LOCUS       NM_017239               5925 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus myosin heavy chain 6 (Myh6), mRNA.
ACCESSION   NM_017239
VERSION     NM_017239.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5925)
  AUTHORS   Forini,F., Nicolini,G., Kusmic,C., D'Aurizio,R., Mercatanti,A.,
            Iervasi,G. and Pitto,L.
  TITLE     T3 Critically Affects the Mhrt/Brg1 Axis to Regulate the Cardiac
            MHC Switch: Role of an Epigenetic Cross-Talk
  JOURNAL   Cells 9 (10), 2155 (2020)
   PUBMED   32987653
  REMARK    GeneRIF: T3 Critically Affects the Mhrt/Brg1 Axis to Regulate the
            Cardiac MHC Switch: Role of an Epigenetic Cross-Talk.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5925)
  AUTHORS   Majewski,L., Nowak,J., Sobczak,M., Karatsai,O., Havrylov,S.,
            Lenartowski,R., Suszek,M., Lenartowska,M. and Redowicz,M.J.
  TITLE     Myosin VI in the nucleus of neurosecretory PC12 cells:
            Stimulation-dependent nuclear translocation and interaction with
            nuclear proteins
  JOURNAL   Nucleus 9 (1), 125-141 (2018)
   PUBMED   29293066
  REMARK    GeneRIF: data provide an insight into mechanisms of involvement of
            myosin VI in nuclear processes via interaction with nuclear
            proteins and support a notion for important role(s) for myosin VI
            in gene expression
REFERENCE   3  (bases 1 to 5925)
  AUTHORS   Sobczak,M., Chumak,V., Pomorski,P., Wojtera,E., Majewski,L.,
            Nowak,J., Yamauchi,J. and Redowicz,M.J.
  TITLE     Interaction of myosin VI and its binding partner DOCK7 plays an
            important role in NGF-stimulated protrusion formation in PC12 cells
  JOURNAL   Biochim Biophys Acta 1863 (7 Pt A), 1589-1600 (2016)
   PUBMED   27018747
  REMARK    GeneRIF: Interaction of myosin VI and its binding partner DOCK7
            plays an important role in NGF-stimulated protrusion formation in
            PC12 cells.
REFERENCE   4  (bases 1 to 5925)
  AUTHORS   Bowles,N.E., Jou,C.J., Arrington,C.B., Kennedy,B.J., Earl,A.,
            Matsunami,N., Meyers,L.L., Etheridge,S.P., Saarel,E.V., Bleyl,S.B.,
            Yost,H.J., Yandell,M., Leppert,M.F., Tristani-Firouzi,M. and
            Gruber,P.J.
  CONSRTM   Baylor Hopkins Centers for Mendelian Genomics
  TITLE     Exome analysis of a family with Wolff-Parkinson-White syndrome
            identifies a novel disease locus
  JOURNAL   Am J Med Genet A 167A (12), 2975-2984 (2015)
   PUBMED   26284702
REFERENCE   5  (bases 1 to 5925)
  AUTHORS   Chandra,V., Gollapudi,S.K. and Chandra,M.
  TITLE     Rat cardiac troponin T mutation (F72L)-mediated impact on thin
            filament cooperativity is divergently modulated by alpha- and
            beta-myosin heavy chain isoforms
  JOURNAL   Am J Physiol Heart Circ Physiol 309 (8), H1260-H1270 (2015)
   PUBMED   26342069
  REMARK    GeneRIF: TnT mutation F72L leads to contractile changes that are
            linked to dilated cardiomyopathy in the presence of MYH6 and
            hypertrophic cardiomyopathy in the presence of MYH7.
REFERENCE   6  (bases 1 to 5925)
  AUTHORS   O'Neill,L., Holbrook,N.J., Fargnoli,J. and Lakatta,E.G.
  TITLE     Progressive changes from young adult age to senescence in mRNA for
            rat cardiac myosin heavy chain genes
  JOURNAL   Cardioscience 2 (1), 1-5 (1991)
   PUBMED   1888877
REFERENCE   7  (bases 1 to 5925)
  AUTHORS   Schuyler,G.T. and Yarbrough,L.R.
  TITLE     Changes in myosin and creatine kinase mRNA levels with cardiac
            hypertrophy and hypothyroidism
  JOURNAL   Basic Res Cardiol 85 (5), 481-494 (1990)
   PUBMED   1703406
REFERENCE   8  (bases 1 to 5925)
  AUTHORS   McNally,E.M., Kraft,R., Bravo-Zehnder,M., Taylor,D.A. and
            Leinwand,L.A.
