LOCUS       NM_019325               6088 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus myosin heavy chain 4 (Myh4), mRNA.
ACCESSION   NM_019325 XM_001078843 XM_340818
VERSION     NM_019325.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6088)
  AUTHORS   Lima,A.R., Martinez,P.F., Damatto,R.L., Cezar,M.D., Guizoni,D.M.,
            Bonomo,C., Oliveira,S.A. Jr., Dal-Pai Silva,M., Zornoff,L.A.,
            Okoshi,K. and Okoshi,M.P.
  TITLE     Heart failure-induced diaphragm myopathy
  JOURNAL   Cell Physiol Biochem 34 (2), 333-345 (2014)
   PUBMED   25060722
REFERENCE   2  (bases 1 to 6088)
  AUTHORS   O'Connell,R.A., Carberry,J. and O'Halloran,K.D.
  TITLE     Sternohyoid and diaphragm muscle form and function during postnatal
            development in the rat
  JOURNAL   Exp Physiol 98 (9), 1386-1400 (2013)
   PUBMED   23709586
REFERENCE   3  (bases 1 to 6088)
  AUTHORS   Watanabe,A., Tatematsu,M., Saeki,K., Shibata,S., Shime,H.,
            Yoshimura,A., Obuse,C., Seya,T. and Matsumoto,M.
  TITLE     Raftlin is involved in the nucleocapture complex to induce
            poly(I:C)-mediated TLR3 activation
  JOURNAL   J Biol Chem 286 (12), 10702-10711 (2011)
   PUBMED   21266579
REFERENCE   4  (bases 1 to 6088)
  AUTHORS   Ogura,Y., Naito,H., Kakigi,R., Akema,T., Sugiura,T., Katamoto,S.
            and Aoki,J.
  TITLE     Different adaptations of alpha-actinin isoforms to exercise
            training in rat skeletal muscles
  JOURNAL   Acta Physiol (Oxf) 196 (3), 341-349 (2009)
   PUBMED   19040707
  REMARK    GeneRIF: Exercise training showed a myosin heavy chain shift from
            type IIb to IIa skeletal muscles.
REFERENCE   5  (bases 1 to 6088)
  AUTHORS   Legerlotz,K., Matthews,K.G., McMahon,C.D. and Smith,H.K.
  TITLE     Botulinum toxin-induced paralysis leads to slower myosin heavy
            chain isoform composition and reduced titin content in juvenile rat
            gastrocnemius muscle
  JOURNAL   Muscle Nerve 39 (4), 472-479 (2009)
   PUBMED   19260067
  REMARK    GeneRIF: although the sarcomeric stability of paralyzed muscle
            might be impaired, moderate mechanical loading does not seem to
            affect paralyzed muscle protein composition
REFERENCE   6  (bases 1 to 6088)
  AUTHORS   Mousavi,K., Parry,D.J. and Jasmin,B.J.
  TITLE     BDNF rescues myosin heavy chain IIB muscle fibers after neonatal
            nerve injury
  JOURNAL   Am J Physiol Cell Physiol 287 (1), C22-C29 (2004)
   PUBMED   14973145
REFERENCE   7  (bases 1 to 6088)
  AUTHORS   Noirez,P., Agbulut,O. and Ferry,A.
  TITLE     Differential modification of myosin heavy chain expression by
            tenotomy in regenerating fast and slow muscles of the rat
  JOURNAL   Exp Physiol 85 (2), 187-191 (2000)
   PUBMED   10751515
REFERENCE   8  (bases 1 to 6088)
  AUTHORS   Lieber,R.L., Bodine,S.C., Burkholder,T.J., Pierotti,D.J. and
            Ryan,A.F.
  TITLE     Cloning and in situ hybridization of type 2A and 2B rat skeletal
            muscle myosin tail region: implications for filament assembly
  JOURNAL   Biochem Biophys Res Commun 197 (3), 1312-1318 (1993)
   PUBMED   8280148
REFERENCE   9  (bases 1 to 6088)
  AUTHORS   Larsson,L. and Moss,R.L.
