtttgctgaa ggacactcaa atccagctgg
     4981 atgacgcagt ccgtgccaat gacgacctga aggagaacat cgccatcgtg gagcggcgca
     5041 acaacctgct gcaggcggag ctggaggagc tgcgggccgt ggtggagcag acggagcggt
     5101 ctcggaagct ggcagagcag gagctgatcg agaccagcga gcgggtgcag ctgctgcact
     5161 cccagaacac cagcctcatc aaccagaaga agaagatgga tgcagacctc tcccagctcc
     5221 agacagaggt ggaggaggcg gtgcaggagt gtaggaacgc agaggagaag gccaagaagg
     5281 ccatcacaga tgccgccatg atggccgagg agctgaagaa ggagcaggac accagcgccc
     5341 acctggagcg catgaagaat aacatggagc agaccatcaa ggacctgcag caccggctgg
     5401 acgaggcaga gcagatcgcc ctcaagggtg gcaagaagca gctgcagaag ctggaggccc
     5461 gggtccggga gctggagaat gagctggagg ctgagcagaa gcgcaatgcg gagtcggtga
     5521 agggcatgag gaagagcgag cggcgcatca aggagctcac ctaccagaca gaggaagaca
     5581 ggaagaacct actgcgactg caggacctgg tggacaagct gcagttaaag gtgaaggcct
     5641 acaagcgcca ggctgaggag gcggaggaac aggccaacac caacctgtcc aagttccgca
     5701 aggtgcagca cgagctggat gaggcagagg agagggcgga cattgccgag tcccaggtca
     5761 acaagctgcg ggccaagagc cgtgacattg gcgccaaggg cctgaatgaa gagtagatct
     5821 tgtgctaccc aaccctaagg atgcctgtga agccctgaga cctggagcct ttgaaacagc
     5881 accttaggca gaaacacaat aaagcaattt tccttcaagc caa
//