  TITLE     Full-length rat alpha and beta cardiac myosin heavy chain
            sequences. Comparisons suggest a molecular basis for functional
            differences
  JOURNAL   J Mol Biol 210 (3), 665-671 (1989)
   PUBMED   2614840
REFERENCE   9  (bases 1 to 5925)
  AUTHORS   McNally,E.M., Gianola,K.M. and Leinwand,L.A.
  TITLE     Complete nucleotide sequence of full length cDNA for rat alpha
            cardiac myosin heavy chain
  JOURNAL   Nucleic Acids Res 17 (18), 7527-7528 (1989)
   PUBMED   2798111
REFERENCE   10 (bases 1 to 5925)
  AUTHORS   Izumo,S., Lompre,A.M., Matsuoka,R., Koren,G., Schwartz,K.,
            Nadal-Ginard,B. and Mahdavi,V.
  TITLE     Myosin heavy chain messenger RNA and protein isoform transitions
            during cardiac hypertrophy. Interaction between hemodynamic and
            thyroid hormone-induced signals
  JOURNAL   J Clin Invest 79 (3), 970-977 (1987)
   PUBMED   2950137
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Apr 25, 2008 this sequence version replaced NM_017239.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X15938.1, SRR26643289.36273.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                JAXUCZ010000015.1  32411678-32411697   c
            21-238              JAXUCZ010000015.1  32411116-32411333   c
            239-382             JAXUCZ010000015.1  32409801-32409944   c
            383-539             JAXUCZ010000015.1  32409414-32409570   c
            540-567             JAXUCZ010000015.1  32409292-32409319   c
            568-679             JAXUCZ010000015.1  32408946-32409057   c
            680-772             JAXUCZ010000015.1  32408611-32408703   c
            773-836             JAXUCZ010000015.1  32407868-32407931   c
            837-935             JAXUCZ010000015.1  32407546-32407644   c
            936-1039            JAXUCZ010000015.1  32407032-32407135   c
            1040-1178           JAXUCZ010000015.1  32406810-32406948   c
            1179-1447           JAXUCZ010000015.1  32406106-32406374   c
            1448-1618           JAXUCZ010000015.1  32405756-32405926   c
            1619-1928           JAXUCZ010000015.1  32405168-32405477   c
            1929-1999           JAXUCZ010000015.1  32404506-32404576   c
            2000-2087           JAXUCZ010000015.1  32404187-32404274   c
            2088-2205           JAXUCZ010000015.1  32403984-32404101   c
            2206-2329           JAXUCZ010000015.1  32403723-32403846   c
            2330-2466           JAXUCZ010000015.1  32403344-32403480   c
            2467-2722           JAXUCZ010000015.1  32400379-32400634   c
            2723-2965           JAXUCZ010000015.1  32399971-32400213   c
            2966-3142           JAXUCZ010000015.1  32399655-32399831   c
            3143-3288           JAXUCZ010000015.1  32399263-32399408   c
            3289-3379           JAXUCZ010000015.1  32398930-32399020   c
            3380-3769           JAXUCZ010000015.1  32397054-32397443   c
            3770-3896           JAXUCZ010000015.1  32396610-32396736   c
            3897-4015           JAXUCZ010000015.1  32396402-32396520   c
            4016-4212           JAXUCZ010000015.1  32395939-32396135   c
            4213-4396           JAXUCZ010000015.1  32395105-32395288   c
            4397-4562           JAXUCZ010000015.1  32394784-32394949   c
            4563-4687           JAXUCZ010000015.1  32394573-32394697   c
            4688-4996           JAXUCZ010000015.1  32393417-32393725   c
            4997-5200           JAXUCZ010000015.1  32392817-32393020   c
            5201-5326           JAXUCZ010000015.1  32390615-32390740   c
            5327-5602           JAXUCZ010000015.1  32390232-32390507   c
            5603-5698           JAXUCZ010000015.1  32389032-32389127   c
            5699-5833           JAXUCZ010000015.1  32388542-32388676   c
            5834-5925           JAXUCZ010000015.1  32388102-32388193   c