  TITLE     Maximum velocity of shortening in relation to myosin isoform
            composition in single fibres from human skeletal muscles
  JOURNAL   J Physiol 472, 595-614 (1993)
   PUBMED   8145163
REFERENCE   10 (bases 1 to 6088)
  AUTHORS   DeNardi,C., Ausoni,S., Moretti,P., Gorza,L., Velleca,M.,
            Buckingham,M. and Schiaffino,S.
  TITLE     Type 2X-myosin heavy chain is coded by a muscle fiber type-specific
            and developmentally regulated gene
  JOURNAL   J Cell Biol 123 (4), 823-835 (1993)
   PUBMED   8227143
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC113948.1.
            
            On or before Jun 25, 2006 this sequence version replaced
            XM_340818.3, XM_001078843.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC113948.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..6088
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..6088
                     /gene="Myh4"
                     /note="myosin heavy chain 4"
                     /db_xref="GeneID:360543"
                     /db_xref="RGD:3139"
     exon            1..8
                     /gene="Myh4"
                     /inference="alignment:Splign:2.1.0"
     exon            9..56
                     /gene="Myh4"
                     /inference="alignment:Splign:2.1.0"
     exon            57..299
                     /gene="Myh4"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..5915
                     /gene="Myh4"
                     /note="2B myosin heavy chain; myosin heavy chain type IIb;
                     myHC-2b; myosin heavy chain 2b; myosin, heavy polypeptide
                     4, skeletal muscle; myosin, heavy chain 4, skeletal
                     muscle"
                     /codon_start=1
                     /product="myosin-4"
                     /protein_id="NP_062198.1"
                     /db_xref="GeneID:360543"
                     /db_xref="RGD:3139"
                     /translation="MSSDAEMAVFGEAAPYLRKSEKERIEAQNKPFDAKSSVFVVDAK
                     ESYVKATVQSREGGKVTAKTEGGATVTVKEDQVFSMNPPKYDKIEDMAMMTHLHEPAV
                     LYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSISD
                     NAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGDKKKEEAPSGKMQGT
                     LEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRV
                     TFQLKAERSYHIFYQVMSNKKPELIEMLLITTNPYDFAYVSQGEITVPSIDDQEELMA
                     TDTAVDILGFTADEKVAIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLTS
                     LNSADLLKALCYPRVKVGNEYVTKGQTVQQVYNSVGALAKAMYEKMFLWMVTRINQQL
                     DTKQPRQYFIGVLDIAGFEIFDFNTLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEG
                     IEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNF
                     QKPKPAKGKAEAHFSLVHYAGTVDYNIIGWLDKNKDPLNETVVGLYQKSGLKTLAFLF
                     SGGQAAEAEGGGGKKGGKKKGSSFQTVSALFRENLNKLMTNLKSTHPHFVRCLIPNET
                     KTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQFI
                     DSKKASEKLLGSIDIDHTQYKFGHTKVFFKAGLLGTLEEMRDEKLAQLITRTQAVCRG
                     YLMRVEFRKMMERRESIFCIQYNVRAFMNVKHWPWMKLYFKIKPLLKSAETEKEMATM
                     KEDFEKAKEDLAKSEAKRKELEEKMVALMQEKNDLQLQVQAEADGLADAEERCDQLIK
                     TKIQLEAKIKELTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEK
                     HATENKVKNLTEEMAGLDENIVKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKTK
                     LEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKE
                     FEMSNLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRE
                     LEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSV
                     AELGEQIDNLQRVKQKLEKEKSELKMEIDDLASNMETVSKAKGNLEKMCRTLEDQLSE
                     VKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELK
                     RQLEEESKAKNALAHALQSARHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTK
                     YETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDV
                     ERSNAACAALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEE
                     SLDQLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKIKKQIDQEKSELQASLEEAE
                     ASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEEIDQLKRNHLRVVESMQSTLDAEIR
                     SRNDALRIKKKMEGDLNEMEIQLNHANRQAAEAIRNLRNTQGMLKDTQLHLDDALRGQ
                     DDLKEQLAMVERRANLMQAEIEELRASLEQTERSRRVAEQELLDASERVQLLHTQNTS
                     LINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLE
                     RMKKNMEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELENEVENEQKRNIEAVK
                     GLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKF
                     RKIQHELEEAEERADIAESQVNKLRVKSREVHTKVISEE"
     exon            300..443
                     /gene="Myh4"
                     /inference="alignment:Splign:2.1.0"
     exon            444..600
                     /gene="Myh4"
                     /inference="alignment:Splign:2.1.0"
     exon            601..628
                     /gene="Myh4"
                     /inference="alignment:Splign:2.1.0"
     exon            629..743
                     /gene="Myh4"
                     /inference="alignment:Splign:2.1.0"
     exon            744..836
                     /gene="Myh4"
                     /inference="alignment:Splign:2.1.0"
     exon            837..900
                     /gene="Myh4"
                     /inference="alignment:Splign:2.1.0"
     exon            901..999
                     /gene="Myh4"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1103
                     /gene="Myh4"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1242
                     /gene="Myh4"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1361
                     /gene="Myh4"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1511
                     /gene="Myh4"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1682
                     /gene="Myh4"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1992
                     /gene="Myh4"
                     /inference="alignment:Splign:2.1.0"
     exon            1993..2063
                     /gene="Myh4"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2151
                     /gene="Myh4"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2269
                     /gene="Myh4"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..2393
                     /gene="Myh4"
                     /inference="alignment:Splign:2.1.0"
     exon            2394..2530
                     /gene="Myh4"
                     /inference="alignment:Splign:2.1.0"
     exon            2531..2786
                     /gene="Myh4"
                     /inference="alignment:Splign:2.1.0"
     exon            2787..3029
                     /gene="Myh4"
                     /inference="alignment:Splign:2.1.0"
     exon            3030..3206
                     /gene="Myh4"
                     /inference="alignment:Splign:2.1.0"
     exon            3207..3352
                     /gene="Myh4"
                     /inference="alignment:Splign:2.1.0"
     exon            3353..3443
                     /gene="Myh4"
                     /inference="alignment:Splign:2.1.0"
     exon            3444..3833
                     /gene="Myh4"
                     /inference="alignment:Splign:2.1.0"
     exon            3834..3960
                     /gene="Myh4"
                     /inference="alignment:Splign:2.1.0"
     exon            3961..4079
                     /gene="Myh4"
                     /inference="alignment:Splign:2.1.0"
     exon            4080..4276
                     /gene="Myh4"
                     /inference="alignment:Splign:2.1.0"
     exon            4277..4460
                     /gene="Myh4"
                     /inference="alignment:Splign:2.1.0"
     exon            4461..4626
                     /gene="Myh4"
                     /inference="alignment:Splign:2.1.0"
     exon            4627..4751
                     /gene="Myh4"
                     /inference="alignment:Splign:2.1.0"
     exon            4752..5060
                     /gene="Myh4"
                     /inference="alignment:Splign:2.1.0"
     exon            5061..5264
                     /gene="Myh4"
                     /inference="alignment:Splign:2.1.0"
     exon            5265..5390
                     /gene="Myh4"
                     /inference="alignment:Splign:2.1.0"
     exon            5391..5561
                     /gene="Myh4"
                     /inference="alignment:Splign:2.1.0"
     exon            5562..5666
                     /gene="Myh4"
                     /inference="alignment:Splign:2.1.0"
     exon            5667..5762
                     /gene="Myh4"
                     /inference="alignment:Splign:2.1.0"
     exon            5763..6019
                     /gene="Myh4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgtaaagta cttgtctgac tcagcctgcc tccttcttca tctggtaaca caagaggtgc
       61 acctggccct aagctgcccc caatagctcg cagccatgag ttccgacgcc gagatggccg
      121 tttttgggga ggctgctcct tacctccgga agtctgaaaa ggagcgaatc gaggctcaga
      181 acaagccttt tgatgccaag tcatcagtgt ttgtggtgga tgctaaggag tcctatgtga
      241 aagcaaccgt gcagagcagg gaagggggga aggtgacggc caagaccgaa ggtggagcta
      301 ctgtcacagt taaagaagat caagtcttct ccatgaaccc tcccaagtac gacaagatcg
      361 aggacatggc catgatgacc cacctccacg agcccgctgt gctgtacaac ctcaaagagc
      421 gttatgcagc ctggatgatc tacacttatt cggggctctt ctgtgtcact gtcaacccct
      481 acaagtggtt gccggtgtac aaccccgagg tggtggcagc ttaccgaggc aaaaagcgac
      541 aggaggcccc gccccacatc ttctccatct ctgataatgc ctaccagttc atgctgacgg
      601 atcgtgagaa ccagtccatc ctgattactg gagaatccgg ggccgggaag actgtgaaca
      661 cgaagcgtgt catccagtac tttgcaacaa ttgcagtcac cggggacaag aagaaggagg
      721 aagcaccttc tggcaaaatg caggggaccc ttgaagatca aatcatcagt gccaaccctc
      781 tgctggaggc ctttggcaat gccaagactg tgaggaacga caactcctcc cgcttcggta