FEATURES             Location/Qualifiers
     source          1..5925
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p13"
     gene            1..5925
                     /gene="Myh6"
                     /gene_synonym="Myh7; MyHC-beta; MyHC-slow; Myhca;
                     Myosin-7"
                     /note="myosin heavy chain 6"
                     /db_xref="GeneID:29556"
                     /db_xref="RGD:62029"
     exon            1..20
                     /gene="Myh6"
                     /gene_synonym="Myh7; MyHC-beta; MyHC-slow; Myhca;
                     Myosin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            21..238
                     /gene="Myh6"
                     /gene_synonym="Myh7; MyHC-beta; MyHC-slow; Myhca;
                     Myosin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            239..382
                     /gene="Myh6"
                     /gene_synonym="Myh7; MyHC-beta; MyHC-slow; Myhca;
                     Myosin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            383..539
                     /gene="Myh6"
                     /gene_synonym="Myh7; MyHC-beta; MyHC-slow; Myhca;
                     Myosin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            540..567
                     /gene="Myh6"
                     /gene_synonym="Myh7; MyHC-beta; MyHC-slow; Myhca;
                     Myosin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            568..679
                     /gene="Myh6"
                     /gene_synonym="Myh7; MyHC-beta; MyHC-slow; Myhca;
                     Myosin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            680..772
                     /gene="Myh6"
                     /gene_synonym="Myh7; MyHC-beta; MyHC-slow; Myhca;
                     Myosin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            773..836
                     /gene="Myh6"
                     /gene_synonym="Myh7; MyHC-beta; MyHC-slow; Myhca;
                     Myosin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            837..935
                     /gene="Myh6"
                     /gene_synonym="Myh7; MyHC-beta; MyHC-slow; Myhca;
                     Myosin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1039
                     /gene="Myh6"
                     /gene_synonym="Myh7; MyHC-beta; MyHC-slow; Myhca;
                     Myosin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1178
                     /gene="Myh6"
                     /gene_synonym="Myh7; MyHC-beta; MyHC-slow; Myhca;
                     Myosin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1447
                     /gene="Myh6"
                     /gene_synonym="Myh7; MyHC-beta; MyHC-slow; Myhca;
                     Myosin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1618
                     /gene="Myh6"
                     /gene_synonym="Myh7; MyHC-beta; MyHC-slow; Myhca;
                     Myosin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1928
                     /gene="Myh6"
                     /gene_synonym="Myh7; MyHC-beta; MyHC-slow; Myhca;
                     Myosin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..1999
                     /gene="Myh6"
                     /gene_synonym="Myh7; MyHC-beta; MyHC-slow; Myhca;
                     Myosin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2087
                     /gene="Myh6"
                     /gene_synonym="Myh7; MyHC-beta; MyHC-slow; Myhca;
                     Myosin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2205
                     /gene="Myh6"
                     /gene_synonym="Myh7; MyHC-beta; MyHC-slow; Myhca;
                     Myosin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2329
                     /gene="Myh6"
                     /gene_synonym="Myh7; MyHC-beta; MyHC-slow; Myhca;