      841 aattcatcag aatccatttc ggtgccacag gcaaactggc ctccgcagat atcgaaacct
      901 atctgctaga gaagtccaga gtcaccttcc agctcaaggc tgaaagaagc tatcacatct
      961 tctaccaagt catgtccaat aagaaaccag agcttatcga gatgctcctg atcaccacca
     1021 acccatatga ctttgcttac gtcagtcaag gtgaaatcac agtgcccagc attgatgacc
     1081 aggaagagtt gatggccaca gacactgccg tggacatcct ggggttcact gcagatgaaa
     1141 aagtggccat ttacaagctc actggtgctg tgatgcacta tgggaacatg aaattcaagc
     1201 aaaagcaaag ggaagagcag gctgagccag acggcactga agtggctgac aaggctgcct
     1261 atctgacaag tctgaactct gctgacctgc tcaaagccct ctgctacccc agggtcaagg
     1321 tcggcaatga gtacgtcacc aaaggccaga cagtgcagca ggtgtacaac tctgtgggcg
     1381 ccctggccaa ggccatgtac gagaagatgt tcctgtggat ggtcacccgc atcaaccagc
     1441 agctggacac caagcagccc aggcagtact tcatcggggt cttggacatc gctggctttg
     1501 agatctttga cttcaacacc ttggagcagc tgtgtatcaa cttcaccaac gagaaactgc
     1561 aacagttttt caaccaccac atgttcgtgc tggagcagga ggagtacaag aaggaaggca
     1621 ttgagtggga gttcatcgac ttcgggatgg acttggcagc ctgcattgag ctcattgaga
     1681 agccgatggg catcttctcc atcctggaag aggagtgcat gttccccaag gcgacagaca
     1741 cctccttcaa gaacaaactg tatgagcagc atcttgggaa gtccaacaac ttccagaagc
     1801 ccaaacctgc caaaggcaag gccgaggccc acttctccct ggtgcactat gcaggcaccg
     1861 tggactacaa cattattggg tggctggaca agaacaagga ccccctgaat gagaccgtgg
     1921 tggggctgta ccagaagtcc gggttgaaga ctctggcttt cctattttct gggggacaag
     1981 ctgctgaagc agagggtggc ggcggaaaga aaggtggcaa gaagaagggt tcttctttcc
     2041 agaccgtgtc agctcttttc agggagaatt taaataagct gatgaccaac ttgaagagca
     2101 cccaccccca ctttgtccga tgcctcattc ccaatgagac taagactcct ggtgccatgg
     2161 agcacgaact ggtcctgcac cagctgaggt gcaacggggt gctggaaggc atccgcatct
     2221 gcaggaaggg gttccccagc aggatcctct acgcagactt caagcagaga tacaaagttc
     2281 tcaatgcaag tgctatcccg gaaggtcagt tcattgatag caagaaggcc tctgagaagc
     2341 ttctaggttc cattgacatc gaccataccc agtacaaatt cggtcacacg aaggttttct
     2401 ttaaagctgg cctgctggga actctagagg agatgcgaga tgaaaagctg gctcagctca
     2461 tcacgcgcac tcaagccgtg tgcagagggt acctgatgag ggtggagttc agaaagatga
     2521 tggagaggag agagtccatc ttctgcatcc agtacaacgt ccgcgccttc atgaacgtca
     2581 agcactggcc ctggatgaag ctgtatttca agatcaaacc cctgctgaag agtgcagaga
     2641 ctgagaagga gatggccacc atgaaggaag attttgagaa ggccaaggag gatctggcaa
     2701 agtcagaggc aaaaaggaaa gaactagaag aaaagatggt ggctctgatg caagagaaaa
     2761 atgatctgca gctccaggtt caagctgaag cagatggctt agctgatgca gaggaaagat
     2821 gcgaccagct gatcaaaact aaaatccaac tggaggccaa aatcaaagag ttgactgaga
     2881 gggctgagga tgaggaagag atcaatgccg agctcaccgc caagaagagg aagctggagg
     2941 acgagtgctc agagctgaag aaagacatcg atgaccttga gctgacactg gccaaggttg
     3001 agaaggagaa gcacgccacg gagaacaagg tgaaaaacct cacagaagag atggcaggct
     3061 tggatgaaaa tattgttaag ctgaccaagg agaagaaggc cctgcaggag gcccaccagc
     3121 agaccctgga tgacctgcag gcagaggagg acaaagtcaa caccctgacc aaagccaaaa
     3181 ccaagctcga acagcaagtg gatgaccttg aaggatcact ggaacaggaa aagaagctga
     3241 ggatggactt agaaagagcc aagaggaaac tggaggggga cctgaaactg gcccaagagt
     3301 ccacaatgga catagaaaat gacaaacagc agctcgatga gaaactcaaa aagaaagagt
     3361 ttgaaatgag caacctgcag agcaagattg aggatgaaca ggccctcggc atgcagctgc
     3421 agaagaagat caaagagttg caggcccgca ttgaggagct ggaggaggaa atcgaggcag