                     Myosin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            2330..2466
                     /gene="Myh6"
                     /gene_synonym="Myh7; MyHC-beta; MyHC-slow; Myhca;
                     Myosin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            2467..2722
                     /gene="Myh6"
                     /gene_synonym="Myh7; MyHC-beta; MyHC-slow; Myhca;
                     Myosin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            2723..2965
                     /gene="Myh6"
                     /gene_synonym="Myh7; MyHC-beta; MyHC-slow; Myhca;
                     Myosin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            2966..3142
                     /gene="Myh6"
                     /gene_synonym="Myh7; MyHC-beta; MyHC-slow; Myhca;
                     Myosin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            3143..3288
                     /gene="Myh6"
                     /gene_synonym="Myh7; MyHC-beta; MyHC-slow; Myhca;
                     Myosin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            3289..3379
                     /gene="Myh6"
                     /gene_synonym="Myh7; MyHC-beta; MyHC-slow; Myhca;
                     Myosin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            3380..3769
                     /gene="Myh6"
                     /gene_synonym="Myh7; MyHC-beta; MyHC-slow; Myhca;
                     Myosin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            3770..3896
                     /gene="Myh6"
                     /gene_synonym="Myh7; MyHC-beta; MyHC-slow; Myhca;
                     Myosin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            3897..4015
                     /gene="Myh6"
                     /gene_synonym="Myh7; MyHC-beta; MyHC-slow; Myhca;
                     Myosin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            4016..4212
                     /gene="Myh6"
                     /gene_synonym="Myh7; MyHC-beta; MyHC-slow; Myhca;
                     Myosin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            4213..4396
                     /gene="Myh6"
                     /gene_synonym="Myh7; MyHC-beta; MyHC-slow; Myhca;
                     Myosin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            4397..4562
                     /gene="Myh6"
                     /gene_synonym="Myh7; MyHC-beta; MyHC-slow; Myhca;
                     Myosin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            4563..4687
                     /gene="Myh6"
                     /gene_synonym="Myh7; MyHC-beta; MyHC-slow; Myhca;
                     Myosin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            4688..4996
                     /gene="Myh6"
                     /gene_synonym="Myh7; MyHC-beta; MyHC-slow; Myhca;
                     Myosin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            4997..5200
                     /gene="Myh6"
                     /gene_synonym="Myh7; MyHC-beta; MyHC-slow; Myhca;
                     Myosin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            5201..5326
                     /gene="Myh6"
                     /gene_synonym="Myh7; MyHC-beta; MyHC-slow; Myhca;
                     Myosin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            5327..5602
                     /gene="Myh6"
                     /gene_synonym="Myh7; MyHC-beta; MyHC-slow; Myhca;
                     Myosin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            5603..5698
                     /gene="Myh6"
                     /gene_synonym="Myh7; MyHC-beta; MyHC-slow; Myhca;
                     Myosin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            5699..5833
                     /gene="Myh6"