     3481 agcgggcctc cagggccaaa gcagagaagc agcgctctga cctctcccgg gaactggagg
     3541 agatcagcga gcggctggaa gaagccggcg gggccacttc agcccagatc gagatgaaca
     3601 agaagagaga ggccgagttc cagaaaatgc gcagggactt ggaggaggcc accctgcagc
     3661 acgaagccac agcagccgct cttcggaaga agcacgcgga cagcgtggct gagctcgggg
     3721 agcagatcga caacctgcag cgggtgaagc agaagctgga gaaggagaag agtgagctga
     3781 agatggagat cgacgacctc gctagcaaca tggagactgt ctccaaagcc aaggggaacc
     3841 ttgagaagat gtgccgcacc ctggaggacc aactgagtga agtgaaaacc aaggaggagg
     3901 agcagcagcg cctgatcaat gagctgtcag cccagaaggc acgcttacac acagagtcag
     3961 gtgagttttc ccgacagctg gatgagaaag atgctatggt ttctcagctc tcccgaggca
     4021 aacaagcgtt tacacaacag attgaggagc taaagaggca gctagaagaa gagtccaagg
     4081 ccaagaacgc gctggcccac gccctgcagt ccgctcgcca cgactgtgac cttctgcggg
     4141 agcagtatga ggaggagcag gaagccaagg ccgagctgca gagggccatg tccaaggcca
     4201 acagcgaggt ggcccagtgg aggacgaaat atgagacgga tgccatccag cgcacggagg
     4261 agctggagga ggccaagaag aagctggctc agcgtctgca ggatgctgag gagcacgtag
     4321 aagctgtgaa ttccaagtgt gcttctcttg aaaagacgaa gcagcggctg cagaatgagg
     4381 tggaggacct catgattgac gtggagaggt ccaacgctgc ctgcgctgcg cttgataaga
     4441 agcagaggaa ctttgacaag gtcctggcag aatggaaaca gaagtatgag gaaactcagg
     4501 ctgagctcga agcctcccag aaggagtccc gttctctcag cacggagctg ttcaaggtga
     4561 agaacgccta tgaggagtct ctggatcaac tggagacgct aaagagagag aacaagaatc
     4621 tacagcagga gatttctgac ctgaccgagc agatcgcaga gggagggaag catatccacg
     4681 agctggagaa aatcaagaag caaattgacc aggaaaagag tgaattacag gcgtctctgg
     4741 aggaagcgga ggcctccctt gagcatgaag aaggtaaaat cctacgcatc cagctggagt
     4801 tgaaccaggt gaaatccgag attgaccgca aaattgctga aaaagacgaa gaaatcgatc
     4861 agctgaagag aaaccacctc agagtagtgg agtccatgca aagcacactg gacgctgaga
     4921 tccgcagcag aaacgatgct ctgaggatta agaagaagat ggagggcgac ctcaatgaaa
     4981 tggaaatcca gttgaaccat gccaaccgcc aggctgcaga ggccatcagg aaccttagga
     5041 acacacaggg aatgctcaag gacacgcagc tgcacctgga cgatgctctc agaggccagg
     5101 atgacttgaa agagcagctg gccatggttg agcgcagggc aaacctgatg caggctgaga
     5161 tcgaggaact cagggcatcc ctggaacaga cagagaggag caggagagtg gctgagcaag
     5221 agctactgga tgccagtgag cgtgtgcagc tcctgcacac ccagaacacc agcctcatca
     5281 acaccaagaa gaagctggag acagacattt cccagatcca gggagagatg gaggacatcg
     5341 tccaggaagc ccgcaatgca gaagagaagg ccaagaaagc catcactgac gccgccatga
     5401 tggcggagga gctgaagaag gagcaggaca ccagcgccca cctggagcgg atgaagaaga
     5461 acatggagca gacggtgaag gacctgcagc accgtctgga cgaggctgag cagctggcgc
     5521 tgaagggcgg caagaagcag atccagaaac tggaggccag agtgagggag cttgaaaacg
     5581 aggtggaaaa tgaacagaag cgcaacattg aagctgtcaa gggtcttcgc aagcatgaga
     5641 gaagagtaaa ggaactcacc taccagaccg aggaggaccg caagaacgtg ctgaggctgc
     5701 aggacctagt ggataaatta cagactaaag tgaaagccta caagagacaa gcagaggagg
     5761 ctgaggaaca atccaacgtc aacctggcca agttccgcaa gatccagcac gagctggagg
     5821 aagccgagga gcgggccgac atcgccgagt cccaggtcaa caagctgcgg gtgaagagcc
     5881 gagaggttca caccaaagtc ataagcgaag aatagctcaa ttccttctgt tgaaaggtga
     5941 cagaagaaat cacacaatgt gacgttcttt gtcactgtcc tgtatatcaa ggaaataaaa
     6001 gctgcagata attttgcaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     6061 aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