                     /gene_synonym="Myh7; MyHC-beta; MyHC-slow; Myhca;
                     Myosin-7"
                     /inference="alignment:Splign:2.1.0"
     exon            5834..5925
                     /gene="Myh6"
                     /gene_synonym="Myh7; MyHC-beta; MyHC-slow; Myhca;
                     Myosin-7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctgtgaaaa gattaaccgg agtttaagag tgacaggatg acggatgccc agatggctga
       61 cttcggggca gcagccccat acctccgcaa gtcagagaag gagcgcctag aggcccagac
      121 ccggcccttt gacatccgca cagagtgctt cgtgcctgat gacaaggagg agtatgtcaa
      181 ggccaagatc gtgtcccggg aagggggcaa ggtcactgcc gaaactgaaa acggcaagac
      241 ggtgactgtg aaggaggacc aggtgatgca gcagaaccct ccgaaattcg acaagatcga
      301 ggacatggcc atgctgacct tcctgcatga gccagctgtg ctctacaatc tcaaggagcg
      361 ctatgcggcc tggatgatct atacctactc aggcctcttc tgtgtcaccg tcaaccccta
      421 taagtggctg ccagtgtaca atgcggaagt ggtagctgcc taccggggca agaagaggag
      481 cgaggctcca ccccacatct tctccatctc tgacaacgcc tatcagtaca tgctgacaga
      541 tcgggagaac cagtccatcc tcatcactgg agaatccgga gcggggaaga ctgtcaacac
      601 gaagcgtgtc atccagtact ttgctagcat tgcagccata ggggaccgta gcaagaagga
      661 caatcctaat gcaaacaagg gcaccctgga ggaccagatt atccaggcta accctgctct
      721 ggaggccttt ggcaacgcca agactgtccg gaatgacaac tcctcccgct ttgggaagtt
      781 catcaggatc cactttggag ccacaggaaa gctggcttct gcagacatag agacctacct
      841 tctggagaag tcccgggtga tcttccagct aaaggctgag aggaactacc atatcttcta
      901 ccagatcctg tccaacaaga agccggagct gctggacatg ctgctggtta ccaacaaccc
      961 gtacgactat gccttcgtct ctcagggaga ggtgtctgtg gcctccattg atgactccga
     1021 ggagcttttg gccactgata gcgcctttga tgtgctgggc ttcacagcag aggagaaggc
     1081 cggtgtctac aagctgacag gcgccatcat gcactatggg aacatgaagt tcaagcagaa
     1141 gcagcgggag gagcaggcgg agccagacgg cacagaagat gctgacaaat ctgcctacct
     1201 catggggctg aactcagccg acctgctcaa gggtctgtgt caccctcggg tgaaggtggg
     1261 taacgagtat gtcaccaagg ggcagagtgt acagcaggtg tactattcca tcggggcact
     1321 ggccaagtca gtgtacgaga agatgttcaa ctggatggtg acacgcatca acgcaaccct
     1381 ggagaccaag cagccacgcc agtacttcat aggtgtcctg gacatcgccg gctttgagat
     1441 ctttgatttc aacagctttg agcagctgtg catcaacttc accaatgaga agctgcagca
     1501 gttcttcaac caccacatgt tcgtgctgga gcaggaggag tacaagaagg aaggcatcga
     1561 gtgggagttc attgacttcg gcatggacct gcaggcctgc atcgacctca tcgagaagcc
     1621 catgggcatc atgtccatcc tggaggagga gtgcatgttc cccaaggcca cagacatgac
     1681 cttcaaggcc aagctgtacg acaaccacct gggcaagtcc aacaacttcc agaagcctcg
     1741 caatgtcaag gggaagcagg aagcccactt ctctctggtc cactatgctg gcaccgtgga
     1801 ctacaacatc ttgggctggc tggagaagaa caaggaccct ctcaacgaga cggtggtggg
     1861 gctgtaccag aagtcctccc tcaaactcat ggccacactc ttctccacct acgcttctgc
     1921 tgataccggt gacagtggga aaggcaaagg aggcaagaag aaaggctcat ccttccagac
     1981 agtgtctgct ctccaccggg aaaatctgaa caagctgatg acaaacctga ggaccaccca
     2041 tcctcacttt gtgcgctgca tcatccccaa tgagcggaag gctccagggg tgatggacaa
     2101 ccccctggtc atgcaccagc tgcgatgcaa cggagtgctg gagggtatcc gcatctgtag
     2161 gaagggcttc cccaaccgca ttctttatgg ggacttccgg cagaggtatc gaatcctgaa
     2221 cccagcagcc atccctgagg ggcaattcat tgatagcagg aaaggggctg agaagctgct
     2281 gggctccctg gacattgacc acaaccagta caagtttggt cacaccaagg tgttcttcaa
     2341 ggcggggctg ctggggctgc tggaggagat gcgagatgag aggctgagcc gcatcatcac
     2401 cagaatccag gctcaagccc gaggccagct catgcgcatt gagttcaaga agatggtgga
     2461 gcgcagggac gccctgctgg ttatccagtg gaacatccgc gccttcatgg gggtcaagaa
     2521 ttggccgtgg atgaagctct acttcaagat caagccgctg ctgaagagcg cagagacaga
     2581 gaaggagatg gccaacatga aggaggagtt cgggcgagtc aaagatgcac tagagaagtc
     2641 tgaggctcgc cgcaaggagc tggaggagaa gatggtgtcc ctgctgcagg agaagaatga
     2701 cctgcagctc caagtgcagg cggaacaaga caacctggca gatgccgagg agcgctgcga
     2761 ccagctgatc aagaacaaga tccagctgga ggccaaggtg aaggagatga ccgagaggct
     2821 ggaggacgag gaggagatga acgccgagct cacggccaag aagcgcaagc tggaagacga
     2881 gtgctcagag ctcaagaaag atatcgatga cctggagctg accctggcca aggtggagaa
     2941 ggaaaagcac gcaacagaga acaaggttaa aaacctgaca gaggagatgg ccgggctgga
     3001 cgagatcatt gccaagctga ccaaggagaa gaaagctctt caagaggccc accagcaagc
     3061 cctagatgac cttcaggctg aggaagacaa ggtcaacaca ctgatcaagt ctaaagtcaa
     3121 gctggagcag caggtggatg atctggaggg atccctggag caggagaaga aggtgcgcat
     3181 ggacctggag cgagcaaagc ggaagctgga gggtgacctg aagctgaccc aggagagcat
     3241 catggacctg gagaacgaca agcttcagct ggaggaaaag ctcaagaaga aagagtttga
     3301 catcagtcag cagaacagta aaatagagga tgagcaggcc ctggcccttc agctgcagaa
     3361 gaaactgaag gaaaaccagg cacgcatcga ggagctggag gaggagctag aggccgagcg
     3421 cacagcccgg gccaaggtgg agaagctgcg ctcagacctg acccgggagc tggaggagat
     3481 cagtgagagg ctagaggaag ccggtggggc cacatctgtg cagatagaga tgaacaagaa
     3541 gcgcgaggcc gagttccaga agatgcggcg ggacctggag gaggccacgc tgcagcatga
     3601 ggccacagcc gcggccctgc gcaagaagca cgcagacagc gtggccgagc tgggcgagca
     3661 gatagacaat ctacagcggg tgaagcagaa gctggagaaa gagaagagcg agttcaaact
     3721 ggagctggat gacgtcacct ccaacatgga gcagatcatc aaggccaagg caaacctgga
     3781 gaaagtgtcc cggacactgg aggaccaggc caatgaatac cgggtgaagt tggaagaagc
     3841 ccagcgctcc ctcaatgact tcaccacaca gcgagccaag ctgcagacag agaacggcga
     3901 gctggctagg caactggaag aaaaggaggc actgatttcc cagctgaccc ggggcaagct
     3961 ctcctatacc cagcagatgg aggacctcaa gaggcagctg gaggaggaag gcaaggccaa
     4021 gaatgccttg gcccacgcac tgcagtcagc ccggcatgac tgcgacctgc tgcgggaaca
     4081 gtacgaagaa gaaatggagg ccaaggccga gctgcagcgt gtcctgtcca aggccaactc
     4141 agaggtggcc cagtggagga ccaagtatga gacggacgcc atacagagga cggaggagct
     4201 ggaggaagcc aagaagaagc tggctcagag gcttcaggat gctgaggagg cagtggaggc
     4261 cgtcaacgcc aagtgctcct ctctggagaa gaccaagcac aggctgcaga acgagatcga
     4321 ggacctgatg gtggatgtgg agcgctccaa tgcggccgcc gcagccctgg acaaaaagca
     4381 gaggaacttc gacaagatcc tggctgagtg gaagcagaag tatgaggagt cccagtcaga
     4441 gctggagtct tcccagaagg aggcgcgctc cctgagcaca gagctcttca agctcaagaa
     4501 tgcctatgag gagtctctgg agcacctgga gaccttcaag cgggagaaca agaacctcca
     4561 ggaggagatc tcagacctga ctgaacagct gggagaaggg ggtaaaaatg tgcacgagct
     4621 ggagaagatc cgcaaacagc tggaggtgga gaagctggaa ctgcagtcag ccctggagga
     4681 ggctgaggcc tccctggagc atgaggaggg caagatcctc cgagcccagc tggagttcaa
     4741 ccagatcaag gcagagatcg aaaggaagct ggcagagaag gacgaggaga tggagcaggc
     4801 caagcgcaac cacctgcggg tggtggactc cctgcagacc tccctggatg ccgagacgcg
     4861 cagccgcaac gaggccctgc gggtgaagaa gaagatggag ggcgacctca atgagatgga
     4921 gatccagctc agtcaggcca atagaatagc ctcagaggcc cagaagcact tgaagaacgc
     4981 ccaagcccac ttgaaggaca cccagctcca gctggatgac gcagtccgtg ccaatgacga
     5041 cctgaaggag aacatcgcca tcgtggagcg gcgcaacacc ctgctgcagg cggagctgga
     5101 ggagctgcgg gccgtggtgg agcagacaga gcggtctcgg aagctggcag agcaggagct
     5161 gatcgagacc agcgagcggg tgcagctgct gcactcccag aacaccagcc tcatcaacca
     5221 gaagaagaag atggatgcag acctctccca gctccagaca gaggtggagg aggcggtgca
     5281 ggagtgtagg aacgcagagg agaaggccaa gaaggccatc acagatgccg ccatgatggc
     5341 cgaggagctg aagaaggagc aggacaccag cgcccacctg gagcgcatga agaagaacat
     5401 ggagcagacc atcaaggacc tgcagcaccg gctggacgag gcagagcaga tcgccctcaa
     5461 gggtggcaag aagcagctgc agaagctgga ggcccgggtc cgggagctgg agaatgagct
     5521 ggaggctgag cagaagcgca atgcggagtc ggtgaagggc atgaggaaga gcgagcggcg
     5581 catcaaggag ctcacctacc agacagagga agacaagaag aacttggtgc ggctgcagga
     5641 cctggtggac aagctgcagt tgaaggtgaa ggcctacaag cgccaggctg aagaggcgga
     5701 ggaacaggcc aacaccaacc tgtccaagtt ccgcaaggtg cagcacgagc tggatgaggc
     5761 agaggagagg gcggacattg ccgagtccca ggtcaacaag ctgcgggcca agagccgtga
     5821 cattggcgcc aagcagaaaa tgcacgatga ggaataacct gtccagcaga aagagcctcg
     5881 ctgttgctat cccacaataa atatgaatgc ttgactttgc ctgta
//
